ADRA2B (adrenoceptor alpha 2B) - Rat Genome Database

Name: ADRA2B
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: ADRA2B (adrenoceptor alpha 2B) Homo sapiens

Analyze

Symbol:

ADRA2B

Name:

adrenoceptor alpha 2B

RGD ID:

731080

HGNC Page

HGNC:282

Description:

Enables alpha2-adrenergic receptor activity and epinephrine binding activity. Involved in adrenergic receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of neuron differentiation. Located in cell surface; cytosol; and intracellular membrane-bounded organelle. Implicated in diabetic neuropathy; hypertension; myocardial infarction; obesity; and type 2 diabetes mellitus.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

aadrenergic, alpha-2b-, receptor; ADRA2B adrenergic, alpha-2B-, receptor; ADRA2L1; ADRA2RL1; ADRARL1; adrenergic receptor alpha 2B; adrenergic, alpha-2B-, receptor; alpha-2 adrenergic receptor subtype C2; alpha-2-adrenergic receptor-like 1; alpha-2B adrenergic receptor; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; alpha-2B-adrenergic receptor; alpha-2BAR; ALPHA2BAR; FAME2; G-protein coupled receptor

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Adra2b (adrenergic receptor, alpha 2b)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, Panther
Rattus norvegicus (Norway rat):	Adra2b (adrenoceptor alpha 2B)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther
Chinchilla lanigera (long-tailed chinchilla):	Adra2b (adrenoceptor alpha 2B)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	ADRA2B (adrenoceptor alpha 2B)	NCBI	Ortholog
Canis lupus familiaris (dog):	ADRA2B (adrenoceptor alpha 2B)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adra2b (adrenoceptor alpha 2B)	NCBI	Ortholog
Sus scrofa (pig):	ADRA2B (adrenoceptor alpha 2B)	HGNC	Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther
Chlorocebus sabaeus (green monkey):	ADRA2B (adrenoceptor alpha 2B)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Adra2b (adrenoceptor alpha 2B)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Adra2b (adrenoceptor alpha 2B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Adra2b (adrenergic receptor, alpha 2b)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adra2b (adrenoceptor alpha 2B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Octalpha2R	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	octr-1	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	adra2b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	adra2b.S	Alliance	DIOPT (Xenbase)
Xenopus laevis (African clawed frog):	adra2b.L	Alliance	DIOPT (Xenbase)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	96,112,876 - 96,116,571 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	96,112,876 - 96,116,571 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	96,778,624 - 96,782,310 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	96,142,350 - 96,145,615 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	96,200,496 - 96,203,762	NCBI
Celera	2	91,219,432 - 91,222,707 (-)	NCBI		Celera
Cytogenetic Map	2	q11.2	NCBI
HuRef	2	90,739,785 - 90,743,060 (-)	NCBI		HuRef
CHM1_1	2	96,782,950 - 96,786,215 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	96,619,491 - 96,623,187 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cyanosis (EXP)

Diabetic Nephropathies (IAGP)

diabetic neuropathy (IAGP)

epilepsy (IAGP)

familial adult myoclonic epilepsy 2 (IAGP)

genetic disease (IAGP)

hepatocellular carcinoma (EXP)

hypertension (IAGP,ISO)

intellectual disability (EXP,IAGP)

lung disease (EXP)

myocardial infarction (IAGP)

obesity (IAGP)

pheochromocytoma (IAGP)

schizophrenia (IAGP)

Sudden Cardiac Death (IAGP)

type 2 diabetes mellitus (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-adrenaline (EXP)

(R)-noradrenaline (EXP)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methoxyidazoxan (EXP)

4,4'-sulfonyldiphenol (ISO)

acetylcholine (ISO)

aflatoxin B1 (EXP)

ammonium chloride (ISO)

aristolochic acid A (EXP)

arsenous acid (EXP)

benzo[a]pyrene (EXP)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP)

butanal (EXP)

C60 fullerene (ISO)

cadmium atom (EXP)

calcium atom (EXP)

calcium(0) (EXP)

cantharidin (ISO)

clonidine (EXP)

clonidine (amino form) (EXP)

clonidine (imino form) (EXP)

Cuprizon (ISO)

diarsenic trioxide (EXP)

dibutyl phthalate (ISO)

dieldrin (ISO)

dimethylarsinic acid (ISO)

dioxygen (ISO)

diquat (ISO)

folic acid (ISO)

lead diacetate (ISO)

Licochalcone B (EXP)

lipopolysaccharide (EXP)

methylarsonic acid (ISO)

N-ethyl-N-nitrosourea (ISO)

N-methyl-4-phenylpyridinium (EXP)

oxymetazoline (EXP)

paracetamol (EXP,ISO)

paraquat (ISO)

pentanal (EXP)

phenylephrine (ISO)

resveratrol (EXP)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (EXP)

sodium arsenate (ISO)

sodium arsenite (EXP,ISO)

sunitinib (EXP)

tamoxifen (ISO)

tetrachloromethane (ISO)

Theaflavin 3,3'-digallate (EXP)

trichloroethene (ISO)

triclosan (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (EXP,ISO)

vancomycin (ISO)

Xylometazoline (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating adrenergic receptor signaling pathway (IBA)

adrenergic receptor signaling pathway (IDA,ISO)

angiogenesis (IEA,ISO)

cell-cell signaling (TAS)

female pregnancy (IEA,ISO)

G protein-coupled receptor signaling pathway (IDA,IEA,ISO)

MAPK cascade (IEA,ISO)

negative regulation of epinephrine secretion (NAS)

negative regulation of norepinephrine secretion (NAS,TAS)

platelet activation (IEA)

positive regulation of blood pressure (IEA,ISO)

positive regulation of MAPK cascade (IBA,IDA,IEA,ISO)

positive regulation of neuron differentiation (IDA)

positive regulation of uterine smooth muscle contraction (IEA,ISO)

regulation of smooth muscle contraction (IEA)

regulation of vascular associated smooth muscle contraction (IEA,ISO)

regulation of vasoconstriction (IEA)

Cellular Component

cell surface (IDA)

cytosol (IDA)

intracellular membrane-bounded organelle (IDA)

membrane (IEA)

plasma membrane (IBA,IEA,TAS)

Molecular Function

adrenergic receptor activity (IEA)

alpha2-adrenergic receptor activity (IBA,IDA,IEA,ISO,TAS)

epinephrine binding (IBA,IDA)

G protein-coupled receptor activity (IEA)

protein binding (IPI)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Amaurosis fugax (IAGP)

EEG abnormality (IAGP)

Focal-onset seizure (IAGP)

Generalized-onset seizure (IAGP)

Hand tremor (IAGP)

Headache (IAGP)

