Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of SLC15A1 mRNA | CTD | PMID:20660070 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:27291303 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Slc15a1 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2-hydroxypropanoic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of SLC15A1 mRNA | CTD | PMID:30851411 | 3,3',5-triiodo-L-thyronine | decreases expression | EXP | | 6480464 | Triiodothyronine results in decreased expression of SLC15A1 mRNA and Triiodothyronine results in decreased expression of SLC15A1 protein | CTD | PMID:26394120 | 3,3',5-triiodo-L-thyronine | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 mRNA] and resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 protein] | CTD | PMID:26394120 | 5-fluorouracil | decreases activity | EXP | | 6480464 | Fluorouracil results in decreased activity of SLC15A1 protein | CTD | PMID:16253763 | 5-fluorouracil | decreases expression | EXP | | 6480464 | Fluorouracil results in decreased expression of SLC15A1 mRNA | CTD | PMID:16253763 | 6-propyl-2-thiouracil | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of SLC15A1 mRNA | CTD | PMID:24780913 | aflatoxin B1 | affects expression | EXP | | 6480464 | Aflatoxin B1 affects the expression of SLC15A1 protein | CTD | PMID:20106945 | AICA ribonucleotide | decreases activity | EXP | | 6480464 | AICA ribonucleotide results in decreased activity of SLC15A1 protein | CTD | PMID:22108913 | ammonium chloride | affects expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of SLC15A1 mRNA | CTD | PMID:16483693 | antirheumatic drug | decreases expression | EXP | | 6480464 | Antirheumatic Agents results in decreased expression of SLC15A1 mRNA | CTD | PMID:24449571 | arsenous acid | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of SLC15A1 mRNA | CTD | PMID:15761015 | aspartame | decreases activity | EXP | | 6480464 | Aspartame results in decreased activity of SLC15A1 protein | CTD | PMID:15846457 | azathioprine | decreases expression | EXP | | 6480464 | Azathioprine results in decreased expression of SLC15A1 mRNA | CTD | PMID:12806628 | benazepril | multiple interactions | EXP | | 6480464 | benazepril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | benzo[a]pyrene | increases expression | ISO | Slc15a1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SLC15A1 mRNA | CTD | PMID:20127859 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of SLC15A1 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | EXP | | 6480464 | Benzo(a)pyrene results in increased methylation of SLC15A1 exon and Benzo(a)pyrene results in increased methylation of SLC15A1 promoter | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | EXP | | 6480464 | benzo(e)pyrene results in increased methylation of SLC15A1 intron | CTD | PMID:30157460 | benzoic acid | affects binding | EXP | | 6480464 | Benzoic Acid analog binds to SLC15A1 protein | CTD | PMID:21147219 | bisphenol A | affects expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of SLC15A1 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | Slc15a1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of SLC15A1 mRNA | CTD | PMID:29161229 | bisphenol A | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of SLC15A1 mRNA | CTD | PMID:30816183 and PMID:32528016 | bisphenol A | increases methylation | ISO | Slc15a1 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of SLC15A1 promoter | CTD | PMID:27312807 | calcitriol | increases activity | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Calcitriol results in increased activity of SLC15A1 protein | CTD | PMID:21240898 and PMID:21341280 | calcitriol | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Calcitriol results in increased expression of SLC15A1 protein | CTD | PMID:21240898 and PMID:21341280 | cefixime | multiple interactions | ISO | Slc15a1 (Mus musculus) | 6480464 | [RAB8A protein results in increased localization of SLC15A1 protein] which results in increased uptake of Cefixime | CTD | PMID:19074526 | cefixime | increases uptake | ISO | Slc15a1 (Mus musculus) | 6480464 | SLC15A1 protein results in increased uptake of Cefixime | CTD | PMID:19074526 | ceftibuten | multiple interactions | EXP | | 6480464 | [Zinc results in decreased activity of SLC15A1 protein] which results in decreased uptake of ceftibuten | CTD | PMID:14567632 | cephalexin | increases transport | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | SLC15A1 protein results in increased transport of Cephalexin | CTD | PMID:19881305 | cephradine | multiple interactions | EXP | | 6480464 | [Zinc results in decreased activity of SLC15A1 protein] which results in decreased uptake of Cephradine | CTD | PMID:14567632 | chromium(6+) | affects expression | ISO | Slc15a1 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of SLC15A1 mRNA | CTD | PMID:28472532 | cilazapril monohydrate | multiple interactions | EXP | | 6480464 | Cilazapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | copper atom | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of SLC15A1 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Copper deficiency results in increased expression of SLC15A1 mRNA | CTD | PMID:26033743 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of