Hnrnpab (heterogeneous nuclear ribonucleoprotein A/B) - Rat Genome Database

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Gene: Hnrnpab (heterogeneous nuclear ribonucleoprotein A/B) Rattus norvegicus
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Symbol: Hnrnpab
Name: heterogeneous nuclear ribonucleoprotein A/B (Ensembl:heteroous nuclear ribonucleoprotein A/B)
RGD ID: 69255
Description: Enables sequence-specific double-stranded DNA binding activity. Involved in cellular response to amino acid stimulus; regulation of cellular localization; and regulation of intracellular mRNA localization. Located in dendrite and neuronal ribonucleoprotein granule. Part of ribonucleoprotein complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human HNRNPAB (heterogeneous nuclear ribonucleoprotein A/B); PARTICIPATES IN spliceosome pathway; INTERACTS WITH (S)-AMPA; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A1F-C1; CArG-binding factor-A; CBF-A; Cgbf; Cgbfa; DBP40; heterogeneous nuclear ribonucleoprotein A/B-like; Hnrpab; LOC100910156; LOC103689931
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,358,004 - 36,363,898 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,358,006 - 36,364,307 (-)EnsemblGRCr8
mRatBN7.21035,857,040 - 35,862,935 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,857,041 - 35,863,344 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1040,551,497 - 40,557,391 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,041,789 - 40,047,683 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,545,198 - 35,551,092 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1039,272,635 - 39,278,529 (-)NCBI
Lyon_Normotensive1039,929,961 - 39,935,855 (-)NCBI
Lyon_Hypertensive1041,624,807 - 41,630,698 (-)NCBI
F344_StmMcwi1041,528,209 - 41,534,101 (-)NCBI
Rnor_6.01034,955,713 - 34,961,662 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,955,716 - 34,961,608 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1037,049,677 - 37,055,282 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01036,821,682 - 36,827,630 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,117,285 - 37,123,177 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,213,782 - 35,219,674 (-)NCBICelera
RGSC_v3.11227,570,905 - 27,583,441 (+)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-AMPA  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3',5'-cyclic UMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (EXP,ISO)
enzyme inhibitor  (ISO)
flavonoids  (EXP)
florfenicol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
LDN-193189  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylseleninic acid  (ISO)
nefazodone  (EXP)
nitrates  (ISO)
nobiletin  (ISO)
okadaic acid  (ISO)
oxycodone  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propiconazole  (EXP)
quartz  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Purification and cloning of type A/B hnRNP proteins involved in transcriptional activation from the Rat spi 2 gene GAGA box. Leverrier S, etal., Biol Chem. 2000 Nov;381(11):1031-40.
5. CArG binding factor A (CBF-A) is involved in transcriptional regulation of the rat Ha-ras promoter. Mikheev AM, etal., Nucleic Acids Res 2000 Oct 1;28(19):3762-70.
6. Landscape of the hnRNP K protein-protein interactome. Mikula M, etal., Proteomics. 2006 Apr;6(8):2395-406.
7. Microarray analysis of the global gene expression profile following hypothermia and transient focal cerebral ischemia. Nagel S, etal., Neuroscience. 2012 Apr 19;208:109-22. doi: 10.1016/j.neuroscience.2012.01.048. Epub 2012 Feb 10.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins. Percipalle P, etal., Nucleic Acids Res. 2002 Apr 15;30(8):1725-34.
10. In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements. Raju CS, etal., Mol Biol Cell. 2011 Jun 1;22(11):1864-77. doi: 10.1091/mbc.E10-11-0904. Epub 2011 Apr 6.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Functional domains involved in the interaction between Orc1 and transcriptional repressor AlF-C that bind to an origin/promoter of the rat aldolase B gene. Saitoh Y, etal., Nucleic Acids Res 2002 Dec 1;30(23):5205-12.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. A novel growth-related nuclear protein binds and inhibits rat aldolase B gene promoter. Yabuki T, etal., Gene 2001 Feb 7;264(1):123-9.
16. HNRNPAB induces epithelial-mesenchymal transition and promotes metastasis of hepatocellular carcinoma by transcriptionally activating SNAIL. Zhou ZJ, etal., Cancer Res. 2014 May 15;74(10):2750-62. doi: 10.1158/0008-5472.CAN-13-2509. Epub 2014 Mar 17.
