Trpc5 (transient receptor potential cation channel, subfamily C, member 5) - Rat Genome Database

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Gene: Trpc5 (transient receptor potential cation channel, subfamily C, member 5) Mus musculus
Analyze
Symbol: Trpc5
Name: transient receptor potential cation channel, subfamily C, member 5
RGD ID: 733335
MGI Page MGI
Description: Enables inositol 1,4,5 trisphosphate binding activity. Involved in neuron apoptotic process and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in dendrite; growth cone; and neuronal cell body. Predicted to be part of calcium channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; immune system; and liver and biliary system. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: capacitative calcium entry channel 2; CCE2; MGC124500; mtrp5; short transient receptor potential channel 5; TR; transient receptor protein 5; TRP-5; trp-related protein 5; TRP5; Trrp5; vtransient receptor potential cation channel, subfamily C, member 5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X143,160,323 - 143,471,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX143,164,667 - 143,471,176 (-)EnsemblGRCm39 Ensembl
GRCm38X144,377,327 - 144,688,180 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX144,381,671 - 144,688,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X140,816,214 - 141,122,723 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X139,628,039 - 139,934,548 (-)NCBIMGSCv36mm8
CeleraX128,337,325 - 128,644,030 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX65.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling. Bush EW, etal., J Biol Chem. 2006 Nov 3;281(44):33487-96. Epub 2006 Sep 1.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Inhibition of the TRPC5 ion channel protects the kidney filter. Schaldecker T, etal., J Clin Invest. 2013 Dec;123(12):5298-309. doi: 10.1172/JCI71165. Epub 2013 Nov 15.
9. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Zhu X, etal., Cell 1996 May 31;85(5):661-71.
Additional References at PubMed
PMID:9553080   PMID:9687496   PMID:9722956   PMID:10349636   PMID:10493832   PMID:10980202   PMID:11042159   PMID:11076861   PMID:11390792   PMID:12477932   PMID:12631560   PMID:14505576  
PMID:15336983   PMID:15385169   PMID:15689561   PMID:15843439   PMID:15987684   PMID:16044320   PMID:16141072   PMID:16141073   PMID:16306123   PMID:16368680   PMID:16460286   PMID:17480026  
PMID:17593972   PMID:17624425   PMID:17626205   PMID:17884814   PMID:18495872   PMID:18832422   PMID:18989690   PMID:19156209   PMID:19299701   PMID:19322198   PMID:19398778   PMID:19450521  
PMID:19521566   PMID:19815560   PMID:19834762   PMID:20390293   PMID:20978238   PMID:21267068   PMID:21430274   PMID:21677750   PMID:21873635   PMID:21968068   PMID:22025699   PMID:22051675  
PMID:22135323   PMID:22157757   PMID:22411552   PMID:22461428   PMID:22539836   PMID:22547824   PMID:22668831   PMID:23188715   PMID:23233529   PMID:23677990   PMID:24117252   PMID:24194600  
PMID:24358869   PMID:24952961   PMID:25347706   PMID:25471572   PMID:26317356   PMID:26520460   PMID:27165180   PMID:27177420   PMID:27411851   PMID:27626380   PMID:27920205   PMID:28099839  
PMID:28237267   PMID:28324107   PMID:28539583   PMID:28636132   PMID:28790178   PMID:28835433   PMID:29061651   PMID:29373286   PMID:29572499   PMID:29793963   PMID:30038709   PMID:30062674  
PMID:30270038   PMID:30413532   PMID:30414390   PMID:30452936   PMID:30521677   PMID:30692584   PMID:30786075   PMID:31285329   PMID:31355338   PMID:31536487   PMID:31844148   PMID:32033274  
PMID:32110987   PMID:32350291   PMID:32359120   PMID:32414784   PMID:32729832   PMID:33771873   PMID:33884443   PMID:34039739   PMID:34203675   PMID:34230483   PMID:34626854   PMID:34836549  
PMID:35589963   PMID:36122525   PMID:36123395   PMID:36257322   PMID:36592529   PMID:36750145   PMID:37185099  


