Gene: MCM4 (minichromosome maintenance complex component 4)  Homo sapiens
Symbol: MCM4
Name: minichromosome maintenance complex component 4
Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC21; CDC21 homolog; CDC54; DNA replication licensing factor MCM4; hCdc21; homolog of S. pombe cell devision cycle 21; MCM4 minichromosome maintenance deficient 4; MGC33310; mini chromosome maintenance deficient 4 homolog (s. cerevisiae); minichromosome maintenance deficient 4; NKCD; NKGCD; OTTHUMP00000226180; OTTHUMP00000226181; OTTHUMP00000226184; P1-CDC21
Orthologs: Mus musculus : Mcm4 (minichromosome maintenance deficient 4 homolog (S. cerevisiae))  MGI
Rattus norvegicus : Mcm4 (minichromosome maintenance complex component 4)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_1848,967,019 - 48,984,976+NCBI
Human Genome Assembly HuRef844,335,726 - 44,353,327+NCBI
Human Genome Assembly GRCh37848,872,763 - 48,890,720+NCBI
Human Genome Assembly Build 36849,036,047 - 49,052,621+NCBI
Human Cytogenetic Map8q11.2 NCBI
Human Genome Assembly849,036,046 - 49,052,621 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

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Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
  
More on MCM4
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 735578
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2013-05-28
Status: ACTIVE



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