SLC15A1 mRNA | CTD | PMID:20106945 | decabromodiphenyl ether | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | decabromobiphenyl ether results in decreased expression of SLC15A1 mRNA | CTD | PMID:23640034 | dextran sulfate | multiple interactions | ISO | Slc15a1 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SLC15A1 mRNA | CTD | PMID:29950665 | diarsenic trioxide | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of SLC15A1 mRNA | CTD | PMID:15761015 | dichlorine | multiple interactions | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | [Ozone co-treated with Chlorine] results in increased expression of SLC15A1 mRNA | CTD | PMID:18636392 | EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor | increases expression | EXP | | 6480464 | Angiotensin-Converting Enzyme Inhibitors results in increased expression of SLC15A1 mRNA | CTD | PMID:25534429 | endosulfan | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of SLC15A1 mRNA | CTD | PMID:29391264 | ethanol | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Ethanol results in decreased expression of SLC15A1 mRNA | CTD | PMID:20655511 | flutamide | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Flutamide results in decreased expression of SLC15A1 mRNA | CTD | PMID:24793618 | fluvastatin | decreases activity | EXP | | 6480464 | fluvastatin results in decreased activity of SLC15A1 protein | CTD | PMID:15846457 | fonofos | increases methylation | EXP | | 6480464 | Fonofos results in increased methylation of SLC15A1 promoter | CTD | PMID:22847954 | fosinopril | multiple interactions | EXP | | 6480464 | Fosinopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | furan | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | furan results in increased expression of SLC15A1 mRNA | CTD | PMID:27387713 | glycylsarcosine | increases uptake | EXP | | 6480464 | SLC15A1 protein results in increased uptake of glycylsarcosine | CTD | PMID:18713951 and PMID:33007874 | glycylsarcosine | affects transport | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | SLC15A1 protein affects the transport of glycylsarcosine | CTD | PMID:21240898 and PMID:21341280 | glycylsarcosine | multiple interactions | EXP | | 6480464 | [Zinc results in decreased activity of SLC15A1 protein] which results in decreased uptake of glycylsarcosine more ... | CTD | PMID:14567632 more ... | glycylsarcosine | decreases activity | EXP | | 6480464 | glycylsarcosine results in decreased activity of SLC15A1 protein | CTD | PMID:20628632 | ibuprofen | affects binding | EXP | | 6480464 | Ibuprofen analog binds to SLC15A1 protein | CTD | PMID:21147219 | isotretinoin | decreases expression | EXP | | 6480464 | Isotretinoin results in decreased expression of SLC15A1 mRNA | CTD | PMID:20436886 | MeIQx | decreases expression | EXP | | 6480464 | 2-amino-3 more ... | CTD | PMID:20816883 | mercury dichloride | decreases expression | ISO | Slc15a1 (Mus musculus) | 6480464 | Mercuric Chloride results in decreased expression of SLC15A1 mRNA | CTD | PMID:31175882 | metformin | multiple interactions | EXP | | 6480464 | Metformin inhibits the reaction [rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein] and Metformin results in decreased activity of and results in decreased expression of SLC15A1 protein | CTD | PMID:22108913 | metformin | increases expression | EXP | | 6480464 | Metformin results in increased expression of SLC15A1 mRNA | CTD | PMID:22108913 | metformin | multiple interactions | ISO | Slc15a1 (Mus musculus) | 6480464 | Metformin inhibits the reaction [rosiglitazone results in increased activity of SLC15A1 protein] | CTD | PMID:22108913 | methapyrilene | increases methylation | EXP | | 6480464 | Methapyrilene results in increased methylation of SLC15A1 intron | CTD | PMID:30157460 | methylmercury chloride | decreases expression | ISO | Slc15a1 (Mus musculus) | 6480464 | methylmercuric chloride results in decreased expression of SLC15A1 mRNA | CTD | PMID:31175882 | Moexipril | multiple interactions | EXP | | 6480464 | moexipril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | N-Nitrosopyrrolidine | decreases expression | EXP | | 6480464 | N-Nitrosopyrrolidine results in decreased expression of SLC15A1 mRNA | CTD | PMID:32234424 | O-methyleugenol | decreases expression | EXP | | 6480464 | methyleugenol results in decreased expression of SLC15A1 mRNA | CTD | PMID:32234424 | ochratoxin A | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | ochratoxin A results in decreased expression of SLC15A1 mRNA | CTD | PMID:29126803 | ozone | multiple interactions | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | [Ozone co-treated with Chlorine] results in increased expression of SLC15A1 mRNA | CTD | PMID:18636392 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SLC15A1 mRNA | CTD | PMID:29067470 | paracetamol | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of SLC15A1 mRNA | CTD | PMID:33387578 | parathion | increases methylation | EXP | | 6480464 | Parathion results in increased methylation of SLC15A1 promoter | CTD | PMID:22847954 | pentane-2,3-dione | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | 2 and 3-pentanedione results in increased expression of SLC15A1 mRNA | CTD | PMID:25710175 | perindopril | multiple interactions | EXP | | 6480464 | Perindopril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | Phe-Ser | affects binding | EXP | | 6480464 | phenylalanylserine analog binds to SLC15A1 protein | CTD | PMID:21147219 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SLC15A1 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | pirinixic acid results in increased expression of SLC15A1 mRNA | CTD | PMID:16751172 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of SLC15A1 mRNA | CTD | PMID:16751172 | progesterone | multiple interactions | EXP | | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of SLC15A1 mRNA | CTD | PMID:20660070 | quinapril hydrochloride | multiple interactions | EXP | | 6480464 | Quinapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | quinaprilat | multiple interactions | EXP | | 6480464 | quinaprilat inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | rac-lactic acid | decreases expression | EXP | | 6480464 | Lactic Acid results in decreased expression of SLC15A1 mRNA | CTD | PMID:30851411 | ramipril | multiple interactions | EXP | | 6480464 | Ramipril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | Repaglinide | decreases activity | EXP | | 6480464 | repaglinide results in decreased activity of SLC15A1 protein | CTD | PMID:15846457 | resveratrol | increases expression | EXP | | 6480464 | resveratrol results in increased expression of SLC15A1 mRNA and resveratrol results in increased expression of SLC15A1 protein | CTD | PMID:26394120 | resveratrol | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | resveratrol results in increased expression of SLC15A1 mRNA and resveratrol results in increased expression of SLC15A1 protein | CTD | PMID:26394120 | resveratrol | multiple interactions | EXP | | 6480464 | resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 mRNA] and resveratrol inhibits the reaction [Triiodothyronine results in decreased expression of SLC15A1 protein] | CTD | PMID:26394120 | rifampicin | decreases expression | EXP | | 6480464 | Rifampin results in decreased expression of SLC15A1 mRNA | CTD | PMID:27199754 | sirolimus | multiple interactions | EXP | | 6480464 | Sirolimus inhibits the reaction [rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein] | CTD | PMID:22108913 | sodium hydrogencarbonate | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Sodium Bicarbonate results in decreased expression of SLC15A1 mRNA | CTD | PMID:29126803 | spirapril | multiple interactions | EXP | | 6480464 | spirapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | terbufos | increases methylation | EXP | | 6480464 | terbufos results in increased methylation of SLC15A1 promoter | CTD | PMID:22847954 | thioacetamide | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of SLC15A1 mRNA | CTD | PMID:34492290 | titanium dioxide | multiple interactions | ISO | Slc15a1 (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SLC15A1 mRNA | CTD | PMID:29950665 | trandolapril | multiple interactions | EXP | | 6480464 | trandolapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine] | CTD | PMID:18713951 | urethane | decreases expression | EXP | | 6480464 | Urethane results in decreased expression of SLC15A1 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | EXP | | 6480464 | Valproic Acid affects the expression of SLC15A1 mRNA | CTD | PMID:25979313 | vanadium atom | decreases expression | EXP | | 6480464 | Vanadium results in decreased expression of SLC15A1 mRNA | CTD | PMID:19000753 | vanadium(0) | decreases expression | EXP | | 6480464 | Vanadium results in decreased expression of SLC15A1 mRNA | CTD | PMID:19000753 | vinclozolin | increases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of SLC15A1 mRNA | CTD | PMID:23034163 | zinc atom | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Zinc deficiency results in decreased expression of SLC15A1 mRNA | CTD | PMID:19111725 | zinc atom | decreases activity | EXP | | 6480464 | Zinc results in decreased activity of SLC15A1 protein | CTD | PMID:14567632 | zinc atom | multiple interactions | EXP | | 6480464 | [Zinc inhibits the reaction [JBP 485 binds to SLC15A1 protein]] which results in decreased uptake of JBP 485 more ... | CTD | PMID:14567632 and PMID:21712612 | zinc atom | multiple interactions | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Zinc inhibits the reaction [Zinc deficiency results in decreased expression of SLC15A1 mRNA] | CTD | PMID:19111725 | zinc(0) | decreases expression | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Zinc deficiency results in decreased expression of SLC15A1 mRNA | CTD | PMID:19111725 | zinc(0) | multiple interactions | ISO | Slc15a1 (Rattus norvegicus) | 6480464 | Zinc inhibits the reaction [Zinc deficiency results in decreased expression of SLC15A1 mRNA] | CTD | PMID:19111725 | zinc(0) | multiple interactions | EXP | | 6480464 | [Zinc inhibits the reaction [JBP 485 binds to SLC15A1 protein]] which results in decreased uptake of JBP 485 more ... | CTD | PMID:14567632 and PMID:21712612 | zinc(0) | decreases activity | EXP | | 6480464 | Zinc results in decreased activity of SLC15A1 protein | CTD | PMID:14567632 | zoledronic acid | increases expression | EXP | | 6480464 | zoledronic acid results in increased expression of SLC15A1 mRNA | CTD | PMID:24714768 | |