Arpp19 (cAMP-regulated phosphoprotein 19) - Rat Genome Database

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Gene: Arpp19 (cAMP-regulated phosphoprotein 19) Rattus norvegicus
Analyze
Symbol: Arpp19 (Ensembl: LOC100360828)
Name: cAMP-regulated phosphoprotein 19 (Ensembl:cAMP-regulated phosphoprotein 19-like)
RGD ID: 71054
Description: Predicted to enable several functions, including potassium channel regulator activity; protein phosphatase 2A binding activity; and protein phosphatase inhibitor activity. Involved in dopamine receptor signaling pathway and positive regulation of Ras protein signal transduction. Predicted to be active in cytoplasm. Orthologous to human ARPP19 (cAMP regulated phosphoprotein 19); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Arpp-19; cyclic AMP phosphoprotein; cyclic AMP phosphoprotein 19kD; cyclic AMP phosphoprotein, 19 kDa; cyclic AMP phosphoprotein, 19kD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC100360828  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8884,660,166 - 84,683,012 (+)NCBIGRCr8
mRatBN7.2875,779,640 - 75,802,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl875,779,523 - 75,802,452 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl8110,813,545 - 110,814,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx881,286,292 - 81,309,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0879,551,923 - 79,574,709 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,385,620 - 77,408,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0881,949,577 - 81,972,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl881,949,877 - 81,968,589 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0881,566,027 - 81,588,675 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4879,824,737 - 79,846,702 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1879,843,790 - 79,865,756 (+)NCBI
Celera875,572,284 - 75,591,379 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP)
captan  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Differential expression of ARPP-16 and ARPP-19, two highly related cAMP-regulated phosphoproteins, one of which is specifically associated with dopamine-innervated brain regions. Girault JA, etal., J Neurosci 1990 Apr;10(4):1124-33.
3. Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19. Irwin N, etal., Proc Natl Acad Sci U S A 2002 Sep 17;99(19):12427-31.
4. Gene Data Set MGD Curation, June 12, 2002
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9653196   PMID:11279279   PMID:12944371   PMID:15489334   PMID:16396499   PMID:21164014  


