Prss21 (serine protease 21) - Rat Genome Database

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Gene: Prss21 (serine protease 21) Rattus norvegicus
Analyze
Symbol: Prss21
Name: serine protease 21
RGD ID: 727870
Description: Predicted to enable serine-type endopeptidase activity. Involved in spermatogenesis. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human PRSS21 (serine protease 21); INTERACTS WITH bisphenol A; fenvalerate; tetrachloromethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eosinophil serine protease-1; Esp-1; protease, serine, 21; Resp-1; testisin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,404,820 - 13,410,195 (+)NCBIGRCr8
mRatBN7.21012,899,820 - 12,905,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,900,535 - 12,905,618 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,645,215 - 17,650,385 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,134,003 - 17,139,173 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,633,311 - 12,638,455 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,214,343 - 13,219,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,214,130 - 13,219,894 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,033,616 - 13,038,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1012,593,436 - 12,599,094 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning, expression analysis, and tissue distribution of esp-1/testisin, a membrane-type serine protease from the rat. Nakamura Y, etal., J Med Invest 2003 Feb;50(1-2):78-86.
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11861648   PMID:23943622  


Genomics

Comparative Map Data
Prss21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,404,820 - 13,410,195 (+)NCBIGRCr8
mRatBN7.21012,899,820 - 12,905,612 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,900,535 - 12,905,618 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,645,215 - 17,650,385 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,134,003 - 17,139,173 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,633,311 - 12,638,455 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,214,343 - 13,219,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,214,130 - 13,219,894 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,033,616 - 13,038,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1012,593,436 - 12,599,094 (+)NCBICelera
Cytogenetic Map10q12NCBI
PRSS21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,817,237 - 2,821,719 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,817,180 - 2,826,304 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,867,238 - 2,871,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,807,165 - 2,811,721 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,807,164 - 2,811,717NCBI
Celera163,067,095 - 3,071,651 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,833,834 - 2,838,393 (+)NCBIHuRef
CHM1_1162,867,197 - 2,871,755 (+)NCBICHM1_1
T2T-CHM13v2.0162,837,810 - 2,842,292 (+)NCBIT2T-CHM13v2.0
Prss21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,087,046 - 24,092,087 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,087,030 - 24,092,088 (+)EnsemblGRCm39 Ensembl
GRCm381723,867,883 - 23,873,121 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1723,868,056 - 23,873,114 (+)EnsemblGRCm38mm10GRCm38
MGSCv371724,005,039 - 24,010,080 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,595,694 - 23,600,734 (+)NCBIMGSCv36mm8
Celera1724,362,209 - 24,367,220 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.11NCBI
PRSS21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,339,762 - 3,345,280 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1167,118,143 - 7,123,661 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,721,788 - 1,726,871 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC479874
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,339,066 - 38,343,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,333,024 - 38,343,470 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,578,707 - 39,582,704 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,649,314 - 38,653,329 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1638,334,707 - 38,338,701 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,306,155 - 38,311,358 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,783,348 - 38,787,361 (+)NCBIUU_Cfam_GSD_1.0
PRSS21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,317,717 - 39,323,150 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,318,134 - 39,322,775 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,699,346 - 40,703,993 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103226924
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,520,825 - 2,532,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,526,827 - 2,532,107 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,380,186 - 28,394,248 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Prss21
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:110
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000073065
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat

Markers in Region
BF400120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21012,901,752 - 12,901,903 (+)MAPPERmRatBN7.2
Rnor_6.01013,216,031 - 13,216,181NCBIRnor6.0
Rnor_5.01013,034,996 - 13,035,146UniSTSRnor5.0
Celera1012,594,654 - 12,594,804UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 8 8 8 7
Below cutoff 3 4 21 15 4 15 2 2 12 1 15 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073065   ⟹   ENSRNOP00000065300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1012,900,535 - 12,905,618 (+)Ensembl
Rnor_6.0 Ensembl1013,214,130 - 13,219,894 (+)Ensembl
RefSeq Acc Id: NM_181477   ⟹   NP_852142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,405,066 - 13,410,195 (+)NCBI
mRatBN7.21012,900,483 - 12,905,612 (+)NCBI
Rnor_6.01013,214,813 - 13,219,890 (+)NCBI
Rnor_5.01013,033,616 - 13,038,855 (+)NCBI
Celera1012,593,436 - 12,599,094 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245872   ⟹   XP_006245934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,410,190 (+)NCBI
mRatBN7.21012,900,093 - 12,905,608 (+)NCBI
Rnor_6.01013,214,343 - 13,219,994 (+)NCBI
Rnor_5.01013,033,616 - 13,038,855 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086242   ⟹   XP_038942170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,409,569 (+)NCBI
mRatBN7.21012,899,821 - 12,904,985 (+)NCBI
RefSeq Acc Id: XM_063269269   ⟹   XP_063125339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,407,239 (+)NCBI
RefSeq Acc Id: XR_005489876
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,409,976 (+)NCBI
mRatBN7.21012,900,100 - 12,905,398 (+)NCBI
RefSeq Acc Id: XR_005489878
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,409,976 (+)NCBI
mRatBN7.21012,900,111 - 12,905,398 (+)NCBI
RefSeq Acc Id: XR_010055198
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,404,820 - 13,409,976 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_852142   ⟸   NM_181477
- Peptide Label: precursor
- UniProtKB: Q80Z40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245934   ⟸   XM_006245872
- Peptide Label: isoform X1
- UniProtKB: M0R778 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065300   ⟸   ENSRNOT00000073065
RefSeq Acc Id: XP_038942170   ⟸   XM_039086242
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063125339   ⟸   XM_063269269
- Peptide Label: isoform X2
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80Z40-F1-model_v2 AlphaFold Q80Z40 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727870 AgrOrtholog
BioCyc Gene G2FUF-25893 BioCyc
Ensembl Genes ENSRNOG00000047969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073065.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:353251 UniProtKB/TrEMBL
NCBI Gene 353251 ENTREZGENE
PANTHER ACROSIN UniProtKB/TrEMBL
  ACROSIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss21 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047969 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt M0R778 ENTREZGENE, UniProtKB/TrEMBL
  Q80Z40 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Prss21  serine protease 21  Prss21  protease, serine, 21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Prss21  protease, serine, 21      Symbol and Name status set to approved 1299863 APPROVED