Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | RGD Reference | Notes | Source | Original Reference(s) | Rhot2 | Rat | (+)-catechin | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RHOT2 mRNA | CTD | PMID:24763279 | Rhot2 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in decreased expression of RHOT2 mRNA | CTD | PMID:22206623 | Rhot2 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Rhot2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHOT2 mRNA | CTD | PMID:17942748 | Rhot2 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of RHOT2 mRNA | CTD | PMID:32145629 | Rhot2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Rhot2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHOT2 mRNA | CTD | PMID:17942748 | Rhot2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RHOT2 mRNA | CTD | PMID:33387578 | Rhot2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Rhot2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RHOT2 mRNA | CTD | PMID:21570461 | Rhot2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RHOT2 mRNA | CTD | PMID:21215274 | Rhot2 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of RHOT2 mRNA | CTD | PMID:21346803 | Rhot2 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of RHOT2 mRNA | CTD | PMID:21346803 | Rhot2 | Rat | 4,4'-sulfonyldiphenol | affects expression | ISO | RHOT2 (Homo sapiens) | 6480464 | bisphenol S affects the expression of RHOT2 protein | CTD | PMID:31945527 | Rhot2 | Rat | acrolein | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... | CTD | PMID:32699268 | Rhot2 | Rat | all-trans-retinoic acid | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Tretinoin] results in decreased expression of RHOT2 protein | CTD | PMID:39571964 | Rhot2 | Rat | alpha-pinene | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... | CTD | PMID:32699268 | Rhot2 | Rat | arsane | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with MIR186] results in decreased more ... | CTD | PMID:40512198 | Rhot2 | Rat | arsenic atom | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with MIR186] results in decreased more ... | CTD | PMID:40512198 | Rhot2 | Rat | benzo[a]pyrene | multiple interactions | ISO | Rhot2 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of RHOT2 mRNA]; Benzo(a)pyrene promotes the more ... | CTD | PMID:19654925 PMID:22228805 | Rhot2 | Rat | benzo[a]pyrene | affects methylation | ISO | RHOT2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of RHOT2 promoter | CTD | PMID:27901495 | Rhot2 | Rat | beta-lapachone | increases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of RHOT2 mRNA | CTD | PMID:38218311 | Rhot2 | Rat | bisphenol A | increases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of RHOT2 mRNA | CTD | PMID:25047013 | Rhot2 | Rat | bisphenol A | decreases methylation | ISO | RHOT2 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of RHOT2 gene | CTD | PMID:31601247 | Rhot2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of RHOT2 mRNA | CTD | PMID:30816183 PMID:32528016 | Rhot2 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of RHOT2 gene | CTD | PMID:28505145 | Rhot2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RHOT2 mRNA | CTD | PMID:25181051 | Rhot2 | Rat | bortezomib | decreases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Bortezomib results in decreased expression of RHOT2 mRNA | CTD | PMID:20977926 | Rhot2 | Rat | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of RHOT2 promoter | CTD | PMID:22457795 | Rhot2 | Rat | cannabidiol | increases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Cannabidiol results in increased expression of RHOT2 mRNA | CTD | PMID:27714895 | Rhot2 | Rat | carbamazepine | affects expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of RHOT2 mRNA | CTD | PMID:24752500 | Rhot2 | Rat | chrysene | increases expression | ISO | Rhot2 (Mus musculus) | 6480464 | chrysene results in increased expression of RHOT2 mRNA | CTD | PMID:26377693 | Rhot2 | Rat | clobetasol | increases expression | ISO | Rhot2 (Mus musculus) | 6480464 | Clobetasol results in increased expression of RHOT2 mRNA | CTD | PMID:27462272 | Rhot2 | Rat | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of RHOT2 mRNA | CTD | PMID:20187946 | Rhot2 | Rat | diclofenac | affects expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Diclofenac affects the expression of RHOT2 mRNA | CTD | PMID:24752500 | Rhot2 | Rat | epoxiconazole | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of RHOT2 mRNA | CTD | PMID:35436446 | Rhot2 | Rat | ethanol | multiple interactions | ISO | Rhot2 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of RHOT2 mRNA | CTD | PMID:30319688 | Rhot2 | Rat | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of RHOT2 gene | CTD | PMID:22079235 | Rhot2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of RHOT2 mRNA | CTD | PMID:22061828 | Rhot2 | Rat | hydrogen peroxide | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RHOT2 protein | CTD | PMID:18951874 | Rhot2 | Rat | ivermectin | decreases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of RHOT2 protein | CTD | PMID:32959892 | Rhot2 | Rat | lead(0) | affects expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Lead affects the expression of RHOT2 mRNA | CTD | PMID:28903495 | Rhot2 | Rat | nobiletin | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | nobiletin inhibits the reaction [sodium arsenate results in decreased expression of RHOT2 protein] | CTD | PMID:38348393 | Rhot2 | Rat | ochratoxin A | affects binding | ISO | RHOT2 (Homo sapiens) | 6480464 | RHOT2 protein binds to ochratoxin A | CTD | PMID:40952447 | Rhot2 | Rat | ozone | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... | CTD | PMID:32699268 PMID:35430440 | Rhot2 | Rat | paclitaxel | affects response to substance | ISO | RHOT2 (Homo sapiens) | 6480464 | RHOT2 protein affects the susceptibility to Paclitaxel | CTD | PMID:16217747 | Rhot2 | Rat | paracetamol | affects expression | ISO | Rhot2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of RHOT2 mRNA | CTD | PMID:17562736 | Rhot2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of RHOT2 mRNA | CTD | PMID:33387578 | Rhot2 | Rat | pirinixic acid | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of RHOT2 mRNA | CTD | PMID:23811191 | Rhot2 | Rat | propiconazole | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | propiconazole results in decreased expression of RHOT2 mRNA | CTD | PMID:21278054 | Rhot2 | Rat | sodium arsenate | decreases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | sodium arsenate results in decreased expression of RHOT2 protein | CTD | PMID:38348393 | Rhot2 | Rat | sodium arsenate | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | nobiletin inhibits the reaction [sodium arsenate results in decreased expression of RHOT2 protein] | CTD | PMID:38348393 | Rhot2 | Rat | sodium arsenite | decreases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of RHOT2 mRNA | CTD | PMID:34032870 PMID:38568856 | Rhot2 | Rat | sodium arsenite | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] which co-treated with MIR186] results in decreased more ... | CTD | PMID:39571964 PMID:40512198 | Rhot2 | Rat | sodium arsenite | increases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of RHOT2 mRNA | CTD | PMID:39719251 | Rhot2 | Rat | sodium fluoride | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of RHOT2 protein | CTD | PMID:28918527 | Rhot2 | Rat | temozolomide | increases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of RHOT2 mRNA | CTD | PMID:31758290 | Rhot2 | Rat | theophylline | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RHOT2 protein | CTD | PMID:18951874 | Rhot2 | Rat | thiram | decreases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Thiram results in decreased expression of RHOT2 mRNA | CTD | PMID:38568856 | Rhot2 | Rat | titanium dioxide | increases methylation | ISO | Rhot2 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of RHOT2 gene | CTD | PMID:35295148 | Rhot2 | Rat | triphenyl phosphate | affects expression | ISO | RHOT2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of RHOT2 mRNA | CTD | PMID:37042841 | Rhot2 | Rat | triptonide | affects expression | ISO | Rhot2 (Mus musculus) | 6480464 | triptonide affects the expression of RHOT2 mRNA | CTD | PMID:33045310 | Rhot2 | Rat | valproic acid | increases methylation | ISO | RHOT2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of RHOT2 gene | CTD | PMID:29154799 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















