Gene: DARS (aspartyl-tRNA synthetase)
Homo sapiens
Symbol:
DARS
Name:
aspartyl-tRNA synthetase
Description:
Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of aminoacyl-tRNA synthetases. Aspartyl-tRNA synthetase charges its cognate tRNA with aspartate during protein biosynthesis. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
aspartate tRNA ligase 1, cytoplasmic; aspartate--tRNA ligase; aspartate--tRNA ligase, cytoplasmic; aspartyl-tRNA synthetase, cytoplasmic; aspRS; cell proliferation-inducing gene 40 protein; cell proliferation-inducing protein 40; DKFZp781B11202; MGC111579; OTTHUMP00000162534
Orthologs:
Mus musculus : Dars
(aspartyl-tRNA synthetase)
MGI
Dars
(aspartyl-tRNA synthetase)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 2 136,164,525 - 136,243,495 - NCBI Human Genome Assembly HuRef 2 128,656,738 - 128,735,990 - NCBI Human Genome Assembly GRCh37 2 136,664,254 - 136,743,222 - NCBI Human Genome Assembly Build 36 2 136,380,724 - 136,459,692 - NCBI Human Cytogenetic Map 2 q21.3 NCBI Human Genome Assembly 2 136,497,985 - 136,576,954 NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol increases expression ISO RGD:732390 6480464 Ethinyl Estradiol results in increased expression of DARS mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:732390 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DARS mRNA CTD PMID:17942748 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions EXP 6480464 Metribolone promotes the reaction [NDRG1 protein binds to DARS protein] CTD PMID:17220478 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:732390 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DARS mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732390 6480464 Tetrachlorodibenzodioxin affects the expression of DARS mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:621167 6480464 2,4-dinitrotoluene affects the expression of DARS mRNA CTD PMID:21346803 3H-1,2-dithiole-3-thione decreases expression ISO RGD:621167 6480464 1,2-dithiol-3-thione results in decreased expression of DARS mRNA CTD PMID:19162173 5-fluorouracil affects expression EXP 6480464 Fluorouracil affects the expression of DARS mRNA CTD PMID:16584549 7,12-dimethyltetraphene affects expression ISO RGD:732390 6480464 9,10-Dimethyl-1,2-benzanthracene affects the expression of DARS mRNA CTD PMID:21785161 ammonium chloride affects expression ISO RGD:621167 6480464 Ammonium Chloride affects the expression of DARS mRNA CTD PMID:16483693 benzo[a]pyrene multiple interactions ISO RGD:732390 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of DARS mRNA CTD PMID:21715664 benzo[a]pyrene affects expression ISO RGD:732390 6480464 Benzo(a)pyrene affects the expression of DARS mRNA CTD PMID:22342234 benzo[a]pyrene multiple interactions ISO RGD:732390 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to DARS promoter] CTD PMID:19654925 benzo[a]pyrene increases expression ISO RGD:732390 6480464 Benzo(a)pyrene results in increased expression of DARS mRNA CTD PMID:20504355 clofibrate decreases expression ISO RGD:621167 6480464 Clofibrate results in decreased expression of DARS protein CTD PMID:16470657 clofibric acid affects expression ISO RGD:621167 6480464 Clofibric Acid affects the expression of DARS mRNA CTD PMID:17602206 copper(2+) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of DARS mRNA CTD PMID:19549813 Delta(9)-tetrahydrocannabinol increases expression ISO RGD:732390 6480464 Tetrahydrocannabinol results in increased expression of DARS mRNA CTD PMID:12237329 disodium selenite increases expression EXP 6480464 Sodium Selenite results in increased expression of DARS mRNA CTD PMID:18175754 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of DARS mRNA CTD PMID:20044591 lead diacetate increases expression ISO RGD:621167 6480464 lead acetate results in increased expression of DARS mRNA CTD PMID:11578147 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of DARS mRNA CTD PMID:21420995 quercetin increases expression EXP 6480464 Quercetin results in increased expression of DARS mRNA CTD PMID:19729006 tert-butyl hydroperoxide increases expression EXP 6480464 tert-Butylhydroperoxide results in increased expression of DARS mRNA CTD PMID:15336504
