ADORA3 (adenosine A3 receptor) - Rat Genome Database

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Gene: ADORA3 (adenosine A3 receptor) Homo sapiens
Analyze
Symbol: ADORA3
Name: adenosine A3 receptor
RGD ID: 735600
HGNC Page HGNC:268
Description: Predicted to enable G protein-coupled adenosine receptor activity. Involved in negative regulation of cell migration and negative regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse; dendrite; and neuromuscular junction.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A3AR; AD026; adenosine receptor A3; bA552M11.5; RP11-552M11.7
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,499,429 - 111,503,633 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,499,429 - 111,503,633 (-)EnsemblGRCh38hg38GRCh38
GRCh371112,042,051 - 112,046,255 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,827,493 - 111,908,120 (-)NCBINCBI36Build 36hg18NCBI36
Build 341111,754,096 - 111,758,785NCBI
Celera1110,272,892 - 110,353,227 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1109,897,418 - 109,977,884 (-)NCBIHuRef
CHM1_11112,140,977 - 112,221,562 (-)NCBICHM1_1
T2T-CHM13v2.01111,514,110 - 111,518,318 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
5. A role for the A3 adenosine receptor in determining tissue levels of cAMP and blood pressure: studies in knock-out mice. Zhao Z, etal., Biochim Biophys Acta 2000 Mar 17;1500(3):280-90.
Additional References at PubMed
PMID:2834384   PMID:7607699   PMID:8234299   PMID:8399349   PMID:8617363   PMID:8889548   PMID:9164961   PMID:9293494   PMID:9380026   PMID:9618527   PMID:9837869   PMID:11111832  
PMID:11214319   PMID:11891221   PMID:12152652   PMID:12406340   PMID:12435805   PMID:12477932   PMID:12600879   PMID:12695530   PMID:12975309   PMID:14688204   PMID:14978250   PMID:15028279  
PMID:15147729   PMID:15240539   PMID:15324660   PMID:15355922   PMID:15489334   PMID:15849244   PMID:16242072   PMID:16282197   PMID:16710414   PMID:16849509   PMID:17170310   PMID:17216675  
PMID:17348028   PMID:17728764   PMID:18051367   PMID:18240029   PMID:18351132   PMID:18577758   PMID:18636149   PMID:18653544   PMID:18996102   PMID:19019667   PMID:19086053   PMID:19095736  
PMID:19426966   PMID:19794965   PMID:19883624   PMID:19913121   PMID:20190146   PMID:20237496   PMID:20379614   PMID:20602615   PMID:20628086   PMID:20716228   PMID:20732875   PMID:21520073  
PMID:21542986   PMID:21675873   PMID:21715680   PMID:21830157   PMID:21841534   PMID:21873635   PMID:22146575   PMID:22217884   PMID:22319752   PMID:22378888   PMID:22433284   PMID:22682496  
PMID:22878643   PMID:22906537   PMID:23027555   PMID:23088669   PMID:23251661   PMID:23263788   PMID:23383108   PMID:23563604   PMID:23741498   PMID:23817552   PMID:23856527   PMID:23953133  
PMID:24024783   PMID:24114647   PMID:24161786   PMID:24750014   PMID:24864134   PMID:25597247   PMID:26186194   PMID:26194548   PMID:27886186   PMID:27893428   PMID:28230290   PMID:28342985  
PMID:28514442   PMID:28714368   PMID:29670017   PMID:29955603   PMID:30660649   PMID:30804043   PMID:31614517   PMID:31758354   PMID:32448869   PMID:32709103   PMID:33007835   PMID:33420353  
PMID:33472058   PMID:33524770   PMID:33961781   PMID:34360719  


Genomics

Comparative Map Data
ADORA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,499,429 - 111,503,633 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,499,429 - 111,503,633 (-)EnsemblGRCh38hg38GRCh38
GRCh371112,042,051 - 112,046,255 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,827,493 - 111,908,120 (-)NCBINCBI36Build 36hg18NCBI36
Build 341111,754,096 - 111,758,785NCBI
Celera1110,272,892 - 110,353,227 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1109,897,418 - 109,977,884 (-)NCBIHuRef
CHM1_11112,140,977 - 112,221,562 (-)NCBICHM1_1
T2T-CHM13v2.01111,514,110 - 111,518,318 (-)NCBIT2T-CHM13v2.0
