KCNG3 (potassium voltage-gated channel modifier subfamily G member 3) - Rat Genome Database

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Gene: KCNG3 (potassium voltage-gated channel modifier subfamily G member 3) Homo sapiens
Analyze
Symbol: KCNG3
Name: potassium voltage-gated channel modifier subfamily G member 3
RGD ID: 735863
HGNC Page HGNC:18306
Description: Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in endoplasmic reticulum and plasma membrane. Part of voltage-gated potassium channel complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: KV10.1; KV6.3; LOC105374537; potassium channel, voltage gated modifier subfamily G, member 3; potassium voltage-gated channel subfamily G member 3; potassium voltage-gated channel, subfamily G, member 3; uncharacterized LOC105374537; voltage-gated potassium channel 6.3; voltage-gated potassium channel Kv10.1; voltage-gated potassium channel subunit Kv10.1; voltage-gated potassium channel subunit Kv6.3; voltage-gated potassium channel subunit Kv6.4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38242,388,352 - 42,493,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl242,442,017 - 42,493,982 (-)EnsemblGRCh38hg38GRCh38
GRCh37242,669,157 - 42,721,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36242,522,661 - 42,574,741 (-)NCBINCBI36Build 36hg18NCBI36
Build 34242,580,807 - 42,632,888NCBI
Celera242,509,472 - 42,561,403 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef242,403,435 - 42,455,714 (-)NCBIHuRef
CHM1_1242,598,567 - 42,650,647 (-)NCBICHM1_1
T2T-CHM13v2.0242,393,706 - 42,499,421 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. Sano Y, etal., FEBS Lett 2002 Feb 13;512(1-3):230-4.
Additional References at PubMed
PMID:12060745   PMID:12477932   PMID:15046870   PMID:15489334   PMID:16382104   PMID:17207965   PMID:19074135   PMID:21873635   PMID:22204340   PMID:26530050   PMID:29117863   PMID:29507755  
PMID:30718673   PMID:32393512   PMID:34857952  


Genomics

Comparative Map Data
KCNG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38242,388,352 - 42,493,982 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl242,442,017 - 42,493,982 (-)EnsemblGRCh38hg38GRCh38
GRCh37242,669,157 - 42,721,122 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36242,522,661 - 42,574,741 (-)NCBINCBI36Build 36hg18NCBI36
Build 34242,580,807 - 42,632,888NCBI
Celera242,509,472 - 42,561,403 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef242,403,435 - 42,455,714 (-)NCBIHuRef
CHM1_1242,598,567 - 42,650,647 (-)NCBICHM1_1
T2T-CHM13v2.0242,393,706 - 42,499,421 (-)NCBIT2T-CHM13v2.0
Kcng3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391783,881,452 - 83,939,595 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1783,893,386 - 83,939,324 (-)EnsemblGRCm39 Ensembl
GRCm381783,574,023 - 83,631,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1783,585,957 - 83,631,895 (-)EnsemblGRCm38mm10GRCm38
MGSCv371783,985,297 - 84,031,235 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361783,494,283 - 83,540,221 (-)NCBIMGSCv36mm8
Celera1787,928,594 - 87,993,545 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1753.64NCBI
Kcng3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8616,803,842 - 16,851,791 (+)NCBIGRCr8
mRatBN7.2611,051,311 - 11,099,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl611,051,134 - 11,099,264 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx611,345,533 - 11,393,536 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0611,654,858 - 11,702,861 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0611,167,797 - 11,215,815 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.066,794,808 - 6,842,758 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl66,794,808 - 6,842,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.066,749,225 - 6,797,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.466,947,526 - 6,995,735 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.166,947,767 - 6,995,429 (-)NCBI
Celera610,756,043 - 10,803,960 (+)NCBICelera
Cytogenetic Map6q12NCBI
