Mrln (myoregulin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Mrln (myoregulin) Rattus norvegicus
Analyze
Symbol: Mrln
Name: myoregulin
RGD ID: 6490783
Description: Predicted to enable enzyme inhibitor activity. Predicted to act upstream of or within negative regulation of calcium ion import into sarcoplasmic reticulum and response to wounding. Predicted to be located in sarcoplasmic reticulum membrane. Orthologous to human MRLN (myoregulin); INTERACTS WITH Aflatoxin B2 alpha (ortholog); benzo[e]pyrene (ortholog); cadmium atom (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100911740; Mln; uncharacterized LOC100911740
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82018,405,858 - 18,422,874 (-)NCBIGRCr8
mRatBN7.22018,406,789 - 18,423,805 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2018,406,707 - 18,428,418 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2019,133,447 - 19,148,467 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02018,488,147 - 18,503,167 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02018,961,105 - 18,976,126 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02019,703,628 - 19,720,596 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02021,840,428 - 21,857,392 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2019,793,904 - 19,808,868 (-)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:24917243   PMID:25640239   PMID:27923914  


Genomics

Comparative Map Data
Mrln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82018,405,858 - 18,422,874 (-)NCBIGRCr8
mRatBN7.22018,406,789 - 18,423,805 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2018,406,707 - 18,428,418 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2019,133,447 - 19,148,467 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02018,488,147 - 18,503,167 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02018,961,105 - 18,976,126 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02019,703,628 - 19,720,596 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02021,840,428 - 21,857,392 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2019,793,904 - 19,808,868 (-)NCBICelera
Cytogenetic Map20p11NCBI
MRLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381059,736,692 - 59,753,455 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1059,736,692 - 59,756,041 (-)EnsemblGRCh38hg38GRCh38
GRCh371061,496,450 - 61,513,213 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map10q21.2NCBI
HuRef1055,484,351 - 55,500,804 (-)NCBIHuRef
CHM1_11061,778,903 - 61,795,356 (-)NCBICHM1_1
T2T-CHM13v2.01060,590,427 - 60,607,189 (-)NCBIT2T-CHM13v2.0
Mrln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391070,040,494 - 70,055,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1070,040,494 - 70,055,541 (+)EnsemblGRCm39 Ensembl
GRCm381070,204,664 - 70,219,711 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1070,204,664 - 70,219,711 (+)EnsemblGRCm38mm10GRCm38
MGSCv371069,667,415 - 69,682,459 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361069,592,753 - 69,615,068 (+)NCBIMGSCv36mm8
Celera1071,295,780 - 71,310,827 (+)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.68NCBI
Mrln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542513,320,062 - 13,333,423 (-)NCBIChiLan1.0ChiLan1.0
MRLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2871,948,648 - 71,965,470 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11071,953,969 - 71,970,796 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01056,270,995 - 56,287,646 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11058,485,998 - 58,502,225 (-)NCBIpanpan1.1PanPan1.1panPan2
MRLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1411,934,651 - 11,947,006 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha412,132,128 - 12,144,478 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0412,197,215 - 12,209,616 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl412,197,284 - 12,197,424 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1412,173,776 - 12,186,177 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0412,292,720 - 12,305,120 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0412,603,697 - 12,616,098 (-)NCBIUU_Cfam_GSD_1.0
Mrln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721369,130,961 - 69,142,813 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366143,217,820 - 3,229,048 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11463,124,188 - 63,152,845 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21468,099,575 - 68,127,654 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1971,539,795 - 71,555,307 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604832,425,299 - 32,440,415 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247913,827,395 - 3,841,119 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mrln
146 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat

Markers in Region
D20Got25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22018,417,169 - 18,417,366 (+)MAPPERmRatBN7.2
Rnor_6.02019,714,008 - 19,714,204NCBIRnor6.0
Rnor_5.02021,850,808 - 21,851,004UniSTSRnor5.0
RGSC_v3.42019,141,881 - 19,142,077UniSTSRGSC3.4
RGSC_v3.42019,141,880 - 19,142,077RGDRGSC3.4
RGSC_v3.12019,155,681 - 19,155,877RGD
Celera2019,804,228 - 19,804,424UniSTS
RH 3.4 Map20229.06UniSTS
RH 3.4 Map20229.06RGD
RH 2.0 Map20259.6RGD
RH129013  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22018,406,830 - 18,407,020 (+)MAPPERmRatBN7.2
Rnor_6.02019,703,670 - 19,703,859NCBIRnor6.0
Rnor_5.02021,840,470 - 21,840,659UniSTSRnor5.0
RGSC_v3.42019,131,543 - 19,131,732UniSTSRGSC3.4
Celera2019,793,946 - 19,794,135UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000094839   ⟹   ENSRNOP00000076414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2018,406,748 - 18,422,167 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097050   ⟹   ENSRNOP00000083104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2018,406,804 - 18,428,418 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100943   ⟹   ENSRNOP00000096300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2018,406,748 - 18,422,167 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105589   ⟹   ENSRNOP00000091354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2018,406,707 - 18,418,721 (-)Ensembl
RefSeq Acc Id: NM_001304741   ⟹   NP_001291670
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82018,405,858 - 18,420,878 (-)NCBI
mRatBN7.22018,406,789 - 18,421,810 (-)NCBI
Rnor_6.02019,703,628 - 19,718,648 (-)NCBI
Celera2019,793,904 - 19,808,868 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601528   ⟹   XP_017457017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82018,405,863 - 18,422,870 (-)NCBI
mRatBN7.22018,406,794 - 18,423,800 (-)NCBI
Rnor_6.02019,703,633 - 19,720,596 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601529   ⟹   XP_017457018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82018,405,863 - 18,422,874 (-)NCBI
mRatBN7.22018,406,794 - 18,423,805 (-)NCBI
Rnor_6.02019,703,633 - 19,720,596 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001291670   ⟸   NM_001304741
- UniProtKB: A0A8I6AUW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457018   ⟸   XM_017601529
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AUW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457017   ⟸   XM_017601528
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AUW5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076414   ⟸   ENSRNOT00000094839
RefSeq Acc Id: ENSRNOP00000083104   ⟸   ENSRNOT00000097050
RefSeq Acc Id: ENSRNOP00000096300   ⟸   ENSRNOT00000100943
RefSeq Acc Id: ENSRNOP00000091354   ⟸   ENSRNOT00000105589

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6490783 AgrOrtholog
BioCyc Gene G2FUF-3980 BioCyc
Ensembl Genes ENSRNOG00000069916 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000094839.1 UniProtKB/TrEMBL
  ENSRNOT00000097050.1 UniProtKB/TrEMBL
  ENSRNOT00000100943 ENTREZGENE
  ENSRNOT00000100943.1 UniProtKB/TrEMBL
  ENSRNOT00000105589.1 UniProtKB/TrEMBL
InterPro Myoregulin UniProtKB/TrEMBL
KEGG Report rno:100911740 UniProtKB/TrEMBL
NCBI Gene LOC100911740 ENTREZGENE
PhenoGen Mrln PhenoGen
RatGTEx ENSRNOG00000069916 RatGTEx
UniProt A0A8I6AUW5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-02-09 Mrln  myoregulin  LOC100911740  uncharacterized LOC100911740  Name and Symbol changed 629549 APPROVED
2015-02-06 LOC100911740  uncharacterized LOC100911740  LOC100911740  uncharacterized LOC100911740  Type changed (type changed from [ncrna] to [protein-coding]) 629549 APPROVED
2012-07-05 LOC100911740  uncharacterized LOC100911740      Symbol and Name status set to provisional 70820 PROVISIONAL