Adora3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,811,737 - 105,816,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,778,174 - 105,816,242 (+)EnsemblGRCm39 Ensembl
GRCm383105,904,421 - 105,908,928 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,870,858 - 105,908,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv373105,673,776 - 105,726,960 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363106,032,542 - 106,036,410 (+)NCBIMGSCv36mm8
Celera3108,059,748 - 108,112,932 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.45NCBI
Adora3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82196,077,042 - 196,080,686 (+)NCBIGRCr8
mRatBN7.22193,352,759 - 193,392,946 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,388,713 - 193,392,357 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2200,983,156 - 200,986,800 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02198,878,989 - 198,882,630 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,695,946 - 193,699,587 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02208,492,231 - 208,536,910 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,530,864 - 208,534,506 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,373,154 - 208,376,803 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,900,059 - 227,955,985 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02227,743,778 - 227,796,705 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42201,157,782 - 201,161,425 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12201,120,535 - 201,124,179 (+)NCBI
Celera2186,090,081 - 186,093,723 (+)NCBICelera
RH 3.4 Map21369.2RGD
Cytogenetic Map2q34NCBI
LOC100980598
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,463,745 - 115,547,180 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,611,926 - 114,693,342 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,144,642 - 114,225,407 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11126,122,352 - 126,202,396 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1126,122,352 - 126,202,396 (+)Ensemblpanpan1.1panPan2
ADORA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11763,895,408 - 63,898,666 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1763,895,408 - 63,898,666 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1763,408,938 - 63,412,242 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01765,066,829 - 65,070,166 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1765,066,642 - 65,071,049 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11763,801,857 - 63,805,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01763,860,662 - 63,863,924 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01764,658,761 - 64,662,034 (+)NCBIUU_Cfam_GSD_1.0
LOC101973578
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505817,309,039 - 17,325,264 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936690152,777 - 168,411 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,854,357 - 108,873,925 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14108,854,300 - 108,857,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24119,036,224 - 119,039,693 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103224223
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,043,367 - 22,127,103 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,106,190 - 22,123,629 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,352,015 - 36,375,319 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adora3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247727,229,093 - 7,232,837 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247727,189,381 - 7,232,919 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADORA3
3 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p13.3-12(chr1:109756630-118650204)x3 copy number gain See cases [RCV000051827] Chr1:109756630..118650204 [GRCh38]
