Oas1b (2-5 oligoadenylate synthetase 1B) - Rat Genome Database

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Gene: Oas1b (2-5 oligoadenylate synthetase 1B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Oas1b (Ensembl: Oas1f)
Name: 2-5 oligoadenylate synthetase 1B (Ensembl:2 ' -5 ' oligoadenylate synthetase 1F)
RGD ID: 708393
Description: Predicted to enable 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Predicted to be involved in defense response to virus and negative regulation of viral genome replication. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol; membrane; and nucleoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; .
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: (2-5')oligo(A) synthase 1B; 2'5' oligoadenylate synthetase-2; 2'5'oligoadenylatesynthetase-2; 2-5A synthase 1B; 25 oligoadenylate synthetase-2; inactive 2'-5'-oligoadenylate synthase 1B; LOC246268; MGC108585
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,385,184 - 41,395,891 (-)NCBIGRCr8
mRatBN7.21235,724,561 - 35,735,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,724,055 - 35,735,242 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,903,584 - 36,914,288 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,514,791 - 37,525,495 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,567,244 - 36,577,948 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,255,762 - 41,266,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,227,825 - 41,307,352 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,117,220 - 43,127,888 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,858,902 - 36,869,570 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,721,783 - 36,732,970 (-)NCBI
Celera1237,387,484 - 37,398,152 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA)
endoplasmic reticulum membrane  (ISS)
membrane  (IBA,IEA)
nucleoplasm  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Human T-cell leukemia virus type 1 Tax protein stimulates the interferon-responsive enhancer element via NF-kappaB activity. Shimizu T, etal., FEBS Lett 2003 Mar 27;539(1-3):73-7.
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Oas1b
177 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:108
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000001853
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001853   ⟹   ENSRNOP00000001853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1235,724,055 - 35,733,534 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000048782   ⟹   ENSRNOP00000042591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1235,724,055 - 35,735,242 (-)Ensembl
RefSeq Acc Id: NM_144752   ⟹   NP_653353
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,385,184 - 41,395,852 (-)NCBI
mRatBN7.21235,724,561 - 35,735,230 (-)NCBI
Rnor_6.01241,255,762 - 41,266,430 (-)NCBI
Rnor_5.01243,117,220 - 43,127,888 (-)NCBI
RGSC_v3.41236,858,902 - 36,869,570 (-)RGD
Celera1237,387,484 - 37,398,152 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089068   ⟹   XP_038944996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,385,184 - 41,395,781 (-)NCBI
mRatBN7.21235,724,561 - 35,735,161 (-)NCBI
RefSeq Acc Id: XM_039089069   ⟹   XP_038944997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,385,184 - 41,393,675 (-)NCBI
mRatBN7.21235,724,561 - 35,732,725 (-)NCBI
RefSeq Acc Id: XR_005491597
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,388,173 - 41,395,891 (-)NCBI
mRatBN7.21235,727,551 - 35,735,271 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_653353   ⟸   NM_144752
- UniProtKB: O70522 (UniProtKB/Swiss-Prot),   Q5BKD0 (UniProtKB/Swiss-Prot),   A0A8L2PZR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038944996   ⟸   XM_039089068
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944997   ⟸   XM_039089069
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000001853   ⟸   ENSRNOT00000001853
RefSeq Acc Id: ENSRNOP00000042591   ⟸   ENSRNOT00000048782
Protein Domains
2'-5'-oligoadenylate synthetase   Polymerase nucleotidyl transferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BKD0-F1-model_v2 AlphaFold Q5BKD0 1-379 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698662
Promoter ID:EPDNEW_R9187
Type:single initiation site
Name:Oas1b_1
Description:2-5 oligoadenylate synthetase 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9188  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01241,266,439 - 41,266,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708393 AgrOrtholog
BioCyc Gene G2FUF-19193 BioCyc
Ensembl Genes ENSRNOG00000033220 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001853.4 UniProtKB/TrEMBL
  ENSRNOT00000048782 ENTREZGENE
  ENSRNOT00000048782.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2'-5'-oligoadenylate synthetase 1, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.460.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7383389 IMAGE-MGC_LOAD
InterPro 2-5-oligoadenylate_synth_N UniProtKB/Swiss-Prot
  2-5-oligoAdlate_synth_1_dom2/C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NT_2-5OAS_ClassI-CCAase UniProtKB/TrEMBL
  NT_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Polymerase_NTP_transf_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246268 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108585 IMAGE-MGC_LOAD
NCBI Gene 246268 ENTREZGENE
PANTHER INACTIVE 2'-5'-OLIGOADENYLATE SYNTHASE 1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11258 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NTP_transf_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAS1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oas1b PhenoGen
PROSITE 25A_SYNTH_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033220 RatGTEx
Superfamily-SCOP PAP/OAS1 substrate-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81301 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2PZR9 ENTREZGENE, UniProtKB/TrEMBL
  A1DZF7_RAT UniProtKB/TrEMBL
  O70522 ENTREZGENE
  OAS1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O70522 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Oas1b  2-5 oligoadenylate synthetase 1B  LOC246268  25 oligoadenylate synthetase-2  Symbol and Name updated 1299863 APPROVED