Kcnq3 (potassium voltage-gated channel subfamily Q member 3) - Rat Genome Database

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Gene: Kcnq3 (potassium voltage-gated channel subfamily Q member 3) Rattus norvegicus
Analyze
Symbol: Kcnq3
Name: potassium voltage-gated channel subfamily Q member 3
RGD ID: 69222
Description: Enables several functions, including calmodulin binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in cellular response to ammonium ion; nervous system development; and potassium ion transmembrane transport. Located in several cellular components, including axon initial segment; cell surface; and neuronal cell body. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in autistic disorder and benign neonatal seizures. Orthologous to human KCNQ3 (potassium voltage-gated channel subfamily Q member 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KQT-like 3; potassium channel subunit alpha KvLQT3; potassium channel, voltage-gated KQT-like subfamily Q, member 3; potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, subfamily Q, member 3; voltage-gated potassium channel subunit Kv7.3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8799,614,089 - 99,914,736 (-)NCBIGRCr8
mRatBN7.2797,730,219 - 98,025,652 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl797,730,465 - 98,025,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx799,483,729 - 99,777,542 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07101,685,392 - 101,979,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07101,604,737 - 101,898,571 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07106,714,479 - 107,009,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7106,717,229 - 107,009,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07106,662,621 - 106,956,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47103,325,185 - 103,627,045 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17103,359,425 - 103,661,275 (-)NCBI
Celera794,285,105 - 94,579,630 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Charlier C, etal., Nat Genet. 1998 Jan;18(1):53-5.
2. Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2. Ekberg J, etal., J Biol Chem. 2007 Apr 20;282(16):12135-42. Epub 2007 Feb 23.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Dysfunction of the Heteromeric KV7.3/KV7.5 Potassium Channel is Associated with Autism Spectrum Disorders. Gilling M, etal., Front Genet. 2013 Apr 16;4:54. doi: 10.3389/fgene.2013.00054. eCollection 2013.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium. Hadley JK, etal., J Neurosci. 2003 Jun 15;23(12):5012-9.
7. A novel mutation of KCNQ3 (c.925T-->C) in a Japanese family with benign familial neonatal convulsions. Hirose S, etal., Ann Neurol. 2000 Jun;47(6):822-6.
8. Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. Li Y, etal., J Biol Chem. 2004 Oct 29;279(44):45399-407. Epub 2004 Aug 10.
9. Calmodulin orchestrates the heteromeric assembly and the trafficking of KCNQ2/3 (Kv7.2/3) channels in neurons. Liu W and Devaux JJ, Mol Cell Neurosci. 2014 Jan;58:40-52. doi: 10.1016/j.mcn.2013.12.005. Epub 2013 Dec 11.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle. Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87.
12. Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts. Oldfield S, etal., Mol Pharmacol. 2009 Dec;76(6):1279-89. doi: 10.1124/mol.109.058008. Epub 2009 Sep 2.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Molecular correlates of the M-current in cultured rat hippocampal neurons. Shah MM, etal., J Physiol 2002 Oct 1;544(Pt 1):29-37.
17. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Wang HS, etal., Science 1998 Dec 4;282(5395):1890-3.
18. K(V)7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells. Wang W, etal., PLoS One. 2011;6(7):e21792. doi: 10.1371/journal.pone.0021792. Epub 2011 Jul 5.
19. The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. Yus-Najera E, etal., J Biol Chem 2002 Aug 9;277(32):28545-53.
20. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model. Zheng Q, etal., Pain. 2013 Mar;154(3):434-48. doi: 10.1016/j.pain.2012.12.005. Epub 2012 Dec 20.
