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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1347157 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IMPA2 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of IMPA2 mRNA | CTD | PMID:16054898 more ... | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1347157 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of IMPA2 mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1553391 | 6480464 | Tetrachlorodibenzodioxin affects the expression of IMPA2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of IMPA2 mRNA | CTD | PMID:16054898 PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1347157 | 6480464 | Tetrachlorodibenzodioxin affects the expression of IMPA2 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of IMPA2 mRNA | CTD | PMID:16054898 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of IMPA2 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of IMPA2 mRNA | CTD | PMID:21346803 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IMPA2 mRNA | CTD | PMID:20959002 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:1553391 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of IMPA2 mRNA | CTD | PMID:20188158 | 5-fluorouracil | increases expression | ISO | RGD:1347157 | 6480464 | Fluorouracil results in increased expression of IMPA2 mRNA | CTD | PMID:16510598 | aflatoxin B1 | decreases expression | ISO | RGD:1347157 | 6480464 | Aflatoxin B1 results in decreased expression of IMPA2 mRNA | CTD | PMID:21641981 | all-trans-retinoic acid | decreases expression | ISO | RGD:1347157 | 6480464 | Tretinoin results in decreased expression of IMPA2 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of IMPA2 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | multiple interactions | ISO | RGD:1553391 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of IMPA2 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:1553391 | 6480464 | Benzo(a)pyrene results in decreased expression of IMPA2 mRNA | CTD | PMID:19770486 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of IMPA2 mRNA | CTD | PMID:19167457 | ciguatoxin CTX1B | affects expression | ISO | RGD:1553391 | 6480464 | Ciguatoxins affects the expression of IMPA2 mRNA | CTD | PMID:18353800 | copper(2+) sulfate | decreases expression | ISO | RGD:1347157 | 6480464 | Copper Sulfate results in decreased expression of IMPA2 mRNA | CTD | PMID:19549813 | coumestrol | increases expression | ISO | RGD:1347157 | 6480464 | Coumestrol results in increased expression of IMPA2 mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | RGD:1347157 | 6480464 | Cyclosporine results in decreased expression of IMPA2 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:1347157 | 6480464 | Cyclosporine results in decreased expression of IMPA2 mRNA | CTD | PMID:20106945 PMID:22147139 | disodium selenite | increases expression | ISO | RGD:1347157 | 6480464 | Sodium Selenite results in increased expression of IMPA2 mRNA | CTD | PMID:18175754 | mitomycin C | affects response to substance | ISO | RGD:1347157 | 6480464 | IMPA2 protein affects the susceptibility to Mitomycin | CTD | PMID:16217747 | paracetamol | affects expression | ISO | RGD:1553391 | 6480464 | Acetaminophen affects the expression of IMPA2 mRNA | CTD | PMID:17562736 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of IMPA2 mRNA | CTD | PMID:19162173 | phenobarbital | affects expression | ISO | RGD:1347157 | 6480464 | Phenobarbital affects the expression of IMPA2 mRNA | CTD | PMID:19159669 | pirinixic acid | increases expression | ISO | RGD:1553391 | 6480464 | pirinixic acid results in increased expression of IMPA2 mRNA | CTD | PMID:20813756 PMID:18301758 | pirinixic acid | increases expression | ISO | RGD:1553391 | 6480464 | pirinixic acid results in increased expression of IMPA2 mRNA | CTD | PMID:18301758 PMID:20813756 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of IMPA2 mRNA | CTD | PMID:19162173 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of IMPA2 mRNA | CTD | PMID:19162173 | quercetin | decreases expression | ISO | RGD:1347157 | 6480464 | Quercetin results in decreased expression of IMPA2 mRNA | CTD | PMID:21632981 | rosiglitazone | increases expression | EXP | | 6480464 | rosiglitazone results in increased expression of IMPA2 mRNA | CTD | PMID:21515302 | streptozocin | increases expression | EXP | | 6480464 | Streptozocin results in increased expression of IMPA2 mRNA | CTD | PMID:16684804 | streptozocin | multiple interactions | EXP | | 6480464 | vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of