Chr1:110299252..119192827 [GRCh37]
Chr1:110100775..118994350 [NCBI36]
Chr1:1p13.3-12
pathogenic
GRCh38/hg38 1p21.2-13.2(chr1:101618097-111703028)x1 copy number loss See cases [RCV000053879] Chr1:101618097..111703028 [GRCh38]
Chr1:102083653..112245650 [GRCh37]
Chr1:101856241..112047173 [NCBI36]
Chr1:1p21.2-13.2
pathogenic
NM_000677.3(ADORA3):c.567C>T (p.Pro189=) single nucleotide variant Malignant melanoma [RCV000059835] Chr1:111500340 [GRCh38]
Chr1:112042962 [GRCh37]
Chr1:111844485 [NCBI36]
Chr1:1p13.2
not provided
GRCh38/hg38 1p21.1-12(chr1:104325484-119977655)x3 copy number gain See cases [RCV000142953] Chr1:104325484..119977655 [GRCh38]
Chr1:104868106..120471049 [GRCh37]
Chr1:104669629..120321801 [NCBI36]
Chr1:1p21.1-12
pathogenic
GRCh38/hg38 1p21.1-13.2(chr1:105468292-112190626)x1 copy number loss See cases [RCV000142760] Chr1:105468292..112190626 [GRCh38]
Chr1:106010914..112733248 [GRCh37]
Chr1:105812437..112534771 [NCBI36]
Chr1:1p21.1-13.2
pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p22.1-11.2(chr1:93837992-121343783)x3 copy number gain See cases [RCV000512354] Chr1:93837992..121343783 [GRCh37]
Chr1:1p22.1-11.2
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p13.3-13.2(chr1:110994179-112360446)x1 copy number loss not provided [RCV000849607] Chr1:110994179..112360446 [GRCh37]
Chr1:1p13.3-13.2
pathogenic
NM_000677.3(ADORA3):c.-581G>A single nucleotide variant not provided [RCV001644083] Chr1:111503935 [GRCh38]
Chr1:112046557 [GRCh37]
Chr1:1p13.2
benign
GRCh37/hg19 1p21.2-12(chr1:102021465-119737478) copy number loss Seizure [RCV001352640] Chr1:102021465..119737478 [GRCh37]
Chr1:1p21.2-12
pathogenic
GRCh37/hg19 1p13.3-11.2(chr1:111647582-121343783) copy number gain not specified [RCV002053602] Chr1:111647582..121343783 [GRCh37]
Chr1:1p13.3-11.2
pathogenic
GRCh37/hg19 1p21.3-13.2(chr1:95046805-114714931) copy number loss not specified [RCV002053503] Chr1:95046805..114714931 [GRCh37]
Chr1:1p21.3-13.2
pathogenic
NC_000001.10:g.(?_111145905)_(114454813_?)del deletion not provided [RCV003113195] Chr1:111145905..114454813 [GRCh37]
Chr1:1p13.3-13.2
pathogenic
NM_020683.7(TMIGD3):c.854G>C (p.Arg285Pro) single nucleotide variant Inborn genetic diseases [RCV002738421] Chr1:111486604 [GRCh38]
Chr1:112029226 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_020683.7(TMIGD3):c.991C>G (p.Pro331Ala) single nucleotide variant Inborn genetic diseases [RCV002737607] Chr1:111483740 [GRCh38]
Chr1:112026362 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_000677.4(ADORA3):c.617A>T (p.Asn206Ile) single nucleotide variant Inborn genetic diseases [RCV002757127] Chr1:111500290 [GRCh38]
Chr1:112042912 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_000677.4(ADORA3):c.681G>T (p.Lys227Asn) single nucleotide variant Inborn genetic diseases [RCV002788732] Chr1:111500226 [GRCh38]
Chr1:112042848 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_020683.7(TMIGD3):c.451A>G (p.Ile151Val) single nucleotide variant Inborn genetic diseases [RCV002763484] Chr1:111490662 [GRCh38]
Chr1:112033284 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_020683.7(TMIGD3):c.715C>T (p.Arg239Trp) single nucleotide variant Inborn genetic diseases [RCV002802583] Chr1:111488767 [GRCh38]
Chr1:112031389 [GRCh37]
Chr1:1p13.2
uncertain significance
NM_020683.7(TMIGD3):c.419T>C (p.Met140Thr) single nucleotide variant Inborn genetic diseases [RCV002679444] Chr1:111490694 [GRCh38]
Chr1:112033316 [GRCh37]
Chr1:1p13.2
uncertain significance
GRCh37/hg19 1p13.3-13.1(chr1:110066946-116672408)x1 copy number loss not provided [RCV003483294] Chr1:110066946..116672408 [GRCh37]
Chr1:1p13.3-13.1
pathogenic
GRCh37/hg19 1p13.3-13.2(chr1:109483388-112293512)x1 copy number loss not provided [RCV003483272] Chr1:109483388..112293512 [GRCh37]
Chr1:1p13.3-13.2
