Gene: RUNX1 (runt-related transcription factor 1)  Homo sapiens
Symbol: RUNX1
Name: runt-related transcription factor 1
Description: Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acute myeloid leukemia 1 protein; AML1; aml1 oncogene; AML1-EVI-1; AML1-EVI-1 fusion protein; AMLCR1; CBF-alpha-2; CBFA2; core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit 2; EVI-1; oncogene AML-1; OTTHUMP00000108696; OTTHUMP00000108697; OTTHUMP00000108699; OTTHUMP00000108700; OTTHUMP00000108702; PEA2-alpha B; PEBP2-alpha B; PEBP2aB; polyomavirus enhancer-binding protein 2 alpha B subunit; runt related transcription factor 1; runt-related transcription factor 1; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit
Orthologs: Mus musculus : Runx1 (runt related transcription factor 1)  MGI
Rattus norvegicus : Runx1 (runt-related transcription factor 1)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_12126,706,970 - 26,968,605-NCBI
Human Genome Assembly HuRef2121,639,088 - 21,900,490-NCBI
Human Genome Assembly GRCh372136,160,098 - 36,421,595-NCBI
Human Genome Assembly Build 362135,081,968 - 35,343,465-NCBI
Human Cytogenetic Map21q22.3 NCBI
Human Genome Assembly2135,081,968 - 35,343,465 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

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RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
  
More on RUNX1
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 736526
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2013-04-30
Status: ACTIVE



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