Agxt_v1 (alanine--glyoxylate aminotransferase, variant 1) - Rat Genome Database

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Gene: Agxt_v1 (alanine--glyoxylate aminotransferase, variant 1) Rattus norvegicus
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Symbol: Agxt_v1
Name: alanine--glyoxylate aminotransferase, variant 1
RGD ID: 728367
Description: aminotransferase enzyme; this isoform is targeted to the mitochondria
ENCODES an splice that exhibits alanine-glyoxylate transaminase activity (inferred); serine-pyruvate transaminase activity (inferred); INVOLVED IN response to hormone
Type: splice  of Agxt  
Previously known as: mitochondrial serine:pyruvate aminotransferase; SPTm
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.1992,616,896 - 92,626,844 (+)NCBI


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mitochondrial targeting signal-induced conformational change and repression of the peroxisomal targeting signal of the precursor for rat liver serine:pyruvate/alanine:glyoxylate aminotransferase. Oda T, etal., J Biochem (Tokyo). 2000 Apr;127(4):665-71.
2. Generation from a single gene of two mRNAs that encode the mitochondrial and peroxisomal serine:pyruvate aminotransferase of rat liver. Oda T, etal., J Biol Chem 1990 May 5;265(13):7513-9.
3. Quantitative cryoimmunogold electron microscopic studies on induction of serine: pyruvate aminotransferase in rat liver mitochondria by administration of glucagon. Satoh S, etal., Cell Struct Funct. 1995 Feb;20(1):89-96.

Genomics


Expression


Sequence

Nucleotide Sequences
GenBank Nucleotide M35270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Agxt_v1  alanine-glyoxylate aminotransferase, variant 1      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondria 632169
gene_cellular_localization targeted to the mitochondria 632169
gene_protein encodes a protein sequence of 414 amino acids of which 24 amino acids comprise the N-terminal mitochondrial targeting peptide sequence and 390 amino acids are in the mature mitochondrial enzyme 632170
gene_transcript has 70 additional nucleotides which encode the mitochondrial targeting N-terminal sequence 632169