Intellectual disability (IAGP)

Myoclonus (IAGP)

Pheochromocytoma (IAGP)

Schizophrenia (IAGP)

Seizure (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	A deletion polymorphism of the alpha2B-adrenergic receptor gene is not associated with late complications in Type 1 diabetic patients.	Heinonen P, etal., Diabet Med. 2005 Feb;22(2):226-8.
3.	Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.	Heinonen P, etal., J Clin Endocrinol Metab 1999 Jul;84(7):2429-33.
4.	Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism.	Laaksonen DE, etal., Med Sci Sports Exerc. 2007 Feb;39(2):227-32.
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	An insertion/deletion polymorphism in the alpha2B adrenoceptor gene is associated with peripheral neuropathy in patients with type 2 diabetes mellitus.	Papanas N, etal., Exp Clin Endocrinol Diabetes. 2007 May;115(5):327-30.
7.	An insertion/deletion polymorphism in the alpha2B adrenoceptor gene is associated with age at onset of type 2 diabetes mellitus.	Papazoglou D, etal., Exp Clin Endocrinol Diabetes. 2006 Sep;114(8):424-7.
8.	Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough.	Philipp M, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R287-95.
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	RGD HPO Phenotype Annotation Pipeline	RGD automated import pipeline for human HPO-to-gene-to-disease annotations
11.	Long-term inhibition of the central alpha(2B)-adrenergic receptor gene via recombinant AAV-delivered antisense in hypertensive rats.	Shenouda SM, etal., Am J Hypertens. 2006 Nov;19(11):1135-43.
12.	Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.	Snapir A, etal., J Am Coll Cardiol. 2003 Jan 15;41(2):190-4.
13.	Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects.	Vasudevan R, etal., Int J Biol Sci. 2008;4(6):362-7. Epub 2008 Oct 5.
14.	Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension.	Von Wowern F, etal., Hypertension. 2004 Mar;43(3):592-7. Epub 2004 Jan 26.

Additional References at PubMed

PMID:2164221	PMID:2169434	PMID:2172775	PMID:2173582	PMID:2842764	PMID:3012234	PMID:9235896	PMID:9435676	PMID:10224112	PMID:10647009	PMID:11056163	PMID:11140838
PMID:11154706	PMID:11313909	PMID:11345359	PMID:11753579	PMID:12401126	PMID:12477932	PMID:12519093	PMID:12629104	PMID:12822042	PMID:12917501	PMID:12946937	PMID:15037199
PMID:15166301	PMID:15309292	PMID:15592690	PMID:15719258	PMID:15731590	PMID:15815621	PMID:15864122	PMID:15864138	PMID:15893292	PMID:15900214	PMID:15900285	PMID:15920038
PMID:16247508	PMID:16269962	PMID:16336817	PMID:16531006	PMID:16645408	PMID:16776624	PMID:16907703	PMID:17215105	PMID:17370102	PMID:17410123	PMID:17595424	PMID:17620957
PMID:17625217	PMID:17660814	PMID:18054844	PMID:18240029	PMID:18456256	PMID:18596718	PMID:18854756	PMID:18996102	PMID:19056576	PMID:19352218	PMID:19477270	PMID:19477404
PMID:19593211	PMID:19728989	PMID:19781422	PMID:19815603	PMID:19826083	PMID:19874574	PMID:20044737	PMID:20051907	PMID:20110158	PMID:20401689	PMID:20424170	PMID:20613626
PMID:20651814	PMID:20692245	PMID:20705341	PMID:20739228	PMID:21159032	PMID:21259387	PMID:21357695	PMID:21854681	PMID:21873635	PMID:21878072	PMID:21942960	PMID:21965191
PMID:22025613	PMID:22170367	PMID:22218095	PMID:22404651	PMID:22560155	PMID:22570080	PMID:22701600	PMID:22743060	PMID:22839581	PMID:23105096	PMID:23225885	PMID:23499426
PMID:23583499	PMID:24058067	PMID:24087960	PMID:24114805	PMID:24149058	PMID:24269973	PMID:24997351	PMID:25127926	PMID:25325286	PMID:25558682	PMID:25904801	PMID:26427149
PMID:26811329	PMID:26899992	PMID:27875276	PMID:27901063	PMID:28115477	PMID:28254464	PMID:28456594	PMID:28482761	PMID:28862946	PMID:28923554	PMID:29039833	PMID:29212846
PMID:29751052	PMID:30858399	PMID:31090375	PMID:32385805	PMID:33900865	PMID:37525034	PMID:37805907

Genomics

Comparative Map Data

ADRA2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	96,112,876 - 96,116,571 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	96,112,876 - 96,116,571 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	96,778,624 - 96,782,310 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	96,142,350 - 96,145,615 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	96,200,496 - 96,203,762	NCBI
Celera	2	91,219,432 - 91,222,707 (-)	NCBI		Celera
Cytogenetic Map	2	q11.2	NCBI
HuRef	2	90,739,785 - 90,743,060 (-)	NCBI		HuRef
CHM1_1	2	96,782,950 - 96,786,215 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	96,619,491 - 96,623,187 (-)	NCBI		T2T-CHM13v2.0

Adra2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	127,205,099 - 127,209,141 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	127,205,128 - 127,209,141 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	127,363,179 - 127,367,221 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	127,363,208 - 127,367,221 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	127,189,022 - 127,192,957 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	127,054,727 - 127,058,662 (+)	NCBI		MGSCv36	mm8
Celera	2	128,605,637 - 128,609,581 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	61.95	NCBI

Adra2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	135,038,481 - 135,042,527 (+)	NCBI		GRCr8
mRatBN7.2	3	114,585,174 - 114,589,220 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	114,585,169 - 114,589,355 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	118,474,365 - 118,478,411 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	127,069,926 - 127,073,972 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	124,730,297 - 124,734,343 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	119,805,941 - 119,809,987 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	119,805,941 - 119,809,987 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	126,332,318 - 126,336,364 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	114,867,357 - 114,869,680 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	114,772,929 - 114,775,253 (+)	NCBI
Celera	3	113,423,833 - 113,427,879 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Adra2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	3,711,031 - 3,714,241 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	3,711,075 - 3,714,450 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADRA2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	32,191,623 - 32,195,678 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	32,194,382 - 32,198,437 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	103,198,432 - 103,202,506 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	97,038,208 - 97,041,901 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	97,040,126 - 97,041,472 (-)	Ensembl	panpan1.1		panPan2

ADRA2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	34,615,121 - 34,618,480 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	34,615,096 - 34,656,791 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	34,384,544 - 34,387,878 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	35,386,143 - 35,389,429 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	35,386,281 - 35,392,341 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	34,515,433 - 34,518,767 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	34,583,739 - 34,587,073 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	34,790,948 - 34,794,282 (+)	NCBI		UU_Cfam_GSD_1.0

