OMP (olfactory marker protein) - Rat Genome Database

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Gene: OMP (olfactory marker protein) Homo sapiens
Analyze
Symbol: OMP
Name: olfactory marker protein
RGD ID: 734264
HGNC Page HGNC:8136
Description: Predicted to enable peptide binding activity. Predicted to be involved in sensory perception of smell. Predicted to act upstream of or within neurogenesis. Predicted to be located in cytoplasm and synapse. Predicted to be active in several cellular components, including axon; cytosol; and neuronal cell body.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory neuronal-specific protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381177,102,840 - 77,103,331 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1177,102,840 - 77,103,331 (+)EnsemblGRCh38hg38GRCh38
GRCh371176,813,886 - 76,814,377 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,491,534 - 76,492,025 (+)NCBINCBI36Build 36hg18NCBI36
Build 341176,491,533 - 76,492,025NCBI
Celera1174,121,370 - 74,121,861 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1173,111,234 - 73,111,725 (+)NCBIHuRef
CHM1_11176,697,137 - 76,697,628 (+)NCBICHM1_1
T2T-CHM13v2.01177,033,417 - 77,033,908 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IBA,IEA)
cytoplasm  (IEA)
cytosol  (IBA,IEA)
neuronal cell body  (IBA,IEA)
nucleus  (IBA,IEA)
synapse  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons. Buiakova OI, etal., Proc Natl Acad Sci U S A 1996 Sep 3;93(18):9858-63.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8034318   PMID:8499899   PMID:8754248   PMID:12054873   PMID:12477932   PMID:12911636   PMID:15489334   PMID:17207965   PMID:19913121   PMID:20628086   PMID:21873635   PMID:32703433  
PMID:33961781   PMID:36309704   PMID:36333725  


