Sacm1l (SAC1 like phosphatidylinositide phosphatase)

Gene: Sacm1l (SAC1 like phosphatidylinositide phosphatase) Rattus norvegicus

Analyze

Symbol:

Sacm1l

Name:

SAC1 like phosphatidylinositide phosphatase

RGD ID:

69223

Description:

Enables phosphatidylinositol-3,5-bisphosphate phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; and phosphatidylinositol-4-phosphate phosphatase activity. Involved in neurotransmitter receptor transport to postsynaptic membrane; phosphatidylinositol dephosphorylation; and vesicle-mediated transport in synapse. Located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Is active in glutamatergic synapse. Orthologous to human SACM1L (SAC1 like phosphatidylinositide phosphatase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

phosphatidylinositide phosphatase SAC1; phosphatidylinositol-3-phosphatase SAC1; phosphatidylinositol-4-phosphate phosphatase; Sac1; SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae); SAC1 (supressor of actin mutations 1, homolog)-like; SAC1 (supressor of actin mutations 1, homolog)-like (S. cerevisiae); SAC1 suppressor of actin mutations 1-like; SAC1 suppressor of actin mutations 1-like (yeast); suppressor of actin 1; suppressor of actin mutations 1-like protein

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	132,053,465 - 132,109,857 (+)	NCBI		GRCr8
mRatBN7.2	8	123,176,017 - 123,232,413 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	123,172,536 - 123,232,413 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	128,765,500 - 128,828,247 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	126,964,469 - 127,027,208 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	124,793,995 - 124,856,731 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	132,607,166 - 132,663,502 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	132,607,166 - 132,663,502 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	131,759,866 - 131,816,202 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	128,302,927 - 128,359,950 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	128,322,663 - 128,379,687 (+)	NCBI
Celera	8	122,286,384 - 122,342,572 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Progressive Microcephaly with Seizures and Cerebral and Cerebellar Atrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

ammonium chloride (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

Bisphenol B (ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

chlorpyrifos (EXP,ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

dexamethasone (ISO)

diazinon (ISO)

dicrotophos (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

indometacin (ISO)

ivermectin (ISO)

methapyrilene (EXP,ISO)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel sulfate (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium fluoride (ISO)

succimer (ISO)

tetrachloromethane (ISO)

tetracycline (ISO)

thapsigargin (EXP)

trichloroethene (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

exocytic insertion of neurotransmitter receptor to postsynaptic membrane (ISO)

neurotransmitter receptor transport to postsynaptic membrane (EXP,IDA,IEP,IMP)

phosphatidylinositol dephosphorylation (IBA,IEA,IMP,ISO)

vesicle-mediated transport in synapse (EXP,IDA,IEP,IMP,ISO)

Cellular Component

AMPA glutamate receptor complex (ISO)

endoplasmic reticulum (IBA,IEA)

endoplasmic reticulum membrane (IDA,IEA,ISO)

endoplasmic reticulum-plasma membrane contact site (IDA,IEA,ISO)

glutamatergic synapse (EXP,IDA,IEP,IMP,ISO)

Golgi apparatus (ISO,ISS)

Golgi membrane (IEA,ISO,ISS)

membrane (IEA)

Molecular Function

phosphatase activity (IMP)

phosphatidylinositol-3,5-bisphosphate phosphatase activity (IDA)

phosphatidylinositol-3-phosphate phosphatase activity (IDA)

phosphatidylinositol-4-phosphate phosphatase activity (IBA,IDA,IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides.	Dickson EJ, etal., J Cell Biol. 2016 Apr 11;213(1):33-48. doi: 10.1083/jcb.201508106. Epub 2016 Apr 4.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity.	Nemoto Y, etal., J Biol Chem 2000 Nov 3;275(44):34293-305.
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
8.	JNK3 couples the neuronal stress response to inhibition of secretory trafficking.	Yang G, etal., Sci Signal. 2013 Jul 9;6(283):ra57. doi: 10.1126/scisignal.2003727.