Genomics

Comparative Map Data
Trpc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X143,160,323 - 143,471,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX143,164,667 - 143,471,176 (-)EnsemblGRCm39 Ensembl
GRCm38X144,377,327 - 144,688,180 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX144,381,671 - 144,688,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X140,816,214 - 141,122,723 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X139,628,039 - 139,934,548 (-)NCBIMGSCv36mm8
CeleraX128,337,325 - 128,644,030 (-)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX65.49NCBI
TRPC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X111,768,011 - 112,082,776 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX111,768,011 - 112,082,776 (-)EnsemblGRCh38hg38GRCh38
GRCh37X111,011,239 - 111,326,004 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,904,198 - 111,212,660 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X110,823,686 - 111,132,149NCBI
CeleraX111,497,049 - 111,805,514 (-)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX100,639,095 - 100,946,273 (-)NCBIHuRef
CHM1_1X110,928,786 - 111,237,228 (-)NCBICHM1_1
T2T-CHM13v2.0X110,216,352 - 110,531,119 (-)NCBIT2T-CHM13v2.0
Trpc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X112,742,828 - 113,027,638 (-)NCBIGRCr8
mRatBN7.2X107,946,163 - 108,230,991 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX107,939,131 - 108,230,991 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX110,094,300 - 110,229,890 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X113,594,020 - 113,729,628 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X111,146,259 - 111,281,824 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X115,624,670 - 115,908,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX115,627,653 - 115,908,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X114,079,131 - 114,359,862 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X33,989,907 - 34,126,175 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X33,897,584 - 34,179,644 (+)NCBI
CeleraX107,338,307 - 107,473,426 (-)NCBICelera
Cytogenetic MapXq34NCBI
Trpc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554903,860,909 - 4,057,275 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554903,777,756 - 4,057,275 (+)NCBIChiLan1.0ChiLan1.0
TRPC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X111,256,348 - 111,566,337 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X111,259,955 - 111,569,945 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X100,886,122 - 101,191,425 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X111,346,804 - 111,648,332 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX111,346,804 - 111,648,201 (-)Ensemblpanpan1.1panPan2
TRPC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X84,835,130 - 84,989,609 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX84,801,096 - 85,116,625 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX70,936,399 - 71,117,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X86,509,906 - 86,696,508 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX86,512,806 - 86,801,707 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X83,981,630 - 84,160,857 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X85,658,324 - 85,832,221 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X85,498,131 - 85,680,673 (-)NCBIUU_Cfam_GSD_1.0
Trpc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X84,110,276 - 84,383,058 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364993,343,669 - 3,543,035 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364993,391,386 - 3,541,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX91,721,644 - 91,988,120 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X91,716,334 - 91,988,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X106,133,833 - 106,399,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X99,546,923 - 99,856,971 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX99,550,595 - 99,736,668 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606524,918,626 - 25,161,347 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248033,666,276 - 3,813,401 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248033,494,311 - 3,812,985 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trpc5
7782 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:233
Count of miRNA genes:207
Interacting mature miRNAs:212
Transcripts:ENSMUST00000040184, ENSMUST00000148240
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
13208552Wght12_mweight 12 (mouse)X94043606149782996Mouse
1301276Tswt_mtestis weight (mouse)Not determinedX138376411150789338Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X121909697152582996Mouse
13208556Lgth14_mbody length 14 (mouse)X94043606149782996Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13824980Ferq1_mgenetic fertility QTL 1 (mouse)X54045360148782996Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse

Markers in Region
AF029983  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X144,382,160 - 144,382,241UniSTSGRCm38
MGSCv37X140,816,703 - 140,816,784UniSTSGRCm37
CeleraX128,337,814 - 128,337,895UniSTS
Cytogenetic MapXF2UniSTS
cM MapX63.0UniSTS
Whitehead/MRC_RHX1674.73UniSTS
DXMit118  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X144,632,777 - 144,632,910UniSTSGRCm38
MGSCv37X141,067,320 - 141,067,453UniSTSGRCm37
CeleraX128,589,021 - 128,589,154UniSTS
Cytogenetic MapXF2UniSTS
cM MapX62.1UniSTS
Whitehead GeneticX50.3UniSTS
Whitehead_YACX UniSTS
Trpc5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X144,418,953 - 144,419,058UniSTSGRCm38
MGSCv37X140,853,496 - 140,853,601UniSTSGRCm37
CeleraX128,374,634 - 128,374,739UniSTS
Cytogenetic MapXF2UniSTS
cM MapX63.0UniSTS
Trrp5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X144,381,446 - 144,382,525UniSTSGRCm38
MGSCv37X140,815,989 - 140,817,068UniSTSGRCm37
CeleraX128,337,100 - 128,338,177UniSTS
Cytogenetic MapXF2UniSTS
cM MapX63.0UniSTS
Trpc5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF2UniSTS
Trpc5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000040184   ⟹   ENSMUSP00000049063
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX143,164,667 - 143,471,176 (-)Ensembl
GRCm38.p6 EnsemblX144,381,671 - 144,688,180 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148240
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX143,201,671 - 143,470,999 (-)Ensembl
GRCm38.p6 EnsemblX144,418,675 - 144,688,003 (-)Ensembl
RefSeq Acc Id: NM_009428   ⟹   NP_033454
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X143,160,323 - 143,471,176 (-)NCBI
GRCm38X144,377,327 - 144,688,180 (-)NCBI
MGSCv37X140,816,214 - 141,122,723 (-)RGD
CeleraX128,337,325 - 128,644,030 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033454   ⟸   NM_009428
- UniProtKB: Q9QWT1 (UniProtKB/Swiss-Prot),   Q61059 (UniProtKB/Swiss-Prot),   Q9R0D4 (UniProtKB/Swiss-Prot),   Q9QX29 (UniProtKB/Swiss-Prot),   Q8C8A8 (UniProtKB/TrEMBL),   Q2KHN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000049063   ⟸   ENSMUST00000040184
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QX29-F1-model_v2 AlphaFold Q9QX29 1-975 view protein structure

Promoters
RGD ID:13681574
Promoter ID:EPDNEW_M24936
Type:single initiation site
Name:Trpc5_1
Description:Mus musculus transient receptor potential cation channel, subfamilyC, member 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X144,638,956 - 144,639,016EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109524 AgrOrtholog
Ensembl Genes ENSMUSG00000041710 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040184 ENTREZGENE
  ENSMUST00000040184.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC5_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109524 ENTREZGENE
NCBI Gene 22067 ENTREZGENE
PANTHER PTHR10117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10117:SF76 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpc5 PhenoGen
PRINTS TRNSRECEPTRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPCHANNEL5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q2KHN9 ENTREZGENE, UniProtKB/TrEMBL
  Q61059 ENTREZGENE
  Q8C8A8 ENTREZGENE, UniProtKB/TrEMBL
  Q9QWT1 ENTREZGENE
  Q9QX29 ENTREZGENE
  Q9R0D4 ENTREZGENE
  TRPC5_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q61059 UniProtKB/Swiss-Prot
  Q9QWT1 UniProtKB/Swiss-Prot
  Q9R0D4 UniProtKB/Swiss-Prot