Genomics

Comparative Map Data
OMP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381177,102,840 - 77,103,331 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1177,102,840 - 77,103,331 (+)EnsemblGRCh38hg38GRCh38
GRCh371176,813,886 - 76,814,377 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,491,534 - 76,492,025 (+)NCBINCBI36Build 36hg18NCBI36
Build 341176,491,533 - 76,492,025NCBI
Celera1174,121,370 - 74,121,861 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1173,111,234 - 73,111,725 (+)NCBIHuRef
CHM1_11176,697,137 - 76,697,628 (+)NCBICHM1_1
T2T-CHM13v2.01177,033,417 - 77,033,908 (+)NCBIT2T-CHM13v2.0
Omp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,792,566 - 97,794,654 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl797,792,566 - 97,794,709 (-)EnsemblGRCm39 Ensembl
GRCm38798,143,359 - 98,145,447 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,143,359 - 98,145,502 (-)EnsemblGRCm38mm10GRCm38
MGSCv377105,291,869 - 105,293,957 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36798,018,551 - 98,020,639 (-)NCBIMGSCv36mm8
Celera798,464,468 - 98,466,556 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.59NCBI
Omp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,851,499 - 161,852,049 (-)NCBIGRCr8
mRatBN7.21152,440,278 - 152,440,828 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,433,652 - 152,441,922 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,427,276 - 160,427,826 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,607,456 - 167,608,006 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,480,977 - 160,481,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,097,159 - 163,097,709 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01169,302,355 - 169,302,905 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,388,635 - 155,389,185 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11155,467,040 - 155,467,591 (-)NCBI
Celera1150,531,133 - 150,531,683 (-)NCBICelera
Cytogenetic Map1q32NCBI
Omp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541414,673,449 - 14,677,141 (-)NCBIChiLan1.0ChiLan1.0
OMP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2978,020,363 - 78,026,963 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,068,540 - 79,069,476 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,151,535 - 72,154,580 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11175,794,525 - 75,795,016 (+)NCBIpanpan1.1PanPan1.1panPan2
OMP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12121,647,895 - 21,651,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2121,475,372 - 21,478,562 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02121,847,532 - 21,850,720 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12121,623,028 - 21,626,214 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02121,839,185 - 21,842,373 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02121,762,901 - 21,766,089 (-)NCBIUU_Cfam_GSD_1.0
Omp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494764,122,622 - 64,126,100 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364985,723,235 - 5,724,875 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OMP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1911,217,620 - 11,222,529 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2912,313,727 - 12,315,728 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Omp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624863179,301 - 189,441 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OMP
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1		 pathogenic
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1		 pathogenic
GRCh38/hg38 11q13.5-22.1(chr11:75941754-98357960)x1 copy number loss See cases [RCV000133838] Chr11:75941754..98357960 [GRCh38]
Chr11:75652798..98228688 [GRCh37]
Chr11:75330446..97733898 [NCBI36]
Chr11:11q13.5-22.1		 pathogenic
NM_006189.1(OMP):c.194T>C (p.Phe65Ser) single nucleotide variant Inborn genetic diseases [RCV003267455] Chr11:77103033 [GRCh38]
Chr11:76814079 [GRCh37]
Chr11:11q13.5		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_006189.1(OMP):c.289C>T (p.Arg97Cys) single nucleotide variant Inborn genetic diseases [RCV003287552] Chr11:77103128 [GRCh38]
Chr11:76814174 [GRCh37]
Chr11:11q13.5		 uncertain significance
NM_006189.1(OMP):c.184C>T (p.Arg62Trp) single nucleotide variant Inborn genetic diseases [RCV002861046] Chr11:77103023 [GRCh38]
Chr11:76814069 [GRCh37]
Chr11:11q13.5		 uncertain significance
NM_006189.1(OMP):c.488T>C (p.Leu163Pro) single nucleotide variant Inborn genetic diseases [RCV002793390] Chr11:77103327 [GRCh38]
Chr11:76814373 [GRCh37]
Chr11:11q13.5		 uncertain significance
NM_006189.1(OMP):c.271C>T (p.Leu91Phe) single nucleotide variant Inborn genetic diseases [RCV002753746] Chr11:77103110 [GRCh38]
Chr11:76814156 [GRCh37]
Chr11:11q13.5		 uncertain significance
NM_006189.1(OMP):c.46G>C (p.Val16Leu) single nucleotide variant Inborn genetic diseases [RCV002983509] Chr11:77102885 [GRCh38]
Chr11:76813931 [GRCh37]
Chr11:11q13.5		 uncertain significance
NM_006189.1(OMP):c.427G>T (p.Val143Phe) single nucleotide variant Inborn genetic diseases [RCV002931241] Chr11:77103266 [GRCh38]
Chr11:76814312 [GRCh37]
Chr11:11q13.5		 uncertain significance
NM_006189.1(OMP):c.269A>C (p.Asp90Ala) single nucleotide variant Inborn genetic diseases [RCV002718395] Chr11:77103108 [GRCh38]
Chr11:76814154 [GRCh37]
Chr11:11q13.5		 uncertain significance
NM_006189.1(OMP):c.196G>A (p.Glu66Lys) single nucleotide variant Inborn genetic diseases [RCV003206351] Chr11:77103035 [GRCh38]
Chr11:76814081 [GRCh37]
Chr11:11q13.5		 uncertain significance
NM_006189.1(OMP):c.78G>A (p.Arg26=) single nucleotide variant not provided [RCV003886804] Chr11:77102917 [GRCh38]
Chr11:76813963 [GRCh37]
Chr11:11q13.5		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:367
Count of miRNA genes:339
Interacting mature miRNAs:355
Transcripts:ENST00000529803
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH70524  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371176,814,454 - 76,814,609UniSTSGRCh37
Build 361176,492,102 - 76,492,257RGDNCBI36
Celera1174,121,938 - 74,122,093RGD
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map11q14UniSTS
HuRef1173,111,802 - 73,111,957UniSTS
GeneMap99-GB4 RH Map11277.11UniSTS
OMP__7185  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371176,813,964 - 76,814,577UniSTSGRCh37
Build 361176,491,612 - 76,492,225RGDNCBI36
Celera1174,121,448 - 74,122,061RGD
HuRef1173,111,312 - 73,111,925UniSTS
UniSTS:480807  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371176,813,886 - 76,814,377UniSTSGRCh37
Build 361176,491,534 - 76,492,025RGDNCBI36
Celera1174,121,370 - 74,121,861RGD
HuRef1173,111,234 - 73,111,725UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 4 1 4
Low 780 210 450 296 223 289 527 60 538 106 549 249 10 40 421
Below cutoff 1028 1402 859 249 641 145 1502 794 1546 236 630 809 112 583 895 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000529803   ⟹   ENSP00000436376
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1177,102,840 - 77,103,331 (+)Ensembl
RefSeq Acc Id: NM_006189   ⟹   NP_006180
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381177,102,840 - 77,103,331 (+)NCBI
GRCh371176,813,886 - 76,814,377 (+)RGD
Build 361176,491,534 - 76,492,025 (+)NCBI Archive
Celera1174,121,370 - 74,121,861 (+)RGD
HuRef1173,111,234 - 73,111,725 (+)ENTREZGENE
CHM1_11176,697,137 - 76,697,628 (+)NCBI
T2T-CHM13v2.01177,033,417 - 77,033,908 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_006180 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20485 (Get FASTA)   NCBI Sequence Viewer  
  AAH69115 (Get FASTA)   NCBI Sequence Viewer  
  AAH69365 (Get FASTA)   NCBI Sequence Viewer  
  EAW75017 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000436376
  ENSP00000436376.1
GenBank Protein P47874 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_006180   ⟸   NM_006189
- UniProtKB: Q562G2 (UniProtKB/Swiss-Prot),   P47874 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000436376   ⟸   ENST00000529803

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47874-F1-model_v2 AlphaFold P47874 1-163 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8136 AgrOrtholog
COSMIC OMP COSMIC
Ensembl Genes ENSG00000254550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000529803 ENTREZGENE
  ENST00000529803.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.390 UniProtKB/Swiss-Prot
GTEx ENSG00000254550 GTEx
HGNC ID HGNC:8136 ENTREZGENE
Human Proteome Map OMP Human Proteome Map
InterPro Olfactory_marker UniProtKB/Swiss-Prot
  Olfactory_marker_sf UniProtKB/Swiss-Prot
KEGG Report hsa:4975 UniProtKB/Swiss-Prot
NCBI Gene 4975 ENTREZGENE
OMIM 164340 OMIM
PANTHER OLFACTORY MARKER PROTEIN UniProtKB/Swiss-Prot
  PTHR15357 UniProtKB/Swiss-Prot
Pfam Olfactory_mark UniProtKB/Swiss-Prot
PharmGKB PA31923 PharmGKB
Superfamily-SCOP SSF63697 UniProtKB/Swiss-Prot
UniProt OMP_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q562G2 ENTREZGENE
UniProt Secondary Q562G2 UniProtKB/Swiss-Prot