Adra2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	82,996,684 - 83,000,132 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936744	251,467 - 252,816 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936744	249,673 - 253,040 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADRA2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	45,760,541 - 45,764,175 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	45,760,966 - 45,762,306 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	48,584,007 - 48,585,347 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADRA2B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	558,876 - 562,959 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	561,057 - 562,400 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	167,968,245 - 167,971,966 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adra2b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	2,226,738 - 2,230,381 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	2,226,809 - 2,230,413 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ADRA2B
32 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 2q11.1-11.2(chr2:95879602-97029672)x3	copy number gain	Global developmental delay [RCV000050366]\|See cases [RCV000050366]	Chr2:95879602..97029672 [GRCh38] Chr2:96545350..97695409 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95879602-97285797)x1	copy number loss	See cases [RCV000051260]	Chr2:95879602..97285797 [GRCh38] Chr2:96545350..98013866 [GRCh37] Chr2:95909077..97380005 [NCBI36] Chr2:2q11.1-11.2	pathogenic
GRCh38/hg38 2q11.2(chr2:96100812-97285797)x1	copy number loss	See cases [RCV000051137]	Chr2:96100812..97285797 [GRCh38] Chr2:96766560..98013866 [GRCh37] Chr2:96130287..97380005 [NCBI36] Chr2:2q11.2	pathogenic
NM_000682.7(ADRA2B):c.675_686delinsGTTTGGCAG (p.His225_Leu229delinsGlnPheGlyArg)	indel	Epilepsy, familial adult myoclonic, 2 [RCV000172992]	Chr2:96115464..96115475 [GRCh38] Chr2:96781203..96781214 [GRCh37] Chr2:2q11.2	pathogenic\|uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95806265-97285797)x3	copy number gain	See cases [RCV000053136]	Chr2:95806265..97285797 [GRCh38] Chr2:96472013..98013866 [GRCh37] Chr2:95835740..97380005 [NCBI36] Chr2:2q11.1-11.2	uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95810453-97024341)x3	copy number gain	See cases [RCV000053137]	Chr2:95810453..97024341 [GRCh38] Chr2:96476201..97690078 [GRCh37] Chr2:95839928..97053805 [NCBI36] Chr2:2q11.1-11.2	uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95880668-97131646)x3	copy number gain	See cases [RCV000053138]	Chr2:95880668..97131646 [GRCh38] Chr2:96546416..97797383 [GRCh37] Chr2:95910143..97161110 [NCBI36] Chr2:2q11.1-11.2	uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95916534-97024341)x3	copy number gain	See cases [RCV000053139]	Chr2:95916534..97024341 [GRCh38] Chr2:96582282..97690078 [GRCh37] Chr2:95946009..97053805 [NCBI36] Chr2:2q11.1-11.2	uncertain significance
GRCh38/hg38 2q11.2(chr2:96100612-97285797)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053140]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053140]\|See cases [RCV000053140]	Chr2:96100612..97285797 [GRCh38] Chr2:96766360..98014007 [GRCh37] Chr2:96130087..97380146 [NCBI36] Chr2:2q11.2	uncertain significance
GRCh38/hg38 2q11.1-12.1(chr2:94817406-103252396)x3	copy number gain	See cases [RCV000052946]	Chr2:94817406..103252396 [GRCh38] Chr2:95618109..103868854 [GRCh37] Chr2:94846878..103235286 [NCBI36] Chr2:2q11.1-12.1	pathogenic
GRCh38/hg38 2p11.2-q11.2(chr2:91443218-102334856)x3	copy number gain	See cases [RCV000052945]	Chr2:91443218..102334856 [GRCh38] Chr2:91617683..102951316 [GRCh37] Chr2:90981410..102317748 [NCBI36] Chr2:2p11.2-q11.2	pathogenic
NM_000682.7(ADRA2B):c.274G>A (p.Asp92Asn)	single nucleotide variant	Epilepsy, familial adult myoclonic, 2 [RCV001331355]	Chr2:96115876 [GRCh38] Chr2:96781615 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.664C>T (p.Arg222Ter)	single nucleotide variant	Epilepsy, familial adult myoclonic, 2 [RCV001331356]\|not provided [RCV000171297]	Chr2:96115486 [GRCh38] Chr2:96781225 [GRCh37] Chr2:2q11.2	likely pathogenic\|uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95493468-96977610)x3	copy number gain	See cases [RCV000133839]	Chr2:95493468..96977610 [GRCh38] Chr2:96159216..97643347 [GRCh37] Chr2:95522943..97007074 [NCBI36] Chr2:2q11.1-11.2	uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95879602-97029672)x3	copy number gain	See cases [RCV000050366]	Chr2:95879602..97029672 [GRCh38] Chr2:96545350..97695409 [GRCh37] Chr2:95909077..97059136 [NCBI36] Chr2:2q11.1-11.2	uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95879602-97029672)x1	copy number loss	See cases [RCV000134141]	Chr2:95879602..97029672 [GRCh38] Chr2:96545350..97695409 [GRCh37] Chr2:95909077..97059136 [NCBI36] Chr2:2q11.1-11.2	pathogenic
GRCh38/hg38 2q11.2(chr2:96073560-97062710)x1	copy number loss	See cases [RCV000135343]	Chr2:96073560..97062710 [GRCh38] Chr2:96739308..97728447 [GRCh37] Chr2:96103035..97092174 [NCBI36] Chr2:2q11.2	pathogenic
GRCh38/hg38 2q11.2(chr2:96100812-97154835)x1	copy number loss	See cases [RCV000137012]	Chr2:96100812..97154835 [GRCh38] Chr2:96766560..97820572 [GRCh37] Chr2:96130287..97184299 [NCBI36] Chr2:2q11.2	uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95337458-99072953)x3	copy number gain	See cases [RCV000138012]	Chr2:95337458..99072953 [GRCh38] Chr2:96003206..99689416 [GRCh37] Chr2:95366933..99055848 [NCBI36] Chr2:2q11.1-11.2	uncertain significance