Additional References at PubMed
PMID:10788442   PMID:11159685   PMID:12223552   PMID:14638935   PMID:16525039   PMID:16527853   PMID:17311847   PMID:17442834   PMID:17724161   PMID:18048450   PMID:18089837   PMID:18448631  
PMID:18786918   PMID:18827480   PMID:19060215   PMID:20885443   PMID:21787867   PMID:22871113   PMID:23623937   PMID:24599470   PMID:25796298   PMID:27445338   PMID:27450567   PMID:27564677  
PMID:31373759   PMID:33512443   PMID:34318654  


Genomics

Comparative Map Data
Kcnq3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8799,614,089 - 99,914,736 (-)NCBIGRCr8
mRatBN7.2797,730,219 - 98,025,652 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl797,730,465 - 98,025,653 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx799,483,729 - 99,777,542 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07101,685,392 - 101,979,218 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07101,604,737 - 101,898,571 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07106,714,479 - 107,009,639 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7106,717,229 - 107,009,330 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07106,662,621 - 106,956,409 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47103,325,185 - 103,627,045 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17103,359,425 - 103,661,275 (-)NCBI
Celera794,285,105 - 94,579,630 (-)NCBICelera
Cytogenetic Map7q33NCBI
KCNQ3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388132,120,861 - 132,481,095 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8132,120,861 - 132,481,095 (-)EnsemblGRCh38hg38GRCh38
GRCh378133,133,108 - 133,493,342 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368133,210,438 - 133,562,186 (-)NCBINCBI36Build 36hg18NCBI36
Build 348133,210,437 - 133,562,186NCBI
Celera8129,316,946 - 129,668,720 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8128,450,644 - 128,810,822 (-)NCBIHuRef
CHM1_18133,173,913 - 133,533,807 (-)NCBICHM1_1
T2T-CHM13v2.08133,243,767 - 133,604,173 (-)NCBIT2T-CHM13v2.0
Kcnq3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391565,858,223 - 66,158,485 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1565,858,236 - 66,158,491 (-)EnsemblGRCm39 Ensembl
GRCm381565,986,374 - 66,286,636 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1565,986,387 - 66,286,642 (-)EnsemblGRCm38mm10GRCm38
MGSCv371565,826,477 - 66,117,786 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361565,824,844 - 66,115,893 (-)NCBIMGSCv36mm8
Celera1567,502,496 - 67,809,639 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1529.16NCBI
Kcnq3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554616,797,018 - 7,119,569 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554616,793,877 - 7,119,859 (-)NCBIChiLan1.0ChiLan1.0
KCNQ3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27149,504,271 - 149,869,035 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18125,018,869 - 125,383,609 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08128,769,930 - 129,134,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18131,747,069 - 132,110,448 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8131,755,454 - 131,815,237 (-)Ensemblpanpan1.1panPan2
KCNQ3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11328,765,472 - 29,062,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1328,773,738 - 29,062,370 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1328,738,298 - 29,035,933 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01329,120,132 - 29,417,368 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1329,126,114 - 29,417,147 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11328,847,191 - 29,144,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01328,946,895 - 29,244,508 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01329,258,881 - 29,556,646 (-)NCBIUU_Cfam_GSD_1.0
