Cdo1 (cysteine dioxygenase type 1) - Rat Genome Database

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Gene: Cdo1 (cysteine dioxygenase type 1) Rattus norvegicus
Analyze
Symbol: Cdo1
Name: cysteine dioxygenase type 1
RGD ID: 69262
Description: Enables cysteine dioxygenase activity and ferrous iron binding activity. Involved in several processes, including L-cysteine catabolic process; lactation; and response to glucagon. Predicted to be located in cytosol. Biomarker of hypertension. Orthologous to human CDO1 (cysteine dioxygenase type 1); PARTICIPATES IN cysteine metabolic pathway; mercaptolactate-cysteine disulfiduria pathway; ocular nonnephropathic cystinosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CDO; CDO-I; cysteine dioxygenase; cysteine dioxygenase 1, cytosolic; cysteine dioxygenase, type I; cytosolic cysteine dioxygenase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,619,076 - 41,633,719 (-)NCBIGRCr8
mRatBN7.21839,432,473 - 39,447,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1839,432,474 - 39,447,296 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1841,465,686 - 41,480,329 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01842,167,931 - 42,182,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,961,030 - 39,975,676 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,702,027 - 40,716,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,701,984 - 40,716,686 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01840,348,054 - 40,362,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41840,914,028 - 40,928,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11840,951,568 - 40,966,212 (-)NCBI
Celera1837,683,907 - 37,698,550 (-)NCBICelera
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-octylphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
Diisodecyl phthalate  (ISO)
diuron  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glafenine  (EXP)
glutathione  (EXP)
hypotaurine  (EXP)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
m-xylene  (EXP)
maneb  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
raloxifene  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)

Molecular Function
cysteine dioxygenase activity  (IBA,IDA,IEA,ISO,TAS)
ferrous iron binding  (IBA,IDA,IEA,ISO)
nickel cation binding  (ISO,ISS)
zinc ion binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Probes of the catalytic site of cysteine dioxygenase. Chai SC, etal., J Biol Chem. 2006 Jun 9;281(23):15774-9. Epub 2006 Apr 11.
2. Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats. Cresenzi CL, etal., J Nutr 2003 Sep;133(9):2697-702.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Isolation and characterization of a cDNA for rat liver cysteine dioxygenase. Hosokawa Y, etal., Biochem Biophys Res Commun 1990 Apr 30;168(2):473-8.
6. Decrease of rat liver cysteine dioxygenase (cysteine oxidase) activity mediated by glucagon. Hosokawa Y, etal., J Biochem. 1978 Aug;84(2):419-24.
7. Immaturity of the enzyme activity and the response to inducers of rat liver cysteine dioxygenase during development. Hosokawa Y, etal., J Biochem. 1980 Aug;88(2):389-94.
8. Effect of acute ethanol administration on S-amino acid metabolism: increased utilization of cysteine for synthesis of taurine rather than glutathione. Jung YS, etal., Adv Exp Med Biol. 2003;526:245-52.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Changes in cysteine dioxygenase and cysteinesulfinate decarboxylase activities and taurine levels in tissues of pregnant or lactating rat dams and their fetuses or pups. Kuo SM and Stipanuk MH, Biol Neonate. 1984;46(5):237-48.
11. Alteration of cerebral taurine biosynthesis in spontaneously hypertensive rats. Kuriyama K, etal., J Neurochem. 1984 Jun;42(6):1600-6.
12. Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes. Kwon YH and Stipanuk MH, Am J Physiol Endocrinol Metab. 2001 May;280(5):E804-15.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Hepatic localisation of rat cysteine dioxygenase. Parsons RB, etal., J Hepatol. 1998 Oct;29(4):595-602.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. Stipanuk MH and Ueki I, J Inherit Metab Dis. 2011 Feb;34(1):17-32. doi: 10.1007/s10545-009-9006-9. Epub 2010 Feb 17.
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Structural organization and tissue-specific expression of the gene encoding rat cysteine dioxygenase. Tsuboyama N, etal., Gene 1996 Nov 28;181(1-2):161-5.
24. Taurine (2-aminoethanesulfonic acid) deficiency creates a vicious circle promoting obesity. Tsuboyama-Kasaoka N, etal., Endocrinology. 2006 Jul;147(7):3276-84. Epub 2006 Apr 20.
Additional References at PubMed
PMID:11602353   PMID:15489334   PMID:15623508   PMID:16262602   PMID:16325423   PMID:16511222   PMID:16611640   PMID:17153587   PMID:17634260   PMID:18308719   PMID:18847220   PMID:21839860  
PMID:22122511   PMID:24084026   PMID:24929188   PMID:25390690  