Genomics

Comparative Map Data
Arpp19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8884,660,166 - 84,683,012 (+)NCBIGRCr8
mRatBN7.2875,779,640 - 75,802,474 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl875,779,523 - 75,802,452 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl8110,813,545 - 110,814,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx881,286,292 - 81,309,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0879,551,923 - 79,574,709 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,385,620 - 77,408,368 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0881,949,577 - 81,972,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl881,949,877 - 81,968,589 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0881,566,027 - 81,588,675 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4879,824,737 - 79,846,702 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1879,843,790 - 79,865,756 (+)NCBI
Celera875,572,284 - 75,591,379 (+)NCBICelera
Cytogenetic Map8q24NCBI
ARPP19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381552,547,045 - 52,569,446 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1552,547,045 - 52,569,883 (-)EnsemblGRCh38hg38GRCh38
GRCh371552,839,242 - 52,861,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361550,626,724 - 50,648,505 (-)NCBINCBI36Build 36hg18NCBI36
Celera1529,734,478 - 29,756,262 (-)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1529,670,423 - 29,691,905 (-)NCBIHuRef
CHM1_11552,957,377 - 52,979,161 (-)NCBICHM1_1
T2T-CHM13v2.01550,355,343 - 50,377,746 (-)NCBIT2T-CHM13v2.0
Arpp19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39974,944,896 - 74,967,595 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl974,944,896 - 74,967,595 (+)EnsemblGRCm39 Ensembl
GRCm38975,037,614 - 75,060,313 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl975,037,614 - 75,060,313 (+)EnsemblGRCm38mm10GRCm38
MGSCv37974,885,421 - 74,908,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36974,824,337 - 74,846,918 (+)NCBIMGSCv36mm8
Celera972,191,852 - 72,214,220 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map942.25NCBI
Arpp19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554092,354,988 - 2,369,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554092,354,988 - 2,369,846 (+)NCBIChiLan1.0ChiLan1.0
ARPP19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21641,783,713 - 41,814,106 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11545,964,075 - 45,994,440 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01531,488,156 - 31,510,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11549,813,313 - 49,835,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1549,813,447 - 49,835,051 (-)Ensemblpanpan1.1panPan2
ARPP19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13018,190,358 - 18,213,054 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3018,118,585 - 18,141,456 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03018,338,280 - 18,361,704 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3018,338,286 - 18,361,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13018,256,897 - 18,280,056 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03018,374,907 - 18,398,057 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03018,480,413 - 18,503,568 (-)NCBIUU_Cfam_GSD_1.0
Arpp19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864096,486,786 - 96,505,080 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647114,334,667 - 14,353,131 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARPP19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,134,851 - 119,157,352 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,134,318 - 119,157,169 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21132,202,587 - 132,221,849 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARPP19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12630,825,846 - 30,844,005 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2630,826,359 - 30,843,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048110,384,413 - 110,404,565 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arpp19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247318,081,894 - 8,103,429 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247318,081,940 - 8,103,429 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arpp19
77 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:90
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000028470, ENSRNOT00000030221
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)87531177784531599Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)87531193882925521Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001395717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ005982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000030221   ⟹   ENSRNOP00000035534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8110,813,545 - 110,814,012 (-)Ensembl
Rnor_6.0 Ensembl881,949,877 - 81,968,589 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098678   ⟹   ENSRNOP00000087184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl875,779,523 - 75,802,452 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117018   ⟹   ENSRNOP00000087694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl875,793,100 - 75,802,452 (+)Ensembl
RefSeq Acc Id: NM_001395717   ⟹   NP_001382646
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,660,397 - 84,683,012 (+)NCBI
mRatBN7.2875,779,855 - 75,802,474 (+)NCBI
RefSeq Acc Id: NM_001395718   ⟹   NP_001382647
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,660,238 - 84,683,012 (+)NCBI
mRatBN7.2875,779,696 - 75,802,474 (+)NCBI
RefSeq Acc Id: NM_001395719   ⟹   NP_001382648
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,660,397 - 84,683,012 (+)NCBI
mRatBN7.2875,779,855 - 75,802,474 (+)NCBI
RefSeq Acc Id: NM_031660   ⟹   NP_113848
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,660,238 - 84,683,012 (+)NCBI
mRatBN7.2875,779,696 - 75,802,474 (+)NCBI
Rnor_6.0881,949,877 - 81,968,589 (+)NCBI
Rnor_5.0881,566,027 - 81,588,675 (+)NCBI
RGSC_v3.4879,824,737 - 79,846,702 (+)RGD
Celera875,572,284 - 75,591,379 (+)RGD
Sequence:
RefSeq Acc Id: XM_039082046   ⟹   XP_038937974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,660,237 - 84,683,012 (+)NCBI
mRatBN7.2875,779,640 - 75,802,474 (+)NCBI
RefSeq Acc Id: XM_063266059   ⟹   XP_063122129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,660,237 - 84,683,012 (+)NCBI
RefSeq Acc Id: XM_063266060   ⟹   XP_063122130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,660,166 - 84,679,566 (+)NCBI
RefSeq Acc Id: XM_063266061   ⟹   XP_063122131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,660,290 - 84,683,012 (+)NCBI
RefSeq Acc Id: XM_063266062   ⟹   XP_063122132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8884,660,184 - 84,683,012 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113848   ⟸   NM_031660
- Peptide Label: isoform b
- UniProtKB: Q712U5 (UniProtKB/Swiss-Prot),   A6I1B0 (UniProtKB/TrEMBL),   A6I1A8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035534   ⟸   ENSRNOT00000030221
RefSeq Acc Id: XP_038937974   ⟸   XM_039082046
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000087694   ⟸   ENSRNOT00000117018
RefSeq Acc Id: ENSRNOP00000087184   ⟸   ENSRNOT00000098678
RefSeq Acc Id: NP_001382647   ⟸   NM_001395718
- Peptide Label: isoform b
- UniProtKB: Q712U5 (UniProtKB/Swiss-Prot),   A6I1B0 (UniProtKB/TrEMBL),   A6I1A8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382646   ⟸   NM_001395717
- Peptide Label: isoform a
- UniProtKB: A6I1A8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382648   ⟸   NM_001395719
- Peptide Label: isoform b
- UniProtKB: Q712U5 (UniProtKB/Swiss-Prot),   A6I1B0 (UniProtKB/TrEMBL),   A6I1A8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122130   ⟸   XM_063266060
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063122132   ⟸   XM_063266062
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063122129   ⟸   XM_063266059
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122131   ⟸   XM_063266061
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q712U5-F1-model_v2 AlphaFold Q712U5 1-112 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71054 AgrOrtholog
BioCyc Gene G2FUF-29826 BioCyc
Ensembl Genes ENSRNOG00000023086 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000063103 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030221.7 UniProtKB/Swiss-Prot
  ENSRNOT00000098678.1 UniProtKB/TrEMBL
  ENSRNOT00000117018.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919944 IMAGE-MGC_LOAD
InterPro Endosulphine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100360828 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  rno:60336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72767 IMAGE-MGC_LOAD
NCBI Gene 60336 ENTREZGENE
PANTHER CAMP-REGULATED PHOSPHOPROTEIN 19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10358 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Endosulfine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arpp19 PhenoGen
RatGTEx ENSRNOG00000023086 RatGTEx
  ENSRNOG00000063103 RatGTEx
UniProt A0A8I6A6T3_RAT UniProtKB/TrEMBL
  A0A8I6A898_RAT UniProtKB/TrEMBL
  A6I1A8 ENTREZGENE, UniProtKB/TrEMBL
  A6I1B0 ENTREZGENE, UniProtKB/TrEMBL
  ARP19_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Arpp19  cAMP-regulated phosphoprotein 19  Arpp-19  cyclic AMP phosphoprotein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Arpp-19  cyclic AMP phosphoprotein  Arpp19  cAMP-regulated phosphoprotein 19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Arpp19        Symbol and Name status set to provisional 70820 PROVISIONAL
2005-05-23   cAMP-regulated phosphoprotein 19  Arpp19  cyclic AMP phosphoprotein, 19 kDa  Name updated 1299863 APPROVED
2002-07-09 Arpp19  cyclic AMP phosphoprotein, 19 kDa      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in all tissues 70802
gene_expression during development protein level was highest in the embryo and decreased during the pre- and postnatal periods 70802
gene_expression expressed in all brain regions including all nonneuronal cells 625586
gene_physical_interaction binds to a region of the GAP-43 mRNA shown to be involved in stabilization of the RNA 625586
gene_process meidates the increase of Gap43 mRNA by nerve growth factor (NGF) in PC12 pheochromocytoma cells 625586