Gene: CLCN3 (chloride voltage-gated channel 3) Homo sapiens
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Symbol: CLCN3
Name: chloride voltage-gated channel 3
Description: This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride channel 3; chloride channel protein 3; chloride channel, voltage-sensitive 3; chloride transporter ClC-3; ClC-3; CLC3; DKFZp564I0463; H(+)/Cl(-) exchange transporter 3; OTTHUMP00000219460; OTTHUMP00000219503; OTTHUMP00000219505; OTTHUMP00000219506
Orthologs:
Mus musculus (house mouse) : Clcn3 (chloride channel, voltage-sensitive 3)  MGI
Rattus norvegicus (Norway rat) : Clcn3 (chloride voltage-gated channel 3)
Chinchilla lanigera (long-tailed chinchilla) : Clcn3 (chloride voltage-gated channel 3)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCN3 (chloride voltage-gated channel 3)
Canis lupus familiaris (dog) : CLCN3 (chloride voltage-gated channel 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcn3 (chloride voltage-gated channel 3)
more info ...
Related Pseudogenes: CLCN3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384169,620,521 - 169,723,187 (+)NCBIGRCh38hg38GRCh38
GRCh374170,541,672 - 170,644,338 (+)NCBIGRCh37hg19GRCh37
Build 364170,778,297 - 170,878,732 (+)NCBINCBI36hg18NCBI36
Build 344170,916,451 - 171,016,886NCBI
Celera4167,874,695 - 167,975,138 (+)NCBI
Cytogenetic Map4q33NCBImapview
HuRef4166,296,448 - 166,399,155 (+)NCBI
CHM1_14170,518,267 - 170,620,908 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

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Nomenclature History
 
More on CLCN3
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
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RGD Object Information
RGD ID: 730986
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2017-09-12
Status: ACTIVE