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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IKBKAP mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of IKBKAP mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IKBKAP mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:734035 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IKBKAP mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of IKBKAP mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:734035 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of IKBKAP mRNA | CTD | PMID:21296121 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of IKBKAP mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:734035 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IKBKAP mRNA | CTD | PMID:20106945 | 2,6-dinitrotoluene | affects expression | ISO | RGD:620072 | 6480464 | 2,6-dinitrotoluene affects the expression of IKBKAP mRNA | CTD | PMID:21346803 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:734035 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of IKBKAP mRNA | CTD | PMID:12419474 | 8-bromo-3',5'-cyclic AMP | increases expression | ISO | RGD:734035 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IKBKAP mRNA | CTD | PMID:22079614 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of IKBKAP mRNA | CTD | PMID:19770486 | amiodarone | increases expression | ISO | RGD:734035 | 6480464 | Amiodarone results in increased expression of IKBKAP mRNA | CTD | PMID:19774075 | ammonium chloride | affects expression | ISO | RGD:620072 | 6480464 | Ammonium Chloride affects the expression of IKBKAP mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of IKBKAP mRNA | CTD | PMID:21715664 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of IKBKAP mRNA | CTD | PMID:22228805 | copper(2+) sulfate | decreases expression | ISO | RGD:734035 | 6480464 | Copper Sulfate results in decreased expression of IKBKAP mRNA | CTD | PMID:19549813 | elemental selenium | decreases expression | ISO | RGD:734035 | 6480464 | Selenium results in decreased expression of IKBKAP mRNA | CTD | PMID:19244175 | mercury atom | decreases expression | ISO | RGD:734035 | 6480464 | Mercury results in decreased expression of IKBKAP mRNA | CTD | PMID:16823088 | mercury(0) | decreases expression | ISO | RGD:734035 | 6480464 | Mercury results in decreased expression of IKBKAP mRNA | CTD | PMID:16823088 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of IKBKAP mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | RGD:734035 | 6480464 | Acetaminophen results in decreased expression of IKBKAP mRNA | CTD | PMID:21420995 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of IKBKAP mRNA | CTD | PMID:21371552 | quercetin | decreases expression | ISO | RGD:734035 | 6480464 | Quercetin results in decreased expression of IKBKAP mRNA | CTD | PMID:21632981 | selenium atom | decreases expression | ISO | RGD:734035 | 6480464 | Selenium results in decreased expression of IKBKAP mRNA | CTD | PMID:19244175 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of IKBKAP mRNA | CTD | PMID:17292431 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Phenotype Annotations
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References - curated| 1. |
Bar-On E, etal., J Bone Joint Surg Am. 2000 Nov;82-A(11):1563-70. |
| 2. |
Coli R, etal., Gene 2001 Nov 14;279(1):81-9. |
| 3. |
Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. |
| 4. |
Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 5. |
MGD and Homologene mouse data transfer |
| 6. |
MGD data from the GO Consortium |
| 7. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 8. |
RGD automated import pipeline |
| 9. |
RGD automated import pipeline for gene-chemical interactions |
| 10. |
RGD Automated Pipelines |
| 11. |
Schuller M, etal., J Hum Genet. 2003;48(6):300-4. Epub 2003 May 28. |
| 12. |
Slaugenhaupt SA, etal., Am J Hum Genet. 2001 Mar;68(3):598-605. Epub 2001 Jan 22. |
| 13. |
Takeoka S, etal., J Hum Genet. 2001;46(2):57-63. |
References - uncurated| PubMed | 10349636 |
| 10922068 | |
| 11042159 | |
| 11076861 | |
| 11747609 | |
| 12477932 | |
| 12520002 | |
| 14610273 | |
| 15782199 | |
| 16141072 | |
| 16141073 | |
| 17644305 | |
| 18303054 | |
| 18799693 | |
| 19015235 | |
| 19185337 | |
| 19500387 | |
| 21267068 | |
| 21677750 | |
| 22046433 | |
| 22854966 | |
| 22922231 |
RGD Disease Portals| Ikbkap has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Ikbkap (Mus musculus) |
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| IKBKAP (Homo sapiens) |
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| Ikbkap (Rattus norvegicus) |
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Position Markers| D4Mit288 |
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| Ikbkap |
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| C78473 |
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| UniSTS:225006 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_026079 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01036135 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01036136 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF140786 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF367244 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF387811 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK004402 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK031367 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK032563 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK035944 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK076152 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK147153 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK165168 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK170341 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK196177 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL807762 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL929577 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC035529 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC052387 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC054468 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466565 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_026079 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_080355 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_080355 | (Get FASTA) |
| GenBank Protein | AAH52387 | (Get FASTA) |
| AAH54468 | (Get FASTA) | |
| AAL36025 | (Get FASTA) | |
| AAL40925 | (Get FASTA) | |
| AAO15309 | (Get FASTA) | |
| BAB23291 | (Get FASTA) | |
| BAC29252 | (Get FASTA) | |
| BAC36221 | (Get FASTA) | |
| BAE27720 | (Get FASTA) | |
| BAE41731 | (Get FASTA) | |
| EDL02256 | (Get FASTA) | |
| EDL02257 | (Get FASTA) | |
| Q7TT37 | (Get FASTA) |
Promoters| RGD ID: | 6835492 | ||||||||||
| Promoter ID: | MM_KWN:37727 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Lung | ||||||||||
| Transcripts: | UC008SXP.1 | ||||||||||
| Position: |
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| RGD ID: | 6835493 | ||||||||||
| Promoter ID: | MM_KWN:37733 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day3, ES_Cell | ||||||||||
| Transcripts: | NM_026079, UC008SXR.1 | ||||||||||
| Position: |
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| RGD ID: | 6877144 | ||||||||||
| Promoter ID: | EPDNEW_M2023 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Ikbkap_1 | ||||||||||
| Description: | inhibitor of kappa light polypeptide enhancer in B-cells, kinasecomplex-associated protein | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000028431 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000030140 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000030140 | ENTREZGENE |
| Entrez Gene | 230233 | ENTREZGENE |
| Gene3D-CATH | 6-blade_b-propeller_TolB-like | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2699 | ENTREZGENE |
| InterPro | 6-blade_b-propeller_TolB-like | UniProtKB/Swiss-Prot |
| IKI3 | UniProtKB/Swiss-Prot | |
| KEGG Report | mmu:230233 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1914544 | ENTREZGENE |
| PANTHER | IKI3 | UniProtKB/Swiss-Prot |
| Pfam | IKI3 | UniProtKB/Swiss-Prot |
| PIRSF | IKAP | UniProtKB/Swiss-Prot |
| UniGene | Mm.282743 | ENTREZGENE |
| UniProt | ELP1_MOUSE | UniProtKB/Swiss-Prot |
| Q3TD73_MOUSE | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-02-07 | Ikbkap | inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein | Ikbkap | inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein | Symbol and/or name change | 39860 | APPROVED |
| More on Ikbkap | |
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Entrez Gene |
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Ensembl Gene |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 734036 |
| Created: | 2004-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-03-19 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




