ANXA7 (annexin A7) - Rat Genome Database

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Keyword

Gene: ANXA7 (annexin A7) Homo sapiens

Symbol:

ANXA7

Name:

annexin A7

Description:

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

annexin A7; annexin VII; annexin-7; ANX7; OTTHUMP00000019812; OTTHUMP00000019813; SNX; SYNEXIN

Orthologs:

Mus musculus : Anxa7 (annexin A7) MGI
Rattus norvegicus : Anxa7 (annexin A7)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	10	75,508,079 - 75,546,731	-	NCBI
Human Genome Assembly HuRef	10	69,129,017 - 69,167,555	-	NCBI
Human Genome Assembly GRCh37	10	75,135,189 - 75,173,841	-	NCBI
Human Genome Assembly Build 36	10	74,805,210 - 74,843,809	-	NCBI
Human Cytogenetic Map	10	q22.2		NCBI
Human Genome Assembly	10	74,805,209 - 74,843,814		NCBI