Gene: Agps (alkylglycerone phosphate synthase)
Mus musculus |
| Symbol: |
Agps
|
| Name: |
alkylglycerone phosphate synthase
|
| Description: |
ENCODES a protein that exhibits alkylglycerone-phosphate synthase activity (ortholog); INVOLVED IN lipid biosynthetic process (ortholog); ASSOCIATED WITH abnormal lens fiber morphology; abnormal lens morphology; abnormal lipid level; ASSOCIATED WITH Chondrodysplasia Punctata, Rhizomelic (ortholog); Liver Neoplasms, Experimental (ortholog); Rhizomelic chondrodysplasia punctata, type 3 (ortholog); FOUND IN mitochondrion; intracellular membrane-bounded organelle (ortholog); peroxisomal membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; paracetamol |
| Type: |
protein-coding
|
| RefSeq Status: |
VALIDATED
|
| Also known as: |
5832437L22; 9930035G10Rik; ADAP-S; ADAPS; Adaps; ADAS; Adas; ADHAPS; Adhaps; ADPS; Adps; ALDHPSY; Aldhpsy; alkyl-DHAP synthase; alkyldihydroxyacetonephosphate synthase, peroxisomal; alkylglycerone-phosphate synthase; AW123847; bs2; OTTMUSP00000014280; OTTMUSP00000014281
|
| Orthologs: |
Homo sapiens : AGPS
(alkylglycerone phosphate synthase)
HGNC
Rattus norvegicus : Agps
(alkylglycerone phosphate synthase)
|
| Related Pseudogenes: |
Gm10292
|
| Latest Assembly: |
Mouse Genome Assembly Build 37
|
| Position: |
| Map | Chr | Position | Strand | Source |
|---|
Mouse Genome Assembly GRCm38 | 2 | 75,832,177 - 75,931,350 | + | NCBI | Mouse cM Map | 2 | | + | NCBI | Mouse Celera Assembly | 2 | 77,493,849 - 77,593,052 | + | NCBI | Mouse Genome Assembly Build 37 | 2 | 75,670,234 - 75,769,407 | + | NCBI | Mouse Genome Assembly Build 36.1 | 2 | 75,670,249 - 75,767,707 | + | NCBI | Mouse Cytogenetic Map | 2 | C3 | | NCBI |
|
| Model |
|
 Disease Annotations |
 Gene-Chemical Interaction Annotations
| (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:732011 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AGPS mRNA | CTD | PMID:22079256 | | 17beta-hydroxy-5alpha-androstan-3-one | decreases expression | ISO | RGD:732011 | 6480464 | Dihydrotestosterone results in decreased expression of AGPS mRNA | CTD | PMID:16631469 | | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732011 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AGPS mRNA | CTD | PMID:17101203 | | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of AGPS mRNA | CTD | PMID:21570461 | | 2,4-dinitrotoluene | affects expression | ISO | RGD:620364 | 6480464 | 2,4-dinitrotoluene affects the expression of AGPS mRNA | CTD | PMID:21346803 | | 2,4-dinitrotoluene | affects expression | ISO | | 6480464 | 2,4-dinitrotoluene affects the expression of AGPS mRNA | CTD | PMID:21346803 | | 2-methylcholine | affects expression | ISO | RGD:732011 | 6480464 | beta-methylcholine affects the expression of AGPS mRNA | CTD | PMID:21179406 | | aflatoxin B1 | decreases expression | ISO | RGD:732011 | 6480464 | Aflatoxin B1 results in decreased expression of AGPS mRNA | CTD | PMID:21641981 | | all-trans-retinoic acid | decreases expression | ISO | RGD:732011 | 6480464 | Tretinoin results in decreased expression of AGPS mRNA | CTD | PMID:15498508 | | benzo[a]pyrene | decreases expression | ISO | RGD:732011 | 6480464 | Benzo(a)pyrene results in decreased expression of AGPS mRNA | CTD | PMID:20064835 | | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of AGPS mRNA | CTD | PMID:21715664 | | cobalt dichloride | decreases expression | ISO | RGD:732011 | 6480464 | cobaltous chloride results in decreased expression of AGPS mRNA | CTD | PMID:19320972 | | copper atom | multiple interactions | ISO | RGD:732011 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of AGPS mRNA | CTD | PMID:20971185 | | copper(0) | multiple