Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of SLC22A7 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:621699 | 6480464 | Ethinyl Estradiol results in decreased expression of SLC22A7 mRNA | CTD | PMID:17108234 | 17beta-estradiol | decreases expression | ISO | RGD:732686 | 6480464 | Estradiol results in decreased expression of SLC22A7 mRNA | CTD | PMID:20106945 | 17beta-estradiol | increases expression | ISO | RGD:621699 | 6480464 | Estradiol results in increased expression of SLC22A7 mRNA | CTD | PMID:11879818 | 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid | increases expression | ISO | RGD:621699 | 6480464 | hexadecafluoro-nonanoic acid results in increased expression of SLC22A7 mRNA | CTD | PMID:21530637 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:621699 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SLC22A7 mRNA | CTD | PMID:16054898 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SLC22A7 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:621699 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SLC22A7 mRNA | CTD | PMID:16054898 PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732686 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SLC22A7 mRNA | CTD | PMID:20106945 PMID:16837569 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732686 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SLC22A7 mRNA | CTD | PMID:16837569 PMID:20106945 | 2-oxoglutaric acid | increases uptake | EXP | | 6480464 | SLC22A7 protein results in increased uptake of alpha-ketoglutaric acid | CTD | PMID:12065749 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | ISO | RGD:621699 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC22A7 mRNA | CTD | PMID:20959002 | 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol | increases expression | ISO | RGD:621699 | 6480464 | 1H,1H,2H,2H-perfluorodecanol results in increased expression of SLC22A7 mRNA | CTD | PMID:21530637 | 5-fluorouracil | increases transport | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased transport of Fluorouracil | CTD | PMID:15901346 | acetylsalicylic acid | decreases activity | ISO | RGD:732686 | 6480464 | Aspirin results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | aflatoxin B1 | affects expression | ISO | RGD:732686 | 6480464 | Aflatoxin B1 affects the expression of SLC22A7 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | RGD:732686 | 6480464 | Aflatoxin B1 results in decreased expression of SLC22A7 mRNA | CTD | PMID:22100608 | allopurinol | increases uptake | EXP | | 6480464 | SLC22A7 protein results in increased uptake of Allopurinol | CTD | PMID:12065749 | allopurinol | increases transport | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased transport of Allopurinol | CTD | PMID:15901346 | ammonium chloride | affects expression | ISO | RGD:621699 | 6480464 | Ammonium Chloride affects the expression of SLC22A7 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:732686 | 6480464 | Benzo(a)pyrene results in decreased expression of SLC22A7 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of SLC22A7 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of SLC22A7 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:732686 | 6480464 | Benzo(a)pyrene results in decreased expression of SLC22A7 mRNA | CTD | PMID:20106945 PMID:21871943 | benzo[a]pyrene | decreases expression | ISO | RGD:732686 | 6480464 | Benzo(a)pyrene results in decreased expression of SLC22A7 mRNA | CTD | PMID:21871943 PMID:20106945 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of SLC22A7 mRNA | CTD | PMID:21715664 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of SLC22A7 mRNA] | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | decreases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in decreased expression of SLC22A7 mRNA | CTD | PMID:19850644 | bromosulfophthalein | multiple interactions | EXP | | 6480464 | Sulfobromophthalein inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] | CTD | PMID:12065749 | bumetanide | multiple interactions | ISO | RGD:732686 | 6480464 | Bumetanide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] | CTD | PMID:15901346 | bumetanide | increases transport | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased transport of Bumetanide | CTD | PMID:15901346 | C60 fullerene | decreases expression | ISO | RGD:621699 | 6480464 | fullerene C60 results in decreased expression of SLC22A7 mRNA | CTD | PMID:19167457 | carbamazepine | decreases expression | ISO | RGD:621699 | 6480464 | Carbamazepine results in decreased expression of SLC22A7 mRNA | CTD | PMID:17381134 | cefoperazone | multiple interactions | EXP | | 6480464 | Cefoperazone inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] | CTD | PMID:12065749 | chloramphenicol | multiple interactions | ISO | RGD:732686 | 6480464 | Chloramphenicol inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] | CTD | PMID:15901346 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC22A7 gene | CTD | PMID:20938992 | cimetidine | increases uptake | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased uptake of Cimetidine | CTD | PMID:16006492 | cimetidine | multiple interactions | EXP | | 6480464 | Cimetidine inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] | CTD | PMID:12065749 | cyclosporin A | decreases expression | ISO | RGD:732686 | 6480464 | Cyclosporine results in decreased expression of SLC22A7 mRNA | CTD | PMID:20106945 | dehydroepiandrosterone sulfate | increases transport | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate | CTD | PMID:15901346 | deoxycholic acid | affects