GRCh38/hg38 2q11.1-11.2(chr2:95766541-97589743)x3	copy number gain	See cases [RCV000137817]	Chr2:95766541..97589743 [GRCh38] Chr2:96432289..98206206 [GRCh37] Chr2:95796016..97572638 [NCBI36] Chr2:2q11.1-11.2	uncertain significance
GRCh38/hg38 2q11.1-13(chr2:94678532-110602409)x3	copy number gain	See cases [RCV000141075]	Chr2:94678532..110602409 [GRCh38] Chr2:95344257..111359986 [GRCh37] Chr2:94707984..111076455 [NCBI36] Chr2:2q11.1-13	pathogenic
GRCh38/hg38 2q11.2(chr2:96066771-97285797)x3	copy number gain	See cases [RCV000142146]	Chr2:96066771..97285797 [GRCh38] Chr2:96732519..98079569 [GRCh37] Chr2:96096246..97432433 [NCBI36] Chr2:2q11.2	uncertain significance
GRCh38/hg38 2q11.2(chr2:96100816-97285797)x3	copy number gain	See cases [RCV000142814]	Chr2:96100816..97285797 [GRCh38] Chr2:96766564..98013954 [GRCh37] Chr2:96130291..97380093 [NCBI36] Chr2:2q11.2	uncertain significance
GRCh38/hg38 2q11.2(chr2:96073560-97513144)x1	copy number loss	See cases [RCV000142800]	Chr2:96073560..97513144 [GRCh38] Chr2:96739308..98066294 [GRCh37] Chr2:96103035..97496039 [NCBI36] Chr2:2q11.2	pathogenic
GRCh38/hg38 2q11.2(chr2:96073560-97589743)x3	copy number gain	See cases [RCV000143142]	Chr2:96073560..97589743 [GRCh38] Chr2:96739308..98206206 [GRCh37] Chr2:96103035..97572638 [NCBI36] Chr2:2q11.2	likely benign
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3	copy number gain	not provided [RCV000752802]	Chr2:14238..243048760 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q11.1-12.3(chr2:95529039-108518266)	copy number gain	See cases [RCV000449270]	Chr2:95529039..108518266 [GRCh37] Chr2:2q11.1-12.3	pathogenic
GRCh37/hg19 2q11.1-13(chr2:95327499-111370025)x4	copy number gain	See cases [RCV000446842]	Chr2:95327499..111370025 [GRCh37] Chr2:2q11.1-13	pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96544602-98118115)x1	copy number loss	See cases [RCV000446002]	Chr2:96544602..98118115 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96698012-97757442)x3	copy number gain	See cases [RCV000445685]	Chr2:96698012..97757442 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
NM_000682.7(ADRA2B):c.276C>G (p.Asp92Glu)	single nucleotide variant	not provided [RCV000441686]	Chr2:96115874 [GRCh38] Chr2:96781613 [GRCh37] Chr2:2q11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:95691600-100587394)	copy number gain	See cases [RCV000447723]	Chr2:95691600..100587394 [GRCh37] Chr2:2q11.1-11.2	pathogenic
NC_000002.11:g.(?_96738407)_(97742073_?)del	deletion	Schizophrenia [RCV000416822]	Chr2:96738407..97742073 [GRCh37] Chr2:96102134..97105800 [NCBI36] Chr2:2q11.1-11.2	likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96778661-97757978)x3	copy number gain	See cases [RCV000448583]	Chr2:96778661..97757978 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)	copy number gain	See cases [RCV000512056]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96468158-97871906)x3	copy number gain	See cases [RCV000511375]	Chr2:96468158..97871906 [GRCh37] Chr2:2q11.1-11.2	likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96097383-97679933)x1	copy number loss	See cases [RCV000511715]	Chr2:96097383..97679933 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96732519-98225552)x3	copy number gain	See cases [RCV000511635]	Chr2:96732519..98225552 [GRCh37] Chr2:2q11.1-11.2	likely benign
GRCh37/hg19 2q11.1-11.2(chr2:96712139-98249638)x1	copy number loss	See cases [RCV000511596]	Chr2:96712139..98249638 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3	copy number gain	See cases [RCV000511212]	Chr2:12771..242783384 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
GRCh37/hg19 2q11.1-12.2(chr2:95518497-107186127)	copy number gain	See cases [RCV000511158]	Chr2:95518497..107186127 [GRCh37] Chr2:2q11.1-12.2	uncertain significance
NM_000682.7(ADRA2B):c.568C>T (p.Leu190Phe)	single nucleotide variant	Inborn genetic diseases [RCV003272116]	Chr2:96115582 [GRCh38] Chr2:96781321 [GRCh37] Chr2:2q11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96735977-98258828)x1	copy number loss	not provided [RCV000682130]	Chr2:96735977..98258828 [GRCh37] Chr2:2q11.1-11.2	likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96544602-98138405)x1	copy number loss	not provided [RCV000682132]	Chr2:96544602..98138405 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3	copy number gain	not provided [RCV000682168]	Chr2:96353030..114045463 [GRCh37] Chr2:2q11.1-13	pathogenic
Single allele	deletion	not provided [RCV000714264]	Chr2:40608411..146900718 [GRCh37] Chr2:2p22.1-q22.3	likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3	copy number gain	not provided [RCV000752804]	Chr2:15672..243101834 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
NC_000002.12:g.(?_96063558)_(97079140_?)del	deletion	Schizophrenia [RCV000754268]	Chr2:96063558..97079140 [GRCh38] Chr2:2q11.2	likely pathogenic
NM_000682.7(ADRA2B):c.567C>T (p.Ile189=)	single nucleotide variant	not provided [RCV000945985]	Chr2:96115583 [GRCh38] Chr2:96781322 [GRCh37] Chr2:2q11.2	benign
NM_000682.7(ADRA2B):c.943G>A (p.Val315Met)	single nucleotide variant	not provided [RCV000878831]	Chr2:96115207 [GRCh38] Chr2:96780955 [GRCh37] Chr2:2q11.2	likely benign
NM_000682.7(ADRA2B):c.1135G>A (p.Val379Ile)	single nucleotide variant	not provided [RCV000877904]	Chr2:96115015 [GRCh38] Chr2:96780763 [GRCh37] Chr2:2q11.2	likely benign
NM_000682.7(ADRA2B):c.911_912insAGAGGA (p.Glu308_Glu309dup)	insertion	not provided [RCV000877779]	Chr2:96115238..96115239 [GRCh38] Chr2:2q11.2	likely benign
