Gene: PSMD4 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 4)  Homo sapiens
Symbol: PSMD4
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 26S protease subunit S5a; 26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; AF; AF-1; angiocidin; antisecretory factor 1; ASF; MCB1; multiubiquitin chain binding protein; multiubiquitin chain-binding protein; OTTHUMP00000014286; OTTHUMP00000014287; proteasome (prosome, macropain) 26s subunit, non-atpase,4; pUB-R5; Rpn10; RPN10 homolog; S5A; S5a/antisecretory factor protein
Orthologs: Mus musculus : Psmd4 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 4)  MGI
Rattus norvegicus : Psmd4 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 4)
Related Pseudogenes: PSMD4P1  
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11157,728,954 - 157,741,710+NCBI
Human Genome Assembly HuRef1122,605,087 - 122,617,599+NCBI
Human Genome Assembly GRCh371151,227,197 - 151,239,955+NCBI
Human Genome Assembly Build 361149,493,821 - 149,506,579+NCBI
Human Cytogenetic Map1q21.3 NCBI
Human Genome Assembly1148,040,269 - 148,053,009 NCBI
Model

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Genomics

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QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
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Additional Information

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Nomenclature History
  
More on PSMD4
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 734297
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2013-03-06
Status: ACTIVE



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