Gene: Pkn1 (protein kinase N1)
Mus musculus
Symbol:
Pkn1
Name:
protein kinase N1
Description:
ENCODES a protein that exhibits protein kinase activity; androgen receptor binding (ortholog); chromatin binding (ortholog); INVOLVED IN hyperosmotic response; protein phosphorylation; epithelial cell migration (ortholog); ASSOCIATED WITH abnormal germinal center B cell physiology; abnormal somatic hypermutation frequency; decreased activation-induced B cell apoptosis; FOUND IN cytoplasm; cytoplasmic membrane-bounded vesicle; cleavage furrow (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bis(2-chloroethyl) sulfide
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
DBK; F730027O18Rik; OTTMUSP00000031688; OTTMUSP00000031747; OTTMUSP00000031748; PAK1; Pkn; PRK1; Prkcl1; protein kinase C-like 1; protein kinase C-like PKN; protein-kinase C-related kinase 1; serine-threonine protein kinase N; serine/threonine kinase 3; serine/threonine-protein kinase N1; Stk3
Orthologs:
Homo sapiens : PKN1
(protein kinase N1)
HGNC
Rattus norvegicus : Pkn1
(protein kinase N1)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 8 83,669,762 - 83,699,179 - NCBI Mouse cM Map 8 40.22 NCBI Mouse Celera Assembly 8 87,960,553 - 87,989,944 - NCBI Mouse Genome Assembly Build 37 8 86,193,995 - 86,223,025 - NCBI Mouse Genome Assembly Build 36.1 8 86,193,995 - 86,223,025 - NCBI Mouse Cytogenetic Map 8 C2 NCBI
Model
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PKN1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1352784 6480464 Tetrachlorodibenzodioxin results in increased expression of PKN1 mRNA CTD PMID:21632981 2,4-dinitrotoluene affects expression ISO RGD:69308 6480464 2,4-dinitrotoluene affects the expression of PKN1 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:69308 6480464 2,6-dinitrotoluene affects the expression of PKN1 mRNA CTD PMID:21346803 all-trans-retinoic acid increases expression ISO RGD:1352784 6480464 Tretinoin results in increased expression of PKN1 mRNA CTD PMID:15498508 ammonium chloride affects expression ISO RGD:69308 6480464 Ammonium Chloride affects the expression of PKN1 mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression ISO RGD:1352784 6480464 Benzo(a)pyrene results in decreased expression of PKN1 mRNA CTD PMID:20106945 benzo[a]pyrene decreases expression ISO RGD:1352784 6480464 Benzo(a)pyrene results in decreased expression of PKN1 mRNA CTD PMID:20106945 PMID:21632981 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PKN1 mRNA CTD PMID:22228805 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of PKN1 mRNA CTD PMID:18955075 cobalt dichloride decreases expression ISO RGD:1352784 6480464 cobaltous chloride results in decreased expression of PKN1 mRNA CTD PMID:19320972 copper(2+) sulfate decreases expression ISO RGD:1352784 6480464 Copper Sulfate results in decreased expression of PKN1 mRNA CTD PMID:19549813 crocidolite asbestos affects expression ISO RGD:1352784 6480464 Asbestos, Crocidolite affects the expression of PKN1 mRNA CTD PMID:17331233 cyclosporin A increases expression ISO RGD:1352784 6480464 Cyclosporine results in increased expression of PKN1 mRNA CTD PMID:20106945 methylphenidate decreases expression EXP 6480464 Methylphenidate results in decreased expression of PKN1 mRNA CTD PMID:22470460 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of PKN1 mRNA CTD PMID:22776087 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PKN1 mRNA CTD PMID:17426115 propiconazole decreases expression EXP 6480464 propiconazole results in decreased expression of PKN1 mRNA CTD PMID:21278054 quercetin decreases expression ISO RGD:1352784 6480464 Quercetin results in decreased expression of PKN1 mRNA CTD PMID:21632981 tamibarotene increases expression ISO RGD:1352784 6480464 Am 80 results in increased expression of PKN1 mRNA; more ... CTD PMID:15498508 vanadium atom decreases expression ISO RGD:1352784 6480464 Vanadium results in decreased expression of PKN1 mRNA CTD PMID:19000753 vanadium(0) decreases expression ISO RGD:1352784 6480464 Vanadium results in decreased expression of PKN1 mRNA CTD PMID:19000753