NM_000682.7(ADRA2B):c.894AGAGGAGGA[1] (p.Glu307_Glu309del)	microsatellite	not provided [RCV000945840]	Chr2:96115239..96115247 [GRCh38] Chr2:96780987..96780997 [GRCh37] Chr2:2q11.2	benign
NC_000002.11:g.(?_96780545)_(96971175_?)dup	duplication	not provided [RCV001031839]	Chr2:96780545..96971175 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
NC_000002.11:g.(?_96780545)_(96994037_?)dup	duplication	not provided [RCV001031880]	Chr2:96780545..96994037 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96747466-98193473)x1	copy number loss	See cases [RCV000790587]	Chr2:96747466..98193473 [GRCh37] Chr2:2q11.1-11.2	likely pathogenic
NM_000682.7(ADRA2B):c.1266C>T (p.Asn422=)	single nucleotide variant	not provided [RCV000945865]	Chr2:96114884 [GRCh38] Chr2:96780632 [GRCh37] Chr2:2q11.2	likely benign
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373)	copy number gain	Mosaic trisomy 2 [RCV002280628]	Chr2:1..243199373 [GRCh37] Chr2:2p25.3-q37.3	pathogenic
NM_000682.7(ADRA2B):c.695C>G (p.Ala232Gly)	single nucleotide variant	not provided [RCV000811978]	Chr2:96115455 [GRCh38] Chr2:96781194 [GRCh37] Chr2:2q11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96552903-98118115)x1	copy number loss	not provided [RCV000848564]	Chr2:96552903..98118115 [GRCh37] Chr2:2q11.1-11.2	pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96515883-98025634)x3	copy number gain	not provided [RCV000845755]	Chr2:96515883..98025634 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
NM_000682.7(ADRA2B):c.636dup (p.Pro213fs)	duplication	not specified [RCV001193900]	Chr2:96115513..96115514 [GRCh38] Chr2:96781252..96781253 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.1070G>A (p.Trp357Ter)	single nucleotide variant	ADRA2B-Related Disorder [RCV003313720]	Chr2:96115080 [GRCh38] Chr2:96780828 [GRCh37] Chr2:2q11.2	not provided
NM_000682.7(ADRA2B):c.1102C>T (p.Arg368Cys)	single nucleotide variant	not provided [RCV001091894]	Chr2:96115048 [GRCh38] Chr2:96780796 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.145C>T (p.Leu49=)	single nucleotide variant	not provided [RCV000886160]	Chr2:96116005 [GRCh38] Chr2:96781744 [GRCh37] Chr2:2q11.2	likely benign
NM_000682.7(ADRA2B):c.120C>T (p.Ser40=)	single nucleotide variant	not provided [RCV000951962]	Chr2:96116030 [GRCh38] Chr2:96781769 [GRCh37] Chr2:2q11.2	benign
NM_000682.7(ADRA2B):c.1293G>A (p.Gln431=)	single nucleotide variant	not provided [RCV000912427]	Chr2:96114857 [GRCh38] Chr2:96780605 [GRCh37] Chr2:2q11.2	likely benign
GRCh37/hg19 2q11.1-11.2(chr2:95341388-100340514)x3	copy number gain	not provided [RCV002473932]	Chr2:95341388..100340514 [GRCh37] Chr2:2q11.1-11.2	likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96732519-98118115)x3	copy number gain	not provided [RCV001005296]	Chr2:96732519..98118115 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96737083-98261802)x1	copy number loss	See cases [RCV001194515]	Chr2:96737083..98261802 [GRCh37] Chr2:2q11.1-11.2	likely pathogenic
NM_000682.7(ADRA2B):c.1079G>A (p.Arg360Gln)	single nucleotide variant	not provided [RCV001591708]	Chr2:96115071 [GRCh38] Chr2:96780819 [GRCh37] Chr2:2q11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96712139-98254657)x1	copy number loss	not provided [RCV001005295]	Chr2:96712139..98254657 [GRCh37] Chr2:2q11.1-11.2	likely pathogenic\|uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96737083-98193473)x3	copy number gain	See cases [RCV001194576]	Chr2:96737083..98193473 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96421161-97765561)x1	copy number loss	not provided [RCV001259642]	Chr2:96421161..97765561 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96544602-97706860)x3	copy number gain	not provided [RCV001259643]	Chr2:96544602..97706860 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96630256-96836549)x3	copy number gain	not provided [RCV001259640]	Chr2:96630256..96836549 [GRCh37] Chr2:2q11.1-11.2	likely benign
GRCh37/hg19 2q11.1-11.2(chr2:96515883-98162176)x3	copy number gain	not provided [RCV001259641]	Chr2:96515883..98162176 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96755045-98021592)	copy number loss	Fetal growth restriction [RCV001352673]	Chr2:96755045..98021592 [GRCh37] Chr2:2q11.1-11.2	pathogenic
NM_000682.7(ADRA2B):c.898_899insGGGAAGAGG (p.Glu299_Glu300insGlyGluGlu)	insertion	Seizure [RCV001281487]	Chr2:96115251..96115252 [GRCh38] Chr2:96780990..96780991 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.649G>A (p.Glu217Lys)	single nucleotide variant	Epilepsy, familial adult myoclonic, 2 [RCV001334559]\|Inborn genetic diseases [RCV002546687]	Chr2:96115501 [GRCh38] Chr2:96781240 [GRCh37] Chr2:2q11.2	uncertain significance
Single allele	deletion	Intellectual disability [RCV001293378]	Chr2:96737083..98193473 [GRCh37] Chr2:2q11.1-11.2	pathogenic
NM_000682.7(ADRA2B):c.293C>A (p.Ser98Ter)	single nucleotide variant	not provided [RCV003489534]	Chr2:96115857 [GRCh38] Chr2:96781596 [GRCh37] Chr2:2q11.2	pathogenic\|uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96544603-98025634)x3	copy number gain	not provided [RCV001832989]	Chr2:96544603..98025634 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
NM_000682.7(ADRA2B):c.622del (p.Arg208fs)	deletion	Seizure [RCV001785227]	Chr2:96115528 [GRCh38] Chr2:96781267 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.943G>C (p.Val315Leu)	single nucleotide variant	not provided [RCV001839066]	Chr2:96115207 [GRCh38] Chr2:96780955 [GRCh37] Chr2:2q11.2	uncertain significance
