Annotation (Toggle Detail/Summary View) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1348941 | 6480464 | decitabine promotes the reaction [IFNG protein results in increased expression of CIITA mRNA] | CTD | PMID:16650406 | 5-azacytidine | multiple interactions | ISO | RGD:1348941 | 6480464 | [Azacitidine results in decreased methylation of CIITA promoter] promotes the reaction [IFNG protein results in increased expression of CIITA mRNA] | CTD | PMID:18829986 PMID:18829986 | 5-azacytidine | multiple interactions | ISO | RGD:1348941 | 6480464 | [Azacitidine promotes the reaction [IFNG protein results in increased expression of CIITA mRNA]] which results in increased expression of HLA-DRA protein; more ... | CTD | PMID:18829986 | 9-cis-retinoic acid | increases expression | ISO | RGD:1348941 | 6480464 | alitretinoin results in increased expression of CIITA mRNA | CTD | PMID:17229644 | all-trans-retinoic acid | increases expression | ISO | RGD:1348941 | 6480464 | Tretinoin results in increased expression of CIITA mRNA | CTD | PMID:17229644 | ammonium chloride | affects expression | ISO | RGD:619813 | 6480464 | Ammonium Chloride affects the expression of CIITA mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of CIITA mRNA | CTD | PMID:21569818 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CIITA mRNA] | CTD | PMID:22228805 | capsaicin | multiple interactions | EXP | | 6480464 | Capsaicin inhibits the reaction [IFNG protein results in increased expression of CIITA mRNA] | CTD | PMID:19825429 | chloroprene | decreases expression | EXP | | 6480464 | Chloroprene results in decreased expression of CIITA mRNA | CTD | PMID:23125180 | diarsenic trioxide | decreases expression | ISO | RGD:1348941 | 6480464 | arsenic trioxide results in decreased expression of CIITA mRNA | CTD | PMID:20458559 | dichloromethane | increases expression | ISO | RGD:619813 | 6480464 | Methylene Chloride results in increased expression of CIITA mRNA | CTD | PMID:20955722 | ethylbenzene | increases expression | ISO | RGD:619813 | 6480464 | ethylbenzene results in increased expression of CIITA mRNA | CTD | PMID:20955722 | melphalan | decreases expression | ISO | RGD:1348941 | 6480464 | Melphalan results in decreased expression of CIITA mRNA | CTD | PMID:22363485 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of CIITA mRNA | CTD | PMID:17426115 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of CIITA mRNA | CTD | PMID:22698814 | simvastatin | multiple interactions | ISO | RGD:1348941 | 6480464 | Simvastatin inhibits the reaction [IFNG results in increased expression of CIITA protein] | CTD | PMID:11219190 | sodium dichromate | decreases expression | EXP | | 6480464 | sodium bichromate results in decreased expression of CIITA mRNA | CTD | PMID:22155349 | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of CIITA mRNA | CTD | PMID:22155349 | tamibarotene | increases expression | ISO | RGD:1348941 | 6480464 | Am 80 results in increased expression of CIITA mRNA; more ... | CTD | PMID:17229644 | trichloroethene | increases expression | ISO | RGD:619813 | 6480464 | Trichloroethylene results in increased expression of CIITA mRNA | CTD | PMID:20955722 | zinc atom | affects expression | ISO | RGD:1348941 | 6480464 | Zinc affects the expression of CIITA mRNA | CTD | PMID:16979875 | zinc(0) | affects expression | ISO | RGD:1348941 | 6480464 | Zinc affects the expression of CIITA mRNA | CTD | PMID:16979875 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Antigen processing and presentation |
| Influenza A | |
| Primary immunodeficiency | |
| Toxoplasmosis | |
| Tuberculosis | |
Phenotype Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Antigen processing and presentation |
| Influenza A | |
| Primary immunodeficiency | |
| Toxoplasmosis | |
| Tuberculosis | |
Phenotype Annotations
|
|
|
References - curated| 1. |
Akkad DA, etal., Int J Immunogenet. 2006 Feb;33(1):59-61. |
| 2. |
Bontron S, etal., Hum Genet. 1997 Apr;99(4):541-6. |
| 3. |
Cai G, etal., J Mol Cell Cardiol. 2005 Apr;38(4):593-605. |
| 4. |
Harnesk K, etal., J Immunol. 2008 Mar 1;180(5):3289-96. |
| 5. |
Kim TW, etal., J Korean Med Sci. 2006 Oct;21(5):877-82. |
| 6. |
Koizumi K, etal., Ann Rheum Dis. 2005 Jun;64(6):947-50. |
| 7. |
Lee YL, etal., J Endod. 2010 Jun;36(6):1021-5. doi: 10.1016/j.joen.2010.03.009. Epub 2010 Apr 21. |
| 8. |