Gene Ontology Annotations
Biological Process aspartyl-tRNA aminoacylation IEA InterPro:IPR004523 2290271 GO_REF:0000002 InterPro GO_REF:0000002 gene expression TAS 2290271 Reactome:REACT_71 Reactome Reactome:REACT_71 protein complex assembly TAS 2290271 PMID:8449960 PINC PMID:8449960 translation TAS 2290271 PMID:8449960 PINC PMID:8449960 tRNA aminoacylation for protein translation TAS 2290271 Reactome:REACT_15306 Reactome Reactome:REACT_15306 tRNA aminoacylation for protein translation TAS 2290271 Reactome:REACT_15482 Reactome Reactome:REACT_15482
1300023 BP46_H Blood pressure QTL 46 (human) 2.26 .00062 Blood pressure systolic 2 75830381 218576756 Human 1357310 AASTH42_H Allergic/atopic asthma related QTL 42 (human) .004 Reversible airflow obstruction 2 113186805 139186805 Human 1559369 BW77_H Body weight QTL 77 (human) 2.4 .00146 Body weight body mass index 2 124259466 150259466 Human 1558699 HRV2_H Heart rate variability QTL 2 (human) 1.81 Heart rate variability low-frequency power 2 59291776 208725006 Human 1559216 SCL61_H Serum cholesterol level QTL 61 (human) 2.6 Lipid level HDL cholesterol 2 124561984 150561984 Human 1558687 SCL13_H Serum cholesterol level QTL 13 (human) 3.5 Lipid level HDL cholesterol 2 123456585 149456585 Human 1559397 SCL105_H Serum cholesterol level QTL 105 (human) 1.6 Lipid level total cholesterol 2 124249848 159559082 Human 1559399 SCL104_H Serum cholesterol level QTL 104 (human) 3.87 Lipid level LDL cholesterol 2 126186729 169645507 Human 1559401 SCL106_H Serum cholesterol level QTL 106 (human) 2.2 Lipid level LDL cholesterol 2 124249848 159559082 Human 1559393 SCL103_H Serum cholesterol level QTL 103 (human) 4.25 Lipid level total cholesterol 2 126186729 169645507 Human 2289243 BW143_H Body weight QTL143 (human) 2.73 .0002 Body weight BMI 2 133208699 230683934 Human 2289245 BW144_H Body weight QTL 144 (human) 2.08 .001 Body weight BMI 2 133208699 230683934 Human 2289315 BW374_H Body weight QTL 374 (human) 2.33 .00053 Body fat amount abdominal 2 135210184 161210184 Human 2289306 BW373_H Body weight QTL 373 (human) 1.97 .00131 Body fat amount abdominal 2 123456585 149456585 Human 2289419 BW402_H Body weight QTL 402 (human) 1.91 Body fat amount percent fat 2 111249982 137249982 Human 2289438 BW403_H Body weight QTL 403 (human) 2.03 Body fat amount none 2 111249982 137249982 Human 1643291 SADIPOQ3_H Serum adiponectin level QTL 3 (human) 1.82 Hormone level serum adiponectin level 2 123456585 149456585 Human 1643465 SLIPL7_H Serum lipid level QTL 7 (human) 2 .001 Lipid level 2 113186805 139186805 Human 2293404 PRSTS239_H Prostate tumor susceptibility QTL 239 (human) .032 Prostate tumor susceptibility 2 135210184 161210184 Human 2289436 BW397_H Body weight QTL 397 (human) 4.04 Body weight BMI 2 85488426 156283230 Human 2292986 PRSTS183_H Prostate tumor susceptibility QTL 183 (human) 5.44 .0026 Prostate tumor susceptibility 2 134786651 160786651 Human 2293395 PRSTS199_H Prostate tumor susceptibility QTL 199 (human) 3.1 Prostate tumor susceptibility 2 134786651 160786651 Human 2314723 INSUL14_H Insulin level QTL 14 (human) 2.1 .188 Insulin level 2 131874289 157874289 Human 2300234 PRSTS353_H Prostate tumor susceptibility QTL 353 (human) .021 Prostate tumor susceptibility 2 135210184 161210184 Human
Gene Ontology Annotations