Kcnq3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053039,286,465 - 9,587,259 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647016,712,703 - 17,009,397 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647016,712,508 - 17,009,648 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNQ3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl48,669,121 - 8,970,342 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.148,669,969 - 8,978,656 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.248,707,508 - 9,006,805 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNQ3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18126,566,288 - 126,921,354 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8126,566,545 - 126,622,712 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603913,185,447 - 13,545,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnq3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473523,441,042 - 23,751,247 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473523,441,042 - 23,752,197 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnq3
1293 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:39
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000006930, ENSRNOT00000074573
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
10450828Scl79Serum cholesterol level QTL 793.50.001blood HDL cholesterol amount (VT:0000184)blood low density lipoprotein cholesterol level (CMO:0000053)789867376101773158Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)793595647106839474Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat

Markers in Region
D7Rat18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,011,396 - 98,011,544 (+)MAPPERmRatBN7.2
Rnor_6.07106,995,385 - 106,995,532NCBIRnor6.0
Rnor_5.07106,942,155 - 106,942,302UniSTSRnor5.0
RGSC_v3.47103,612,740 - 103,612,887UniSTSRGSC3.4
RGSC_v3.47103,612,739 - 103,612,887RGDRGSC3.4
RGSC_v3.17103,646,970 - 103,647,117RGD
Celera794,565,424 - 94,565,579UniSTS
RH 3.4 Map7678.2RGD
RH 3.4 Map7678.2UniSTS
RH 2.0 Map7531.1RGD
FHH x ACI Map746.7299RGD
Cytogenetic Map7q33UniSTS
D7Got81  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,960,870 - 97,961,107 (+)MAPPERmRatBN7.2
Rnor_6.07106,944,740 - 106,944,974NCBIRnor6.0
Rnor_5.07106,892,767 - 106,893,001UniSTSRnor5.0
RGSC_v3.47103,561,783 - 103,562,018RGDRGSC3.4
RGSC_v3.47103,561,784 - 103,562,018UniSTSRGSC3.4
RGSC_v3.17103,596,014 - 103,596,248RGD
RH 3.4 Map7677.1UniSTS
RH 3.4 Map7677.1RGD
RH 2.0 Map7529.9RGD
Cytogenetic Map7q33UniSTS
BF400035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,963,860 - 97,963,995 (+)MAPPERmRatBN7.2
Rnor_6.07106,947,728 - 106,947,862NCBIRnor6.0
Rnor_5.07106,895,755 - 106,895,889UniSTSRnor5.0
RGSC_v3.47103,564,772 - 103,564,906UniSTSRGSC3.4
Celera794,518,301 - 94,518,435UniSTS
RH 3.4 Map7679.5UniSTS
Cytogenetic Map7q33UniSTS
RH144157  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,730,712 - 97,730,880 (+)MAPPERmRatBN7.2
Rnor_6.07106,714,973 - 106,715,140NCBIRnor6.0
Rnor_5.07106,663,115 - 106,663,282UniSTSRnor5.0
RGSC_v3.47103,325,444 - 103,325,611UniSTSRGSC3.4
Celera794,285,599 - 94,285,766UniSTS
RH 3.4 Map7672.8UniSTS
Cytogenetic Map7q33UniSTS
BE102380  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,730,599 - 97,730,775 (+)MAPPERmRatBN7.2
Rnor_6.07106,714,860 - 106,715,035NCBIRnor6.0
Rnor_5.07106,663,002 - 106,663,177UniSTSRnor5.0
RGSC_v3.47103,325,331 - 103,325,506UniSTSRGSC3.4
Celera794,285,486 - 94,285,661UniSTS
RH 3.4 Map7671.9UniSTS
Cytogenetic Map7q33UniSTS
AU046741  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,736,536 - 97,736,823 (+)MAPPERmRatBN7.2
mRatBN7.2797,736,649 - 97,736,823 (+)MAPPERmRatBN7.2
Rnor_6.07106,720,910 - 106,721,251NCBIRnor6.0
Rnor_6.07106,721,078 - 106,721,251NCBIRnor6.0
Rnor_5.07106,669,220 - 106,669,393UniSTSRnor5.0
Rnor_5.07106,669,052 - 106,669,393UniSTSRnor5.0
RGSC_v3.47103,331,381 - 103,331,554UniSTSRGSC3.4
Celera794,291,536 - 94,291,709UniSTS
Cytogenetic Map7q33UniSTS
BF416665  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2798,002,380 - 98,002,579 (+)MAPPERmRatBN7.2
Rnor_6.07106,986,265 - 106,986,463NCBIRnor6.0
Rnor_5.07106,933,035 - 106,933,233UniSTSRnor5.0
RGSC_v3.47103,603,721 - 103,603,919UniSTSRGSC3.4
Celera794,556,405 - 94,556,603UniSTS
RH 3.4 Map7679.5UniSTS
Cytogenetic Map7q33UniSTS
BF390526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2797,877,581 - 97,877,781 (+)MAPPERmRatBN7.2
Rnor_6.07106,861,674 - 106,861,873NCBIRnor6.0
Rnor_5.07106,810,377 - 106,810,576UniSTSRnor5.0
RGSC_v3.47103,472,015 - 103,472,214UniSTSRGSC3.4
Celera794,432,370 - 94,432,569UniSTS
RH 3.4 Map7679.5UniSTS
Cytogenetic Map7q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 52
Low 8 10 3 18 2 16 2
Below cutoff 1 26 17 11 16 11 5 5 4 28 20 9 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006930   ⟹   ENSRNOP00000006930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl797,730,465 - 98,025,343 (-)Ensembl