interactions | ISO | RGD:732011 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of AGPS mRNA | CTD | PMID:20971185 | | copper(2+) sulfate | increases expression | ISO | RGD:732011 | 6480464 | Copper Sulfate results in increased expression of AGPS mRNA | CTD | PMID:19549813 | | cyclosporin A | increases expression | ISO | RGD:732011 | 6480464 | Cyclosporine results in increased expression of AGPS mRNA | CTD | PMID:20106945 | | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of AGPS mRNA | CTD | PMID:17562736 | | paracetamol | decreases expression | ISO | RGD:732011 | 6480464 | Acetaminophen results in decreased expression of AGPS mRNA | CTD | PMID:21420995 | | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of AGPS mRNA | CTD | PMID:23091169 | | pirinixic acid | multiple interactions | ISO | RGD:732011 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AGPS mRNA | CTD | PMID:19710929 | | rosiglitazone | increases expression | ISO | | 6480464 | rosiglitazone results in increased expression of AGPS protein | CTD | PMID:18543250 | | rosiglitazone | increases expression | ISO | RGD:620364 | 6480464 | rosiglitazone results in increased expression of AGPS protein | CTD | PMID:18543250 | | tamibarotene | affects expression | ISO | RGD:732011 | 6480464 | Am 80 affects the expression of AGPS mRNA; more ... | CTD | PMID:15498508 | | trimellitic anhydride | increases expression | EXP | | 6480464 | trimellitic anhydride results in increased expression of AGPS mRNA | CTD | PMID:19042947 | |
Biological Process
| lipid biosynthetic process | | ISO | UniProtKB:O00116 | 2290270 | MGI:MGI:2154458 | MGI | MGI:MGI:2154458 |
| lipid metabolic process | | IEA | UniProtKB-KW:KW-0443 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| oxidation-reduction process | | IEA | InterPro:IPR016166|InterPro:IPR016167|InterPro:IPR006094 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
Cellular Component
| intracellular membrane-bounded organelle | | ISO | UniProtKB:O00116 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| mitochondrion | | IDA | | 2290270 | MGI:MGI:3852644|PMID:18614015 | MGI | MGI:MGI:3852644 PMID:18614015 |
| peroxisomal membrane | | ISO | UniProtKB:O00116 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| peroxisome | | ISO | UniProtKB:O00116 | 2290270 | MGI:MGI:2154458 | MGI | MGI:MGI:2154458 |
Molecular Function
| alkylglycerone-phosphate synthase activity | | ISO | UniProtKB:O00116 | 2290270 | MGI:MGI:2154458 | MGI | MGI:MGI:2154458 |
| catalytic activity | | IEA | InterPro:IPR016166|InterPro:IPR016167|InterPro:IPR016164|InterPro:IPR004113 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| flavin adenine dinucleotide binding | | IEA | InterPro:IPR016166|InterPro:IPR016167|InterPro:IPR016164|InterPro:IPR004113|InterPro:IPR006094 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| oxidoreductase activity | | IEA | InterPro:IPR006094 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| oxidoreductase activity, acting on CH-OH group of donors | | IEA | InterPro:IPR016166 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| transferase activity | | IEA | UniProtKB-KW:KW-0808 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| UDP-N-acetylmuramate dehydrogenase activity | | IEA | InterPro:IPR016167|InterPro:IPR006094 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| 1300811 | Obq3_m | obesity QTL 3 (mouse) | | | Not determined | | 2 | 74875992 | 108876133 | Mouse |
| 4141648 | Tmc1m1_m | Tmc1 modifier 1 (mouse) | | | Not determined | | 2 | 71417710 | 129114321 | Mouse |
| 4141672 | Brml14_m | bone response to mechanical loading 14 (mouse) | | | Not determined | | 2 | 67657700 | 101657955 | Mouse |