Additional References at PubMed

PMID:22632720	PMID:24209621	PMID:25013167	PMID:29461204	PMID:30659099	PMID:31505169	PMID:31806350

Genomics

Comparative Map Data

Sacm1l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	132,053,465 - 132,109,857 (+)	NCBI		GRCr8
mRatBN7.2	8	123,176,017 - 123,232,413 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	123,172,536 - 123,232,413 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	128,765,500 - 128,828,247 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	126,964,469 - 127,027,208 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	124,793,995 - 124,856,731 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	132,607,166 - 132,663,502 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	132,607,166 - 132,663,502 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	131,759,866 - 131,816,202 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	128,302,927 - 128,359,950 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	128,322,663 - 128,379,687 (+)	NCBI
Celera	8	122,286,384 - 122,342,572 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

SACM1L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	45,689,396 - 45,745,409 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	45,689,056 - 45,745,412 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	45,730,888 - 45,786,901 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	45,705,947 - 45,761,905 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	45,705,946 - 45,761,904	NCBI
Celera	3	45,668,700 - 45,724,522 (+)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	45,775,115 - 45,830,941 (+)	NCBI		HuRef
CHM1_1	3	45,680,731 - 45,736,559 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	45,705,375 - 45,761,083 (+)	NCBI		T2T-CHM13v2.0

Sacm1l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	123,358,818 - 123,421,665 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	123,358,824 - 123,421,665 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	123,529,753 - 123,592,600 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	123,529,759 - 123,592,600 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	123,439,000 - 123,501,716 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	123,378,580 - 123,441,296 (+)	NCBI		MGSCv36	mm8
Celera	9	123,982,316 - 124,047,496 (+)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	74.08	NCBI

Sacm1l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	26,229,840 - 26,280,516 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	26,231,597 - 26,280,516 (-)	NCBI	ChiLan1.0	ChiLan1.0

SACM1L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	45,653,967 - 45,709,677 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	45,658,749 - 45,714,444 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	45,596,775 - 45,652,482 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	46,704,539 - 46,760,105 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	46,704,565 - 46,760,104 (+)	Ensembl	panpan1.1		panPan2

SACM1L
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	42,731,674 - 42,791,455 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	42,720,249 - 42,791,402 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	42,648,744 - 42,708,307 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	43,216,790 - 43,276,240 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	43,216,794 - 43,276,251 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	42,457,062 - 42,516,486 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	42,864,579 - 42,923,977 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	43,139,544 - 43,199,143 (-)	NCBI		UU_Cfam_GSD_1.0

Sacm1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	197,843,903 - 197,900,798 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936695	196,238 - 253,128 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SACM1L
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	28,817,132 - 28,891,685 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	28,816,977 - 28,906,503 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	31,719,695 - 31,794,148 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SACM1L
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	7,159,701 - 7,214,368 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	7,159,809 - 7,214,555 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	159,951,795 - 160,006,471 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sacm1l
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	75,113,012 - 75,169,561 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	75,107,294 - 75,169,527 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sacm1l
352 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	444
Count of miRNA genes:	245
Interacting mature miRNAs:	302
Transcripts:	ENSRNOT00000007223
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat

Markers in Region

D8Rat116

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	123,180,023 - 123,180,222 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	132,611,122 - 132,611,318	NCBI	Rnor6.0
Rnor_5.0	8	131,763,822 - 131,764,018	UniSTS	Rnor5.0
RGSC_v3.4	8	128,306,882 - 128,307,079	RGD	RGSC3.4
RGSC_v3.4	8	128,306,883 - 128,307,079	UniSTS	RGSC3.4
RGSC_v3.1	8	128,326,536 - 128,326,932	RGD
Celera	8	122,290,340 - 122,290,536	UniSTS
SHRSP x BN Map	8	84.17	RGD
SHRSP x BN Map	8	84.17	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	41	57	41	19	41	8	8	74	35	36	11	8
Low		2						3			5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001357497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_053798	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063264777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM060902	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM095674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM108005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM108115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM134775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000007223 ⟹ ENSRNOP00000007223

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	123,186,796 - 123,232,413 (+)	Ensembl
Rnor_6.0 Ensembl	8	132,607,166 - 132,663,502 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000109426 ⟹ ENSRNOP00000080652

