Lrpl1 (LDL receptor related protein like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Lrpl1 (LDL receptor related protein like 1) Rattus norvegicus
Analyze
Symbol: Lrpl1 (Ensembl: LOC100910088)
Name: LDL receptor related protein like 1 (Ensembl:prolow-density lipoprotein receptor-related protein 1-like)
RGD ID: 6499975
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis. Predicted to be located in membrane.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07026032.1; LOC100910088; LOC290790; low-density lipoprotein receptor-related protein 1B-like; low-density lipoprotein receptor-related protein 2-like; prolow-density lipoprotein receptor-related protein 1-like; RGD1565014; similar to Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan)
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81663,125,523 - 63,174,708 (-)NCBIGRCr8
mRatBN7.21656,422,145 - 56,471,368 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1656,422,138 - 56,471,065 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01659,997,090 - 60,046,457 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1660,008,769 - 60,018,283 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01659,653,665 - 59,738,171 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41660,118,425 - 60,167,512 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1654,474,111 - 54,523,570 (-)NCBICelera
Cytogenetic Map16q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Lrpl1
540 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079224   ⟹   ENSRNOP00000094150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1656,422,138 - 56,471,065 (-)Ensembl
RefSeq Acc Id: XM_008771306   ⟹   XP_008769528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81663,125,523 - 63,174,681 (-)NCBI
mRatBN7.21656,422,242 - 56,471,313 (-)NCBI
Rnor_6.01659,997,115 - 60,046,457 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095034   ⟹   XP_038950962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81663,125,523 - 63,174,680 (-)NCBI
mRatBN7.21656,422,145 - 56,471,311 (-)NCBI
RefSeq Acc Id: XM_039095035   ⟹   XP_038950963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81663,133,796 - 63,174,708 (-)NCBI
mRatBN7.21656,430,428 - 56,471,368 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008769528 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950962 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950963 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000094150
  ENSRNOP00000094150.1
Reference Protein Sequences
RefSeq Acc Id: XP_008769528   ⟸   XM_008771306
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038950962   ⟸   XM_039095034
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GL13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950963   ⟸   XM_039095035
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000094150   ⟸   ENSRNOT00000079224
Protein Domains
EGF-like

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-11175 BioCyc
Ensembl Genes ENSRNOG00000054809 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079224.2 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  2.40.128.620 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  cEGF UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
NCBI Gene LOC100910088 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/TrEMBL
  MEGALIN, ISOFORM A UniProtKB/TrEMBL
Pfam cEGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PhenoGen Lrpl1 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054809 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF57424 UniProtKB/TrEMBL
  YWTD domain UniProtKB/TrEMBL
UniProt A0A8I6GL13 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Lrpl1  LDL receptor related protein like 1  LOC100910088  prolow-density lipoprotein receptor-related protein 1-like  Symbol and Name Changed 1299863 APPROVED
2022-06-02 LOC100910088  prolow-density lipoprotein receptor-related protein 1-like  AABR07026032.1    Data merged from RGD:15008964 737654 PROVISIONAL
2019-11-08 AABR07026032.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2015-08-13 LOC100910088  prolow-density lipoprotein receptor-related protein 1-like  RGD1565014  similar to Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan)  Data merged from RGD:1565014 737654 PROVISIONAL
2012-07-05 LOC100910088  prolow-density lipoprotein receptor-related protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1565014  similar to Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan)   RGD1565014_predicted  similar to Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-10 RGD1565014_predicted  similar to Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan) (predicted)      Name updated 1299863 APPROVED
2006-03-07 RGD1565014_predicted  similar to Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan) (predicted)  LOC290790  similar to Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290790  similar to Low-density lipoprotein receptor-related protein 4 precursor (LDLR dan)      Symbol and Name status set to provisional 70820 PROVISIONAL