Genomics

Comparative Map Data
Cdo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81841,619,076 - 41,633,719 (-)NCBIGRCr8
mRatBN7.21839,432,473 - 39,447,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1839,432,474 - 39,447,296 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1841,465,686 - 41,480,329 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01842,167,931 - 42,182,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01839,961,030 - 39,975,676 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01840,702,027 - 40,716,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1840,701,984 - 40,716,686 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01840,348,054 - 40,362,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41840,914,028 - 40,928,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11840,951,568 - 40,966,212 (-)NCBI
Celera1837,683,907 - 37,698,550 (-)NCBICelera
Cytogenetic Map18q11NCBI
CDO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385115,804,733 - 115,816,659 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5115,804,733 - 115,816,659 (-)EnsemblGRCh38hg38GRCh38
GRCh375115,140,430 - 115,152,356 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365115,168,329 - 115,180,304 (-)NCBINCBI36Build 36hg18NCBI36
Build 345115,168,330 - 115,180,304NCBI
Celera5111,088,830 - 111,100,805 (-)NCBICelera
Cytogenetic Map5q22.3NCBI
HuRef5110,321,120 - 110,333,095 (-)NCBIHuRef
CHM1_15114,573,041 - 114,585,035 (-)NCBICHM1_1
T2T-CHM13v2.05116,317,131 - 116,330,485 (-)NCBIT2T-CHM13v2.0
Cdo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391846,846,260 - 46,861,569 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1846,846,260 - 46,861,462 (-)EnsemblGRCm39 Ensembl
GRCm381846,713,193 - 46,728,502 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1846,713,193 - 46,728,395 (-)EnsemblGRCm38mm10GRCm38
MGSCv371846,872,859 - 46,887,996 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361846,838,536 - 46,853,673 (-)NCBIMGSCv36mm8
Celera1848,072,450 - 48,087,588 (-)NCBICelera
Cytogenetic Map18CNCBI
cM Map1824.75NCBI
Cdo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540835,593,767 - 35,605,189 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540835,593,981 - 35,605,189 (-)NCBIChiLan1.0ChiLan1.0
CDO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24111,049,670 - 111,061,831 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15109,203,331 - 109,215,493 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05111,159,041 - 111,170,965 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15116,955,295 - 116,967,506 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5116,955,295 - 116,967,506 (-)Ensemblpanpan1.1panPan2
CDO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1115,512,996 - 5,524,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl115,371,378 - 5,524,562 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha115,663,614 - 5,675,242 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0115,504,785 - 5,516,418 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl115,363,481 - 5,516,371 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1115,459,998 - 5,471,611 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0115,531,165 - 5,542,773 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0115,783,374 - 5,794,991 (-)NCBIUU_Cfam_GSD_1.0
Cdo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213128,281,092 - 128,292,536 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936742979,368 - 993,257 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936742981,863 - 993,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2119,927,772 - 119,940,665 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12119,927,768 - 119,940,690 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22124,815,757 - 124,827,728 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12319,049,612 - 19,061,783 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2319,049,262 - 19,061,740 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603459,346,740 - 59,359,207 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247336,062,502 - 6,075,210 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247336,062,716 - 6,074,583 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdo1
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:435
Count of miRNA genes:237
Interacting mature miRNAs:274
Transcripts:ENSRNOT00000000172
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat

Markers in Region
D18Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,433,272 - 39,433,416 (+)MAPPERmRatBN7.2
Rnor_6.01840,702,827 - 40,702,970NCBIRnor6.0
Rnor_5.01840,348,854 - 40,348,997UniSTSRnor5.0
RGSC_v3.41840,914,821 - 40,914,964UniSTSRGSC3.4
Celera1837,684,700 - 37,684,843UniSTS
Cytogenetic Map18q11UniSTS
D18Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,442,611 - 39,442,747 (+)MAPPERmRatBN7.2
Rnor_6.01840,712,166 - 40,712,301NCBIRnor6.0
Rnor_5.01840,358,193 - 40,358,328UniSTSRnor5.0
RGSC_v3.41840,924,160 - 40,924,295UniSTSRGSC3.4
Celera1837,694,039 - 37,694,174UniSTS
Cytogenetic Map18q11UniSTS
RH127714  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,432,624 - 39,432,808 (+)MAPPERmRatBN7.2
Rnor_6.01840,702,179 - 40,702,362NCBIRnor6.0
Rnor_5.01840,348,206 - 40,348,389UniSTSRnor5.0
RGSC_v3.41840,914,173 - 40,914,356UniSTSRGSC3.4
Celera1837,684,052 - 37,684,235UniSTS
Cytogenetic Map18q11UniSTS
RH139615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21839,445,603 - 39,445,817 (+)MAPPERmRatBN7.2
Rnor_6.01840,715,157 - 40,715,370NCBIRnor6.0
Rnor_5.01840,361,184 - 40,361,397UniSTSRnor5.0
RGSC_v3.41840,927,151 - 40,927,364UniSTSRGSC3.4
Celera1837,697,030 - 37,697,243UniSTS
Cytogenetic Map18q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 8 8 8
Medium 1 9 49 33 9 33 5 5 74 35 36 11 5
Low 2 34 10 3 6 5 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000172   ⟹   ENSRNOP00000000172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1839,432,480 - 39,447,124 (-)Ensembl
Rnor_6.0 Ensembl1840,701,984 - 40,716,686 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096478   ⟹   ENSRNOP00000079228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1839,432,474 - 39,446,935 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107879   ⟹   ENSRNOP00000077468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1839,433,994 - 39,447,296 (-)Ensembl
RefSeq Acc Id: NM_052809   ⟹   NP_434696
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81841,619,076 - 41,633,719 (-)NCBI
mRatBN7.21839,432,480 - 39,447,124 (-)NCBI
Rnor_6.01840,702,034 - 40,716,677 (-)NCBI
Rnor_5.01840,348,054 - 40,362,746 (-)NCBI
RGSC_v3.41840,914,028 - 40,928,671 (-)RGD
Celera1837,683,907 - 37,698,550 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_434696   ⟸   NM_052809
- UniProtKB: Q6NS32 (UniProtKB/Swiss-Prot),   P21816 (UniProtKB/Swiss-Prot),   A6IWW6 (UniProtKB/TrEMBL),   A0A8I5ZKB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000172   ⟸   ENSRNOT00000000172
RefSeq Acc Id: ENSRNOP00000077468   ⟸   ENSRNOT00000107879
RefSeq Acc Id: ENSRNOP00000079228   ⟸   ENSRNOT00000096478

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21816-F1-model_v2 AlphaFold P21816 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700767
Promoter ID:EPDNEW_R11291
Type:single initiation site
Name:Cdo1_1
Description:cysteine dioxygenase type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01840,716,701 - 40,716,761EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69262 AgrOrtholog
BioCyc Gene G2FUF-7623 BioCyc
BioCyc Pathway CYSTEINE-DEG-PWY [L-cysteine degradation I] BioCyc
  PWY-5331 [taurine biosynthesis I] BioCyc
BioCyc Pathway Image CYSTEINE-DEG-PWY BioCyc
  PWY-5331 BioCyc
Ensembl Genes ENSRNOG00000000158 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018164 UniProtKB/Swiss-Prot
  ENSRNOG00060011390 UniProtKB/Swiss-Prot
  ENSRNOG00065019206 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000172 ENTREZGENE
  ENSRNOT00000000172.6 UniProtKB/Swiss-Prot
  ENSRNOT00000096478.1 UniProtKB/TrEMBL
  ENSRNOT00000107879.1 UniProtKB/TrEMBL
  ENSRNOT00055030795 UniProtKB/Swiss-Prot
  ENSRNOT00060019291 UniProtKB/Swiss-Prot
  ENSRNOT00065032348 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7100321 IMAGE-MGC_LOAD
InterPro CDO_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC_Cupin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81718 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91599 IMAGE-MGC_LOAD
NCBI Gene 81718 ENTREZGENE
PANTHER CYSTEINE DIOXYGENASE TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12918 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CDO_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdo1 PhenoGen
RatGTEx ENSRNOG00000000158 RatGTEx
  ENSRNOG00055018164 RatGTEx
  ENSRNOG00060011390 RatGTEx
  ENSRNOG00065019206 RatGTEx
Superfamily-SCOP SSF51182 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZKB1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMI6_RAT UniProtKB/TrEMBL
  A6IWW4_RAT UniProtKB/TrEMBL
  A6IWW5_RAT UniProtKB/TrEMBL
  A6IWW6 ENTREZGENE, UniProtKB/TrEMBL
  A6IWW7_RAT UniProtKB/TrEMBL
  A6IWW8_RAT UniProtKB/TrEMBL
  CDO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6NS32 ENTREZGENE
UniProt Secondary Q6NS32 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Cdo1  cysteine dioxygenase type 1  Cdo1  cysteine dioxygenase, type I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Cdo1  cysteine dioxygenase, type I  Cdo1  cysteine dioxygenase 1, cytosolic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Cdo1  cysteine dioxygenase 1, cytosolic      Name updated 1299863 APPROVED
2002-06-10 Cdo1  cytosolic cysteine dioxygenase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, kidney, lung, and brain 632438
gene_protein predicted protein consists of 200 aa residues and masses 23 kDa 68765
gene_transcript gene spans around 15 kb and comprises 5 exons 632438