Lindholm E, etal., PLoS One. 2006 Dec 20;1:e64. |
| 9. |
Linga-Reddy MV, etal., Tissue Antigens. 2007 Nov;70(5):412-4. Epub 2007 Aug 17. |
| 10. |
Martinez A, etal., Ann Rheum Dis. 2010 Jan;69(1):309-11. Epub . |
| 11. |
MGD data from the GO Consortium |
| 12. |
MGD IEA |
| 13. |
O'Doherty C, etal., Tissue Antigens. 2007 Sep;70(3):247-51. |
| 14. |
Okamoto H, etal., Ann Rheum Dis. 2007 Sep;66(9):1263-4. |
| 15. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 16. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 17. |
Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88. |
| 18. |
Repique CJ, etal., Scand J Immunol. 2003 Jul;58(1):15-22. |
| 19. |
RGD automated import pipeline |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
Sims TN, etal., Transplantation. 1997 Dec 27;64(12):1657-64. |
| 22. |
Skinningsrud B, etal., J Clin Endocrinol Metab. 2008 Sep;93(9):3310-7. Epub 2008 Jul 1. |
| 23. |
Swanberg M, etal., Nat Genet 2005 May;37(5):486-94. Epub 2005 Apr 10. |
| 24. |
Takeuchi O, etal., J Am Soc Nephrol. 2003 Nov;14(11):2823-32. |
| 25. |
Wiszniewski W, etal., J Immunol. 2001 Aug 1;167(3):1787-94. |
| 26. |
Zuvich RL, etal., Hum Mol Genet. 2011 Sep 1;20(17):3517-24. Epub 2011 Jun 8. |
References - uncurated| PubMed | 10201997 |
| 10204493 | |
| 10349636 | |
| 10438942 | |
| 10452977 | |
| 10637268 | |
| 11042159 | |
| 11076861 | |
| 11217851 | |
| 11514597 | |
| 11532347 | |
| 11564890 | |
| 11721060 | |
| 11937578 | |
| 11970984 | |
| 11978778 | |
| 12102254 | |
| 12218125 | |
| 12471103 | |
| 12477932 | |
| 12506036 | |
| 12525570 | |
| 12538670 | |
| 12748124 | |
| 12923292 | |
| 14681479 | |
| 14764672 | |
| 14768052 | |
| 15100295 | |
| 15162420 | |
| 15322541 | |
| 15446308 | |
| 15494498 | |
| 15596523 | |
| 15661876 | |
| 15876426 | |
| 15964851 | |
| 16081800 | |
| 16141072 | |
| 16141073 | |
| 16210330 | |
| 16226503 | |
| 16226504 | |
| 16254146 | |
| 16280321 | |
| 16547269 | |
| 16569676 | |
| 16602821 | |
| 16703565 | |
| 16717113 | |
| 16783635 | |
| 16863914 | |
| 16908858 | |
| 16982097 | |
| 17072917 | |
| 17088432 | |
| 17346795 | |
| 17627890 | |
| 17724129 | |
| 17982082 | |
| 18245089 | |
| 18287559 | |
| 18292501 | |
| 18337172 | |
| 18359773 | |
| 18483774 | |
| 18768863 | |
| 18799151 | |
| 18923103 | |
| 19041327 | |
| 19224634 | |
| 19234195 | |
| 19481818 | |
| 19897249 | |
| 20038602 | |
| 20059953 | |
| 20080304 | |
| 20211142 | |
| 20363966 | |
| 20431619 | |
| 20696698 | |
| 20705943 | |
| 21203976 | |
| 21216962 | |
| 21267068 | |
| 21321116 | |
| 21478404 | |
| 21481937 | |
| 21499269 | |
| 21576360 | |
| 22084437 | |
| 22218223 | |
| 22294690 | |
| 22315415 | |
| 22341446 | |
| 22552229 | |
| 22645137 | |
| 22908323 | |
| 22988097 | |
| 23144170 | |
| 23264660 | |
| 8294875 | |
| 8620527 | |
| 8624807 | |
| 8990384 | |
| 8995190 | |
| 9164958 | |
| 9184229 | |
| 9491996 | |
| 9521055 | |
| 9548512 | |
| 9885917 |
RGD Disease Portals| Ciita has been annotated in the following RGD Disease Portals. |
|||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
Comparative Map Data| Ciita (Mus musculus) |
|
|||||||||||||||||||||||||||||||||||
| CIITA (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Ciita (Rattus norvegicus) |
|
QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001243760 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001243761 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_007575 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHY01125776 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01125777 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01125778 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01125779 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01125780 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01125781 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01125782 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01125783 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC122352 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF000006 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF000007 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF042158 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF042159 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF100709 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF100710 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK040723 