Gene: AKAP13 (A kinase (PRKA) anchor protein 13)  Homo sapiens
Symbol: AKAP13
Name: A kinase (PRKA) anchor protein 13
Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A-kinase anchor protein 13; A-kinase anchoring protein; AKAP-13; AKAP-13; AKAP-Lbc; ARHGEF13; breast cancer nuclear receptor-binding auxiliary protein; BRX; c-lbc; FLJ11952; FLJ43341; guanine nucleotide exchange factor Lbc; HA-3; Ht31; human thyroid-anchoring protein 31; LBC; LBC oncogene; lymphoid blast crisis oncogene; non-oncogenic Rho GTPase-specific GTP exchange factor; p47; p47; PRKA13; protein kinase A-anchoring protein 13; PROTO-LB; PROTO-LBC
Orthologs: Mus musculus : Akap13 (A kinase (PRKA) anchor protein 13)  MGI
Rattus norvegicus : Akap13 (A kinase (PRKA) anchor protein 13)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11565,649,452 - 66,018,480+NCBI
Human Genome Assembly HuRef1561,986,401 - 62,354,887+NCBI
Human Genome Assembly GRCh371585,923,847 - 86,292,589+NCBI
Human Genome Assembly Build 361583,724,875 - 84,093,590+NCBI
Human Cytogenetic Map15q24-q25 NCBI
Human Genome Assembly1584,021,271 - 84,093,590 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

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QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
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Additional Information

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Nomenclature History
  
More on AKAP13
Entrez Gene
Ensembl Gene
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Vista + UCSC

RGD Object Information
RGD ID: 736118
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2013-04-30
Status: ACTIVE



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