expression | EXP | | 6480464 | Deoxycholic Acid affects the expression of SLC22A7 mRNA | CTD | PMID:21914718 | deoxycholic acid | multiple interactions | EXP | | 6480464 | SLCO1A1 protein affects the susceptibility to [Deoxycholic Acid affects the expression of SLC22A7 mRNA] | CTD | PMID:21914718 | dexamethasone | increases expression | ISO | RGD:621699 | 6480464 | Dexamethasone results in increased expression of SLC22A7 protein | CTD | PMID:19922765 | dexamethasone | decreases expression | ISO | RGD:621699 | 6480464 | Dexamethasone results in decreased expression of SLC22A7 mRNA | CTD | PMID:19922765 | diclofenac | decreases activity | ISO | RGD:732686 | 6480464 | Diclofenac results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | diclofenac | multiple interactions | ISO | RGD:732686 | 6480464 | Diclofenac inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] | CTD | PMID:15901346 | enalapril | multiple interactions | EXP | | 6480464 | Enalapril inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] | CTD | PMID:12065749 | erythromycin A | multiple interactions | ISO | RGD:732686 | 6480464 | Erythromycin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] | CTD | PMID:15901346 | erythromycin A | multiple interactions | EXP | | 6480464 | Erythromycin inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] | CTD | PMID:12065749 | estrone 3-sulfate | multiple interactions | ISO | RGD:732686 | 6480464 | Succinates promotes the reaction [SLC22A7 protein results in increased uptake of estrone sulfate]; more ... | CTD | PMID:15901346 | estrone 3-sulfate | increases uptake | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased uptake of estrone sulfate | CTD | PMID:15901346 | felbamate | decreases expression | ISO | RGD:621699 | 6480464 | felbamate results in decreased expression of SLC22A7 mRNA | CTD | PMID:17381134 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC22A7 gene | CTD | PMID:20938992 | furosemide | multiple interactions | ISO | RGD:732686 | 6480464 | Furosemide inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] | CTD | PMID:15901346 | gabapentin | increases expression | ISO | RGD:621699 | 6480464 | gabapentin results in increased expression of SLC22A7 mRNA | CTD | PMID:17381134 | gabapentin | decreases expression | ISO | RGD:621699 | 6480464 | gabapentin results in decreased expression of SLC22A7 mRNA | CTD | PMID:17381134 | ibuprofen | multiple interactions | ISO | RGD:732686 | 6480464 | Ibuprofen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] | CTD | PMID:15901346 | ibuprofen | decreases activity | ISO | RGD:732686 | 6480464 | Ibuprofen results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | indocyanine green | multiple interactions | EXP | | 6480464 | Indocyanine Green inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] | CTD | PMID:12065749 | indomethacin | multiple interactions | ISO | RGD:732686 | 6480464 | Indomethacin inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] | CTD | PMID:15901346 | indomethacin | decreases activity | ISO | RGD:732686 | 6480464 | Indomethacin results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | ketoprofen | decreases activity | ISO | RGD:732686 | 6480464 | Ketoprofen results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | L-ascorbic acid | increases transport | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased transport of Ascorbic Acid | CTD | PMID:15901346 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SLC22A7 gene | CTD | PMID:20938992 | methotrexate | increases uptake | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased uptake of Methotrexate | CTD | PMID:15901346 | methotrexate | increases uptake | EXP | | 6480464 | SLC22A7 protein results in increased uptake of Methotrexate | CTD | PMID:12065749 | methylmercury(1+) | decreases expression | ISO | RGD:621699 | 6480464 | methylmercury II results in decreased expression of SLC22A7 mRNA | CTD | PMID:17905399 | microcystin-LR | decreases expression | EXP | | 6480464 | cyanoginosin LR results in decreased expression of SLC22A7 mRNA | CTD | PMID:17654400 | minocycline | multiple interactions | ISO | RGD:732686 | 6480464 | Minocycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] | CTD | PMID:11855680 | naproxen | decreases activity | ISO | RGD:732686 | 6480464 | Naproxen results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | ochratoxin A | decreases expression | ISO | RGD:621699 | 6480464 | ochratoxin A results in decreased expression of SLC22A7 mRNA | CTD | PMID:19538982 | ochratoxin A | increases uptake | EXP | | 6480464 | SLC22A7 protein results in increased uptake of ochratoxin A | CTD | PMID:12065749 | ochratoxin A | increases expression | ISO | RGD:621699 | 6480464 | ochratoxin A results in increased expression of SLC22A7 protein | CTD | PMID:19538982 | oxytetracycline | multiple interactions | ISO | RGD:732686 | 6480464 | Oxytetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] | CTD | PMID:11855680 | p-aminohippuric acid | increases uptake | EXP | | 6480464 | SLC22A7 protein results in increased uptake of p-Aminohippuric Acid | CTD | PMID:12065749 | p-aminohippuric acid | increases uptake | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased uptake of p-Aminohippuric Acid | CTD | PMID:15901346 | paclitaxel | increases transport | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased transport of Paclitaxel | CTD | PMID:15901346 | paracetamol | multiple interactions | ISO | RGD:732686 | 6480464 | Acetaminophen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] | CTD | PMID:15901346 | paracetamol | decreases