Adcy10 (adenylate cyclase 10) - Rat Genome Database

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Gene: Adcy10 (adenylate cyclase 10) Rattus norvegicus
Analyze
Symbol: Adcy10
Name: adenylate cyclase 10
RGD ID: 708450
Description: Enables ATPase binding activity; adenylate cyclase activity; and manganese ion binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of apoptotic process; and regulation of reactive oxygen species biosynthetic process. Located in several cellular components, including astrocyte end-foot; central region of growth cone; and neuronal cell body. Orthologous to human ADCY10 (adenylate cyclase 10); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenylate cyclase 10 (soluble); adenylate cyclase type 10; germ cell soluble adenylyl cyclase; LOC59320; Sac; soluble adenylyl cyclase; testicular soluble adenylyl cyclase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,280,595 - 80,366,939 (+)NCBIGRCr8
mRatBN7.21377,747,752 - 77,833,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1377,768,468 - 77,833,951 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1380,364,714 - 80,453,344 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01381,668,713 - 81,757,332 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01378,914,792 - 79,003,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01383,701,952 - 83,787,010 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,721,300 - 83,787,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01388,583,534 - 88,667,840 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41381,208,090 - 81,302,902 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11381,222,277 - 81,317,089 (+)NCBI
Celera1377,464,675 - 77,547,216 (+)NCBICelera
Cytogenetic Map13q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cAMP biosynthetic process  (IDA,IMP,ISO)
cellular response to inorganic substance  (ISO,ISS)
epithelial cilium movement involved in extracellular fluid movement  (ISO,ISS)
glucose catabolic process  (IMP)
intracellular signal transduction  (IEA)
mitochondrial ATP transmembrane transport  (IMP)
negative regulation of cardiac muscle cell contraction  (IMP)
negative regulation of mitochondrial membrane potential  (IMP)
negative regulation of reactive oxygen species biosynthetic process  (IMP)
neuron projection extension  (IMP)
neuron projection maintenance  (IMP)
neuron projection retraction  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of ATP biosynthetic process  (IMP)
positive regulation of axon extension  (IMP)
positive regulation of cAMP-dependent protein kinase activity  (IMP)
positive regulation of cardiac muscle cell apoptotic process  (IMP)
positive regulation of cardiac muscle hypertrophy  (IMP)
positive regulation of glycogen catabolic process  (IMP)
positive regulation of intrinsic apoptotic signaling pathway  (IDA)
positive regulation of mitochondrial depolarization  (IMP)
positive regulation of ossification  (IMP)
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IMP)
positive regulation of peptidyl-threonine phosphorylation  (IMP)
positive regulation of protein targeting to mitochondrion  (IMP)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IDA)
regulation of membrane repolarization  (IMP)
regulation of mitophagy  (IMP)
spermatid development  (IEP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. Appukuttan A, etal., Cardiovasc Res. 2012 Feb 1;93(2):340-9. doi: 10.1093/cvr/cvr306. Epub 2011 Nov 21.
2. Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase. Appukuttan A, etal., Cardiovasc Res. 2013 Sep 1;99(4):734-42. doi: 10.1093/cvr/cvt137. Epub 2013 May 31.
3. Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Buck J, etal., Proc Natl Acad Sci U S A 1999 Jan 5;96(1):79-84.
4. Inhibition of Intracellular Type 10 Adenylyl Cyclase Protects Cortical Neurons Against Reperfusion-Induced Mitochondrial Injury and Apoptosis. Chagtoo M, etal., Mol Neurobiol. 2018 Mar;55(3):2471-2482. doi: 10.1007/s12035-017-0473-y. Epub 2017 Apr 6.
5. Autoinhibitory regulation of soluble adenylyl cyclase. Chaloupka JA, etal., Mol Reprod Dev. 2006 Mar;73(3):361-8. doi: 10.1002/mrd.20409.
6. Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Choi HB, etal., Neuron. 2012 Sep 20;75(6):1094-104. doi: 10.1016/j.neuron.2012.08.032.
7. Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth. Corredor RG, etal., J Neurosci. 2012 May 30;32(22):7734-44. doi: 10.1523/JNEUROSCI.5288-11.2012.
8. The functional association between the sodium/bicarbonate cotransporter (NBC) and the soluble adenylyl cyclase (sAC) modulates cardiac contractility. Espejo MS, etal., Pflugers Arch. 2020 Jan;472(1):103-115. doi: 10.1007/s00424-019-02331-x. Epub 2019 Nov 22.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Regulation of AMPK activity by type 10 adenylyl cyclase: contribution to the mitochondrial biology, cellular redox and energy homeostasis. Jayarajan V, etal., Cell Mol Life Sci. 2019 Dec;76(24):4945-4959. doi: 10.1007/s00018-019-03152-y. Epub 2019 Jun 6.
11. Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. Kolodecik TR, etal., PLoS One. 2012;7(7):e41320. doi: 10.1371/journal.pone.0041320. Epub 2012 Jul 23.
12. Manganese ion dependent adenylate cyclase activity in rat testes: purification and properties. Kornblihtt AR, etal., Biochemistry. 1981 Mar 3;20(5):1262-7.
13. Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. Kumar S, etal., J Biol Chem. 2009 May 29;284(22):14760-8. Epub 2009 Mar 31.
14. Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. Martinez J, etal., J Neurosci. 2014 Jul 9;34(28):9281-9. doi: 10.1523/JNEUROSCI.1434-14.2014.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. Paunescu TG, etal., Am J Physiol Renal Physiol. 2008 Jan;294(1):F130-8. Epub 2007 Oct 24.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
24. Soluble adenylyl cyclase: A novel player in cardiac hypertrophy induced by isoprenaline or pressure overload. Schirmer I, etal., PLoS One. 2018 Feb 21;13(2):e0192322. doi: 10.1371/journal.pone.0192322. eCollection 2018.
25. Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. Stessin AM, etal., J Biol Chem. 2006 Jun 23;281(25):17253-8. Epub 2006 Apr 20.
26. The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function. Teodoro JS, etal., Int J Mol Sci. 2020 Jul 11;21(14):4896. doi: 10.3390/ijms21144896.
27. Pulsed electromagnetic fields promote bone formation by activating the sAC-cAMP-PKA-CREB signaling pathway. Wang YY, etal., J Cell Physiol. 2019 Mar;234(3):2807-2821. doi: 10.1002/jcp.27098. Epub 2018 Aug 1.
28. Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Wu KY, etal., Nat Neurosci. 2006 Oct;9(10):1257-64. Epub 2006 Sep 10.
29. Expression of the soluble adenylyl cyclase during rat spermatogenesis: evidence for cytoplasmic sites of cAMP production in germ cells. Xie F and Conti M, Dev Biol. 2004 Jan 1;265(1):196-206. doi: 10.1016/j.ydbio.2003.09.020.