| 1301660 | Iba1_m | induction of brown adipocytes 1 (mouse) | | | Not determined | | 2 | 67657700 | 101657955 | Mouse |
| 5491197 | Mobq5_m | multigenic obesity QTL 5 (mouse) | | | Not determined | | 2 | 65277459 | 162502742 | Mouse |
| 1300871 | Mob5_m | multigenic obesity 5 (mouse) | | | Not determined | | 2 | 65277459 | 162502742 | Mouse |
| 1301873 | Hsl1_m | hyperoxia susceptibility locus 1 (mouse) | | | Not determined | | 2 | 63579967 | 97580114 | Mouse |
| 1558970 | Pbmd2_m | peak bone mineral density 2 (mouse) | | | Not determined | | 2 | 63015767 | 97015926 | Mouse |
| 1301703 | Bomd3_m | bone mineral density 3 (mouse) | | | Not determined | | 2 | 63015767 | 97015926 | Mouse |
| 1302174 | Dssc2_m | dextran sodium sulfate induced colitis QTL2 (mouse) | | | Not determined | | 2 | 63015767 | 97015926 | Mouse |
| 1301344 | Lith1_m | lithogenic gene 1 (mouse) | | | Not determined | | 2 | 63015767 | 97015926 | Mouse |
| 1300662 | Etohila_m | ethanol induced locomotor activity (mouse) | | | Not determined | | 2 | 63015767 | 97015926 | Mouse |
| 1301405 | Etohr_m | ethanol response acute (mouse) | | | Not determined | | 2 | 63015767 | 97015926 | Mouse |
| 4141406 | Alpq2_m | alcohol preference QTL 2 (mouse) | | | Not determined | | 2 | 57531830 | 91532001 | Mouse |
| 4140996 | Bwtq8_m | body weight QTL 8 (mouse) | | | Not determined | | 2 | 54417710 | 88417858 | Mouse |
| 1301438 | Ltsd2_m | lung tumor shape-determining 2 (mouse) | | | Not determined | | 2 | 53588173 | 87588291 | Mouse |
| 1300896 | Sluc2_m | susceptibility to lung cancer 2 (mouse) | | | Not determined | | 2 | 53588173 | 87588291 | Mouse |
| 1301059 | Hrtfm1_m | heart failure modifier 1 (mouse) | | | Not determined | | 2 | 52303093 | 86303218 | Mouse |
| 1300875 | Taste1_m | taste-saccharin preference 1 (mouse) | | | Not determined | | 2 | 50930888 | 84930991 | Mouse |
| 1357838 | Noan1_m | nitrous oxide antinociception 1 (mouse) | | | Not determined | | 2 | 49563989 | 83564166 | Mouse |
| 5491198 | Mobq7_m | multigenic obesity QTL 7 (mouse) | | | Not determined | | 2 | 48277459 | 82277647 | Mouse |
| 1300568 | Hdl1_m | high density lipoprotein (HDL) level 1 (mouse) | | | Not determined | | 2 | 48277459 | 82277647 | Mouse |
| 1301747 | Eae21_m | experimental allergic encephalomyelitis 21 (mouse) | | | Not determined | | 2 | 48277459 | 82277647 | Mouse |
| 1302182 | Mob7_m | multigenic obesity 7 (mouse) | | | Not determined | | 2 | 48277459 | 82277647 | Mouse |
| 1301235 | Alcw4_m | alcohol withdrawal 4 (mouse) | | | Not determined | | 2 | 48277459 | 82277647 | Mouse |
| 1302085 | Mobe1_m | modifier of obesity 1 (mouse) | | | Not determined | | 2 | 48277459 | 82277647 | Mouse |
| 1301939 | Ptz1a_m | pentylenetetrazol induced seizure susceptibility 1a (mouse) | | | Not determined | | 2 | 43528325 | 77528469 | Mouse |
| 1301769 | Orgwq2_m | organ weight QTL 2 (mouse) | | | Not determined | | 2 | 43528325 | 77528469 | Mouse |
| 1301402 | Ap2q_m | alcohol preference 2 QTL (mouse) | | | Not determined | | 2 | 43528325 | 77528469 | Mouse |
| 1301067 | Daq17_m | directional asymmetry QTL 17 (mouse) | | | Not determined | | 2 | 43528325 | 77528469 | Mouse |
| 1301411 | Pitm1_m | prion incubation time 1 (mouse) | | | Not determined | | 2 | 43528325 | 77528469 | Mouse |
| 1300788 | Cia2_m | collagen induced arthritis QTL 2 (mouse) | | | Not determined | | 2 | 43528325 | 77528469 | Mouse |
| 1301480 | Pbwg1_m | postnatal body weight growth 1 (mouse) | | | Not determined | | 2 | 41783118 | 75783242 | Mouse |
| 4141854 | T2dm2sa_m | type 2 diabetes mellitus 2 in SMXA RI mice (mouse) | | | Not determined | | 2 | 29273455 | 148358750 | Mouse |