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2050
Count of miRNA genes:843
Interacting mature miRNAs:1028
Transcripts:ENST00000241356, ENST00000369716, ENST00000369717, ENST00000414219, ENST00000442484, ENST00000443498, ENST00000463993, ENST00000472933, ENST00000486342, ENST00000495493
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH69986  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371112,026,012 - 112,026,162UniSTSGRCh37
Build 361111,827,535 - 111,827,685RGDNCBI36
Celera1110,272,934 - 110,273,084RGD
Cytogenetic Map1p13.2UniSTS
HuRef1109,897,460 - 109,897,610UniSTS
GeneMap99-GB4 RH Map1353.69UniSTS
NCBI RH Map1846.5UniSTS
GDB:632846  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371112,042,347 - 112,042,532UniSTSGRCh37
Build 361111,843,870 - 111,844,055RGDNCBI36
Celera1110,289,272 - 110,289,457RGD
Cytogenetic Map1p13.2UniSTS
HuRef1109,913,772 - 109,913,957UniSTS
ADORA3_1557  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371112,041,858 - 112,042,690UniSTSGRCh37
Build 361111,843,381 - 111,844,213RGDNCBI36
Celera1110,288,783 - 110,289,615RGD
HuRef1109,913,283 - 109,914,115UniSTS
SHGC-12531  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371112,042,141 - 112,042,475UniSTSGRCh37
Build 361111,843,664 - 111,843,998RGDNCBI36
Celera1110,289,066 - 110,289,400RGD
Cytogenetic Map1p13.2UniSTS
HuRef1109,913,566 - 109,913,900UniSTS
Stanford-G3 RH Map15197.0UniSTS
GeneMap99-GB4 RH Map1351.58UniSTS
Whitehead-RH Map1411.4UniSTS
Whitehead-YAC Contig Map1 UniSTS
GeneMap99-G3 RH Map15153.0UniSTS
ADORA3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371112,042,689 - 112,043,099UniSTSGRCh37
Build 361111,844,212 - 111,844,622RGDNCBI36
Celera1110,289,614 - 110,290,024RGD
HuRef1109,914,114 - 109,914,524UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 103 132 95 5 93 1 297 26 467 3 10 86 4 143 215
Low 2049 2451 1131 267 992 125 2661 1292 2780 81 1065 1006 142 1024 1693
Below cutoff 64 385 211 136 353 120 1064 781 325 43 66 136 16 37 848

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_032119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH003597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL390195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL391063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY136749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF432324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM675096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX283401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD013875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GM047590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM765141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN855714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L20463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L22607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X76981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000241356   ⟹   ENSP00000241356
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1111,499,429 - 111,503,633 (-)Ensembl
RefSeq Acc Id: ENST00000486342
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1111,500,510 - 111,503,087 (-)Ensembl
RefSeq Acc Id: ENST00000495493
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1111,499,931 - 111,503,633 (-)Ensembl
RefSeq Acc Id: ENST00000632535   ⟹   ENSP00000488073
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1111,499,828 - 111,503,412 (-)Ensembl
RefSeq Acc Id: NM_000677   ⟹   NP_000668
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,499,429 - 111,503,633 (-)NCBI
GRCh371112,025,970 - 112,106,602 (-)NCBI
Build 361111,843,574 - 111,848,266 (-)NCBI Archive
HuRef1109,897,418 - 109,977,884 (-)ENTREZGENE
CHM1_11112,157,050 - 112,161,659 (-)NCBI
T2T-CHM13v2.01111,514,110 - 111,518,318 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001302678   ⟹   NP_001289607