Additional References at PubMed
PMID:12609998   PMID:14512417   PMID:15659711   PMID:17591988   PMID:19144954   PMID:23686854   PMID:24567411  


Genomics

Comparative Map Data
Adcy10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81380,280,595 - 80,366,939 (+)NCBIGRCr8
mRatBN7.21377,747,752 - 77,833,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1377,768,468 - 77,833,951 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1380,364,714 - 80,453,344 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01381,668,713 - 81,757,332 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01378,914,792 - 79,003,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01383,701,952 - 83,787,010 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1383,721,300 - 83,787,018 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01388,583,534 - 88,667,840 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41381,208,090 - 81,302,902 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11381,222,277 - 81,317,089 (+)NCBI
Celera1377,464,675 - 77,547,216 (+)NCBICelera
Cytogenetic Map13q23NCBI
ADCY10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,809,386 - 167,914,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,809,386 - 167,914,215 (-)EnsemblGRCh38hg38GRCh38
GRCh371167,778,623 - 167,883,372 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,045,506 - 166,149,964 (-)NCBINCBI36Build 36hg18NCBI36
Build 341164,510,540 - 164,614,998NCBI
Celera1140,887,888 - 140,992,712 (-)NCBICelera
Cytogenetic Map1q24.2NCBI
HuRef1139,024,896 - 139,129,092 (-)NCBIHuRef
CHM1_11169,200,865 - 169,305,664 (-)NCBICHM1_1
T2T-CHM13v2.01167,160,872 - 167,265,599 (-)NCBIT2T-CHM13v2.0
Adcy10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391165,309,114 - 165,404,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1165,312,752 - 165,404,343 (+)EnsemblGRCm39 Ensembl
GRCm381165,483,518 - 165,576,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,485,183 - 165,576,774 (+)EnsemblGRCm38mm10GRCm38
MGSCv371167,415,314 - 167,506,904 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361167,321,858 - 167,413,448 (+)NCBIMGSCv36mm8
Celera1167,931,319 - 168,021,551 (+)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map172.83NCBI
Adcy10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554629,207,314 - 9,278,621 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554629,196,984 - 9,278,850 (+)NCBIChiLan1.0ChiLan1.0
ADCY10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,848,277 - 81,957,079 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1181,516,261 - 81,625,530 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01143,239,576 - 143,404,038 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,023,671 - 147,129,705 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,023,671 - 147,129,705 (-)Ensemblpanpan1.1panPan2
ADCY10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1730,576,445 - 30,660,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl730,577,591 - 30,660,926 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha730,114,468 - 30,197,885 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0730,395,203 - 30,479,360 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl730,395,909 - 30,479,360 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1730,235,622 - 30,319,191 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0730,266,955 - 30,350,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0730,505,414 - 30,588,892 (+)NCBIUU_Cfam_GSD_1.0
Adcy10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344100,415,703 - 100,483,395 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648118,274,154 - 18,330,173 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648118,274,158 - 18,330,136 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl483,098,290 - 83,205,454 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1483,103,768 - 83,205,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2490,773,869 - 90,880,759 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12561,129,837 - 61,228,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2561,140,293 - 61,230,117 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605562,864,231 - 62,951,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248265,845,001 - 5,897,497 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248265,844,868 - 5,897,541 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adcy10
637 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000004326
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)137402391880753406Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
BF390833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21377,754,938 - 77,755,111 (+)MAPPERmRatBN7.2
Rnor_6.01383,707,768 - 83,707,940NCBIRnor6.0
Rnor_5.01388,587,226 - 88,587,398UniSTSRnor5.0
RGSC_v3.41381,211,716 - 81,211,888UniSTSRGSC3.4
Celera1377,468,305 - 77,468,477UniSTS
RH 3.4 Map13478.4UniSTS
Cytogenetic Map13q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 7
Low 1 2 45 29 18 29 5 5 25 8 9 10 5
Below cutoff 2 41 10 10 1 10 3 6 49 26 25 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF081941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000082677   ⟹   ENSRNOP00000072356
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1377,768,468 - 77,833,951 (+)Ensembl