Gene Ontology Annotations
Biological Process
chromatin modification IEA UniProtKB-KW:KW-0156 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 epithelial cell migration ISO UniProtKB:Q16512 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 histone H3-T11 phosphorylation ISO UniProtKB:Q16512 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 hyperosmotic response IDA 2290270 MGI:MGI:2673048|PMID:12783890 MGI MGI:MGI:2673048 PMID:12783890 phosphorylation IEA UniProtKB-KW:KW-0418 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 protein phosphorylation ISO UniProtKB:Q63433 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein phosphorylation IMP 2290270 MGI:MGI:2673048|PMID:12783890 GOC MGI:MGI:2673048 PMID:12783890 protein phosphorylation IEA EC:2.7.11.13 2290270 MGI:MGI:2152096 GOC MGI:MGI:2152096 protein phosphorylation ISO UniProtKB:Q16512 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of cell motility ISO UniProtKB:Q16512 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of transcription from RNA polymerase II promoter ISO UniProtKB:Q16512 2290270 MGI:MGI:4834177 MGI MGI:MGI:4834177 regulation of transcription, DNA-dependent IEA UniProtKB-KW:KW-0805 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 signal transduction IEA InterPro:IPR011072 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 transcription, DNA-dependent IEA UniProtKB-KW:KW-0804 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
4140967 Bmd39_m bone mineral density 39 (mouse) Not determined 8 33127016 119762600 Mouse 4141082 Raml4_m radiation induced acute myeloid leukemia 4 (mouse) Not determined 8 56569352 90569499 Mouse 1301506 Aevm1_m autoimmune extremity vasculitis in MRL mice 1 (mouse) Not determined 8 56811716 90811892 Mouse 1301952 Im3_m immunoregulatory 3 (mouse) Not determined 8 57230513 91230662 Mouse 4141692 Eeq2_m exercise endurance QTL 2 (mouse) Not determined 8 57716979 91717125 Mouse 4140972 Bpq23_m blood pressure QTL 23 (mouse) Not determined 8 60928397 94928515 Mouse 1301688 Orch6_m autoimmune orchitis resistance 6 (mouse) Not determined 8 63310749 97310875 Mouse 4141797 Skmw16_m skeletal muscle weight 16 (mouse) Not determined 8 66463446 100463595 Mouse 1357531 Ssta6_m susceptibility to Salmonella typhimurium antigens 6 (mouse) Not determined 8 66463446 100463595 Mouse 1301946 Prxsh_m preaxial shift (mouse) Not determined 8 67433952 101434094 Mouse 1558895 Nsila6_m novelty/stress induced locomotor activation 6 (mouse) Not determined 8 67839067 101839184 Mouse 4142283 Imraq2_m immune response to AAV2 QTL 2 (mouse) Not determined 8 72829274 106829394 Mouse 1301767 Fcsa2_m femoral cross-sectional area 2 (mouse) Not determined 8 72829274 106829394 Mouse 1558780 Idd22_m insulin dependent diabetes susceptibility 22 (mouse) Not determined 8 73626802 107626908 Mouse 4141122 Chlq5_m circulating hormone level QTL 5 (mouse) Not determined 8 73920080 107920292 Mouse 4142484 Vmmt8_m vertebral morphology and mechanical traits 8 (mouse) Not determined 8 73920080 107920292 Mouse 1357647 Fmgty7_m femur geometry 7 (mouse) Not determined 8 73920080 107920292 Mouse 1301872 Cd4ts3_m CD4 T cell subset 3 (mouse) Not determined 8 73920080 107920292 Mouse 1300920 Pitm3_m prion incubation time 3 (mouse) Not determined 8 75726394 109726497 Mouse 1558890 Lith18_m lithogenic gene 18 (mouse) Not determined 8 78199416 112199522 Mouse 1357470 Obq16_m obesity QTL 16 (mouse) Not determined 8 78209247 112209396 Mouse 1301808 Nhdlq1_m non-HDL QTL 1 (mouse) Not determined 8 78209247 112209396 Mouse 1301874 Hdlq16_m HDL QTL 16 (mouse) Not determined 8 78209247 112209396 Mouse 1301099 Cbm2_m cerebellum weight 2 (mouse) Not determined 8 81042513 115042603 Mouse 1301581 Char2_m P. chabaudi malaria resistance QTL 2 (mouse) Not determined 8 81606078 115606303 Mouse