NC_000002.11:g.(?_96780545)_(97475254_?)dup	duplication	not provided [RCV001981292]	Chr2:96780545..97475254 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1	copy number loss	See cases [RCV002287563]	Chr2:11504318..111365996 [GRCh37] Chr2:2p25.1-q13	pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96628608-96981369)x3	copy number gain	not provided [RCV002472784]	Chr2:96628608..96981369 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
NM_000682.7(ADRA2B):c.1127T>G (p.Val376Gly)	single nucleotide variant	Inborn genetic diseases [RCV002991877]	Chr2:96115023 [GRCh38] Chr2:96780771 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.874T>C (p.Ser292Pro)	single nucleotide variant	Inborn genetic diseases [RCV002739976]	Chr2:96115276 [GRCh38] Chr2:96781015 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.79A>G (p.Ile27Val)	single nucleotide variant	Inborn genetic diseases [RCV002762854]	Chr2:96116071 [GRCh38] Chr2:96781810 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.490T>C (p.Cys164Arg)	single nucleotide variant	Inborn genetic diseases [RCV002884435]	Chr2:96115660 [GRCh38] Chr2:96781399 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.280C>G (p.Leu94Val)	single nucleotide variant	Inborn genetic diseases [RCV002787738]	Chr2:96115870 [GRCh38] Chr2:96781609 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.628A>G (p.Lys210Glu)	single nucleotide variant	Inborn genetic diseases [RCV002717681]\|not provided [RCV003491272]	Chr2:96115522 [GRCh38] Chr2:96781261 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.382C>A (p.Arg128Ser)	single nucleotide variant	Inborn genetic diseases [RCV002809889]	Chr2:96115768 [GRCh38] Chr2:96781507 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.242G>A (p.Arg81Gln)	single nucleotide variant	Inborn genetic diseases [RCV002812609]	Chr2:96115908 [GRCh38] Chr2:96781647 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.202T>A (p.Phe68Ile)	single nucleotide variant	Inborn genetic diseases [RCV002703316]\|not provided [RCV003491301]	Chr2:96115948 [GRCh38] Chr2:96781687 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.379C>A (p.Arg127Ser)	single nucleotide variant	Inborn genetic diseases [RCV003215441]	Chr2:96115771 [GRCh38] Chr2:96781510 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.1093C>T (p.Arg365Trp)	single nucleotide variant	not provided [RCV003489537]	Chr2:96115057 [GRCh38] Chr2:96780805 [GRCh37] Chr2:2q11.2	uncertain significance
Single allele	deletion	not provided [RCV003448678]	Chr2:96555654..97769352 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:95773428-102550061)x3	copy number gain	not provided [RCV003484069]	Chr2:95773428..102550061 [GRCh37] Chr2:2q11.1-11.2	likely pathogenic
GRCh37/hg19 2q11.1-11.2(chr2:96732520-97671333)x3	copy number gain	not provided [RCV003484070]	Chr2:96732520..97671333 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96732520-99142320)x3	copy number gain	not provided [RCV003484071]	Chr2:96732520..99142320 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
NM_000682.7(ADRA2B):c.1058G>A (p.Gly353Asp)	single nucleotide variant	not provided [RCV003489535]	Chr2:96115092 [GRCh38] Chr2:96780840 [GRCh37] Chr2:2q11.2	uncertain significance
NM_000682.7(ADRA2B):c.836A>G (p.Asn279Ser)	single nucleotide variant	not provided [RCV003489536]	Chr2:96115314 [GRCh38] Chr2:96781053 [GRCh37] Chr2:2q11.2	uncertain significance
GRCh37/hg19 2q11.1-11.2(chr2:96735977-98212850)x3	copy number gain	not specified [RCV003986352]	Chr2:96735977..98212850 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
NM_000682.7(ADRA2B):c.1126G>A (p.Val376Ile)	single nucleotide variant	ADRA2B-related condition [RCV003943823]	Chr2:96115024 [GRCh38] Chr2:96780772 [GRCh37] Chr2:2q11.2	likely benign
NM_000682.7(ADRA2B):c.1242C>T (p.Ile414=)	single nucleotide variant	not provided [RCV003886047]	Chr2:96114908 [GRCh38] Chr2:96780656 [GRCh37] Chr2:2q11.2	likely benign
NM_000682.7(ADRA2B):c.894AGAGGAGGA[3] (p.Glu309_Cys310insGluGluGlu)	microsatellite	ADRA2B-related condition [RCV003909725]	Chr2:96115238..96115239 [GRCh38] Chr2:96780986..96780987 [GRCh37] Chr2:2q11.2	benign
NM_000682.7(ADRA2B):c.1233C>T (p.Phe411=)	single nucleotide variant	ADRA2B-related condition [RCV003967083]	Chr2:96114917 [GRCh38] Chr2:96780665 [GRCh37] Chr2:2q11.2	likely benign
Single allele	deletion	Pheochromocytoma [RCV003986083]	Chr2:96693904..96930791 [GRCh37] Chr2:2q11.1-11.2	uncertain significance
NM_000682.7(ADRA2B):c.*2C>A	single nucleotide variant	ADRA2B-related condition [RCV003964080]	Chr2:96114795 [GRCh38] Chr2:96780543 [GRCh37] Chr2:2q11.2	likely benign
NM_000682.7(ADRA2B):c.21C>T (p.Tyr7=)	single nucleotide variant	ADRA2B-related condition [RCV003921727]	Chr2:96116129 [GRCh38] Chr2:96781868 [GRCh37] Chr2:2q11.2	likely benign
GRCh37/hg19 2q11.1-11.2(chr2:96780545-98098961)x1	copy number loss	not provided [RCV003885488]	Chr2:96780545..98098961 [GRCh37] Chr2:2q11.1-11.2	pathogenic
NM_000682.7(ADRA2B):c.36A>G (p.Thr12=)	single nucleotide variant	ADRA2B-related condition [RCV003909852]	Chr2:96116114 [GRCh38] Chr2:96781853 [GRCh37] Chr2:2q11.2	benign
NM_000682.7(ADRA2B):c.483C>T (p.Arg161=)	single nucleotide variant	ADRA2B-related condition [RCV003899653]	Chr2:96115667 [GRCh38] Chr2:96781406 [GRCh37] Chr2:2q11.2	likely benign
NM_000682.7(ADRA2B):c.783C>T (p.Thr261=)	single nucleotide variant	ADRA2B-related condition [RCV003896564]	Chr2:96115367 [GRCh38] Chr2:96781106 [GRCh37] Chr2:2q11.2	likely benign

