Taar7b (trace amine-associated receptor 7b) - Rat Genome Database

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Pathways
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Gene: Taar7b (trace amine-associated receptor 7b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Taar7b
Name: trace amine-associated receptor 7b
RGD ID: 631392
Description: Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ta12; taR-12; taR-7b; trace amine associated receptor 7b; trace amine receptor 12; trace amine receptor 7b; trace-amine-associated receptor 7b
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8123,260,078 - 23,261,154 (-)NCBIGRCr8
mRatBN7.2121,440,832 - 21,441,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,440,832 - 21,441,908 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx121,217,915 - 21,218,991 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,217,954 - 27,219,030 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,417,696 - 21,418,772 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,518,560 - 22,519,636 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,518,560 - 22,519,636 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0123,993,502 - 23,994,578 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,967,019 - 21,968,095 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,969,963 - 21,970,965 (-)NCBI
Celera120,185,275 - 20,186,351 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Trace amines: identification of a family of mammalian G protein-coupled receptors. Borowsky B, etal., Proc Natl Acad Sci U S A 2001 Jul 31;98(16):8966-71.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:15718104   PMID:17556730  


Genomics

Variants

.
Variants in Taar7b
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:26
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000021559
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1124744506Rat
2298546Neuinf4Neuroinflammation QTL 45.1nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1128736750Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1132356093Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1132356093Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1132356093Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1592587724697545Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)11148148232355910Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

reproductive system
High
Medium
Low
Below cutoff 15

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021559   ⟹   ENSRNOP00000021559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,440,832 - 21,441,908 (-)Ensembl
Rnor_6.0 Ensembl122,518,560 - 22,519,636 (-)Ensembl
RefSeq Acc Id: NM_175586   ⟹   NP_783176
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,260,078 - 23,261,154 (-)NCBI
mRatBN7.2121,440,832 - 21,441,908 (-)NCBI
Rnor_6.0122,518,560 - 22,519,636 (-)NCBI
Rnor_5.0123,993,502 - 23,994,578 (-)NCBI
RGSC_v3.4121,967,019 - 21,968,095 (-)RGD
Celera120,185,275 - 20,186,351 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_783176 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK71251 (Get FASTA)   NCBI Sequence Viewer  
  AAV70131 (Get FASTA)   NCBI Sequence Viewer  
  EDL87754 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021559
  ENSRNOP00000021559.3
  ENSRNOP00055043841
  ENSRNOP00060039405
  ENSRNOP00065026614
GenBank Protein Q923X8 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_783176   ⟸   NM_175586
- UniProtKB: Q923X6 (UniProtKB/Swiss-Prot),   Q5QD22 (UniProtKB/Swiss-Prot),   Q923X8 (UniProtKB/Swiss-Prot),   A6JUM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021559   ⟸   ENSRNOT00000021559
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923X8-F1-model_v2 AlphaFold Q923X8 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631392 AgrOrtholog
BioCyc Gene G2FUF-62087 BioCyc
Ensembl Genes ENSRNOG00000046302 Ensembl
  ENSRNOG00000071181 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055030573 UniProtKB/Swiss-Prot
  ENSRNOG00060027291 UniProtKB/Swiss-Prot
  ENSRNOG00065019733 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021559 ENTREZGENE
  ENSRNOT00000021559.5 UniProtKB/Swiss-Prot
  ENSRNOT00055053041 UniProtKB/Swiss-Prot
  ENSRNOT00060047338 UniProtKB/Swiss-Prot
  ENSRNOT00065033251 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAAR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 294126 ENTREZGENE
PANTHER HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRACE AMINE-ASSOCIATED RECEPTOR 7A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Taar7b PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRACEAMINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046302 RatGTEx
  ENSRNOG00000071181 RatGTEx
  ENSRNOG00055030573 RatGTEx
  ENSRNOG00060027291 RatGTEx
  ENSRNOG00065019733 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JUM5 ENTREZGENE, UniProtKB/TrEMBL
  Q5QD22 ENTREZGENE
  Q923X6 ENTREZGENE
  Q923X8 ENTREZGENE, UniProtKB/Swiss-Prot
  TAA7E_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5QD22 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-20 Taar7b  trace amine-associated receptor 7b  Taar7b  trace-amine-associated receptor 7b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Taar7b  trace-amine-associated receptor 7b  Ta12  trace amine receptor 12  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-02-11 Tar12  trace amine receptor 12      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function functions as neurotransmitters for biogenic amines along with the orphan receptor PNR 634071
gene_product member of the rhodopsin mammalian G protein-coupled receptor family 634071