Odaph (odontogenesis associated phosphoprotein) - Rat Genome Database

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Gene: Odaph (odontogenesis associated phosphoprotein) Rattus norvegicus
Analyze
Symbol: Odaph
Name: odontogenesis associated phosphoprotein
RGD ID: 6489816
Description: Predicted to be involved in positive regulation of enamel mineralization. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A4. Orthologous to human ODAPH (odontogenesis associated phosphoprotein); INTERACTS WITH 17beta-estradiol (ortholog); 2-palmitoylglycerol (ortholog); acrylamide (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100911949; odontogenesis-associated phosphoprotein; uncharacterized LOC100911949; uncharacterized protein C4orf26 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,356,104 - 16,364,420 (-)NCBIGRCr8
mRatBN7.21416,071,835 - 16,080,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,073,058 - 16,080,129 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1416,085,362 - 16,093,679 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,404,253 - 17,412,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01416,096,382 - 16,104,699 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,575,295 - 17,583,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,575,758 - 17,582,823 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,492,753 - 17,500,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1415,465,276 - 15,473,195 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
Additional References at PubMed
PMID:22901946  


Genomics

Comparative Map Data
Odaph
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,356,104 - 16,364,420 (-)NCBIGRCr8
mRatBN7.21416,071,835 - 16,080,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,073,058 - 16,080,129 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1416,085,362 - 16,093,679 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,404,253 - 17,412,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01416,096,382 - 16,104,699 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,575,295 - 17,583,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,575,758 - 17,582,823 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,492,753 - 17,500,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1415,465,276 - 15,473,195 (-)NCBICelera
Cytogenetic Map14p22NCBI
ODAPH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38475,556,066 - 75,565,893 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl475,556,048 - 75,565,871 (+)EnsemblGRCh38hg38GRCh38
GRCh37476,481,276 - 76,491,103 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36476,700,282 - 76,708,951 (+)NCBINCBI36Build 36hg18NCBI36
Celera473,777,392 - 73,786,055 (+)NCBICelera
Cytogenetic Map4q21.1NCBI
HuRef472,228,125 - 72,237,965 (+)NCBIHuRef
CHM1_1476,458,040 - 76,467,887 (+)NCBICHM1_1
T2T-CHM13v2.0478,896,230 - 78,906,039 (+)NCBIT2T-CHM13v2.0
Odaph
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,135,332 - 92,143,176 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl592,135,334 - 92,143,179 (+)EnsemblGRCm39 Ensembl
GRCm38591,987,473 - 91,995,317 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl591,987,475 - 91,995,320 (+)EnsemblGRCm38mm10GRCm38
MGSCv37592,416,499 - 92,424,343 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36593,062,673 - 93,070,520 (+)NCBIMGSCv36mm8
Celera590,130,731 - 90,138,701 (+)NCBICelera
Cytogenetic Map5E2NCBI
cM Map545.68NCBI
Odaph
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554741,502,791 - 1,509,294 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554741,502,798 - 1,509,307 (+)NCBIChiLan1.0ChiLan1.0
ODAPH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2354,508,671 - 54,517,446 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1454,691,688 - 54,706,601 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0448,640,355 - 48,649,546 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1454,474,726 - 54,484,548 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,471,278 - 54,484,548 (-)Ensemblpanpan1.1panPan2
ODAPH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132133,974 - 141,303 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32133,816 - 140,958 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,740,983 - 41,747,967 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.032157,536 - 164,520 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl32157,378 - 164,520 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.132154,446 - 161,439 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.032112,634 - 119,621 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03240,053,050 - 40,060,040 (-)NCBIUU_Cfam_GSD_1.0
Odaph
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,948,181 - 11,955,567 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936598400,214 - 407,597 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ODAPH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,215,152 - 71,226,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,215,091 - 71,225,787 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,281,974 - 75,291,896 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ODAPH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,062,924 - 24,073,371 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl724,063,695 - 24,072,500 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660372,390,890 - 2,399,782 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Odaph
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624730292,466 - 298,311 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Odaph
60 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 41 41 27 9 27 7 10 74 35 36 11 7
Below cutoff 2 2 12 11 7 11 1 1 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087686   ⟹   ENSRNOP00000074004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,073,058 - 16,080,129 (-)Ensembl
Rnor_6.0 Ensembl1417,575,758 - 17,582,823 (-)Ensembl
RefSeq Acc Id: NM_001399585   ⟹   NP_001386514
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,356,104 - 16,364,420 (-)NCBI
mRatBN7.21416,071,835 - 16,080,151 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386514 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A0A0G2K6Z9 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074004
  ENSRNOP00000074004.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000074004   ⟸   ENSRNOT00000087686
RefSeq Acc Id: NP_001386514   ⟸   NM_001399585
- Peptide Label: precursor
- UniProtKB: A0A0G2K6Z9 (UniProtKB/Swiss-Prot),   A0A8L2R861 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K6Z9-F1-model_v2 AlphaFold A0A0G2K6Z9 1-127 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6489816 AgrOrtholog
BioCyc Gene G2FUF-16240 BioCyc
Ensembl Genes ENSRNOG00000059582 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087686 ENTREZGENE
  ENSRNOT00000087686.2 UniProtKB/TrEMBL
InterPro ODAPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100911949 UniProtKB/TrEMBL
NCBI Gene LOC100911949 ENTREZGENE
PANTHER ODONTOGENESIS ASSOCIATED PHOSPHOPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR40376 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ODAPH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Odaph PhenoGen
RatGTEx ENSRNOG00000059582 RatGTEx
UniProt A0A0G2K6Z9 ENTREZGENE
  A0A8L2R861 ENTREZGENE, UniProtKB/TrEMBL
  ODAPH_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-05 Odaph  odontogenesis associated phosphoprotein  LOC100911949  uncharacterized LOC100911949  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911949  uncharacterized LOC100911949      Symbol and Name status set to provisional 70820 PROVISIONAL