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	123,172,536 - 123,232,413 (+)	Ensembl

RefSeq Acc Id:

NM_001357497 ⟹ NP_001344426

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	132,053,465 - 132,109,857 (+)	NCBI
mRatBN7.2	8	123,176,017 - 123,232,413 (+)	NCBI

RefSeq Acc Id:

NM_053798 ⟹ NP_446250

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	132,053,465 - 132,109,857 (+)	NCBI
mRatBN7.2	8	123,176,017 - 123,232,413 (+)	NCBI
Rnor_6.0	8	132,607,166 - 132,663,502 (+)	NCBI
Rnor_5.0	8	131,759,866 - 131,816,202 (+)	NCBI
RGSC_v3.4	8	128,302,927 - 128,359,950 (+)	RGD
Celera	8	122,286,384 - 122,342,572 (+)	RGD

Sequence:

show sequence

GGGGTACACTGCGGGTGGAGCGAAGCGGAGGAAGGTGCACGATGGCGGCCACAGCCTACGAGCA
TCTGAAGCTGCATATTACACCTGAAAAGTTTTATGTGGAAGCTTGTGATGATGGAGCAGATGAT
GTACTCATCATTGACCGCGTGTCTACAGAGGTCACCCTTGCAGTCAAAAAAGATGTTCCCCCTT
CTGCTGTTACAAGACCAATATATGGGATAATGGGCACAATCCATCTGGTGGCAGGCAATTATCT
TGTTGTCATTACCAAAAAGATGAAAGTAGGTGAATTTTTTAATCATGTAATCTGGAAAGCCACA
GATTTTGATGTTCTTTCTTATAAGAAGACAATGTTACACTTAACTGATATTCAGTTACAAGATA
ATAAAACTTTCCTAGCAATGCTAAACCATGTCTTGAGTACGGATGGATTTTACTTTTCAACAAC
ATATGACTTGACCCATACTTTGCAACGGCTATCTAACACGAGTCCAGAATTCCAAGAAATGAGT
CTCCTAGAAAGGGCAGATCAGCGGTTTGTATGGAACGGGCATCTGCTCAGAGAACTGTCTGCTC
AGCCAGAGGTCCATCGGTTTGCTCTTCCTGTGTTGCATGGCTTTATTACTATGCATTCATGTTC
TATTAACGGGAAATATTTTGATTGGATTCTCATCTCCCGGAGGAGTTGTTTCAGAGCCGGTGTG
CGTTATTATGTGAGAGGAATTGATTCTGAAGGCCACGCAGCTAACTTTGTAGAAACAGAACAGA
TTGTGCACTACAGTGGGAACAGGGCTTCATTTGTACAGACTCGAGGATCAATACCTGTTTTCTG
GTCACAAAGACCAAATCTAAAGTACAAACCAGATCCACAGATCAACAAAGTAGCAAATCACATG
GATGGTTTCCAAAGGCATTTTGATTCACAAGTAATTATTTATGGAAAACAAGTAATAATTAATC
TGGTGAACCATAAGGGATCAGAGAAACCACTTGAGCAAACATTTGCAAAAATGGTGTCATCCTT
GGGAAGTGGGATGATCAGATATATTGCCTTTGACTTCCATAAGGAGTGTAAAAATATGAGATGG
GATCGACTGAGTATTTTATTGGATCAAGTAGCAGAAATGCAGGATGAATTAAGTTATTTTTTAG
TAGACTCTGCTGGCAAGGTGGTGACAAACCAGGAAGGAGTTTTCCGCAGCAACTGTATGGATTG
TCTAGACAGAACGAATGTGATACAGAGTTTATTAGCTCGGCGTTCCCTTCAGGCACAGCTGCAG
AGACTAGGAGTTTTGCATGTGGGACAAAAGCTTGAAGAACAAGATGAGTTTGAGAAGATTTACA
AAAATGCCTGGGCCGATAATGCTAATGCTTGTGCCAAACAGTATGCAGGAACCGGTGCCTTGAA