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1005
Count of miRNA genes:	651
Interacting mature miRNAs:	730
Transcripts:	ENST00000409345
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH80277

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	96,780,313 - 96,780,501	UniSTS	GRCh37
Build 36	2	96,144,040 - 96,144,228	RGD	NCBI36
Celera	2	91,221,123 - 91,221,311	RGD
Cytogenetic Map	2	q11.1	UniSTS
HuRef	2	90,741,476 - 90,741,664	UniSTS
GeneMap99-GB4 RH Map	2	331.09	UniSTS

ADRA2B__4260

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	96,780,421 - 96,781,332	UniSTS	GRCh37
Build 36	2	96,144,148 - 96,145,059	RGD	NCBI36
Celera	2	91,221,231 - 91,222,151	RGD
HuRef	2	90,741,584 - 90,742,504	UniSTS

UniSTS:481696

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	96,780,495 - 96,781,888	UniSTS	GRCh37
Celera	2	91,221,305 - 91,222,707	UniSTS
HuRef	2	90,741,658 - 90,743,060	UniSTS

UniSTS:483802

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	2	96,780,271 - 96,781,888	UniSTS	GRCh37
Celera	2	91,221,081 - 91,222,707	UniSTS
HuRef	2	90,741,434 - 90,743,060	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

entire extraembryonic component

High

Medium

207

404

163

867

199

269

434

508

Low

2058

1775

1349

386

345

235

3330

1941

2245

123

1080

1205

155

770

2240

Below cutoff

651

918

1106

186

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_032950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_000682	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA887330	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC092603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF005900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF316895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY548167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC133021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC136537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF475329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV806541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ057076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU332847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KF573706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M34041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M38742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000620793 ⟹ ENSP00000480573

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	2	96,112,876 - 96,116,571 (-)	Ensembl

RefSeq Acc Id:

NM_000682 ⟹ NP_000673

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	2	96,112,876 - 96,116,571 (-)	NCBI
GRCh37	2	96,778,623 - 96,782,281 (-)	NCBI
Build 36	2	96,142,350 - 96,145,615 (-)	NCBI Archive
HuRef	2	90,739,785 - 90,743,060 (-)	ENTREZGENE
CHM1_1	2	96,782,950 - 96,786,311 (-)	NCBI
T2T-CHM13v2.0	2	96,619,491 - 96,623,187 (-)	NCBI

Sequence:

show sequence

ACTCCCCTGCAGGCGCGGCTGGGGCGAAAGCCTGCGAGCTGAGCGGGCGCAAGGTCCTCCGCGC
CTCCTTTAAGAACCGGCCCAGCCCGGCCCGCGCCCCCAGAGCGTACGGCATCCGCGTGGCGGGA
GGGCGCGACTTTCTCCGGTCCCGGGCGGGACGGGGACGGCGGCGGGACAACTTGGGAAACTTCT
CTGGGGCGGACGGCAGGGACCCCGGGCACCGGTGGAGGAGGATGTAGGAGGGCGGCTGCTGGTC
CTGGGTGTTCCCGACCTCCTAGGCCCCGCTCGTCCAGGCCATGGGGCTCCAGCGCCCTCGGCGC
CGCCCGAGGGGCGACGCTCTTGTCTAGCCGAGCCGGGCAGCGCTGTCGTCCACGGTGCGCACTG
GGCGGGCAGCGCTCCCTCTGCCCACCTCCCGCCCCGTCATGGACCACCAGGACCCCTACTCCGT
GCAGGCCACAGCGGCCATAGCGGCGGCCATCACCTTCCTCATTCTCTTTACCATCTTCGGCAAC
GCTCTGGTCATCCTGGCTGTGTTGACCAGCCGCTCGCTGCGCGCCCCTCAGAACCTGTTCCTGG
TGTCGCTGGCCGCCGCCGACATCCTGGTGGCCACGCTCATCATCCCTTTCTCGCTGGCCAACGA
GCTGCTGGGCTACTGGTACTTCCGGCGCACGTGGTGCGAGGTGTACCTGGCGCTCGACGTGCTC
TTCTGCACCTCGTCCATCGTGCACCTGTGCGCCATCAGCCTGGACCGCTACTGGGCCGTGAGCC
GCGCGCTGGAGTACAACTCCAAGCGCACCCCGCGCCGCATCAAGTGCATCATCCTCACTGTGTG
GCTCATCGCCGCCGTCATCTCGCTGCCGCCCCTCATCTACAAGGGCGACCAGGGCCCCCAGCCG
CGCGGGCGCCCCCAGTGCAAGCTCAACCAGGAGGCCTGGTACATCCTGGCCTCCAGCATCGGAT
CTTTCTTTGCTCCTTGCCTCATCATGATCCTTGTCTACCTGCGCATCTACCTGATCGCCAAACG
CAGCAACCGCAGAGGTCCCAGGGCCAAGGGGGGGCCTGGGCAGGGTGAGTCCAAGCAGCCCCGA
CCCGACCATGGTGGGGCTTTGGCCTCAGCCAAACTGCCAGCCCTGGCCTCTGTGGCTTCTGCCA
GAGAGGTCAACGGACACTCGAAGTCCACTGGGGAGAAGGAGGAGGGGGAGACCCCTGAAGATAC
TGGGACCCGGGCCTTGCCACCCAGTTGGGCTGCCCTTCCCAACTCAGGCCAGGGCCAGAAGGAG
GGTGTTTGTGGGGCATCTCCAGAGGATGAAGCTGAAGAGGAGGAAGAGGAGGAGGAGGAGGAGG
AAGAGTGTGAACCCCAGGCAGTGCCAGTGTCTCCGGCCTCAGCTTGCAGCCCCCCGCTGCAGCA
GCCACAGGGCTCCCGGGTGCTGGCCACCCTACGTGGCCAGGTGCTCCTGGGCAGGGGCGTGGGT
GCTATAGGTGGGCAGTGGTGGCGTCGACGGGCGCAGCTGACCCGGGAGAAGCGCTTCACCTTCG
TGCTGGCTGTGGTCATTGGCGTTTTTGTGCTCTGCTGGTTCCCCTTCTTCTTCAGCTACAGCCT
GGGAGCCATCTGCCCGAAGCACTGCAAGGTGCCCCATGGCCTCTTCCAGTTCTTCTTCTGGATC
GGCTACTGCAACAGCTCACTGAACCCTGTTATCTACACCATCTTCAACCAGGACTTCCGCCGTG
CCTTCCGGAGGATCCTGTGCCGCCCGTGGACCCAGACGGCCTGGTGAGCCCGCCTGCGCTGCCC
CTGTGGGGTTGGTGCGGTGGCGCCGGGGTCACCCTGCTTCTTGCCCTGCTGTGTGTGGCTGCCT
CCCCTGGGCTTTCTGCTCCCTGCCCAGATCCTGTAGGCCTCATCTTAGGAACCCCTTGGGAGGG
GTGGGCAGGGGGGCTGCTAGCAAGGGTCCCAGTGAAGCTTCCCCTTGCCGGCTTAGCTGTGGGG
GACCCCTTCTCCACCCTCTCCCTGAGCACAGGCCGATGGAGGTGGTTCAAATCCTCTGGAACAT
AGCCAAGACCAGGAGAAGAGAGAGCACTTTCTTCCCAGAGCCCCATGCTCTCCAGACCAATGTC
TGGGCTTCCCTTTCTTGAGGACCTTGTGTTCCTGGCAGGTCACTTGCTTGTGGTGTTTTCGTTT
CTTTTTCATCTCCCCCCCACCCACAAAGAGCACGGAGCCAGCCTTCCACTTTTCCCAGTGGGGC
CTGCTGCTGAGGGGGAGGAAGAAACGAAGACTGATCACCCACGCTAGGCACTCGCGGTCCCTGG
CAGGCGCTGGGATGGGGGCTTATGGGGTGGCATCGTCTCTGGGCCCTCCTTTCCCCCTTTGCCT
GTTTTCGGATCTGTGGTTCCTTTGAAAGCCAGAACAATGGATCGGCTTCCTTACCCAGCACCCC
TCCGGTAGGTGGGTGGCCACGTGGATGCCTCGCTGGGGCGGTCTTGGAGGCCTGGTCTCTGCCT
CGACGGGAGATCCCCGATCACTGGCATTCACCCCCTGCAAAAATCGGGGCGACAATAGCTCACT
GCCTACTTGCTGCAGGGAGATGAAAGGCTTTGCAGAAAGCTTTGAGCTCTGTGGGGGAACACAC
TAGAGAACCAAAAATGTGATTATATGGTGATATAAAAATCCCTTTCCTCTGTGTTTACCACCAC
CTGTCTTCCTGTAGACTTTTGTTCTGTCCCTGGGGTGTGTGAATTCCTACCCCGAACTGGAAGC
CGGGAGTGGCAGACAGAATCACTATTTCAAGTTAAAGGATCTCTTTGAGAATGTGTTCTTCTGG
CTGCAAAGGTCTGAGTTATTACGCTACATGACAACGTTTCGACATTTCACCGGCAACACCAAGA
GGGTTTTTAGTGGCTTGGGTCTCCCCAGTGGGGGATAAGTCTTTTGTCATCAAGGAGGCAAATT
GTCTCCCCAAGACAGCTCAAAATATCCACACCTCGGCAACAGTCTAAGATGAGAGCCTGTGACA
GGTGGCAGCGCCCCCAGGTGGGGTACTGGCATCAGAGCCTGGTGCGCCCCTAGGGGAGCCTCCC
ACTGGAGTGCCCGGCCAGGTCTCCAAGCCCCAAATGAGTCCTTGTGAACCACAACTGATCCCCC
CAGGTGGGTGCTTGTGGACTGCCTCGGACCCAGCCACGCTGCTCCCCGCAATGCTGATGGGGCT
GTGCATTGAGGACCCCTGCTTCCTGGTTCTCAGTCCCACCCCAAAACCTGGCACCCAGAACAGT
TGGAAGTGTGGAAAGGAGGTTTATCGGCCTTCCCTTGGAGAGGGCCTGGCTTCAACATTGGGCC
AGTAGGCATCTTAGCTTGGCAGGTGTCGGGGGAATGGGCCAGATGGACCTGCTAGATTTGGAAG
GGCACCGAGGGAGTTTTCTGGGTGTAGAGAGAATGGAGGGGACCAAAAAGAGTCCTTCCTGGGG
TGTGGGAGGCTTCCCAGCTTGGTCCTCAGTGGGTTGTTGAGGCCAGAGTATCGCCCTGGGATGT
GGTGGGGAGCTGGGCCAGGAGAGGGACTGACTGTGACCCTCTGCTGGCCGGTCTTGTGTGCGCC
CCATGGGACCCCCAGTGTTCTTGCCTGTGACCTCTTATTGCGACATGCAGGTGGTGTTTTTTTT
TTTTTTAAACTCTGAGCTATTTTATCAATAAAGGATATTTTGTAATAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_000673	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA51666	(Get FASTA)	NCBI Sequence Viewer
	AAA62823	(Get FASTA)	NCBI Sequence Viewer
	AAB62558	(Get FASTA)	NCBI Sequence Viewer
	AAI33022	(Get FASTA)	NCBI Sequence Viewer
	AAI36538	(Get FASTA)	NCBI Sequence Viewer
	AAK01635	(Get FASTA)	NCBI Sequence Viewer
	AAS55646	(Get FASTA)	NCBI Sequence Viewer
	AAX93218	(Get FASTA)	NCBI Sequence Viewer
	AAY43127	(Get FASTA)	NCBI Sequence Viewer
	ABY87536	(Get FASTA)	NCBI Sequence Viewer
	EAW71390	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000480573
	ENSP00000480573.1
GenBank Protein	P18089	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_000673 ⟸ NM_000682

