Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1331922 | 6480464 | Ethinyl Estradiol affects the expression of NEXN mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of NEXN mRNA | CTD | PMID:17557909 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1354261 | 6480464 | Tetrachlorodibenzodioxin affects the expression of NEXN mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1331922 | 6480464 | Tetrachlorodibenzodioxin affects the expression of NEXN mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of NEXN mRNA | CTD | PMID:22298810 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:1331922 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of NEXN mRNA | CTD | PMID:18648102 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of NEXN mRNA | CTD | PMID:16483693 | ammonium hexachloroplatinate | affects expression | ISO | RGD:1354261 | 6480464 | ammonium hexachloroplatinate affects the expression of NEXN mRNA | CTD | PMID:19527780 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of NEXN mRNA | CTD | PMID:21839799 | calcitriol | increases expression | ISO | RGD:1354261 | 6480464 | Calcitriol results in increased expression of NEXN mRNA | CTD | PMID:16002434 | choline | multiple interactions | ISO | RGD:1331922 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NEXN mRNA | CTD | PMID:20938992 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of NEXN mRNA | CTD | PMID:22023808 | cocaine | multiple interactions | ISO | RGD:1331922 | 6480464 | [Cocaine co-treated with FOS protein mutant form] results in decreased expression of NEXN mRNA | CTD | PMID:18355967 | crocidolite asbestos | increases expression | ISO | RGD:1354261 | 6480464 | Asbestos, Crocidolite results in increased expression of NEXN mRNA | CTD | PMID:18687144 | dibutyl phthalate | increases expression | ISO | RGD:1331922 | 6480464 | Dibutyl Phthalate results in increased expression of NEXN mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:1331922 | 6480464 | Dibutyl Phthalate results in increased expression of NEXN mRNA | CTD | PMID:17361019 PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of NEXN mRNA | CTD | PMID:21266533 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of NEXN mRNA | CTD | PMID:21658437 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of NEXN mRNA | CTD | PMID:21551480 | doxorubicin | decreases expression | ISO | RGD:1331922 | 6480464 | Doxorubicin results in decreased expression of NEXN mRNA | CTD | PMID:17888722 | folic acid | multiple interactions | ISO | RGD:1331922 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NEXN mRNA | CTD | PMID:20938992 | hexamethylene diisocyanate | affects expression | ISO | RGD:1354261 | 6480464 | 1,6-hexamethylene diisocyanate affects the expression of NEXN mRNA | CTD | PMID:19527780 | L-methionine | multiple interactions | ISO | RGD:1331922 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NEXN mRNA | CTD | PMID:20938992 | levonorgestrel | multiple interactions | ISO | RGD:1354261 | 6480464 | [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of NEXN mRNA | CTD | PMID:19074003 | nickel atom | decreases expression | ISO | RGD:1331922 | 6480464 | Nickel results in decreased expression of NEXN mRNA | CTD | PMID:18922574 | ochratoxin A | increases expression | EXP | | 6480464 | ochratoxin A results in increased expression of NEXN mRNA | CTD | PMID:22124623 | quercetin | decreases expression | ISO | RGD:1354261 | 6480464 | Quercetin results in decreased expression of NEXN mRNA | CTD | PMID:21632981 | tamoxifen | affects expression | ISO | RGD:1331922 | 6480464 | Tamoxifen affects the expression of NEXN mRNA | CTD | PMID:17555576 | tetrachloromethane | affects expression | ISO | RGD:1331922 | 6480464 | Carbon Tetrachloride affects the expression of NEXN mRNA | CTD | PMID:17484886 | trimellitic anhydride | affects expression | ISO | RGD:1354261 | 6480464 | trimellitic anhydride affects the expression of NEXN mRNA | CTD | PMID:19527780 | zidovudine | multiple interactions | ISO | RGD:1354261 | 6480464 | [Zidovudine co-treated with IFNA1 protein] results in increased expression of NEXN mRNA | CTD | PMID:20370541 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
References - curated| 1. |
Ohtsuka T, etal., J Cell Biol 1998 Nov 30;143(5):1227-38. |
| 2. |
RGD automated data pipeline |
| 3. |
RGD automated import pipeline for gene-chemical interactions |
| 4. |
RGD Automated Pipelines |
References - uncurated| PubMed | 19881492 |
RGD Disease Portals| Nexn has been annotated in the following RGD Disease Portals. |
|||
![]() |
| ||
![]() |
| ||
Comparative Map Data| Nexn (Rattus norvegicus) |
|
||||||||||||||||||||||||||||||||||||||||
| NEXN (Homo sapiens) |
|
||||||||||||||||||||||||||||||||||||||||
| Nexn (Mus musculus) |
|
Position Markers| AA799423 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_139231 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_631977 | ||||||||||||||||||||
| Peptide Label: | isoform b | ||||||||||||||||||||
| Position: |
|
| RefSeq Acc Id: | NM_139230 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_631976 | ||||||||||||||||||||
| Peptide Label: | isoform s | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_631976 | (Get FASTA) |
| NP_631977 | (Get FASTA) | |
| GenBank Protein | AAC95128 | (Get FASTA) |
| AAC95129 | (Get FASTA) | |
| ACH96580 | (Get FASTA) | |
| EDL82493 | (Get FASTA) | |
| EDL82494 | (Get FASTA) | |
| EDL82495 | (Get FASTA) | |
| EDL82496 | (Get FASTA) | |
| Q9Z2J4 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000012512 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000016968 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000058811 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000016967 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000066780 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Entrez Gene | 246172 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 44892 | ENTREZGENE |
| InterPro | Ig-like | UniProtKB/Swiss-Prot |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Ig_I-set | UniProtKB/Swiss-Prot | |
| Ig_sub | UniProtKB/Swiss-Prot | |
| Myosin_light_chain_kin-rel | UniProtKB/Swiss-Prot | |
| Nexilin | UniProtKB/Swiss-Prot | |
| IPI | IPI00209938 | UniProtKB/Swiss-Prot |
| IPI00396852 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:246172 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | Myosin_light_chain_kin-rel | UniProtKB/Swiss-Prot |
| PTHR22964:SF4 | UniProtKB/Swiss-Prot | |
| Pfam | I-set | UniProtKB/Swiss-Prot |
| PROSITE | IG_LIKE | UniProtKB/Swiss-Prot |
| SMART | SM00409 | UniProtKB/Swiss-Prot |
| UniGene | Rn.107975 | ENTREZGENE |
| UniProt | NEXN_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-25 | Nexn | nexilin (F actin binding protein) | Nexn | nexilin | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2004-12-14 | Nexn | nexilin | LOC246172 | Symbol updated | 10779 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_protein | big b-nexilin and small s-nexillin isoforms are products of nexillin splicing variants | 1299387 |
| More on Nexn | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 708354 |
| Created: | 2003-09-23 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




