Igf2bp1 (insulin-like growth factor 2 mRNA binding protein 1) - Rat Genome Database

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Gene: Igf2bp1 (insulin-like growth factor 2 mRNA binding protein 1) Rattus norvegicus
Analyze
Symbol: Igf2bp1
Name: insulin-like growth factor 2 mRNA binding protein 1
RGD ID: 708580
Description: Enables mRNA 3'-UTR binding activity. Involved in RNA localization and dendrite arborization. Located in axon; dendritic spine; and neuronal cell body. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: B-actin zipcode-binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; IMP-1; Imp1; insulin-like growth factor 2 binding protein 1; insulin-like growth factor 2 mRNA-binding protein 1; insulin-like growth factor 2, binding protein 1; rZBP-1; VICKZ family member 1; ZBP1; zipcode-binding protein-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,405,021 - 81,447,814 (-)NCBIGRCr8
mRatBN7.21080,908,300 - 80,951,097 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,908,076 - 80,951,129 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,857,301 - 85,899,408 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,355,335 - 85,397,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,747,478 - 80,789,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,774,178 - 83,823,323 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,780,203 - 83,822,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,579,028 - 83,628,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,671,084 - 84,714,648 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,685,453 - 84,729,018 (-)NCBI
Celera1079,676,729 - 79,719,122 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses. Eom T, etal., J Neurosci 2003 Nov 12;23(32):10433-44.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1. Guo H, etal., Cell Death Dis. 2018 Jul 26;9(8):816. doi: 10.1038/s41419-018-0868-3.
4. Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon. Hamilton KE, etal., Mol Cancer Res. 2015 Nov;13(11):1478-86. doi: 10.1158/1541-7786.MCR-15-0224. Epub 2015 Jul 20.
5. Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons. Perycz M, etal., J Neurosci. 2011 Apr 6;31(14):5271-85. doi: 10.1523/JNEUROSCI.2387-10.2011.
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons. Tiruchinapalli DM, etal., J Neurosci. 2003 Apr 15;23(8):3251-61.
Additional References at PubMed
PMID:9178888   PMID:9891060   PMID:12477932   PMID:15601260   PMID:17101699   PMID:17289661   PMID:17878234   PMID:18490442   PMID:19029303   PMID:20080952   PMID:20631164   PMID:21209918  
PMID:22658674   PMID:22681889   PMID:23100434   PMID:23897586   PMID:24192035  


Genomics

Comparative Map Data
Igf2bp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,405,021 - 81,447,814 (-)NCBIGRCr8
mRatBN7.21080,908,300 - 80,951,097 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1080,908,076 - 80,951,129 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1085,857,301 - 85,899,408 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01085,355,335 - 85,397,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01080,747,478 - 80,789,863 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01083,774,178 - 83,823,323 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,780,203 - 83,822,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,579,028 - 83,628,914 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,671,084 - 84,714,648 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,685,453 - 84,729,018 (-)NCBI
Celera1079,676,729 - 79,719,122 (-)NCBICelera
Cytogenetic Map10q26NCBI
IGF2BP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,996,558 - 49,056,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,997,385 - 49,056,145 (+)EnsemblGRCh38hg38GRCh38
GRCh371747,074,747 - 47,133,507 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,429,773 - 44,488,506 (+)NCBINCBI36Build 36hg18NCBI36
Celera1743,529,020 - 43,588,502 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1742,441,949 - 42,500,581 (+)NCBIHuRef
CHM1_11747,140,077 - 47,198,718 (+)NCBICHM1_1
T2T-CHM13v2.01749,859,908 - 49,919,501 (+)NCBIT2T-CHM13v2.0
Igf2bp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391195,847,989 - 95,896,770 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1195,847,989 - 95,896,766 (-)EnsemblGRCm39 Ensembl
GRCm381195,957,163 - 96,005,944 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1195,957,163 - 96,005,940 (-)EnsemblGRCm38mm10GRCm38
MGSCv371195,818,477 - 95,867,258 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,778,822 - 95,822,002 (-)NCBIMGSCv36mm8
Celera11105,607,858 - 105,656,580 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.08NCBI
Igf2bp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,312,715 - 12,348,663 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,312,715 - 12,348,663 (-)NCBIChiLan1.0ChiLan1.0
IGF2BP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21916,042,863 - 16,101,303 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11718,008,913 - 18,067,542 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,479,806 - 8,538,336 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,461,552 - 8,519,550 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,468,240 - 8,519,552 (-)Ensemblpanpan1.1panPan2
IGF2BP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1925,199,287 - 25,240,693 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl925,198,805 - 25,240,578 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,660,181 - 24,703,349 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0925,994,308 - 26,036,588 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl925,993,861 - 26,034,618 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1924,762,182 - 24,805,339 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,020,613 - 25,063,780 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0925,149,583 - 25,192,753 (+)NCBIUU_Cfam_GSD_1.0
Igf2bp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,605,834 - 24,645,145 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,430,008 - 12,469,083 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,430,343 - 12,468,794 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGF2BP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1225,197,058 - 25,243,272 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11225,196,955 - 25,244,660 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,162,754 - 25,209,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IGF2BP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,405,923 - 69,461,613 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,406,549 - 69,459,175 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,510,372 - 40,569,936 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igf2bp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,353,005 - 5,385,521 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,352,932 - 5,391,617 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Igf2bp1
218 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:219
Count of miRNA genes:153
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000008139
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat

