Annotation (Toggle Detail/Summary View) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:731429 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ITGA6 mRNA | CTD | PMID:22079256 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of ITGA6 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:621633 | 6480464 | Ethinyl Estradiol results in increased expression of ITGA6 mRNA | CTD | PMID:17108234 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of ITGA6 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ITGA6 mRNA | CTD | PMID:19465110 PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731429 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ITGA6 mRNA | CTD | PMID:23152189 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ITGA6 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:621633 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ITGA6 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ITGA6 mRNA | CTD | PMID:19933214 PMID:19465110 | 2-methoxyethanol | increases expression | ISO | RGD:621633 | 6480464 | methyl cellosolve results in increased expression of ITGA6 mRNA | CTD | PMID:21061450 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of ITGA6 mRNA | CTD | PMID:18648102 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:731429 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of ITGA6 mRNA | CTD | PMID:12419474 | aflatoxin B1 | increases expression | ISO | RGD:731429 | 6480464 | Aflatoxin B1 results in increased expression of ITGA6 mRNA | CTD | PMID:22100608 | all-trans-retinoic acid | multiple interactions | ISO | RGD:731429 | 6480464 | Thiophenes analog promotes the reaction [Tretinoin results in increased expression of ITGA6 mRNA] | CTD | PMID:16140955 | all-trans-retinoic acid | multiple interactions | ISO | RGD:731429 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in decreased expression of ITGA6 mRNA | CTD | PMID:15894607 | all-trans-retinoic acid | increases expression | ISO | RGD:731429 | 6480464 | Tretinoin results in increased expression of ITGA6 mRNA | CTD | PMID:16140955 PMID:16054129 | all-trans-retinoic acid | increases expression | ISO | RGD:731429 | 6480464 | Tretinoin results in increased expression of ITGA6 mRNA | CTD | PMID:16054129 PMID:16140955 | ammonium chloride | affects expression | ISO | RGD:621633 | 6480464 | Ammonium Chloride affects the expression of ITGA6 mRNA | CTD | PMID:16483693 | arachidonic acid | increases expression | ISO | RGD:731429 | 6480464 | Arachidonic Acid results in increased expression of ITGA6 mRNA | CTD | PMID:16704987 | arsenite(3-) | increases expression | EXP | | 6480464 | arsenite results in increased expression of ITGA6 mRNA | CTD | PMID:18191166 | benzo[a]pyrene | decreases expression | ISO | RGD:731429 | 6480464 | Benzo(a)pyrene results in decreased expression of ITGA6 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of ITGA6 mRNA | CTD | PMID:21569818 | bis(2-chloroethyl) sulfide | multiple interactions | ISO | RGD:731429 | 6480464 | Mustard Gas affects the expression of [ITGA6 protein binds to ITGB4 protein] | CTD | PMID:12880345 | bis(2-chloroethyl) sulfide | decreases expression | ISO | RGD:731429 | 6480464 | Mustard Gas results in decreased expression of ITGA6 protein | CTD | PMID:12880345 | cadmium atom | increases expression | ISO | RGD:731429 | 6480464 | Cadmium results in increased expression of ITGA6 mRNA | CTD | PMID:22562489 | cadmium dichloride | increases expression | ISO | RGD:731429 | 6480464 | Cadmium Chloride results in increased expression of ITGA6 mRNA | CTD | PMID:12160620 | calciol | increases expression | EXP | | 6480464 | Cholecalciferol results in increased expression of ITGA6 mRNA | CTD | PMID:17170073 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGA6 mRNA | CTD | PMID:20938992 | cobalt dichloride | decreases expression | ISO | RGD:731429 | 6480464 | cobaltous chloride results in decreased expression of ITGA6 mRNA | CTD | PMID:19320972 | copper(2+) sulfate | increases expression | ISO | RGD:731429 | 6480464 | Copper Sulfate results in increased expression of ITGA6 mRNA | CTD | PMID:19549813 | dasatinib (anhydrous) | decreases expression | ISO | RGD:731429 | 6480464 | dasatinib results in decreased expression of ITGA6 mRNA | CTD | PMID:20579391 | diarsenic trioxide | multiple interactions | ISO | RGD:731429 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in decreased expression of ITGA6 mRNA | CTD | PMID:15894607 | diazepam | decreases expression | ISO | RGD:731429 | 6480464 | Diazepam results in decreased expression of ITGA6 mRNA | CTD | PMID:19114084 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ITGA6 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ITGA6 mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:621633 | 6480464 | Dibutyl Phthalate results in increased expression of ITGA6 mRNA | CTD | PMID:21266533 | diethylstilbestrol | increases expression | ISO | RGD:621633 | 6480464 | Diethylstilbestrol results in increased expression of ITGA6 mRNA | CTD | PMID:17011747 | diuron | increases expression | ISO | RGD:621633 | 6480464 | Diuron results in increased expression of ITGA6 mRNA | CTD | PMID:21551480 | eugenol | increases expression | ISO | RGD:731429 | 6480464 | Eugenol results in increased expression of ITGA6 mRNA | CTD | PMID:17936526 | folic acid | affects expression | ISO | RGD:731429 | 6480464 | Folic Acid affects the expression of ITGA6 mRNA | CTD | PMID:16361273 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGA6 mRNA | CTD | PMID:20938992 | fonofos | increases methylation | ISO | RGD:731429 | 6480464 | Fonofos results in increased methylation of ITGA6 promoter | CTD | PMID:22847954 | hydrogen peroxide | affects expression | ISO | RGD:731429 | 6480464 | Hydrogen Peroxide affects the expression of ITGA6 mRNA | CTD | PMID:20044591 | iron atom | increases expression | ISO | RGD:621633 | 6480464 | Iron deficiency results in increased expression of ITGA6 mRNA | CTD | PMID:16629162 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ITGA6 mRNA | CTD | PMID:20938992 | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of ITGA6 mRNA | CTD | PMID:20542052 | losartan | decreases expression | ISO | RGD:621633 | 6480464 | Losartan results in decreased expression of ITGA6 protein | CTD | PMID:15100363 | methotrexate | affects expression | EXP | | 6480464 | Methotrexate affects the expression of ITGA6 mRNA | CTD | PMID:18502557 | mifepristone | increases expression | ISO | RGD:731429 | 6480464 | Mifepristone results in increased expression of ITGA6 mRNA | CTD | PMID:17584828 | N-nitrosodiethylamine | increases expression | ISO | RGD:621633 | 6480464 | Diethylnitrosamine results in increased expression of ITGA6 mRNA | CTD | PMID:19638242 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of ITGA6 mRNA | CTD | PMID:17562736 | parathion | increases methylation | ISO | RGD:731429 | 6480464 | Parathion results in increased methylation of ITGA6 promoter | CTD | PMID:22847954 | pirinixic acid | multiple interactions | ISO | RGD:731429 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ITGA6 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of ITGA6 mRNA | CTD | PMID:18301758 PMID:20813756 | quercetin | increases expression | ISO | RGD:731429 | 6480464 | Quercetin results in increased expression of ITGA6 mRNA | CTD | PMID:15309432 | riddelliine | decreases expression | ISO | RGD:621633 | 6480464 | riddelliine results in decreased expression of ITGA6 mRNA | CTD | PMID:18047727 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of ITGA6 mRNA | CTD | PMID:17555576 | terbufos | increases methylation | ISO | RGD:731429 | 6480464 | terbufos results in increased methylation of ITGA6 promoter | CTD | PMID:22847954 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:731429 | 6480464 | tert-Butylhydroperoxide results in decreased expression of ITGA6 mRNA | CTD | PMID:12419474 | tert-butyl hydroperoxide | increases expression | EXP | | 6480464 | tert-Butylhydroperoxide results in increased expression of ITGA6 mRNA | CTD | PMID:15003993 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| Cell adhesion molecules (CAMs) | |
| Dilated cardiomyopathy | |
| ECM-receptor interaction | |
| Focal adhesion | |
| Hematopoietic cell lineage | |
| Hypertrophic cardiomyopathy (HCM) | |
| Pathways in cancer | |
| PI3K-Akt signaling pathway | |
| Regulation of actin cytoskeleton | |
| Small cell lung cancer | |
| Toxoplasmosis | |
| Pathway Interaction Database | a6b1 and a6b4 Integrin signaling (PID:200190) |
| Alpha6 beta4 integrin-ligand interactions (PID:200125) | |
| Arf6 trafficking events (PID:200057) | |
| Beta1 integrin cell surface interactions (PID:200016) | |
| CXCR4-mediated signaling events (PID:200099) | |
| Integrin family cell surface interactions (PID:200039) | |
| Validated targets of C-MYC transcriptional repression (PID:200200) | |
Phenotype Annotations
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References - curated| 1. |
Buck CA, etal., Cell Adhes Commun 1996 Aug;4(2):69-87. |
| 2. |
Herlevsen M, etal., J Cell Sci 2003 Nov 1;116(Pt 21):4373-90. Epub 2003 Sep 16. |
| 3. |
MGD data from the GO Consortium |
| 4. |
MGD IEA |
| 5. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 6. |
RGD automated import pipeline |
| 7. |
RGD automated import pipeline for gene-chemical interactions |
| 8. |
RGD Automated Pipelines |
| 9. |
Ruzzi L, etal., J Clin Invest. 1997 Jun 15;99(12):2826-31. |
| 10. |
Takada Y, etal., Genome Biol. 2007;8(5):215. |
References - uncurated| PubMed | 10079228 |
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RGD Disease Portals| Itga6 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Itga6 (Mus musculus) |
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| ITGA6 (Homo sapiens) |
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| Itga6 (Rattus norvegicus) |
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Position Markers| RH135860 |
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| X69902 |
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| RH138432 |
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| Itga6 |
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| Itga6 |
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| Itga6 |
