Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | Prkab2 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of PRKAB2 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | multiple interactions | ISO | Prkab2 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PRKAB2 mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | ISO | Prkab2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PRKAB2 mRNA | CTD | PMID:22206623 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | EXP | | 6480464 | Dihydrotestosterone results in increased expression of PRKAB2 mRNA | CTD | PMID:29581250 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:27291303 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:19095052 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PRKAB2 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Prkab2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PRKAB2 mRNA | CTD | PMID:21570461 and PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PRKAB2 mRNA | CTD | PMID:20106945 and PMID:21632981 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Prkab2 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PRKAB2 mRNA | CTD | PMID:20188158 | 3-methylcholanthrene | multiple interactions | EXP | | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to PRKAB2 promoter] | CTD | PMID:20348232 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Prkab2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of PRKAB2 gene | CTD | PMID:31683443 | 4-vinylcyclohexene dioxide | affects expression | ISO | Prkab2 (Mus musculus) | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of PRKAB2 mRNA | CTD | PMID:20829426 | 6-propyl-2-thiouracil | decreases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of PRKAB2 mRNA | CTD | PMID:30047161 | adefovir pivoxil | decreases expression | EXP | | 6480464 | adefovir dipivoxil results in decreased expression of PRKAB2 mRNA | CTD | PMID:25596134 | aflatoxin B1 | increases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of PRKAB2 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | EXP | | 6480464 | Aflatoxin B1 results in decreased methylation of PRKAB2 gene | CTD | PMID:27153756 | amitrole | decreases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of PRKAB2 mRNA | CTD | PMID:30047161 | ammonium chloride | affects expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of PRKAB2 mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | EXP | | 6480464 | Antirheumatic Agents results in increased expression of PRKAB2 mRNA | CTD | PMID:24449571 | atrazine | decreases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Atrazine results in decreased expression of PRKAB2 mRNA | CTD | PMID:30360616 | atrazine | multiple interactions | ISO | Prkab2 (Mus musculus) | 6480464 | Lycopene inhibits the reaction [Atrazine results in decreased expression of PRKAB2 mRNA] | CTD | PMID:30360616 | benzo[a]pyrene | decreases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of PRKAB2 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of PRKAB2 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of PRKAB2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PRKAB2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | increases expression | EXP | | 6480464 | 7 more ... | CTD | PMID:26238291 | bisphenol A | decreases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of PRKAB2 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | Prkab2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PRKAB2 mRNA | CTD | PMID:32156529 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of PRKAB2 mRNA | CTD | PMID:25596134 | caffeine | decreases phosphorylation | EXP | | 6480464 | Caffeine results in decreased phosphorylation of PRKAB2 protein | CTD | PMID:35688186 | cantharidin | decreases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Cantharidin results in decreased expression of PRKAB2 mRNA | CTD | PMID:36907384 | carbamazepine | affects expression | EXP | | 6480464 | Carbamazepine affects the expression of PRKAB2 mRNA | CTD | PMID:25979313 | carbon nanotube | decreases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of PRKAB2 mRNA | CTD | PMID:25554681 | chloroacetaldehyde | decreases expression | EXP | | 6480464 | chloroacetaldehyde results in decreased expression of PRKAB2 mRNA | CTD | PMID:25596134 | chlorpyrifos | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Chlorpyrifos results in increased expression of PRKAB2 mRNA | CTD | PMID:17452286 | choline | multiple interactions | ISO | Prkab2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRKAB2 mRNA | CTD | PMID:20938992 | cidofovir anhydrous | decreases expression | EXP | | 6480464 | Cidofovir results in decreased expression of PRKAB2 mRNA | CTD | PMID:25596134 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of PRKAB2 mRNA | CTD | PMID:25596134 | clodronic acid | decreases expression | EXP | | 6480464 | Clodronic Acid results in decreased expression of PRKAB2 mRNA | CTD | PMID:25596134 | copper atom | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PRKAB2 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | EXP | | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of PRKAB2 mRNA | CTD | PMID:20971185 | coumarin | affects phosphorylation | EXP | | 6480464 | coumarin affects the phosphorylation of PRKAB2 protein | CTD | PMID:35688186 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of PRKAB2 mRNA | CTD | PMID:25562108 | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of PRKAB2 mRNA | CTD | PMID:25596134 | decabromodiphenyl ether | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | decabromobiphenyl ether results in increased expression of PRKAB2 mRNA | CTD | PMID:23640034 | diazinon | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Diazinon results in increased expression of PRKAB2 mRNA | CTD | PMID:17452286 | dibutyl phthalate | decreases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Dibutyl Phthalate results in decreased expression of PRKAB2 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of PRKAB2 mRNA | CTD | PMID:17361019 and PMID:21266533 | dioxygen | decreases expression | EXP | | 6480464 | Oxygen deficiency results in decreased expression of PRKAB2 mRNA | CTD | PMID:25596134 | doxorubicin | decreases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of PRKAB2 mRNA | CTD | PMID:17888722 | ethanol | affects splicing | ISO | Prkab2 (Mus musculus) | 6480464 | Ethanol affects the splicing of PRKAB2 