Gene: IL5RA (interleukin 5 receptor, alpha)  Homo sapiens
Symbol: IL5RA
Name: interleukin 5 receptor, alpha
Description: The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD125; CD125 antigen; CDw125; HSIL5R3; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA; IL5R; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain; interleukin-5 receptor alpha subunit; interleukin-5 receptor subunit alpha; MGC26560; OTTHUMP00000115257; OTTHUMP00000115373; OTTHUMP00000206892; OTTHUMP00000206893; OTTHUMP00000206894; OTTHUMP00000206895; OTTHUMP00000206896; OTTHUMP00000206919
Orthologs: Mus musculus : Il5ra (interleukin 5 receptor, alpha)  MGI
Rattus norvegicus : Il5ra (interleukin 5 receptor, alpha)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_133,044,133 - 3,088,145-NCBI
Human Genome Assembly HuRef33,042,189 - 3,086,251-NCBI
Human Genome Assembly GRCh3733,108,008 - 3,152,058-NCBI
Human Genome Assembly Build 3633,086,421 - 3,127,031-NCBI
Human Cytogenetic Map3p26-p24 NCBI
Human Genome Assembly33,106,856 - 3,127,031 NCBI
Model

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Sequence

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Additional Information

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Nomenclature History
  
More on IL5RA
Entrez Gene
Ensembl Gene
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Vista + UCSC

RGD Object Information
RGD ID: 735921
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2013-03-06
Status: ACTIVE



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