Gene: USF1 (upstream transcription factor 1)
Homo sapiens
Symbol:
USF1
Name:
upstream transcription factor 1
Description:
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
bHLHb11; class B basic helix-loop-helix protein 11; FCHL; FCHL1; HYPLIP1; major late transcription factor 1; MLTF; MLTFI; OTTHUMP00000029691; OTTHUMP00000029693; OTTHUMP00000029695; OTTHUMP00000228974; UEF; upstream stimulatory factor 1
Orthologs:
Mus musculus : Usf1
(upstream transcription factor 1)
MGI
Usf1
(upstream transcription factor 1)
Related Pseudogenes:
USF1P1
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 167,505,239 - 167,511,954 - NCBI Human Genome Assembly HuRef 1 132,366,984 - 132,373,689 - NCBI Human Genome Assembly GRCh37 1 161,009,041 - 161,015,757 - NCBI Human Genome Assembly Build 36 1 159,275,665 - 159,282,381 - NCBI Human Cytogenetic Map 1 q22-q23 NCBI Human Genome Assembly 1 157,822,114 - 157,828,830 NCBI
Model
Gene-Chemical Interaction Annotations
(R)-noradrenaline multiple interactions EXP 6480464 USF1 protein affects the reaction [Norepinephrine results in increased metabolism of Lipids]; more ... CTD PMID:15985485 1,3-dinitrobenzene increases expression ISO RGD:620974 6480464 3-dinitrobenzene results in increased expression of USF1 mRNA CTD PMID:21983209 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551792 6480464 Tetrachlorodibenzodioxin affects the expression of USF1 mRNA CTD PMID:21570461 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1551792 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of USF1 mRNA CTD PMID:20188158 amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of USF1 mRNA CTD PMID:19774075 ammonium chloride affects expression ISO RGD:620974 6480464 Ammonium Chloride affects the expression of USF1 mRNA CTD PMID:16483693 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of USF1 mRNA CTD PMID:22316170 benzo[a]pyrene increases expression ISO RGD:1551792 6480464 Benzo(a)pyrene results in increased expression of USF1 mRNA CTD PMID:22228805 cadmium atom multiple interactions ISO RGD:1551792 6480464 USF1 affects the reaction [Cadmium results in increased expression of MT1 mRNA] CTD PMID:10605938 dibutyl phthalate increases expression ISO RGD:620974 6480464 Dibutyl Phthalate results in increased expression of USF1 mRNA CTD PMID:21266533 dobutamine multiple interactions EXP 6480464 USF1 protein affects the reaction [Dobutamine results in increased metabolism of Lipids]; more ... CTD PMID:15985485 ethanol decreases expression ISO RGD:620974 6480464 Ethanol results in decreased expression of USF1 mRNA CTD PMID:15353170 lead diacetate decreases expression ISO RGD:1551792 6480464 lead acetate results in decreased expression of USF1 mRNA CTD PMID:21829687 pirinixic acid decreases expression ISO RGD:1551792 6480464 pirinixic acid results in decreased expression of USF1 mRNA CTD PMID:16221962 terbutaline multiple interactions EXP 6480464 USF1 gene polymorphism promotes the reaction [Terbutaline results in increased metabolism of Lipids]; more ... CTD PMID:15985485 vanadium atom increases activity EXP 6480464 Vanadium results in increased activity of USF1 protein CTD PMID:19000753 vanadium(0) increases activity EXP 6480464 Vanadium results in increased activity of USF1 protein CTD PMID:19000753
1581540 BP60_H Blood pressure QTL 60 (human) Blood pressure hypertension susceptibility 1 19957148 198620398 Human 1357381 BW57_H Body weight QTL 57 (human) 1 .0001 Body weight fat free mass after exercise training 1 91558770 166956374 Human 2289241 SLIPL21_H Serum lipid level QTL 21 (human) 3.39 .014402 Lipid level lipoprotein level 1 119678264 162362069 Human 2316338 GLUCO223_H Glucose level QTL 223 (human) 3.09 .00008 Glucose level 1 139437503 165437503 Human 2293485 PRSTS288_H Prostate tumor susceptibility QTL 288 (human) .031 Prostate tumor susceptibility 1 144932827 170932827 Human 2316705 GLUCO265_H Glucose level QTL 265 (human) 2.5 .00066 Glucose level 1 147767637 173767637 Human 2314801 GLUCO120_H Glucose level QTL 120 (human) Glucose level non-insulin dependent 1 148192596 174192596 Human 1298491 BP5_H Blood pressure QTL 5 (human) 2.96 Blood pressure diastolic 1 149361992 175361992 Human 1643514 BW260_H Body weight QTL 260 (human) 1.6 .00328 Body weight body mass index 1 149361992 175361992 Human 2301804 PRSTS430_H Prostate tumor susceptibility QTL 430 (human) 2.93 .0002 Prostate tumor susceptibility 1 150559802 176559802 Human 2289201 BW345_H Body weight QTL 345 (human) .0148 Body fat amount percent fat 1 150559802 176559802 Human 2293474 PRSTS289_H Prostate tumor susceptibility QTL 289 (human) .003 Prostate tumor susceptibility 1 150559802 176559802 Human 1643072 BW150_H Body weight QTL 150 (human) .0297 Body fat amount percent body fat 1 152437380 178437380 Human 2314796 GLUCO121_H Glucose level QTL 121 (human) Glucose level non-insulin dependent 1 153596141 179596141 Human 2299879 PRSTS314_H Prostate tumor susceptibility QTL 314 (human) .13 Prostate tumor susceptibility 1 157523759 183523759 Human 2299880 PRSTS313_H Prostate tumor susceptibility QTL 313 (human) .01 Prostate tumor susceptibility 1 157523759 183523759 Human 2315058 GLUCO133_H Glucose level QTL 133 (human) 4.295 .02 Glucose level 1 159682467 161192914 Human 2314798 GLUCO117_H Glucose level QTL 117 (human) Glucose level non-insulin dependent 1 160595542 162210154 Human
Gene-Chemical Interaction Annotations