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | EXP | | 6480464 | Ethyl Methanesulfonate results in increased expression of PRKAB2 mRNA | CTD | PMID:23649840 | fenofibrate | increases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Fenofibrate results in increased expression of PRKAB2 mRNA | CTD | PMID:21318169 | fenofibrate | multiple interactions | ISO | Prkab2 (Mus musculus) | 6480464 | [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of PRKAB2 mRNA | CTD | PMID:21318169 | flutamide | decreases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Flutamide results in decreased expression of PRKAB2 mRNA | CTD | PMID:24793618 | folic acid | multiple interactions | ISO | Prkab2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRKAB2 mRNA more ... | CTD | PMID:20938992 and PMID:22206623 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of PRKAB2 mRNA | CTD | PMID:21867686 | formaldehyde | increases expression | EXP | | 6480464 | Formaldehyde results in increased expression of PRKAB2 mRNA | CTD | PMID:23649840 | FR900359 | increases phosphorylation | EXP | | 6480464 | FR900359 results in increased phosphorylation of PRKAB2 protein | CTD | PMID:37730182 | graphite | affects expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Graphite affects the expression of PRKAB2 mRNA | CTD | PMID:29933104 | hydrogen peroxide | affects expression | EXP | | 6480464 | Hydrogen Peroxide affects the expression of PRKAB2 mRNA | CTD | PMID:20044591 | ibuprofen | decreases expression | EXP | | 6480464 | Ibuprofen results in decreased expression of PRKAB2 mRNA | CTD | PMID:25596134 | ifosfamide | affects expression | EXP | | 6480464 | Ifosfamide affects the expression of PRKAB2 mRNA | CTD | PMID:25596134 | L-methionine | multiple interactions | ISO | Prkab2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRKAB2 mRNA | CTD | PMID:20938992 | lead(0) | affects expression | EXP | | 6480464 | Lead affects the expression of PRKAB2 mRNA | CTD | PMID:28903495 | leflunomide | decreases expression | EXP | | 6480464 | leflunomide results in decreased expression of PRKAB2 mRNA | CTD | PMID:28988120 | lycopene | multiple interactions | ISO | Prkab2 (Mus musculus) | 6480464 | Lycopene inhibits the reaction [Atrazine results in decreased expression of PRKAB2 mRNA] | CTD | PMID:30360616 | manganese(II) chloride | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | manganese chloride results in increased expression of PRKAB2 mRNA | CTD | PMID:28801915 | menadione | affects expression | EXP | | 6480464 | Vitamin K 3 affects the expression of PRKAB2 mRNA | CTD | PMID:20044591 | menadione | decreases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Vitamin K 3 results in decreased expression of PRKAB2 mRNA | CTD | PMID:25270620 | metformin | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Metformin results in increased expression of PRKAB2 mRNA | CTD | PMID:25596134 | methimazole | decreases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of PRKAB2 mRNA | CTD | PMID:30047161 | methotrexate | increases expression | EXP | | 6480464 | Methotrexate results in increased expression of PRKAB2 mRNA | CTD | PMID:24449571 | methyl methanesulfonate | increases expression | EXP | | 6480464 | Methyl Methanesulfonate results in increased expression of PRKAB2 mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | EXP | | 6480464 | methylmercuric chloride results in increased expression of PRKAB2 mRNA | CTD | PMID:28001369 | mono(2-ethylhexyl) phthalate | increases expression | ISO | Prkab2 (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of PRKAB2 mRNA | CTD | PMID:32522588 | N-methyl-4-phenylpyridinium | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of PRKAB2 mRNA | CTD | PMID:28801915 | nickel atom | decreases expression | EXP | | 6480464 | Nickel results in decreased expression of PRKAB2 mRNA | CTD | PMID:25583101 | nickel sulfate | decreases expression | EXP | | 6480464 | nickel sulfate results in decreased expression of PRKAB2 mRNA | CTD | PMID:22714537 | ozone | multiple interactions | ISO | Prkab2 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PRKAB2 mRNA | CTD | PMID:34911549 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PRKAB2 mRNA | CTD | PMID:21420995 | paracetamol | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of PRKAB2 mRNA | CTD | PMID:33387578 | phenethyl isothiocyanate | increases expression | EXP | | 6480464 | phenethyl isothiocyanate results in increased expression of PRKAB2 mRNA | CTD | PMID:26678675 | quercetin | decreases expression | EXP | | 6480464 | Quercetin results in decreased expression of PRKAB2 mRNA | CTD | PMID:21632981 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of PRKAB2 mRNA | CTD | PMID:28595984 more ... | sunitinib | increases expression | EXP | | 6480464 | Sunitinib results in increased expression of PRKAB2 mRNA | CTD | PMID:31533062 | testosterone enanthate | affects expression | EXP | | 6480464 | testosterone enanthate affects the expression of PRKAB2 mRNA | CTD | PMID:17440010 | tetrachloromethane | affects expression | ISO | Prkab2 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of PRKAB2 mRNA | CTD | PMID:17484886 | tetrachloromethane | increases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of PRKAB2 mRNA | CTD | PMID:31919559 | tetrachloromethane | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of PRKAB2 mRNA | CTD | PMID:31150632 | tetracycline | increases expression | ISO | Prkab2 (Mus musculus) | 6480464 | Tetracycline results in increased expression of PRKAB2 mRNA | CTD | PMID:16917069 | thimerosal | decreases expression | EXP | | 6480464 | Thimerosal results in decreased expression of PRKAB2 mRNA | CTD | PMID:27188386 | thioacetamide | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of PRKAB2 mRNA | CTD | PMID:23411599 | Triptolide | increases expression | ISO | Prkab2 (Rattus norvegicus) | 6480464 | triptolide results in increased expression of PRKAB2 mRNA | CTD | PMID:23639586 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of PRKAB2 mRNA | CTD | PMID:23179753 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of PRKAB2 mRNA | CTD | PMID:25979313 | zinc atom | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of PRKAB2 mRNA | CTD | PMID:22171008 | zinc(0) | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of PRKAB2 mRNA | CTD | PMID:22171008 | zoledronic acid | decreases expression | EXP | | 6480464 | zoledronic acid results in decreased expression of PRKAB2 mRNA | CTD | PMID:25596134 | |