Rnor_6.0 Ensembl7106,717,229 - 106,753,592 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000074573   ⟹   ENSRNOP00000065354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl797,730,465 - 98,025,343 (-)Ensembl
Rnor_6.0 Ensembl7106,717,232 - 107,009,330 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109659   ⟹   ENSRNOP00000093985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl797,730,465 - 98,025,653 (-)Ensembl
RefSeq Acc Id: NM_031597   ⟹   NP_113785
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,619,298 - 99,914,720 (-)NCBI
mRatBN7.2797,730,219 - 98,025,652 (-)NCBI
Rnor_6.07106,714,479 - 107,009,639 (-)NCBI
Rnor_5.07106,662,621 - 106,956,409 (-)NCBI
RGSC_v3.47103,325,185 - 103,627,045 (-)RGD
Celera794,285,105 - 94,579,630 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063263127   ⟹   XP_063119197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,614,089 - 99,650,879 (-)NCBI
RefSeq Acc Id: XM_063263128   ⟹   XP_063119198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,614,089 - 99,914,735 (-)NCBI
RefSeq Acc Id: XR_010052948
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,632,223 - 99,914,736 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113785   ⟸   NM_031597
- UniProtKB: O88944 (UniProtKB/Swiss-Prot),   Q9Z240 (UniProtKB/Swiss-Prot),   F1LPA2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006930   ⟸   ENSRNOT00000006930
RefSeq Acc Id: ENSRNOP00000065354   ⟸   ENSRNOT00000074573
RefSeq Acc Id: ENSRNOP00000093985   ⟸   ENSRNOT00000109659
RefSeq Acc Id: XP_063119198   ⟸   XM_063263128
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119197   ⟸   XM_063263127
- Peptide Label: isoform X1
Protein Domains
Ion transport   Potassium channel voltage dependent KCNQ C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88944-F1-model_v2 AlphaFold O88944 1-873 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69222 AgrOrtholog
BioCyc Gene G2FUF-33128 BioCyc
Ensembl Genes ENSRNOG00000005206 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055025295 UniProtKB/Swiss-Prot
  ENSRNOG00060004007 UniProtKB/Swiss-Prot
  ENSRNOG00065004436 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006930.8 UniProtKB/TrEMBL
  ENSRNOT00000074573.3 UniProtKB/TrEMBL
  ENSRNOT00000109659 ENTREZGENE
  ENSRNOT00000109659.1 UniProtKB/Swiss-Prot
  ENSRNOT00055043647 UniProtKB/Swiss-Prot
  ENSRNOT00060006715 UniProtKB/Swiss-Prot
  ENSRNOT00065006485 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  6.10.140.1910 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin-G_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_KCNQ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
KEGG Report rno:29682 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29682 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQ_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQC3-Ank-G_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnq3 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQ3CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNQCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005206 RatGTEx
  ENSRNOG00055025295 RatGTEx
  ENSRNOG00060004007 RatGTEx
  ENSRNOG00065004436 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UI30_RAT UniProtKB/TrEMBL
  A6HRQ8_RAT UniProtKB/TrEMBL
  A6HRQ9_RAT UniProtKB/TrEMBL
  A6HRR0_RAT UniProtKB/TrEMBL
  F1LPA2 ENTREZGENE, UniProtKB/TrEMBL
  KCNQ3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9Z240 ENTREZGENE
UniProt Secondary Q9Z240 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnq3  potassium voltage-gated channel subfamily Q member 3  Kcnq3  potassium channel, voltage-gated KQT-like subfamily Q, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnq3  potassium channel, voltage-gated KQT-like subfamily Q, member 3  Kcnq3  potassium voltage-gated channel, KQT-like subfamily, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Kcnq3  potassium voltage-gated channel, KQT-like subfamily, member 3  Kcnq3  potassium voltage-gated channel, subfamily Q, member 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Kcnq3  potassium voltage-gated channel, subfamily Q, member 3       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in smooth muscle cells of the stomach 625508
gene_expression expressed at high levels in the brain but not in heart 625508
gene_physical_interaction interacts with calmodulin (CaM) 634683
gene_product 424 bp 625508