SFTPA1 (surfactant protein A1) - Rat Genome Database

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Keyword

Gene: SFTPA1 (surfactant protein A1) Homo sapiens

Symbol:

SFTPA1

Name:

surfactant protein A1

Description:

This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

35 kDa pulmonary surfactant-associated protein; alveolar proteinosis protein; COLEC4; collectin-4; FLJ50593; FLJ51913; FLJ61144; FLJ77898; FLJ79095; FLJ99559; MGC133365; MGC198590; OTTHUMP00000019928; OTTHUMP00000019929; OTTHUMP00000019930; OTTHUMP00000019931; PSAP; PSP-A; PSPA; pulmonary surfactant-associated protein A1; SFTP1; SFTPA1B; SP-A; SP-A1; SPA; SPA1; surfactant protein A1 variant AB'D' 6A; surfactant protein A1 variant AB'D' 6A2; surfactant protein A1 variant AB'D' 6A3; surfactant protein A1 variant AB'D' 6A4; surfactant protein A1 variant ACD' 6A; surfactant protein A1 variant ACD' 6A2; surfactant protein A1 variant ACD' 6A3; surfactant protein A1 variant ACD' 6A4; surfactant protein A1 variant AD' 6A; surfactant protein A1 variant AD' 6A2; surfactant protein A1 variant AD' 6A3; surfactant protein A1 variant AD' 6A4; surfactant protein A1B; surfactant, pulmonary-associated protein A1A; surfactant, pulmonary-associated protein A1B

Orthologs:

Mus musculus : Sftpa1 (surfactant associated protein A1) MGI
Rattus norvegicus : Sftpa1 (surfactant protein A1)

Latest Assembly:

Human Genome Assembly GRCh37

NCBI Annotation Information:

Note: In the NCBI Build 36 reference assembly, there were four SFTPA genes on chromosome 10, with the SFTPA1/SFTPA2 gene pair being centromeric to a SFTPA1B/SFTPA2B pair. In June 2009, the Genome Reference Consortium determined that the duplicated region containing one of these gene pairs is in error, and thus, only one SFTPA1/SFTPA2 pair is present in the GRCh37 reference assembly. The HUGO Gene Nomenclature Committee (HGNC) retired the symbol SFTPA1B, because its sequence is redundant with SFTPA1. [14 Jun 2007]

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	10	81,743,377 - 81,747,880	+	NCBI
Human Genome Assembly HuRef	10	75,365,719 - 75,370,230	+	NCBI
Human Genome Assembly GRCh37	10	81,370,695 - 81,375,199	+	NCBI
Human Genome Assembly Build 36	10	81,040,722 - 81,045,208	+	NCBI
Human Cytogenetic Map	10	q22.3		NCBI
Human Genome Assembly	10	81,360,663 - 81,363,921		NCBI