Markers in Region
BI276370  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21080,908,117 - 80,908,207 (+)MAPPERmRatBN7.2
Rnor_6.01083,780,021 - 83,780,110NCBIRnor6.0
Rnor_5.01083,584,871 - 83,584,960UniSTSRnor5.0
RGSC_v3.41084,670,902 - 84,670,991UniSTSRGSC3.4
Celera1079,676,547 - 79,676,636UniSTS
RH 3.4 Map10743.8UniSTS
Cytogenetic Map10q31UniSTS
UniSTS:498743  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21080,912,390 - 80,913,180 (+)MAPPERmRatBN7.2
Rnor_6.01083,784,293 - 83,785,082NCBIRnor6.0
Rnor_5.01083,589,142 - 83,589,931UniSTSRnor5.0
RGSC_v3.41084,675,175 - 84,675,964UniSTSRGSC3.4
Celera1079,680,819 - 79,681,608UniSTS
Cytogenetic Map10q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 16 16 16 35 16 20
Low 6 13 12 12 14 8 13 2
Below cutoff 4 11 7 6 7 4 4 10 11 4 9 4

Sequence


RefSeq Acc Id: ENSRNOT00000008139   ⟹   ENSRNOP00000008139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1080,908,076 - 80,951,129 (-)Ensembl
Rnor_6.0 Ensembl1083,780,203 - 83,822,996 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119485   ⟹   ENSRNOP00000095130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1080,908,076 - 80,951,129 (-)Ensembl
RefSeq Acc Id: NM_175594   ⟹   NP_783184
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81081,405,021 - 81,447,814 (-)NCBI
mRatBN7.21080,908,300 - 80,951,097 (-)NCBI
Rnor_6.01083,780,203 - 83,822,996 (-)NCBI
Rnor_5.01083,579,028 - 83,628,914 (-)NCBI
RGSC_v3.41084,671,084 - 84,714,648 (-)RGD
Celera1079,676,729 - 79,719,122 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_783184 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI61831 (Get FASTA)   NCBI Sequence Viewer  
  AAO16210 (Get FASTA)   NCBI Sequence Viewer  
  EDM05776 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008139
  ENSRNOP00000008139.3
  ENSRNOP00000095130.1
  ENSRNOP00055046572
  ENSRNOP00060036725
  ENSRNOP00065023761
GenBank Protein Q8CGX0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_783184   ⟸   NM_175594
- UniProtKB: B1WBP3 (UniProtKB/Swiss-Prot),   Q8CGX0 (UniProtKB/Swiss-Prot),   A0A8I6AN86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008139   ⟸   ENSRNOT00000008139
RefSeq Acc Id: ENSRNOP00000095130   ⟸   ENSRNOT00000119485
Protein Domains
KH   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGX0-F1-model_v2 AlphaFold Q8CGX0 1-577 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708580 AgrOrtholog
BioCyc Gene G2FUF-23524 BioCyc
Ensembl Genes ENSRNOG00000006122 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032679 UniProtKB/Swiss-Prot
  ENSRNOG00060025575 UniProtKB/Swiss-Prot
  ENSRNOG00065017872 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008139 ENTREZGENE
  ENSRNOT00000008139.6 UniProtKB/Swiss-Prot
  ENSRNOT00000119485.1 UniProtKB/TrEMBL
  ENSRNOT00055056466 UniProtKB/Swiss-Prot
  ENSRNOT00060044288 UniProtKB/Swiss-Prot
  ENSRNOT00065029916 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.310.210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9023972 IMAGE-MGC_LOAD
InterPro IGF2BP1_RRM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGF2BP1_RRM2 UniProtKB/Swiss-Prot
  KH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:303477 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187312 IMAGE-MGC_LOAD
NCBI Gene 303477 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR 2 MRNA-BINDING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KH DOMAIN CONTAINING RNA BINDING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Igf2bp1 PhenoGen
PROSITE KH_TYPE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006122 RatGTEx
  ENSRNOG00055032679 RatGTEx
  ENSRNOG00060025575 RatGTEx
  ENSRNOG00065017872 RatGTEx
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00322 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AN86 ENTREZGENE, UniProtKB/TrEMBL
  B1WBP3 ENTREZGENE
  IF2B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B1WBP3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Igf2bp1  insulin-like growth factor 2 mRNA binding protein 1  Igf2bp1  insulin-like growth factor 2, binding protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Igf2bp1  insulin-like growth factor 2, binding protein 1  Imp1    Symbol updated 1299863 APPROVED
2004-02-11 Ppil3  insulin-like growth factor 2, binding protein 1  Imp1  IGF-II mRNA-binding protein 1  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED