Gene: Scn4b (sodium channel, voltage-gated, type IV, beta)
Rattus norvegicus
Symbol:
Scn4b
Name:
sodium channel, voltage-gated, type IV, beta
Description:
ENCODES a protein that exhibits ion channel binding (ortholog); sodium channel regulator activity (ortholog); voltage-gated sodium channel activity (ortholog); INVOLVED IN AV node cell to bundle of His cell communication (ortholog); cardiac muscle contraction (ortholog); membrane depolarization involved in regulation of cardiac muscle cell action potential (ortholog); ASSOCIATED WITH Long QT Syndrome (ortholog); Long Qt Syndrome 10 (ortholog); FOUND IN plasma membrane; intercalated disc (ortholog); voltage-gated sodium channel complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; dibutyl phthalate
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
sodium channel accessory subunit; sodium channel beta 4 subunit; sodium channel subunit beta-4; sodium channel, type 4, beta subunit; sodium channel, type IV, beta; sodium channel, voltage-gated, type IV, beta
Orthologs:
Homo sapiens : SCN4B
(sodium channel, voltage-gated, type IV, beta subunit)
HGNC
Scn4b
(sodium channel, type IV, beta)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 8 q22 NCBI RGSC Genome Assembly v5.0 8 48,067,555 - 48,082,728 + NCBI RGSC Genome Assembly v3.4 8 48,091,561 - 48,106,735 + NCBI Rat Celera Assembly 8 45,031,630 - 45,046,803 + NCBI Genome Assembly 3.1 8 48,109,134 - 48,115,501 + NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1620406 6480464 Tetrachlorodibenzodioxin results in increased expression of SCN4B mRNA CTD PMID:20159946 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SCN4B mRNA CTD PMID:20558275 PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SCN4B mRNA CTD PMID:22298810 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of SCN4B mRNA CTD PMID:21839799 diazoxide decreases expression ISO RGD:1620406 6480464 Isoproterenol results in decreased expression of SCN4B mRNA CTD PMID:20003209 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of SCN4B mRNA CTD PMID:21266533 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of SCN4B mRNA CTD PMID:21396975 indole-3-methanol multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SCN4B mRNA CTD PMID:22129741 isoprenaline decreases expression ISO RGD:1620406 6480464 Isoproterenol results in decreased expression of SCN4B mRNA CTD PMID:20003209 ketamine increases expression EXP 6480464 Ketamine results in increased expression of SCN4B mRNA CTD PMID:20080153 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of SCN4B mRNA CTD PMID:18164116 N-nitrosodiethylamine multiple interactions EXP 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of SCN4B mRNA CTD PMID:22129741 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of SCN4B mRNA CTD PMID:16221955 pirinixic acid increases expression ISO RGD:1620406 6480464 pirinixic acid results in increased expression of SCN4B mRNA CTD PMID:18301758 vancomycin increases expression ISO RGD:1620406 6480464 Vancomycin results in increased expression of SCN4B mRNA CTD PMID:18930951
71120 Niddm21 Non-insulin dependent diabetes mellitus QTL 21 3.73 Glucose level postprandial 8 3039822 61462321 Rat 2317032 Ginf2 Gastrointestinal inflammation QTL 2 3.21 .005 Gastrointestinal inflammation 8 5914098 50914098 Rat 2317036 Livw3 Liver weight QTL 3 2.43 .01 Liver weight 8 5914098 50914098 Rat 2317048 Ginf1 Gastrointestinal inflammation QTL 1 3.52 .005 Gastrointestinal inflammation gut score 8 5914098 50914098 Rat 2301416 Bp315 Blood pressure QTL 315 .008 Blood pressure mean arterial 8 7408118 52408118 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 Brain/spinal cord inflammation demyelination 8 8294860 115338082 Rat 1354595 Despr4 Despair related QTL 4 .0036 Activity level immobility level 8 9008612 54008612 Rat 1354627 Despr14 Despair related QTL 14 .0056 Activity level swimming level 8 9008612 54008612 Rat 1598824 Memor4 Memory QTL 4 2.5 Memory navigation-spatial 8 9581132 56397678 Rat 61353 Bp35 Blood pressure QTL 35 Blood pressure 8 9581132 103685771 Rat 2317030 Wbc5 White blood cell count QTL 5 3.21 .005 White blood cell count 8 10116155 55116155 Rat 2317051 Aia18 Adjuvant induced arthritis QTL 18 2.42 Joint/bone inflammation adjuvant induced 8 10116155 55116155 Rat 1558646 Swd5 Spike wave discharge measurement QTL 5 3.45 .00036 Spike wave discharge measurement frequency 8 16442230 61442230 Rat 631271 Cati1 Cataract Ihara QTL 1 .001 Cataract susceptibility 8 16468237 61468237 Rat 731182 Uae24 Urinary albumin excretion QTL 24 6.4 Renal function urine albumin level 8 19815642 98451660 Rat 631842 Inf1 Infertility severity QTL 1 4.1 .001 Seminal vesicle mass 8 26358063 71358063 Rat 1359021 Bp271 Blood pressure QTL 271 1.8 Blood pressure mean arterial 8 27021985 49403011 Rat 631648 Stl5 Serum triglyceride level QTL 5 4 .0003 Lipid level triglyceride 8 28414004 58991068 Rat 1358892 Kidm26 Kidney mass QTL 26 3.69 Kidney mass 8 28414004 103684785 Rat 1358896 Bp262 Blood pressure QTL 262 2.89 Blood pressure post sympathetic nervous system block 8 28414004 103684785 Rat 1358907 Cm40 Cardiac mass QTL 40 1.89 Cardiac mass 8 28414004 103684785 Rat 2303572 Insul13 Insulin level QTL 13 2 Insulin level 8 29077622 74077622 Rat 2303564 Gluco43 Glucose level QTL 43 3 Glucose level fasting 8 29077622 74077622 Rat 1300146 Rf17 Renal function QTL 17 2.9 Renal function salt-loaded renal blood flow 8 29559446 74559446 Rat 1331804 Cm30 Cardiac mass QTL 30 3.77443 Cardiac mass 8 29559446 103672447 Rat 2302278 Gluco36 Glucose level QTL 36 4.2 Glucose level 8 30878636 53049477 Rat 724514 Uae15 Urinary albumin excretion QTL 15 2.9 Renal function urine albumin level 8 30878636 74178909 Rat 1549908 Neudeg1 Neurodegradation QTL 1 5 0 Neurodegradation motoneuron cell number 8 31508524 98947320 Rat 1331744 Bp217 Blood pressure QTL 217 3.398 Blood pressure systolic 8 32203394 61853629 Rat 1359033 Bp273 Blood pressure QTL 273 Blood pressure response to intrathecal cytisine 8 32203394 64762616 Rat 2313046 Bss78 Bone structure and strength QTL 78 3.5 .0001 Bone strength 8 32203394 86628010 Rat 2313057 Bss76 Bone structure and strength QTL 76 3 .0001 Bone structure 8 32203394 86628010 Rat 2313067 Bss77 Bone structure and strength QTL 77 3.1 .0001 Bone structure 8 32203394 86628010 Rat 2313088 Bss75 Bone structure and strength QTL 75 3.1 .0001 Bone structure 8 32203394 86628010 Rat 724540 Uae8 Urinary albumin excretion QTL 8 5 Renal function urine abumin level 8 32203394 98986263 Rat 1578755 Pur5 Proteinuria QTL 5 3.3 .0001 Renal function urine protein level 8 32203394 98986263 Rat 1578765 Klgr1 Kidney lesion grade QTL 1 3.3 .0001 Renal histology kidney lesion grade 8 32203499 98986085 Rat 1578769 Uae31 Urinary albumin excretion QTL 31 3.3 .001 Renal function urine albumin level 8 32203499 98986085 Rat 2316950 Scl66 Serum cholesterol level QTL 66 4.1 Lipid level serum cholesterol 8 32203499 110106272 Rat 1298065 Scl16 Serum cholesterol level QTL 16 3.8 Lipid level cholesterol 8 33897608 78897608 Rat 1582222 Epfw2 Epididymal fat weight QTL 2 3.2 .0005 Epididymal fat weight 8 34808657 79808657 Rat 1331838 Niddm61 Non-insulin dependent diabetes mellitus QTL 61 3.53 .0004 Insulin level fasting 8 38003289 103665018 Rat 61358 Bp39 Blood pressure QTL 39 2 Blood pressure 8 38902937 83902937 Rat 737824 Hcar10 Hepatocarcinoma resistance QTL 10 2.9 Liver tumor resistance nodule number 8 43313902 87122960 Rat 1358906 Bp253 Blood pressure QTL 253 4 .0004 Blood pressure post sympathetic nervous system block 8 43313902 98451660 Rat 1554321 Bmd3 Bone mineral density QTL 3 7.9 .0001 Bone mineral density distal femur volumetric BMD by pQCT 8 43561064 129041809 Rat 1331769 Rf39 Renal function QTL 39 3.871 Renal function urine volume 8 44484215 103672447 Rat 1298079 Activ2 Activity QTL 2 9.5 .000001 Activity level novel environment 8 44484215 129041809 Rat 631216 Stl9 Serum triglyceride level QTL 9 4.71 .0001 Lipid level triglyceride 8 44484347 74178405 Rat 5684993 Bmd84 Bone mineral density QTL 84 4.1 Bone mineral density bone mineral content 8 45291674 53049477 Rat 70161 Bp62 Blood pressure QTL 62 2.9 .001 Blood pressure salt-loaded systolic 8 45291674 94514282 Rat
Gene-Chemical Interaction Annotations
