Casp9_v1 (caspase-9-carboxyl-terminal divergent) - Rat Genome Database

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Gene: Casp9_v1 (caspase-9-carboxyl-terminal divergent) Rattus norvegicus
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Symbol: Casp9_v1
Name: caspase-9-carboxyl-terminal divergent
RGD ID: 69064
Description: splice form of the cysteine protease; involved in regulating cell death by acting as a dominant negative form of Caspase 9
Type: protein-coding  of Casp9  
Previously known as: Case-9-CTD; Casp-9-CTD
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
RGSC_v3.45160,700,549 - 160,721,800 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,714,440 - 160,723,108 (+)NCBI


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of a novel isoform of caspase-9 that inhibits apoptosis. Angelastro JM, etal., J Biol Chem 2001 Apr 13;276(15):12190-200.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline

Genomics


Expression


Sequence

Nucleotide Sequences
GenBank Nucleotide AY008275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Protein Sequences
Ensembl Protein ENSRNOP00000017972.5
Protein Domains
CARD   Caspase family p10   Caspase family p20

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000012944 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017972.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1460 UniProtKB/TrEMBL
  Death Domain, Fas UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD_CASP9 UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
KEGG Report rno:58918 UniProtKB/TrEMBL
NCBI Gene Casp9_v1
  Casp9_v1 ENTREZGENE
PANTHER CASPASE UniProtKB/TrEMBL
  CASPASE-9 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PhenoGen Casp9_v1 PhenoGen
PIRSF Caspase_ICE UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012944 RatGTEx
SMART CARD UniProtKB/TrEMBL
  CASc UniProtKB/TrEMBL
Superfamily-SCOP Caspase-like UniProtKB/TrEMBL
  DEATH domain UniProtKB/TrEMBL
UniProt A0A9K3Y7W8_RAT UniProtKB/TrEMBL
  Q9JHK1_RAT UniProtKB/TrEMBL
UniProt Secondary F1M776 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Casp9_v1  caspase-9-carboxyl-terminal divergent  Casp-9-CTD  Caspase-9-carboxyl-terminal divergent  Symbol and Name updated 629477 APPROVED
2002-06-10 Casp-9-CTD  Caspase-9-carboxyl-terminal divergent      Symbol and Name status set to provisional 70585 PROVISIONAL
2002-05-16 Casp9_v1  Caspase-9-carboxyl-terminal divergent      This gene has been found to be a splice varient of Casp9 62424 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression primarily cytoplasmic and excluded from the nucleus 62424
gene_process acts as a inhibitor to protect cells from low-level accidental activation of full-length casp9 following mitochondrial cytochrome c release. 62424
gene_transcript isoform of caspase-9 in which the small caspase subunit (amino acids 327-383) found in full-length caspase-9 is replaced by an alternative sequence 62424