Tmem249 (transmembrane protein 249) - Rat Genome Database

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Gene: Tmem249 (transmembrane protein 249) Rattus norvegicus
Analyze
Symbol: Tmem249
Name: transmembrane protein 249
RGD ID: 6496784
Description: Predicted to be located in sperm principal piece. Predicted to be part of CatSper complex. Orthologous to human TMEM249 (transmembrane protein 249); INTERACTS WITH aristolochic acid A (ortholog); benzo[a]pyrene (ortholog); rotenone (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cation channel sperm-associated auxiliary subunit TMEM249; LOC100910811; putative transmembrane protein C8orfK29-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,137,814 - 110,140,081 (-)NCBIGRCr8
mRatBN7.27108,256,535 - 108,259,429 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,257,160 - 108,262,513 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07117,599,001 - 117,601,894 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07117,586,632 - 117,589,525 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7104,607,913 - 104,610,775 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tmem249
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87110,137,814 - 110,140,081 (-)NCBIGRCr8
mRatBN7.27108,256,535 - 108,259,429 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7108,257,160 - 108,262,513 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07117,599,001 - 117,601,894 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07117,586,632 - 117,589,525 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera7104,607,913 - 104,610,775 (-)NCBICelera
Cytogenetic Map7q34NCBI
TMEM249
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,353,228 - 144,354,931 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8144,352,219 - 144,354,954 (-)EnsemblGRCh38hg38GRCh38
GRCh378145,576,888 - 145,578,591 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera8141,752,267 - 141,753,886 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8140,690,971 - 140,693,207 (-)NCBIHuRef
CHM1_18145,615,307 - 145,617,690 (-)NCBICHM1_1
T2T-CHM13v2.08145,521,857 - 145,523,560 (-)NCBIT2T-CHM13v2.0
Tmem249
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391576,417,411 - 76,419,197 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1576,417,413 - 76,419,566 (-)EnsemblGRCm39 Ensembl
GRCm381576,533,211 - 76,534,997 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1576,533,213 - 76,535,366 (-)EnsemblGRCm38mm10GRCm38
MGSCv371576,363,643 - 76,365,361 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361576,360,466 - 76,362,188 (-)NCBIMGSCv36mm8
Celera1578,033,655 - 78,035,376 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1536.03NCBI
Tmem249
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554542,974,713 - 2,976,454 (-)NCBIChiLan1.0ChiLan1.0
TMEM249
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27161,839,384 - 161,842,478 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18137,369,303 - 137,372,369 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08141,115,959 - 141,119,290 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18144,106,167 - 144,108,545 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8144,106,167 - 144,108,616 (-)Ensemblpanpan1.1panPan2
TMEM249
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11337,778,698 - 37,780,774 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1337,778,730 - 37,780,385 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1337,741,325 - 37,743,401 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01338,254,259 - 38,256,335 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,254,291 - 38,255,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,946,095 - 37,948,164 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,054,747 - 38,056,817 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01338,531,103 - 38,533,167 (-)NCBIUU_Cfam_GSD_1.0
Tmem249
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303466,297 - 467,824 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364707,892,463 - 7,893,914 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM249
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4428,535 - 431,282 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14428,339 - 430,393 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24516,634 - 518,690 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM249
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18138,565,041 - 138,567,099 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8138,565,177 - 138,566,548 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660391,293,642 - 1,296,560 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem249
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473512,494,338 - 12,496,246 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

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Variants in Tmem249
19 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)794811085116738842Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat

Markers in Region
RH141683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27108,259,660 - 108,260,110 (+)MAPPERmRatBN7.2
Rnor_6.07117,602,126 - 117,602,575NCBIRnor6.0
Rnor_5.07117,589,757 - 117,590,206UniSTSRnor5.0
RGSC_v3.47114,587,828 - 114,588,277UniSTSRGSC3.4
Celera7104,611,007 - 104,611,456UniSTS
RH 3.4 Map7795.4UniSTS
Cytogenetic Map7q34UniSTS


Expression


Sequence


RefSeq Acc Id: XM_063264466   ⟹   XP_063120536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87110,137,814 - 110,140,081 (-)NCBI
Protein Sequences
Protein RefSeqs XP_063120536 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079545.1
RefSeq Acc Id: XP_063120536   ⟸   XM_063264466

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6496784 AgrOrtholog
BioCyc Gene G2FUF-32921 BioCyc
Ensembl Genes ENSRNOG00000025497 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000106788.1 UniProtKB/TrEMBL
InterPro TMEM249 UniProtKB/TrEMBL
NCBI Gene LOC100910811 ENTREZGENE
PANTHER PTHR35442 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 249 UniProtKB/TrEMBL
Pfam DUF4579 UniProtKB/TrEMBL
PhenoGen Tmem249 PhenoGen
RatGTEx ENSRNOG00000025497 RatGTEx
UniProt A0A8I5ZMX4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-19 Tmem249  transmembrane protein 249  LOC100910811  putative transmembrane protein C8orfK29-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910811  putative transmembrane protein C8orfK29-like      Symbol and Name status set to provisional 70820 PROVISIONAL