Rnor_6.0 Ensembl1383,721,300 - 83,787,018 (+)Ensembl
RefSeq Acc Id: NM_021684   ⟹   NP_067716
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,284,316 - 80,366,939 (+)NCBI
mRatBN7.21377,751,312 - 77,833,952 (+)NCBI
Rnor_6.01383,704,139 - 83,787,002 (+)NCBI
Rnor_5.01388,583,534 - 88,667,840 (+)NCBI
RGSC_v3.41381,208,090 - 81,302,902 (+)RGD
Celera1377,464,675 - 77,547,216 (+)RGD
Sequence:
RefSeq Acc Id: XM_008769677   ⟹   XP_008767899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,366,932 (+)NCBI
mRatBN7.21377,747,752 - 77,833,925 (+)NCBI
Rnor_6.01383,701,952 - 83,787,010 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769678   ⟹   XP_008767900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,366,932 (+)NCBI
mRatBN7.21377,747,752 - 77,833,925 (+)NCBI
Rnor_6.01383,701,952 - 83,787,010 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091049   ⟹   XP_038946977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,309,936 - 80,366,932 (+)NCBI
mRatBN7.21377,776,945 - 77,833,945 (+)NCBI
RefSeq Acc Id: XM_039091050   ⟹   XP_038946978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,321,195 - 80,366,932 (+)NCBI
mRatBN7.21377,788,204 - 77,833,945 (+)NCBI
RefSeq Acc Id: XM_039091051   ⟹   XP_038946979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,321,195 - 80,366,932 (+)NCBI
mRatBN7.21377,788,204 - 77,833,945 (+)NCBI
RefSeq Acc Id: XM_039091052   ⟹   XP_038946980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,330,320 - 80,366,932 (+)NCBI
mRatBN7.21377,797,328 - 77,833,945 (+)NCBI
RefSeq Acc Id: XM_063272564   ⟹   XP_063128634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,366,932 (+)NCBI
RefSeq Acc Id: XM_063272565   ⟹   XP_063128635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,366,932 (+)NCBI
RefSeq Acc Id: XM_063272566   ⟹   XP_063128636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,358,114 (+)NCBI
RefSeq Acc Id: XM_063272567   ⟹   XP_063128637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,280,595 - 80,351,352 (+)NCBI
RefSeq Acc Id: XM_063272568   ⟹   XP_063128638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81380,334,546 - 80,366,932 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_067716   ⟸   NM_021684
- UniProtKB: Q9Z286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767899   ⟸   XM_008769677
- Peptide Label: isoform X1
- UniProtKB: Q9Z286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008767900   ⟸   XM_008769678
- Peptide Label: isoform X1
- UniProtKB: Q9Z286 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072356   ⟸   ENSRNOT00000082677
RefSeq Acc Id: XP_038946977   ⟸   XM_039091049
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038946978   ⟸   XM_039091050
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946979   ⟸   XM_039091051
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038946980   ⟸   XM_039091052
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063128635   ⟸   XM_063272565
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128634   ⟸   XM_063272564
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063128636   ⟸   XM_063272566
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128637   ⟸   XM_063272567
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063128638   ⟸   XM_063272568
- Peptide Label: isoform X9
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z286-F1-model_v2 AlphaFold Q9Z286 1-1608 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708450 AgrOrtholog
BioCyc Gene G2FUF-17567 BioCyc
Ensembl Genes ENSRNOG00000053410 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055017594 UniProtKB/Swiss-Prot
  ENSRNOG00060009857 UniProtKB/Swiss-Prot
  ENSRNOG00065019680 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082677.2 UniProtKB/Swiss-Prot
  ENSRNOT00055029771 UniProtKB/Swiss-Prot
  ENSRNOT00060016643 UniProtKB/Swiss-Prot
  ENSRNOT00065033166 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro A/G_cyclase UniProtKB/Swiss-Prot
  Adenylate_cyclase_typ10 UniProtKB/Swiss-Prot
  Nucleotide_cyclase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:59320 UniProtKB/Swiss-Prot
NCBI Gene 59320 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TESTICULAR SOLUBLE ADENYLYL CYCLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Guanylate_cyc UniProtKB/Swiss-Prot
PhenoGen Adcy10 PhenoGen
PIRSF Soluble_adenylyl_cyclase UniProtKB/Swiss-Prot
PROSITE GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053410 RatGTEx
  ENSRNOG00055017594 RatGTEx
  ENSRNOG00060009857 RatGTEx
  ENSRNOG00065019680 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
  SSF55073 UniProtKB/Swiss-Prot
  TPR-like UniProtKB/TrEMBL
UniProt A6IDH3_RAT UniProtKB/TrEMBL
  ADCYA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Adcy10  adenylate cyclase 10  Adcy10  adenylate cyclase 10 (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adcy10  adenylate cyclase 10 (soluble)  Adcy10  adenylate cyclase 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Adcy10  adenylate cyclase 10  Adcy10  adenylate cyclase 10 (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Adcy10  adenylate cyclase 10 (soluble)      Symbol and Name updated 1299863 APPROVED
2005-09-30 LOC59320        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed preferentially in testis 1299450