Kcng3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554419,816,209 - 9,860,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554419,813,391 - 9,859,960 (-)NCBIChiLan1.0ChiLan1.0
KCNG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21283,914,398 - 84,019,873 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A83,918,371 - 84,023,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A42,513,259 - 42,593,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A43,392,545 - 43,443,078 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A43,392,545 - 43,443,084 (-)Ensemblpanpan1.1panPan2
KCNG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11733,999,911 - 34,080,415 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,022,261 - 34,080,603 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1733,804,516 - 33,851,663 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01734,802,688 - 34,850,084 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11733,927,604 - 33,975,280 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01733,989,902 - 34,037,224 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,207,516 - 34,255,093 (-)NCBIUU_Cfam_GSD_1.0
Kcng3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629237,750,522 - 37,787,396 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365089,178,964 - 9,220,221 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365089,179,131 - 9,216,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl397,830,678 - 97,885,064 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1397,830,795 - 97,887,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23103,965,694 - 104,021,093 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11464,756,221 - 64,812,337 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1464,756,825 - 64,810,421 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604547,094,441 - 47,151,636 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcng3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473824,130,784 - 24,173,631 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473824,127,981 - 24,173,728 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KCNG3
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p25.3-16.1(chr2:66097-55570637)x3 copy number gain See cases [RCV000052933] Chr2:66097..55570637 [GRCh38]
Chr2:66097..55797773 [GRCh37]
Chr2:56097..55651277 [NCBI36]
Chr2:2p25.3-16.1		 pathogenic
GRCh38/hg38 2p22.3-21(chr2:32849247-45016061)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052942]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052942]|See cases [RCV000052942] Chr2:32849247..45016061 [GRCh38]
Chr2:33074314..45243200 [GRCh37]
Chr2:32927818..45096704 [NCBI36]
Chr2:2p22.3-21		 pathogenic
GRCh38/hg38 2p22.1-16.1(chr2:40738282-57863821)x3 copy number gain See cases [RCV000052943] Chr2:40738282..57863821 [GRCh38]
Chr2:40965422..58090956 [GRCh37]
Chr2:40818926..57944460 [NCBI36]
Chr2:2p22.1-16.1		 pathogenic
GRCh38/hg38 2p21(chr2:41999414-42915744)x3 copy number gain See cases [RCV000052944] Chr2:41999414..42915744 [GRCh38]
Chr2:42226554..43142884 [GRCh37]
Chr2:42080058..42996388 [NCBI36]
Chr2:2p21		 pathogenic
NM_133329.5(KCNG3):c.666-1G>A single nucleotide variant Malignant melanoma [RCV000065595] Chr2:42444580 [GRCh38]
Chr2:42671720 [GRCh37]
Chr2:42525224 [NCBI36]
Chr2:2p21		 not provided
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p21(chr2:42347475-42611298)x1 copy number loss See cases [RCV000142198] Chr2:42347475..42611298 [GRCh38]
Chr2:42574615..42838438 [GRCh37]
Chr2:42428119..42691942 [NCBI36]
Chr2:2p21		 uncertain significance|conflicting data from submitters
GRCh38/hg38 2p25.3-21(chr2:236816-45983232)x3 copy number gain See cases [RCV000143682] Chr2:236816..45983232 [GRCh38]
Chr2:236816..46210371 [GRCh37]
Chr2:226816..46063875 [NCBI36]
Chr2:2p25.3-21		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p23.3-16.1(chr2:27861707-60790985)x3 copy number gain See cases [RCV000454271] Chr2:27861707..60790985 [GRCh37]
Chr2:2p23.3-16.1		 pathogenic
GRCh37/hg19 2p23.2-21(chr2:28069882-43543420)x3 copy number gain See cases [RCV000447397] Chr2:28069882..43543420 [GRCh37]
Chr2:2p23.2-21		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NC_000002.11:g.38121110_47669522inv inversion Hereditary nonpolyposis colorectal neoplasms [RCV002231155] Chr2:38121110..47669522 [GRCh37]
Chr2:2p22.2-21		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p22.3-16.1(chr2:34792916-56676541)x3 copy number gain not provided [RCV000682169] Chr2:34792916..56676541 [GRCh37]
Chr2:2p22.3-16.1		 pathogenic
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3		 likely pathogenic
GRCh37/hg19 2p24.1-16.3(chr2:22665048-52850368)x3 copy number gain not provided [RCV000752875] Chr2:22665048..52850368 [GRCh37]
Chr2:2p24.1-16.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p21(chr2:42575687-42838431)x1 copy number loss not provided [RCV000845690] Chr2:42575687..42838431 [GRCh37]
Chr2:2p21		 uncertain significance
GRCh37/hg19 2p23.3-21(chr2:24881528-43460021)x3 copy number gain not provided [RCV001532444] Chr2:24881528..43460021 [GRCh37]
Chr2:2p23.3-21		 likely pathogenic
NM_133329.6(KCNG3):c.1111A>G (p.Met371Val) single nucleotide variant Inborn genetic diseases [RCV003253603] Chr2:42444134 [GRCh38]
Chr2:42671274 [GRCh37]
Chr2:2p21		 uncertain significance
GRCh37/hg19 2p23.3-21(chr2:24601818-43466284)x3 copy number gain See cases [RCV001581099] Chr2:24601818..43466284 [GRCh37]
Chr2:2p23.3-21		 pathogenic
GRCh37/hg19 2p21(chr2:42706834-42886431)x1 copy number loss not provided [RCV001258531] Chr2:42706834..42886431 [GRCh37]
Chr2:2p21		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p22.1-21(chr2:39751028-43437611) copy number loss not specified [RCV002052471] Chr2:39751028..43437611 [GRCh37]
Chr2:2p22.1-21		 uncertain significance
NC_000002.11:g.(?_38121051)_(47710088_?)dup duplication Hereditary nonpolyposis colorectal neoplasms [RCV003122260] Chr2:38121051..47710088 [GRCh37]
Chr2:2p22.2-21		 uncertain significance
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13		 pathogenic
NM_133329.6(KCNG3):c.437A>C (p.Glu146Ala) single nucleotide variant Inborn genetic diseases [RCV002765308] Chr2:42493065 [GRCh38]
Chr2:42720205 [GRCh37]
Chr2:2p21		 uncertain significance
NM_133329.6(KCNG3):c.632G>A (p.Arg211Lys) single nucleotide variant Inborn genetic diseases [RCV002767174] Chr2:42492870 [GRCh38]
Chr2:42720010 [GRCh37]
Chr2:2p21		 uncertain significance
NM_133329.6(KCNG3):c.362C>T (p.Ser121Phe) single nucleotide variant Inborn genetic diseases [RCV002747969] Chr2:42493140 [GRCh38]
Chr2:42720280 [GRCh37]
Chr2:2p21		 uncertain significance
NM_133329.6(KCNG3):c.697A>G (p.Thr233Ala) single nucleotide variant Inborn genetic diseases [RCV002723277] Chr2:42444548 [GRCh38]
Chr2:42671688 [GRCh37]
Chr2:2p21		 uncertain significance
NM_133329.6(KCNG3):c.169G>C (p.Glu57Gln) single nucleotide variant Inborn genetic diseases [RCV003209701] Chr2:42493333 [GRCh38]
Chr2:42720473 [GRCh37]
Chr2:2p21		 uncertain significance
GRCh37/hg19 2p23.1-21(chr2:30814984-42798684)x1 copy number loss not specified [RCV003986376] Chr2:30814984..42798684 [GRCh37]
Chr2:2p23.1-21		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1470
Count of miRNA genes:540
Interacting mature miRNAs:608
Transcripts:ENST00000306078, ENST00000394973
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G63099  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37242,716,722 - 42,717,025UniSTSGRCh37
Build 36242,570,226 - 42,570,529RGDNCBI36
Celera242,556,885 - 42,557,188RGD
Cytogenetic Map2p21UniSTS
HuRef242,451,207 - 42,451,500UniSTS
D2S1825  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37242,696,627 - 42,696,859UniSTSGRCh37
Build 36242,550,131 - 42,550,363RGDNCBI36
Celera242,536,930 - 42,537,162RGD
Cytogenetic Map2p21UniSTS
HuRef242,430,895 - 42,431,127UniSTS
Whitehead-RH Map2198.5UniSTS
RH143571  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37242,720,091 - 42,720,323UniSTSGRCh37
Build 36242,573,595 - 42,573,827RGDNCBI36
Celera242,560,256 - 42,560,488RGD
Cytogenetic Map2p21UniSTS
HuRef242,454,568 - 42,454,800UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1 1 1 5 1 112 1 13 12
Low 266 475 15 18 15 827 40 1936 58 642 264 3 1 2 663 1
Below cutoff 1481 956 548 214 572 81 2398 779 1393 207 719 931 140 954 1225 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000306078   ⟹   ENSP00000304127
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl242,442,017 - 42,493,982 (-)Ensembl
RefSeq Acc Id: ENST00000394973   ⟹   ENSP00000378424
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl242,442,032 - 42,493,977 (-)Ensembl
RefSeq Acc Id: NM_133329   ⟹   NP_579875
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38242,442,017 - 42,493,982 (-)NCBI
GRCh37242,669,157 - 42,721,237 (-)RGD
Build 36242,522,661 - 42,574,741 (-)NCBI Archive
Celera242,509,472 - 42,561,403 (-)RGD
HuRef242,403,435 - 42,455,714 (-)RGD
CHM1_1242,598,567 - 42,650,647 (-)NCBI
T2T-CHM13v2.0242,447,453 - 42,499,421 (-)NCBI
Sequence:
RefSeq Acc Id: NM_172344   ⟹   NP_758847
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38242,442,017 - 42,493,982 (-)NCBI
GRCh37242,669,157 - 42,721,237 (-)RGD
Build 36242,522,661 - 42,574,741 (-)NCBI Archive
Celera242,509,472 - 42,561,403 (-)RGD
HuRef242,403,435 - 42,455,714 (-)RGD
CHM1_1242,598,567 - 42,650,647 (-)NCBI
T2T-CHM13v2.0242,447,453 - 42,499,421 (-)NCBI
Sequence:
RefSeq Acc Id: XR_007069666
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38242,388,352 - 42,493,982 (-)NCBI
RefSeq Acc Id: XR_008486299
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0242,393,706 - 42,499,421 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_579875   ⟸   NM_133329
- Peptide Label: isoform 1
- UniProtKB: Q53SC1 (UniProtKB/Swiss-Prot),   Q8TAE7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_758847   ⟸   NM_172344
- Peptide Label: isoform 2
- UniProtKB: Q8TAE7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000304127   ⟸   ENST00000306078
RefSeq Acc Id: ENSP00000378424   ⟸   ENST00000394973

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8TAE7-F1-model_v2 AlphaFold Q8TAE7 1-436 view protein structure

Promoters
RGD ID:6860174
Promoter ID:EPDNEW_H3252
Type:initiation region
Name:KCNG3_1
Description:potassium voltage-gated channel modifier subfamily G member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38242,493,977 - 42,494,037EPDNEW
RGD ID:6797326
Promoter ID:HG_KWN:32398
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:ENST00000404422,   ENST00000405592,   ENST00000407047,   NM_133329,   NM_172344
Position:
Human AssemblyChrPosition (strand)Source
Build 36242,574,426 - 42,575,627 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18306 AgrOrtholog
COSMIC KCNG3 COSMIC
Ensembl Genes ENSG00000171126 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000306078 ENTREZGENE
  ENST00000306078.2 UniProtKB/Swiss-Prot
  ENST00000394973 ENTREZGENE
  ENST00000394973.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
GTEx ENSG00000171126 GTEx
HGNC ID HGNC:18306 ENTREZGENE
Human Proteome Map KCNG3 Human Proteome Map
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv9 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  T1-type_BTB UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:170850 UniProtKB/Swiss-Prot
NCBI Gene 170850 ENTREZGENE
OMIM 606767 OMIM
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY G MEMBER 3 UniProtKB/Swiss-Prot
  PTHR11537 UniProtKB/Swiss-Prot
Pfam BTB_2 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PharmGKB PA30036 PharmGKB
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KV9CHANNEL UniProtKB/Swiss-Prot
  KVCHANNEL UniProtKB/Swiss-Prot
SMART BTB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt KCNG3_HUMAN UniProtKB/Swiss-Prot
  Q53SC1 ENTREZGENE
  Q8TAE7 ENTREZGENE
UniProt Secondary Q53SC1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-14 KCNG3  potassium voltage-gated channel modifier subfamily G member 3  LOC105374537  uncharacterized LOC105374537  Data merged from RGD:38662523 737654 PROVISIONAL
2016-02-10 KCNG3  potassium voltage-gated channel modifier subfamily G member 3  KCNG3  potassium channel, voltage gated modifier subfamily G, member 3  Symbol and/or name change 5135510 APPROVED
2015-01-20 KCNG3  potassium channel, voltage gated modifier subfamily G, member 3  KCNG3  potassium voltage-gated channel, subfamily G, member 3  Symbol and/or name change 5135510 APPROVED