GLRX (glutaredoxin (thioltransferase))

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Keyword

Gene: GLRX (glutaredoxin (thioltransferase)) Homo sapiens

Symbol:

GLRX

Name:

glutaredoxin (thioltransferase)

Description:

This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

FLJ43648; glutaredoxin 1 (thioltransferase); glutaredoxin-1; GRX; GRX1; MGC117407; OTTHUMP00000149979; OTTHUMP00000222608; OTTHUMP00000222609; OTTHUMP00000222610; OTTHUMP00000222611; thioltransferase-1; TTase-1

Orthologs:

Mus musculus : Glrx (glutaredoxin) MGI
Rattus norvegicus : Glrx (glutaredoxin (thioltransferase))

Related Pseudogenes:

GLRXP1 GLRXP2 GLRXP3

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	5	95,433,246 - 95,442,270	-	NCBI
Human Genome Assembly HuRef	5	90,339,863 - 90,348,899	-	NCBI
Human Genome Assembly GRCh37	5	95,149,553 - 95,158,577	-	NCBI
Human Genome Assembly Build 36	5	95,175,431 - 95,184,137	-	NCBI
Human Cytogenetic Map	5	q14		NCBI
Human Genome Assembly	5	95,175,430 - 95,184,137		NCBI