Additional References at PubMed
PMID:15342744   PMID:17273560   PMID:17289661   PMID:22658674   PMID:22681889   PMID:23907535   PMID:24625528   PMID:28131823   PMID:35352799  


Genomics

Comparative Map Data
Hnrnpab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,358,004 - 36,363,898 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1036,358,006 - 36,364,307 (-)EnsemblGRCr8
mRatBN7.21035,857,040 - 35,862,935 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,857,041 - 35,863,344 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1040,551,497 - 40,557,391 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,041,789 - 40,047,683 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,545,198 - 35,551,092 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1039,272,635 - 39,278,529 (-)NCBI
Lyon_Normotensive1039,929,961 - 39,935,855 (-)NCBI
Lyon_Hypertensive1041,624,807 - 41,630,698 (-)NCBI
F344_StmMcwi1041,528,209 - 41,534,101 (-)NCBI
Rnor_6.01034,955,713 - 34,961,662 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,955,716 - 34,961,608 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1037,049,677 - 37,055,282 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01036,821,682 - 36,827,630 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41037,117,285 - 37,123,177 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1035,213,782 - 35,219,674 (-)NCBICelera
RGSC_v3.11227,570,905 - 27,583,441 (+)NCBI
Cytogenetic Map10q22NCBI
HNRNPAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385178,204,533 - 178,211,163 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5178,204,479 - 178,216,389 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh375177,631,534 - 177,638,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365177,564,114 - 177,570,790 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345177,564,113 - 177,570,789NCBI
Celera5173,258,497 - 173,265,171 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5172,357,799 - 172,364,473 (+)NCBIHuRef
CHM1_15177,063,918 - 177,070,606 (+)NCBICHM1_1
T2T-CHM13v2.05178,754,824 - 178,761,448 (+)NCBIT2T-CHM13v2.0
Hnrnpab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,490,927 - 51,497,708 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,487,363 - 51,510,327 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381151,600,100 - 51,606,881 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1151,600,100 - 51,606,847 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371151,413,602 - 51,420,383 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361151,443,523 - 51,450,270 (-)NCBIMGSCv36mm8
Celera1156,171,430 - 56,178,210 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.11NCBI
Hnrnpab
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,060,829 - 2,065,416 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554082,060,288 - 2,064,998 (-)NCBIChiLan1.0ChiLan1.0
HNRNPAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24173,146,592 - 173,153,282 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15171,286,162 - 171,292,839 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05173,364,301 - 173,370,974 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15180,622,362 - 180,628,209 (+)NCBIPanPan1.1PanPan1.1panPan2
HNRNPAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1113,355,051 - 3,360,376 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl113,355,050 - 3,360,258 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha113,498,638 - 3,505,066 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0113,331,321 - 3,337,750 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl113,331,325 - 3,337,599 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1113,301,752 - 3,308,179 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0113,383,069 - 3,389,498 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0113,621,655 - 3,628,090 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hnrnpab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11158,060,575 - 158,105,412 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024407213113,473,382 - 113,517,602 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936647478,443 - 484,570 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936647478,445 - 520,361 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNRNPAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1280,186,998 - 80,194,155 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2281,799,657 - 81,810,402 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNRNPAB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1234,043,912 - 4,050,869 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366607511,195,612 - 11,202,622 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.12379,891,942 - 79,903,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Hnrnpab
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473341,387,068 - 41,403,701 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462473341,398,123 - 41,403,617 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl44,883,101 - 4,889,389 (-)Ensembl
Hnrnpab
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1934,188,282 - 34,194,132 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Hnrnpab
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:500
Count of miRNA genes:206
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000004885, ENSRNOT00000033056, ENSRNOT00000065584
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH138480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21035,856,612 - 35,856,776 (+)MAPPERmRatBN7.2
Rnor_6.01037,048,973 - 37,049,136NCBIRnor6.0
Rnor_6.01034,955,287 - 34,955,450NCBIRnor6.0
Rnor_5.01036,821,255 - 36,821,418UniSTSRnor5.0
Rnor_5.01034,727,633 - 34,727,796UniSTSRnor5.0
RGSC_v3.41037,116,856 - 37,117,019UniSTSRGSC3.4
Celera1035,213,353 - 35,213,516UniSTS
RH 3.4 Map10386.5UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
271 150 730 1585 4037 977 1697 133 856 490 838 150 5339 2574 449 3962 38 1382 722 896 160 158