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| Itga6 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_008397 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01017202 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01017203 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01017204 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01017205 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK018033 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK028752 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK033255 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK034186 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK045391 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK052244 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK077276 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK083717 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK159653 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK193318 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK195380 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL928963 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC023816 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC024571 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC049132 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC058095 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466519 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X63251 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X69902 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_008397 | |||||||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_032423 | |||||||||||||||||||||||||
| Peptide Label: | precursor | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_032423 | (Get FASTA) |
| GenBank Protein | AAH49132 | (Get FASTA) |
| AAH58095 | (Get FASTA) | |
| BAC28623 | (Get FASTA) | |
| BAC32340 | (Get FASTA) | |
| BAC39003 | (Get FASTA) | |
| BAE35264 | (Get FASTA) | |
| CAA49527 | (Get FASTA) | |
| EDL27096 | (Get FASTA) | |
| EDL27097 | (Get FASTA) | |
| EDL27098 | (Get FASTA) | |
| Q61739 | (Get FASTA) |
Promoters| RGD ID: | 6831627 | ||||||||||
| Promoter ID: | MM_KWN:29647 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung | ||||||||||
| Transcripts: | ENSMUST00000036783, ENSMUST00000112101, OTTMUST00000032063, OTTMUST00000032065, UC008KBD.1 | ||||||||||
| Position: |
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| RGD ID: | 6874780 | ||||||||||
| Promoter ID: | EPDNEW_M841 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Itga6_1 | ||||||||||
| Description: | integrin alpha 6 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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| RGD ID: | 6831632 | ||||||||||
| Promoter ID: | MM_KWN:29648 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day3 | ||||||||||
| Transcripts: | UC008KBE.1 | ||||||||||
| Position: |
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| RGD ID: | 6831631 | ||||||||||
| Promoter ID: | MM_KWN:29650 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Kidney | ||||||||||
| Transcripts: | OTTMUST00000032070 | ||||||||||
| Position: |
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| RGD ID: | 6831624 | ||||||||||
| Promoter ID: | MM_KWN:29651 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day3, 3T3L1_Day4, Kidney | ||||||||||
| Transcripts: | OTTMUST00000032067, OTTMUST00000033060 | ||||||||||
| Position: |
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| RGD ID: | 6830886 | ||||||||||
| Promoter ID: | MM_KWN:29652 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day4, Kidney | ||||||||||
| Transcripts: | UC008KBG.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000027111 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000028522 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000028522 | ENTREZGENE |
| Entrez Gene | 16403 | ENTREZGENE |
| Germonline | ENSMUSG00000027111 | |
| HomoloGene Group ID | 20091 | ENTREZGENE |
| InterPro | FG-GAP | UniProtKB/TrEMBL |
| Int_alpha_beta-p | UniProtKB/Swiss-Prot | |
| Integrin_alpha | UniProtKB/Swiss-Prot | |
| Integrin_alpha-2 | UniProtKB/Swiss-Prot | |
| Integrin_alpha_C_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00227969 | UniProtKB/Swiss-Prot |
| IPI00420835 | UniProtKB/Swiss-Prot | |
| IPI00752327 | UniProtKB/TrEMBL | |
| IPI00974964 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:16403 | ENTREZGENE, UniProtKB/TrEMBL |
| MGD | MGI:96605 | ENTREZGENE |
| Pfam | FG-GAP | UniProtKB/TrEMBL |
| Integrin_alpha | UniProtKB/TrEMBL | |
| Integrin_alpha2 | UniProtKB/Swiss-Prot | |
| PRINTS | INTEGRINA | UniProtKB/Swiss-Prot |
| PROSITE | FG_GAP | UniProtKB/Swiss-Prot |
| INTEGRIN_ALPHA | UniProtKB/Swiss-Prot | |
| SMART | Int_alpha | UniProtKB/Swiss-Prot |
| UniGene | Mm.225096 | ENTREZGENE |
| UniProt | F6VSK8_MOUSE | UniProtKB/TrEMBL |
| ITA6_MOUSE | UniProtKB/Swiss-Prot | |
| Q3TWK2_MOUSE | UniProtKB/TrEMBL | |
| Q6PEE8_MOUSE | UniProtKB/TrEMBL | |
| Q80ZI8_MOUSE | UniProtKB/TrEMBL | |
| Q8BNH0_MOUSE | UniProtKB/TrEMBL | |
| Q8CC06_MOUSE | UniProtKB/TrEMBL |
| More on Itga6 | |
![]() |
Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 731430 |
| Created: | 2004-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-04-23 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