- UniProtKB:

Q53RF2 (UniProtKB/Swiss-Prot), Q4TUH9 (UniProtKB/Swiss-Prot), A2RUS0 (UniProtKB/Swiss-Prot), Q9BZK0 (UniProtKB/Swiss-Prot), P18089 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATL
IIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRR
IKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVY
LRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEK
EEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPA
SACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCW
FPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQT
AW

hide sequence

RefSeq Acc Id:

ENSP00000480573 ⟸ ENST00000620793

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P18089-F1-model_v2	AlphaFold	P18089	1-450	view protein structure

Promoters

RGD ID:

6796748

Promoter ID:

HG_KWN:33914

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, Lymphoblastoid

Transcripts:

NM_000682, UC002SVI.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	2	96,146,086 - 96,146,597 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:282	AgrOrtholog
COSMIC	ADRA2B	COSMIC
Ensembl Genes	ENSG00000274286	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000620793	ENTREZGENE
	ENST00000620793.2	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
GTEx	ENSG00000274286	GTEx
HGNC ID	HGNC:282	ENTREZGENE
Human Proteome Map	ADRA2B	Human Proteome Map
InterPro	ADR_fam	UniProtKB/Swiss-Prot
	ADRA2B_rcpt	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
KEGG Report	hsa:151	UniProtKB/Swiss-Prot
NCBI Gene	151	ENTREZGENE
OMIM	104260	OMIM
PANTHER	ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot
	ALPHA-2B ADRENERGIC RECEPTOR	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PharmGKB	ADRA2B	RGD, PharmGKB
PRINTS	ADRENERGICR	UniProtKB/Swiss-Prot
	ADRENRGCA2BR	UniProtKB/Swiss-Prot
	GPCRRHODOPSN	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	A2RUS0	ENTREZGENE
	ADA2B_HUMAN	UniProtKB/Swiss-Prot
	L8E8D5_HUMAN	UniProtKB/TrEMBL
	P18089	ENTREZGENE
	Q4TUH9	ENTREZGENE
	Q53RF2	ENTREZGENE
	Q9BZK0	ENTREZGENE
UniProt Secondary	A2RUS0	UniProtKB/Swiss-Prot
	Q4TUH9	UniProtKB/Swiss-Prot
	Q53RF2	UniProtKB/Swiss-Prot
	Q9BZK0	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-05-15	ADRA2B	adrenoceptor alpha 2B	ADRA2B	adrenergic, alpha-2B-, receptor	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Human Phenotype Annotations - HPO

Imported Human Phenotype Annotations - ClinVar

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Human Phenotype Annotations - HPO

Imported Human Phenotype Annotations - ClinVar