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003750817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF216753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB780765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK473681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB886977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB886979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC944386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC944388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004885   ⟹   ENSRNOP00000004885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,358,019 - 36,363,790 (-)Ensembl
mRatBN7.2 Ensembl1035,857,055 - 35,862,827 (-)Ensembl
Rnor_6.0 Ensembl1034,956,052 - 34,961,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000033056   ⟹   ENSRNOP00000038183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,358,006 - 36,363,898 (-)Ensembl
mRatBN7.2 Ensembl1035,857,041 - 35,862,935 (-)Ensembl
Rnor_6.0 Ensembl1034,955,716 - 34,961,608 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000065584   ⟹   ENSRNOP00000062597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1036,358,006 - 36,364,307 (-)Ensembl
mRatBN7.2 Ensembl1035,857,042 - 35,863,344 (-)Ensembl
Rnor_6.0 Ensembl1037,049,677 - 37,055,282 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086193   ⟹   ENSRNOP00000069174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1037,049,677 - 37,055,282 (-)Ensembl
RefSeq Acc Id: NM_031330   ⟹   NP_112620
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,358,006 - 36,363,898 (-)NCBI
mRatBN7.21035,857,042 - 35,862,935 (-)NCBI
Dahl_SR_JrHsd1039,272,635 - 39,278,529 (-)NCBI
Lyon_Normotensive1039,929,961 - 39,935,855 (-)NCBI
Lyon_Hypertensive1041,624,807 - 41,630,698 (-)NCBI
F344_StmMcwi1041,528,209 - 41,534,101 (-)NCBI
Rnor_6.01034,955,716 - 34,961,608 (-)NCBI
Rnor_5.01036,821,682 - 36,827,630 (-)NCBI
RGSC_v3.41037,117,285 - 37,123,177 (-)RGD
Celera1035,213,782 - 35,219,674 (-)RGD
Sequence:
RefSeq Acc Id: XM_063269960   ⟹   XP_063126030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,358,004 - 36,363,616 (-)NCBI
RefSeq Acc Id: NP_112620   ⟸   NM_031330
- UniProtKB: Q9QX80 (UniProtKB/TrEMBL),   E9PTS0 (UniProtKB/TrEMBL),   Q6NYB6 (UniProtKB/TrEMBL),   O88311 (UniProtKB/TrEMBL),   A0ACM8Q1X4 (UniProtKB/TrEMBL),   F7F9P3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062597   ⟸   ENSRNOT00000065584
Ensembl Acc Id: ENSRNOP00000038183   ⟸   ENSRNOT00000033056
Ensembl Acc Id: ENSRNOP00000069174   ⟸   ENSRNOT00000086193
Ensembl Acc Id: ENSRNOP00000004885   ⟸   ENSRNOT00000004885
RefSeq Acc Id: XP_063126030   ⟸   XM_063269960
- Peptide Label: isoform X1
- UniProtKB: A6HE59 (UniProtKB/TrEMBL),   Q9QX81 (UniProtKB/TrEMBL),   A0ACM8Q215 (UniProtKB/TrEMBL),   O88311 (UniProtKB/TrEMBL)
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QX81-F1-model_v2 AlphaFold Q9QX81 1-332 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697140
Promoter ID:EPDNEW_R7665
Type:single initiation site
Name:LOC103689931_1
Description:heterogeneous nuclear ribonucleoprotein A/B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01034,961,614 - 34,961,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69255 AgrOrtholog
BioCyc Gene G2FUF-25198 BioCyc
Ensembl Genes ENSRNOG00000003645 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046272 Ensembl
Ensembl Transcript ENSRNOT00000004885 ENTREZGENE
  ENSRNOT00000004885.9 UniProtKB/TrEMBL
  ENSRNOT00000033056 ENTREZGENE
  ENSRNOT00000033056.7 UniProtKB/TrEMBL
  ENSRNOT00000065584.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621982 IMAGE-MGC_LOAD
InterPro CARG-binding_factor_N UniProtKB/TrEMBL
  hnRNPAB_RRM1 UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
KEGG Report rno:83498 UniProtKB/TrEMBL
MGC_CLONE MGC:72406 IMAGE-MGC_LOAD
NCBI Gene 83498 ENTREZGENE
PANTHER HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A/B UniProtKB/TrEMBL
  RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN UniProtKB/TrEMBL
Pfam CBFNT UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
PhenoGen Hnrnpab PhenoGen
PROSITE RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003645 RatGTEx
  ENSRNOG00000046272 RatGTEx
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A8J8XXQ6_RAT UniProtKB/TrEMBL
  A0ACM8Q1X4 ENTREZGENE, UniProtKB/TrEMBL
  A0ACM8Q215 ENTREZGENE, UniProtKB/TrEMBL
  A6HE59 ENTREZGENE, UniProtKB/TrEMBL
  E9PTS0 ENTREZGENE
  F7F9P3 ENTREZGENE
  O88311 ENTREZGENE, UniProtKB/TrEMBL
  Q6NYB6 ENTREZGENE
  Q9QX80 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX81 ENTREZGENE
UniProt Secondary E9PTS0 UniProtKB/TrEMBL
  F7F9P3 UniProtKB/TrEMBL
  Q6NYB6 UniProtKB/TrEMBL
  Q9QX81 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hnrnpab  heterogeneous nuclear ribonucleoprotein A/B  LOC103689931  heterogeneous nuclear ribonucleoprotein A/B  Data merged from RGD:9343685 737654 PROVISIONAL
2015-08-11 Hnrnpab  heterogeneous nuclear ribonucleoprotein A/B  LOC100910156  heterogeneous nuclear ribonucleoprotein A/B-like  Data merged from RGD:6499693 737654 APPROVED
2014-08-25 LOC103689931  heterogeneous nuclear ribonucleoprotein A/B      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100910156  heterogeneous nuclear ribonucleoprotein A/B-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-05-19 Hnrnpab  heterogeneous nuclear ribonucleoprotein A/B  Hnrpab  heterogeneous nuclear ribonucleoprotein A/B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hnrpab  heterogeneous nuclear ribonucleoprotein A/B      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains separate domains to bind DNA sequence-specifically and to repress transcription 628366
gene_expression enriched in fetal livers and regenerating livers 68198
gene_function binds to the rat aldolase B promoter 68198
gene_process may be involved in in repression of the Aldob gene 68198
gene_process binds directly to Orc1, a subunit of the origin recognition complex (ORC) and may mediate recruiting ORC to regulate replication initiation and/or transcription repression 628366
gene_product member of the hnRNP family containing two RNA-binding domains (RRM or RBD) 628366