IMPA2 mRNA] | CTD | PMID:16684804 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1347157 | 6480464 | tert-Butylhydroperoxide results in decreased expression of IMPA2 mRNA | CTD | PMID:15336504 | trimellitic anhydride | increases expression | ISO | RGD:1553391 | 6480464 | trimellitic anhydride results in increased expression of IMPA2 mRNA | CTD | PMID:19042947 | troglitazone | increases expression | EXP | | 6480464 | troglitazone results in increased expression of IMPA2 mRNA | CTD | PMID:21515302 | valproic acid | increases expression | ISO | RGD:1347157 | 6480464 | Valproic Acid results in increased expression of IMPA2 mRNA | CTD | PMID:19101580 | vanadyl sulfate | multiple interactions | EXP | | 6480464 | vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of IMPA2 mRNA] | CTD | PMID:16684804 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Inositol phosphate metabolism |
| Metabolic pathways | |
| Phosphatidylinositol signaling system | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Inositol phosphate metabolism |
| Metabolic pathways | |
| Phosphatidylinositol signaling system | |
References - curated| 1. |
MGD data from the GO Consortium |
| 2. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 3. |
RGD automated data pipeline |
| 4. |
RGD automated import pipeline for gene-chemical interactions |
| 5. |
RGD comprehensive gene curation |
| 6. |
Shamir A, etal., Gene 2001 Jun 27;271(2):285-91. |
| 7. |
Sjoholt G, etal., Mol Psychiatry. 2004 Jun;9(6):621-9. |
| 8. |
Yoon IS, etal., Mol Psychiatry. 2001 Nov;6(6):678-83. |
| 9. |
Yoshikawa T, etal., Mol Psychiatry. 1997 Sep;2(5):393-7. |
| 10. |
Yoshikawa T, etal., Mol Psychiatry. 2001 Mar;6(2):202-10. |
References - uncurated
RGD Disease Portals| Impa2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Impa2 (Rattus norvegicus) |
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| IMPA2 (Homo sapiens) |
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| Impa2 (Mus musculus) |
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Position Markers| RH128133 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_172224 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06095631 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06095632 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095660 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095661 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095662 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY160191 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC083544 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473971 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CQ964661 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_172224 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_757378 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_757378 | (Get FASTA) |
| GenBank Protein | AAH83544 | (Get FASTA) |
| AAN47010 | (Get FASTA) | |
| CAI30714 | (Get FASTA) | |
| EDM14721 | (Get FASTA) | |
| EDM14722 | (Get FASTA) | |
| Q8CIN7 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000018516 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000025147 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000025147 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 282636 | ENTREZGENE |
| Germonline | ENSRNOG00000018516 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 22799 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7191219 | IMAGE-MGC_LOAD |
| InterPro | Inositol_monoP_metal-BS | UniProtKB/Swiss-Prot |
| Inositol_monoPase_Li-sen | UniProtKB/Swiss-Prot | |
| Inositol_monophosphatase | UniProtKB/Swiss-Prot | |
| Inositol_monophosphatase_CS | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:282636 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:93085 | IMAGE-MGC_LOAD |
| PANTHER | Inositol_P | UniProtKB/Swiss-Prot |
| Pfam | Inositol_P | UniProtKB/Swiss-Prot |
| PRINTS | IMPHPHTASES | UniProtKB/Swiss-Prot |
| LIIMPHPHTASE | UniProtKB/Swiss-Prot | |
| PROSITE | IMP_1 | UniProtKB/Swiss-Prot |
| IMP_2 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.856 | ENTREZGENE |
| UniProt | IMPA2_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2005-01-20 | Impa2 | inositol (myo)-1(or 4)-monophosphatase 2 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2003-02-27 | Impa2 | inositol (myo)-1(or 4)-monophosphatase 2 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Impa2 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 628692 |
| Created: | 2003-02-27 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




