LOC100911252 (peptidyl-prolyl cis-trans isomerase A-like) - Rat Genome Database

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Gene: LOC100911252 (peptidyl-prolyl cis-trans isomerase A-like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: LOC100911252
Name: peptidyl-prolyl cis-trans isomerase A-like
RGD ID: 6493676
Description: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in apoptotic process and protein folding. Predicted to be located in cytoplasm; extracellular region; and nucleus. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to several human genes including PPIA (peptidylprolyl isomerase A).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100363465; TRIMCyp-like
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8442,794,961 - 42,795,713 (+)NCBIGRCr8
mRatBN7.2441,828,873 - 41,829,619 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl441,828,867 - 41,829,622 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0440,004,617 - 40,005,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl440,004,654 - 40,005,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0439,838,801 - 39,839,547 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4438,844,514 - 39,011,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera437,178,155 - 37,178,916 (+)NCBICelera
Cytogenetic Map4q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:34550449  


Genomics

Variants

.
Variants in LOC100911252
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000046350
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43258419952754138Rat
8655949Rf62Renal function QTL 6222blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)43443011944463908Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
2290374Gluco32Glucose level QTL 326.27blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43717795044463908Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 1 9 2 10 2 13 5 9 2
Below cutoff 3 27 36 28 9 28 6 7 37 26 19 8 6

Sequence


RefSeq Acc Id: ENSRNOT00000046350   ⟹   ENSRNOP00000072211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl440,004,654 - 40,005,148 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119647   ⟹   ENSRNOP00000086377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl441,828,867 - 41,829,622 (+)Ensembl
RefSeq Acc Id: XM_039108606   ⟹   XP_038964534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8442,794,961 - 42,795,713 (+)NCBI
mRatBN7.2441,828,873 - 41,829,619 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038964534 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086377
  ENSRNOP00000086377.1
RefSeq Acc Id: ENSRNOP00000072211   ⟸   ENSRNOT00000046350
RefSeq Acc Id: XP_038964534   ⟸   XM_039108606
- UniProtKB: A0A8I6A629 (UniProtKB/TrEMBL),   A6IKT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086377   ⟸   ENSRNOT00000119647
Protein Domains
PPIase cyclophilin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2E4-F1-model_v2 AlphaFold A0A0G2K2E4 1-164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692887
Promoter ID:EPDNEW_R3407
Type:single initiation site
Name:LOC100911252_1
Description:peptidyl-prolyl cis-trans isomerase A-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0440,004,611 - 40,004,671EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6493676 AgrOrtholog
BioCyc Gene G2FUF-45613 BioCyc
Ensembl Genes ENSRNOG00000031045 Ensembl
  ENSRNOG00000062896 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000119647.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.100.10 UniProtKB/TrEMBL
InterPro Cyclophilin-like_dom_sf UniProtKB/TrEMBL
  Cyclophilin-type_PPIase UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_CS UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_dom UniProtKB/TrEMBL
NCBI Gene LOC100911252 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/TrEMBL
PhenoGen LOC100911252 PhenoGen
PIRSF Peptidylpro_ismrse UniProtKB/TrEMBL
PRINTS CSAPPISMRASE UniProtKB/TrEMBL
PROSITE CSA_PPIASE_1 UniProtKB/TrEMBL
  CSA_PPIASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031045 RatGTEx
  ENSRNOG00000062896 RatGTEx
Superfamily-SCOP SSF50891 UniProtKB/TrEMBL
UniProt A0A8I6A629 ENTREZGENE, UniProtKB/TrEMBL
  A6IKT9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 LOC100911252  peptidyl-prolyl cis-trans isomerase A-like  LOC100363465  TRIMCyp-like  Data merged from RGD:2322980 737654 PROVISIONAL
2012-07-05 LOC100911252  peptidyl-prolyl cis-trans isomerase A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-06 LOC100363465  TRIMCyp-like      Symbol and Name status set to provisional 70820 PROVISIONAL