expression | ISO | RGD:732686 | 6480464 | Acetaminophen results in decreased expression of SLC22A7 mRNA | CTD | PMID:21420995 | paracetamol | decreases activity | ISO | RGD:732686 | 6480464 | Acetaminophen results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of SLC22A7 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | increases expression | ISO | RGD:621699 | 6480464 | perfluorooctane sulfonic acid results in increased expression of SLC22A7 mRNA | CTD | PMID:18692542 | perfluorooctanoic acid | affects transport | ISO | RGD:621699 | 6480464 | SLC22A7 protein affects the transport of perfluorooctanoic acid | CTD | PMID:11879818 | perfluorooctanoic acid | increases expression | ISO | RGD:621699 | 6480464 | perfluorooctanoic acid results in increased expression of SLC22A7 mRNA | CTD | PMID:21530637 | phenacetin | decreases activity | ISO | RGD:732686 | 6480464 | Phenacetin results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | phenobarbital | multiple interactions | EXP | | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SLC22A7 mRNA] | CTD | PMID:19482888 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of SLC22A7 mRNA | CTD | PMID:19482888 PMID:19850644 | phenobarbital | decreases expression | ISO | RGD:621699 | 6480464 | Phenobarbital results in decreased expression of SLC22A7 mRNA | CTD | PMID:17381134 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of SLC22A7 mRNA | CTD | PMID:19850644 PMID:19482888 | phenobarbital | multiple interactions | EXP | | 6480464 | NR1I3 protein promotes the reaction [Phenobarbital results in decreased expression of SLC22A7 mRNA] | CTD | PMID:19850644 | phenobarbital | decreases expression | ISO | RGD:732686 | 6480464 | Phenobarbital results in decreased expression of SLC22A7 mRNA | CTD | PMID:16837569 | phenytoin | decreases expression | ISO | RGD:621699 | 6480464 | Phenytoin results in decreased expression of SLC22A7 mRNA | CTD | PMID:17381134 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid co-treated with PPARA] results in decreased expression of SLC22A7 mRNA | CTD | PMID:20813756 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of SLC22A7 mRNA | CTD | PMID:19850644 PMID:20813756 | pirinixic acid | multiple interactions | EXP | | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of SLC22A7 mRNA] | CTD | PMID:19850644 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of SLC22A7 mRNA | CTD | PMID:20813756 PMID:19850644 | piroxicam | decreases activity | ISO | RGD:732686 | 6480464 | Piroxicam results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of SLC22A7 mRNA | CTD | PMID:21278054 | prostaglandin E2 | increases transport | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased transport of Dinoprostone | CTD | PMID:15901346 | prostaglandin E2 | increases uptake | EXP | | 6480464 | SLC22A7 protein results in increased uptake of Dinoprostone | CTD | PMID:12065749 | prostaglandin F2alpha | increases uptake | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased uptake of Dinoprost | CTD | PMID:15901346 | ranitidine | increases uptake | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased uptake of Ranitidine | CTD | PMID:16006492 | resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Dietary Fats affects the expression of SLC22A7 mRNA] | CTD | PMID:17086191 | rifampicin | decreases expression | ISO | RGD:732686 | 6480464 | Rifampin results in decreased expression of SLC22A7 mRNA | CTD | PMID:16837569 | salicylic acid | decreases activity | ISO | RGD:732686 | 6480464 | Salicylic Acid results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | salicylic acid | increases uptake | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased uptake of Salicylic Acid | CTD | PMID:12388633 | sulindac | decreases activity | ISO | RGD:732686 | 6480464 | Sulindac results in decreased activity of SLC22A7 protein | CTD | PMID:12388633 | testosterone | decreases expression | ISO | RGD:621699 | 6480464 | Testosterone results in decreased expression of SLC22A7 mRNA | CTD | PMID:11879818 | tetracycline | multiple interactions | ISO | RGD:732686 | 6480464 | Acetaminophen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]; more ... | CTD | PMID:15901346 | tetracycline | multiple interactions | ISO | RGD:732686 | 6480464 | Tetracycline inhibits the reaction [SLC22A7 protein results in increased uptake of Anions] | CTD | PMID:11855680 | tetracycline | increases uptake | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased uptake of Tetracycline | CTD | PMID:11855680 | tetracycline | increases transport | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased transport of Tetracycline | CTD | PMID:15901346 | trans-resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Dietary Fats affects the expression of SLC22A7 mRNA] | CTD | PMID:17086191 | trichloroethene | decreases expression | ISO | RGD:621699 | 6480464 | Trichloroethylene results in decreased expression of SLC22A7 mRNA | CTD | PMID:19448997 | valproic acid | decreases expression | ISO | RGD:621699 | 6480464 | Valproic Acid results in decreased expression of SLC22A7 mRNA | CTD | PMID:17381134 | valproic acid | increases uptake | EXP | | 6480464 | SLC22A7 protein results in increased uptake of Valproic Acid | CTD | PMID:12065749 | vancomycin | increases expression | EXP | | 6480464 | Vancomycin results in increased expression of SLC22A7 mRNA | CTD | PMID:18930951 | zidovudine | increases uptake | ISO | RGD:732686 | 6480464 | SLC22A7 protein results in increased uptake of Zidovudine | CTD | PMID:15901346 | | |||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process