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,499,429 - 111,503,633 (-)NCBI
CHM1_11112,157,050 - 112,161,659 (-)NCBI
T2T-CHM13v2.01111,514,110 - 111,518,318 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001302679   ⟹   NP_001289608
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,499,429 - 111,503,633 (-)NCBI
CHM1_11112,157,050 - 112,161,659 (-)NCBI
T2T-CHM13v2.01111,514,110 - 111,518,318 (-)NCBI
Sequence:
RefSeq Acc Id: NP_000668   ⟸   NM_000677
- Peptide Label: isoform A
- UniProtKB: Q6UWU0 (UniProtKB/Swiss-Prot),   P33765 (UniProtKB/Swiss-Prot),   A2A3P4 (UniProtKB/Swiss-Prot),   Q9BYZ1 (UniProtKB/Swiss-Prot),   P0DMS8 (UniProtKB/Swiss-Prot),   B2R7S2 (UniProtKB/TrEMBL),   H6VQ59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289608   ⟸   NM_001302679
- Peptide Label: isoform C
- UniProtKB: H6VQ59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289607   ⟸   NM_001302678
- Peptide Label: isoform B
- UniProtKB: A0A0J9YWR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000241356   ⟸   ENST00000241356
RefSeq Acc Id: ENSP00000488073   ⟸   ENST00000632535
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DMS8-F1-model_v2 AlphaFold P0DMS8 1-318 view protein structure

Promoters
RGD ID:6856610
Promoter ID:EPDNEW_H1470
Type:initiation region
Name:ADORA3_1
Description:adenosine A3 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1471  EPDNEW_H1472  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,503,633 - 111,503,693EPDNEW
RGD ID:6856612
Promoter ID:EPDNEW_H1471
Type:initiation region
Name:ADORA3_2
Description:adenosine A3 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1470  EPDNEW_H1472  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,505,038 - 111,505,098EPDNEW
RGD ID:6856614
Promoter ID:EPDNEW_H1472
Type:single initiation site
Name:ADORA3_3
Description:adenosine A3 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1470  EPDNEW_H1471  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,505,467 - 111,505,527EPDNEW
RGD ID:6784566
Promoter ID:HG_KWN:4126
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:ENST00000335940,   OTTHUMT00000032476,   OTTHUMT00000032477
Position:
Human AssemblyChrPosition (strand)Source
Build 361111,833,771 - 111,834,271 (-)MPROMDB
RGD ID:6784564
Promoter ID:HG_KWN:4128
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid,   NB4
Transcripts:NM_000677,   NM_020683,   OTTHUMT00000033066,   OTTHUMT00000033067
Position:
Human AssemblyChrPosition (strand)Source
Build 361111,847,694 - 111,848,194 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:268 AgrOrtholog
COSMIC ADORA3 COSMIC
Ensembl Genes ENSG00000282608 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000241356 ENTREZGENE
  ENST00000241356.5 UniProtKB/Swiss-Prot
  ENST00000632535 ENTREZGENE
  ENST00000632535.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000282608 GTEx
HGNC ID HGNC:268 ENTREZGENE
Human Proteome Map ADORA3 Human Proteome Map
InterPro Adeno_A3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenosn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:140 UniProtKB/Swiss-Prot
NCBI Gene 140 ENTREZGENE
OMIM 600445 OMIM
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR UniProtKB/TrEMBL
  ADENOSINE RECEPTOR A3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADORA3 RGD, PharmGKB
PRINTS ADENOSINEA3R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADENOSINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YWR0 ENTREZGENE, UniProtKB/TrEMBL
  A2A3P4 ENTREZGENE
  AA3R_HUMAN UniProtKB/Swiss-Prot
  B2R7S2 ENTREZGENE, UniProtKB/TrEMBL
  H6VQ59 ENTREZGENE, UniProtKB/TrEMBL
  P0DMS8 ENTREZGENE
  P33765 ENTREZGENE
  Q6UWU0 ENTREZGENE
  Q9BYZ1 ENTREZGENE
UniProt Secondary A2A3P4 UniProtKB/Swiss-Prot
  P33765 UniProtKB/Swiss-Prot
  Q6UWU0 UniProtKB/Swiss-Prot
  Q9BYZ1 UniProtKB/Swiss-Prot