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK138822 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK143956 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK153609 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK155184 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK155311 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC107330 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC107331 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466521 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U46562 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U60653 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_007575 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_031601 | |||||||||||||||||||||||||
| Peptide Label: | isoform 2 | |||||||||||||||||||||||||
| Position: |
|
| RefSeq Acc Id: | XR_105754 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | NON-CODING | ||||||||||
| Position: |
|
| RefSeq Acc Id: | XR_106998 |
| RefSeq Status: | |
| Type: | NON-CODING |
| Position: | No map positions available. |
| RefSeq Acc Id: | NM_001243760 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001230689 | ||||||||||||||||||||
| Peptide Label: | isoform 1 | ||||||||||||||||||||
| Position: |
|
| RefSeq Acc Id: | NM_001243761 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001230690 | ||||||||||||||||||||
| Peptide Label: | isoform 3 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_001230689 | (Get FASTA) |
| NP_001230690 | (Get FASTA) | |
| NP_031601 | (Get FASTA) | |
| GenBank Protein | AAB05004 | (Get FASTA) |
| AAB48859 | (Get FASTA) | |
| AAB92364 | (Get FASTA) | |
| AAB92365 | (Get FASTA) | |
| AAC34366 | (Get FASTA) | |
| AAC34367 | (Get FASTA) | |
| AAF06838 | (Get FASTA) | |
| AAF06839 | (Get FASTA) | |
| AAI07331 | (Get FASTA) | |
| AAI07332 | (Get FASTA) | |
| AAI40359 | (Get FASTA) | |
| AAI48700 | (Get FASTA) | |
| BAC30683 | (Get FASTA) | |
| BAE23789 | (Get FASTA) | |
| BAE25629 | (Get FASTA) | |
| BAE32115 | (Get FASTA) | |
| BAE33100 | (Get FASTA) | |
| BAE33182 | (Get FASTA) | |
| EDK97316 | (Get FASTA) | |
| EDK97317 | (Get FASTA) | |
| EDK97318 | (Get FASTA) | |
| EDK97319 | (Get FASTA) | |
| P79621 | (Get FASTA) |
Promoters| RGD ID: | 6826911 | ||||||||||
| Promoter ID: | MM_KWN:20081 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Spleen | ||||||||||
| Transcripts: | ENSMUST00000100187, NM_007575 | ||||||||||
| Position: |
|
| RGD ID: | 6826787 | ||||||||||
| Promoter ID: | MM_KWN:20082 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Lung | ||||||||||
| Transcripts: | ENSMUST00000100186, UC007YDV.1, UC007YDW.1 | ||||||||||
| Position: |
|
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000022504 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000023147 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000023147 | ENTREZGENE |
| Entrez Gene | 12265 | ENTREZGENE |
| Germonline | ENSMUSG00000022504 | |
| HomoloGene Group ID | 207 | ENTREZGENE |
| InterPro | Leu-rich_rpt_2_copies | UniProtKB/Swiss-Prot |
| MHC_II_transact | UniProtKB/Swiss-Prot | |
| NACHT_NTPase | UniProtKB/Swiss-Prot | |
| IPI | IPI00108982 | UniProtKB/Swiss-Prot |
| IPI00115417 | UniProtKB/Swiss-Prot | |
| IPI00652697 | UniProtKB/TrEMBL | |
| IPI00655168 | UniProtKB/TrEMBL | |
| IPI00742270 | UniProtKB/Swiss-Prot | |
| IPI00990826 | UniProtKB/TrEMBL | |
| IPI00990961 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:12265 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:108445 | ENTREZGENE |
| Pfam | LRR_4 | UniProtKB/Swiss-Prot |
| PRINTS | MHCIIACTVATR | UniProtKB/Swiss-Prot |
| PROSITE | NACHT | UniProtKB/Swiss-Prot |
| UniGene | Mm.249560 | ENTREZGENE |
| UniProt | C2TA_MOUSE | UniProtKB/Swiss-Prot |
| Q3KND9_MOUSE | UniProtKB/TrEMBL | |
| Q3KNE0_MOUSE | UniProtKB/TrEMBL | |
| Q3TR57_MOUSE | UniProtKB/TrEMBL | |
| Q3U2F8_MOUSE | UniProtKB/TrEMBL | |
| Q3U2P0_MOUSE | UniProtKB/TrEMBL | |
| Q3U5G4_MOUSE | UniProtKB/TrEMBL | |
| Q3UNW8_MOUSE | UniProtKB/TrEMBL | |
| Q3UU40_MOUSE | UniProtKB/TrEMBL | |
| Q8HW99_MOUSE | UniProtKB/TrEMBL |
| More on Ciita | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
MGI Report |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 734236 |
| Created: | 2004-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-03-12 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