GACTGACTTTACAAGAACTGGAAAAAGAACTCAGTTGGGACTGGTAATGGATGGCTTCAACTCA
TTATTACGGTACTACAAGAACAACTTTTCTGATGGATTTAGACAAGATTCTATAGACTTATTTC
TTGGAAACTACTCAGTGGATGAATTAGACTCTCACAGTCCTTTAAGTGTTCCAAGGGACTGGAA
ATTCCTGGCGTTGCCTATCATCATGGTTGTTGCCTTTTCAATGTGCATCATCTGTTTGCTTATG
GCTGGTGACACTTGGACAGAAACACTGGCATATGTCCTCTTCTGGGGAGTTGCAAGCATTGGAA
CATTTTTTATTATTCTTTACAATGGCAAAGATTTTGTTGATGCTCCCAGACTTGTACAGAAAGA
AAAGATAGACTGAATTTGTGTTTGTGGAAAGCGGCTTGGCTTGGAAGACTCCATGATACAGAAC
TGGAGTCTTTACTGACCTGCTTTCCACATGAACCCCAAGGTCTTCTTAAAGCCTTTATCCAAAA
GTACCTCTTGTGATTTGGGCTGGGTGATGTCTTAGAATTGATCTGATATTACTGCTTTGATGAT
CTCTTTACTGTTGGGATGGTTATATTTATAATTTGAAGCTATAGTATAATTAAAATGTAGCTTA
AATTCAGCTCACAGAACAGAAGAAATCTATTCACTGTCAAGTCAGAAGTTCACAGATAAGTAAT
ATATTTTAAAAAATTTAACTTCTTTCATTATTTAAAACAAAATTATTTTTCTAGCTCTGTTTCA
TTATAGTCACTGTTAGCAAGCATTTTTTCCATGTATCTTTGGGCTTTTCTTAAGAGTTTAATAA
TATGCTAATTCTACTATGCTTAGAGAATGTCTCTTAAAGGTCAGGCAGTTTGCTAAGCTGTGAT
TTCACAGTGAGGGAGAGGAGAATGGGATCTAGAGTCATTTGAAATTGCTTGAGCTGCTAGCAGC
TTAAATGTCATGAAAAGTTCAGATATATTTTATCTTTTTTAAATGGTATAAATGAAATCAAAGA
ATGTAAAGTCTGTCTCTTATGCTAAAGGTCCAAAGTCACCTCTTTTTAAGAACTGCTCCATTGT
GGAAAATACACTAGACTGCCAGCTGCTGCTTCTCATATCTTGTAGGATTTTATTATTGGTTGCT
CATTGAGACATGCAGACCTCAGAGAAGGTCTTGTGCTAGACTTGATTCACACTTGGGGTAGCAG
TTGCTTTTCCTGCATGGCACTCTGGCTTTATCACCCTGACAAGGTTTGTATTCACTGTCAATAA
GTGTCTGAAATTTAGTGCTTCCAGGTAGCCATAGTTCTCCAAATCAAGGACCAACTTTAATTTA
TGCATAAACAGACTGAAAACCACGCTTCAGAGCTGTGCATAGTTGTGAGACAGGTTATATATTA
AAATTGTAATTATGAGGTTTAGATATTAGAACAGTGTATAAGGTAGTATCACTGCGCTATCTTA
GAACAATTCAGTTAAACACTATGCTATATCAGTGTTTTGCTTTAAAATATGTGGTTTTTTTTCT
AATAGTACCTTATGTTAAATATTTCTAAAAGCGCCTTTAACATTACCTTTTTTTCAACATTATC
TTTTATAAACAATAAGTTATTGCTTTTAGAAACTCTGGGAAAATCCTGTGTAGTTTAAAATCAG
TCATTAAAGCTCACTATAGGGTAGTAAATAGAGCCGCCTGCTCTGACACGTGTAAGCAGTTTGT
TCCAAGATGAAACATGAAGCCACGTCTGCTGTGATGTGCTATTCAGAAGCTGCTGGGCATTTTA
CAGTGAGCACTTCATGCCAACACCACGTGGAACCAGTAGTGTGGCTGCTTTGCAAGGAGTAATG
TCAGAGGGTTAGGCTGCAAGTGATCAGTGTTTGAGAGCCCTGCAGTGATCTTGTTTAACTCATT
TACTGTACATCCATATGCAAAAATAAAATGCCATATTCTTTT

hide sequence

RefSeq Acc Id:

XM_063264777 ⟹ XP_063120847

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	132,068,271 - 132,109,857 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001344426	(Get FASTA)	NCBI Sequence Viewer
	NP_446250	(Get FASTA)	NCBI Sequence Viewer
	XP_063120847	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL76757	(Get FASTA)	NCBI Sequence Viewer
	EDL76758	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000007223.6
	ENSRNOP00000080652
	ENSRNOP00000080652.1
GenBank Protein	Q9ES21	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_446250 ⟸ NM_053798
- Peptide Label:	isoform 1
- UniProtKB:	Q9ES21 (UniProtKB/Swiss-Prot), A6I4B9 (UniProtKB/TrEMBL), A0A8L2Q2L9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAATAYEHLKLHITPEKFYVEACDDGADDVLIIDRVSTEVTLAVKKDVPPSAVTRPIYGIMGTI HLVAGNYLVVITKKMKVGEFFNHVIWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLST DGFYFSTTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVHRFALPVLHG FITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYSGNRASFVQT RGSIPVFWSQRPNLKYKPDPQINKVANHMDGFQRHFDSQVIIYGKQVIINLVNHKGSEKPLEQT FAKMVSSLGSGMIRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGKVVTNQEGV FRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQ YAGTGALKTDFTRTGKRTQLGLVMDGFNSLLRYYKNNFSDGFRQDSIDLFLGNYSVDELDSHSP LSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGVASIGTFFIILYNGKDFVD APRLVQKEKID hide sequence

RefSeq Acc Id:

ENSRNOP00000007223 ⟸ ENSRNOT00000007223

RefSeq Acc Id:	NP_001344426 ⟸ NM_001357497
- Peptide Label:	isoform 1x
- UniProtKB:	A0A8L2Q2L9 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000080652 ⟸ ENSRNOT00000109426

RefSeq Acc Id:	XP_063120847 ⟸ XM_063264777
- Peptide Label:	isoform X1

Protein Domains

SAC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9ES21-F1-model_v2	AlphaFold	Q9ES21	1-587	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696410

Promoter ID:

EPDNEW_R6935

Type:

initiation region

Name:

Sacm1l_1

Description:

SAC1 like phosphatidylinositide phosphatase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	132,607,110 - 132,607,170	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69223	AgrOrtholog
BioCyc Gene	G2FUF-28612	BioCyc
BioCyc Pathway	PWY-6368 [3-phosphoinositide degradation]	BioCyc
BioCyc Pathway Image	PWY-6368	BioCyc
Ensembl Genes	ENSRNOG00000005149	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007223.6	UniProtKB/TrEMBL
	ENSRNOT00000109426	ENTREZGENE
	ENSRNOT00000109426.1	UniProtKB/TrEMBL
InterPro	SAC_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:116482	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	116482	ENTREZGENE
PANTHER	PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Syja_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sacm1l	PhenoGen
PROSITE	SAC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000005149	RatGTEx
TIGR	TC217389
UniProt	A0A8I5ZR90_RAT	UniProtKB/TrEMBL
	A0A8L2Q2L9	ENTREZGENE, UniProtKB/TrEMBL
	A6I4B9	ENTREZGENE, UniProtKB/TrEMBL
	Q9ES21	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-19	Sacm1l	SAC1 like phosphatidylinositide phosphatase	Sacm1l	SAC1 suppressor of actin mutations 1-like (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-18	Sacm1l	SAC1 suppressor of actin mutations 1-like (yeast)	Sacm1l	SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Sacm1l	SAC1 (supressor of actin mutations 1, homolog)-like (S. cerevisiae)			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to the endoplasmic reticulum	68842
gene_expression	expressed in cerebellar Purkinje cells	68842

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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