Vom2r75 (vomeronasal 2 receptor, 75) - Rat Genome Database

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Pathways
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Gene: Vom2r75 (vomeronasal 2 receptor, 75) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vom2r75
Name: vomeronasal 2 receptor, 75
RGD ID: 708414
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane; INTERACTS WITH 6-propyl-2-thiouracil; aflatoxin B1; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC286980; LOC286986; pheromone receptor (Go-VN13B)-like; putative pheromone receptor (Go-VN13B); putative pheromone receptor Go-VN13C; vomeronasal 2 receptor 75
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81884,553 - 114,196 (-)NCBIGRCr8
mRatBN7.21870,194 - 99,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1870,207 - 96,630 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1886,035 - 112,381 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018873,874 - 900,220 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01887,944 - 114,290 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01811,936 - 38,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1811,949 - 38,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01811,564 - 38,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41834,185 - 61,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1864,411 - 90,840 (-)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Herrada G and Dulac C, Cell 1997 Aug 22;90(4):763-73.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17382427  


Genomics

Variants

.
Variants in Vom2r75
158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:184
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000036914
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 6 5
Below cutoff 1 6 4 5 5 8 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000036914   ⟹   ENSRNOP00000032871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,207 - 96,630 (-)Ensembl
Rnor_6.0 Ensembl1811,949 - 38,374 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111566   ⟹   ENSRNOP00000097185
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1870,207 - 96,630 (-)Ensembl
RefSeq Acc Id: NM_001419486   ⟹   NP_001406415
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81884,553 - 114,196 (-)NCBI
mRatBN7.21870,194 - 99,837 (-)NCBI
RefSeq Acc Id: NM_173320   ⟹   NP_775442
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81884,558 - 110,989 (-)NCBI
mRatBN7.21870,199 - 96,630 (-)NCBI
Rnor_6.01811,941 - 38,374 (-)NCBI
Rnor_5.01811,564 - 38,663 (-)NCBI
RGSC_v3.41834,185 - 61,266 (-)RGD
Celera1864,411 - 90,840 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001406415 (Get FASTA)   NCBI Sequence Viewer  
  NP_775442 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53332 (Get FASTA)   NCBI Sequence Viewer  
  AAC53333 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032871
  ENSRNOP00000032871.3
  ENSRNOP00000097185
Reference Protein Sequences
RefSeq Acc Id: NP_775442   ⟸   NM_173320
- Peptide Label: isoform 2 precursor
- UniProtKB: A6KNC0 (UniProtKB/TrEMBL),   O35271 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032871   ⟸   ENSRNOT00000036914
RefSeq Acc Id: ENSRNOP00000097185   ⟸   ENSRNOT00000111566
RefSeq Acc Id: NP_001406415   ⟸   NM_001419486
- Peptide Label: isoform 1 precursor
- UniProtKB: G3V911 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V911-F1-model_v2 AlphaFold G3V911 1-802 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708414 AgrOrtholog
BioCyc Gene G2FUF-8448 BioCyc
Ensembl Genes ENSRNOG00000022955 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036914 ENTREZGENE
  ENSRNOT00000036914.4 UniProtKB/TrEMBL
  ENSRNOT00000111566 ENTREZGENE
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  GPCR_3_vmron_rcpt_2 UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
KEGG Report rno:286986 UniProtKB/TrEMBL
NCBI Gene 286986 ENTREZGENE
PANTHER EC2-V2R PHEROMONE RECEPTOR PROTEIN-RELATED UniProtKB/TrEMBL
  PTHR24061 UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Vom2r75 PhenoGen
PRINTS GPCRMGR UniProtKB/TrEMBL
  VOMERONASL2R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022955 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
  SSF81665 UniProtKB/TrEMBL
UniProt A6KNC0 ENTREZGENE, UniProtKB/TrEMBL
  G3V911 ENTREZGENE, UniProtKB/TrEMBL
  O35271 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-02 Vom2r75  vomeronasal 2 receptor, 75  LOC286980  putative pheromone receptor (Go-VN13B)  Data merged from RGD:708397 737654 APPROVED
2008-07-23 Vom2r75  vomeronasal 2 receptor, 75    vomeronasal 2 receptor 75  Symbol and Name updated 1299863 APPROVED
2008-05-01 Vom2r75  vomeronasal 2 receptor 75  LOC286986  putative pheromone receptor Go-VN13C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC286980  putative pheromone receptor (Go-VN13B)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-02-09 LOC286986  putative pheromone receptor Go-VN13C      Symbol and Name status set to provisional 70820 PROVISIONAL