Gene: Csnk1e (casein kinase 1, epsilon)
Mus musculus
Symbol:
Csnk1e
Name:
casein kinase 1, epsilon
Description:
ENCODES a protein that exhibits protein kinase activity; protein serine/threonine kinase activity (ortholog); INVOLVED IN cellular protein localization; negative regulation of Wnt receptor signaling pathway; positive regulation of canonical Wnt receptor signaling pathway; PARTICIPATES IN Hedgehog signaling pathway; p53 signaling pathway; Wnt signaling pathway; ASSOCIATED WITH prolonged circadian period; shortened circadian period; ASSOCIATED WITH Carcinoma, Ductal, Breast (ortholog); FOUND IN nucleus; ribonucleoprotein complex; cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol; aflatoxin B1
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AI426939; AI551861; AW457082; casein kinase I isoform epsilon; CK1epsilon; CKI, epsilon; CKI-epsilon; CKIe; KC1 epsilon; KC1epsilon; OTTMUSP00000037966; OTTMUSP00000037968; tau
Orthologs:
Homo sapiens : CSNK1E
(casein kinase 1, epsilon)
HGNC
Rattus norvegicus : Csnk1e
(casein kinase 1, epsilon)
Latest Assembly:
Mouse Genome Assembly Build 37
Position:
Map Chr Position Strand Source Mouse Genome Assembly GRCm38 15 79,417,852 - 79,442,057 - NCBI Mouse cM Map 15 - NCBI Mouse Celera Assembly 15 81,541,134 - 81,565,319 - NCBI Mouse Genome Assembly Build 37 15 79,248,282 - 79,272,487 - NCBI Mouse Genome Assembly Build 36.1 15 79,248,286 - 79,272,437 - NCBI Mouse Cytogenetic Map 15 E1 NCBI
Model
Gene-Chemical Interaction Annotations
17beta-estradiol affects expression ISO RGD:732829 6480464 Estradiol affects the expression of CSNK1E mRNA CTD PMID:22574217 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CSNK1E mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression ISO RGD:62045 6480464 2,4-dinitrotoluene affects the expression of CSNK1E mRNA CTD PMID:21346803 2-butoxyethanol increases expression EXP 6480464 n-butoxyethanol results in increased expression of CSNK1E mRNA CTD PMID:19812364 5-fluorouracil affects expression ISO RGD:732829 6480464 Fluorouracil affects the expression of CSNK1E mRNA CTD PMID:16584549 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of CSNK1E mRNA CTD PMID:19770486 aflatoxin B1 increases expression ISO RGD:732829 6480464 Aflatoxin B1 results in increased expression of CSNK1E mRNA CTD PMID:22100608 ammonium chloride affects expression ISO RGD:62045 6480464 Ammonium Chloride affects the expression of CSNK1E mRNA CTD PMID:16483693 amphetamine affects response to substance ISO RGD:732829 6480464 CSNK1E gene polymorphism affects the susceptibility to Amphetamine CTD PMID:16237383 amphetamine increases response to substance ISO RGD:732829 6480464 CSNK1E protein results in increased susceptibility to Amphetamine CTD PMID:16237383 benzene decreases expression ISO RGD:732829 6480464 Benzene results in decreased expression of CSNK1E mRNA CTD PMID:19162166 benzo[a]pyrene multiple interactions EXP 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of CSNK1E mRNA CTD PMID:21715664 bisphenol A decreases expression ISO RGD:732829 6480464 bisphenol A results in decreased expression of CSNK1E mRNA CTD PMID:20678512 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of CSNK1E mRNA CTD PMID:21266533 disodium selenite increases expression ISO RGD:732829 6480464 Sodium Selenite results in increased expression of CSNK1E mRNA CTD PMID:18175754 elemental selenium multiple interactions ISO RGD:732829 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of CSNK1E mRNA CTD PMID:19244175 elemental selenium increases expression ISO RGD:732829 6480464 Selenium results in increased expression of CSNK1E mRNA CTD PMID:19244175 hydrogen peroxide multiple interactions ISO RGD:732829 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CSNK1E protein CTD PMID:18951874 lead(0) affects phosphorylation ISO RGD:62045 6480464 Lead affects the phosphorylation of CSNK1E protein CTD PMID:22387731 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of CSNK1E mRNA CTD PMID:17562736 phenobarbital multiple interactions EXP 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CSNK1E mRNA] CTD PMID:19482888 phenobarbital affects expression ISO RGD:732829 6480464 Phenobarbital affects the expression of CSNK1E mRNA CTD PMID:19159669 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of CSNK1E mRNA CTD PMID:19482888 pirinixic acid multiple interactions ISO RGD:732829 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CSNK1E mRNA CTD PMID:19710929 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of CSNK1E mRNA CTD PMID:21278054 selenium atom multiple interactions ISO RGD:732829 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of CSNK1E mRNA CTD PMID:19244175 selenium atom increases expression ISO RGD:732829 6480464 Selenium results in increased expression of CSNK1E mRNA CTD PMID:19244175 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of CSNK1E mRNA CTD PMID:17484886 theophylline multiple interactions ISO RGD:732829 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of CSNK1E protein CTD PMID:18951874 vancomycin decreases expression EXP 6480464 Vancomycin results in decreased expression of CSNK1E mRNA CTD PMID:18930951
Biological Process
cellular protein localization IDA 2290270 MGI:MGI:3029636|PMID:14966280 MGI MGI:MGI:3029636 PMID:14966280 circadian rhythm TAS 2290270 MGI:MGI:2179885|PMID:12024206 MGI MGI:MGI:2179885 PMID:12024206 negative regulation of Wnt receptor signaling pathway IGI MGI:MGI:94941 2290270 MGI:MGI:3029636|PMID:14966280 MGI MGI:MGI:3029636 PMID:14966280 phosphorylation IEA UniProtKB-KW:KW-0418 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 positive regulation of canonical Wnt receptor signaling pathway IGI MGI:MGI:94941 2290270 MGI:MGI:3029636|PMID:14966280 MGI MGI:MGI:3029636 PMID:14966280 positive regulation of canonical Wnt receptor signaling pathway IGI MGI:MGI:106613 2290270 MGI:MGI:3721039|PMID:17606995 MGI MGI:MGI:3721039 PMID:17606995 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 2290270 MGI:MGI:3849793|PMID:19414593 UniProtKB MGI:MGI:3849793 PMID:19414593 protein phosphorylation IDA 2290270 MGI:MGI:3029636|PMID:14966280 MGI MGI:MGI:3029636 PMID:14966280 protein phosphorylation ISO RGD:62045 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 protein phosphorylation IDA 2290270 MGI:MGI:3849793|PMID:19414593 UniProtKB MGI:MGI:3849793 PMID:19414593 Wnt receptor signaling pathway IEA UniProtKB-KW:KW-0879 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194
Cellular Component
cytoplasm ISO RGD:62045 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 nucleus IDA 2290270 MGI:MGI:3849793|PMID:19414593 UniProtKB MGI:MGI:3849793 PMID:19414593 nucleus ISO RGD:62045 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 ribonucleoprotein complex IDA 2290270 MGI:MGI:5085959|PMID:21709260 MGI MGI:MGI:5085959 PMID:21709260
Molecular Function
ATP binding IEA InterPro:IPR000719|InterPro:IPR017441 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098 ATP binding IEA UniProtKB-KW:KW-0067 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 kinase activity IEA UniProtKB-KW:KW-0418 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 nucleotide binding IEA UniProtKB-KW:KW-0547 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 protein binding IPI UniProtKB:O35973|UniProtKB:O54943 2290270 MGI:MGI:3849793|PMID:19414593 UniProtKB MGI:MGI:3849793 PMID:19414593 protein kinase activity IDA 2290270 MGI:MGI:3849793|PMID:19414593 UniProtKB MGI:MGI:3849793 PMID:19414593 protein serine/threonine kinase activity ISO RGD:62045 2290270 MGI:MGI:4417868 RGD MGI:MGI:4417868 transferase activity IEA UniProtKB-KW:KW-0808 2290270 MGI:MGI:1354194 UniProtKB MGI:MGI:1354194 transferase activity, transferring phosphorus-containing groups IEA InterPro:IPR011009 2290270 MGI:MGI:2152098 UniProtKB MGI:MGI:2152098
1300644 Fob3_m F-line obesity QTL 3 (mouse) 11.3 Not determined 15 43977147 89207467 Mouse 1357756 Alaa4_m alopecia areata 4 (mouse) Not determined 15 46349352 80349551 Mouse 1301006 Hfib1_m hepatic fibrogenesis 1 (mouse) Not determined 15 47266047 81266192 Mouse 1301860 Gct3_m granulosa cell tumorigenesis 3 (mouse) Not determined 15 47369309 81369404 Mouse 4141931 Vmmt13_m vertebral morphology and mechanical traits 13 (mouse) Not determined 15 48076746 82076890 Mouse 1357477 Lgdr2_m liver Gapd decay rate 2 (mouse) Not determined 15 48076746 82076890 Mouse 1301429 Pcir3_m periosteal circumference 3 (mouse) Not determined 15 48425075 82425209 Mouse 4141667 Dbm4_m diabetes modifier 4 (mouse) Not determined 15 49078834 82076890 Mouse 4142198 Hbtq_m habituation QTL (mouse) Not determined 15 51120421 85120546 Mouse 1301472 Pain1_m pain 1 (mouse) Not determined 15 51603920 85604207 Mouse 1301708 Cocrb14_m cocaine related behavior 14 (mouse) Not determined 15 51765096 85765232 Mouse 1301413 Daq14_m directional asymmetry QTL 14 (mouse) Not determined 15 51969216 85969330 Mouse 1301062 Pltpq4_m phospholipid transfer protein activity QTL 4 (mouse) Not determined 15 51969216 85969330 Mouse 4141372 Bwtq12_m body weight QTL 12 (mouse) Not determined 15 51969216 85969330 Mouse 1558976 Ptnu4_m proteinuria 4 (mouse) Not determined 15 51969216 85969330 Mouse 1302074 Bmd4_m bone mineral density 4 (mouse) Not determined 15 56154867 103347903 Mouse 1300800 Ses3_m salmonella enteritidis susceptibility 3 (mouse) Not determined 15 57075586 91075734 Mouse 1357407 Pfat4_m predicted fat percentage 4 (mouse) 8.6 Body fat amount predicted fat percentage 15 57075586 91075734 Mouse 1300538 Disso2_m dissociation of activity 2 (mouse) Not determined 15 57745784 91745947 Mouse 1300844 Emo2_m emotionality 2 (mouse) Not determined 15 58304716 92304861 Mouse 4142246 Qbis4_m QTL for body weight independent of sex 4 (mouse) Not determined 15 61407245 95407357 Mouse 1301601 Faq9_m fluctuating asymmetry QTL 9 (mouse) Not determined 15 63110132 97110224 Mouse 4142487 Bmd37_m bone mineral density 37 (mouse) Not determined 15 63110132 97110224 Mouse 1558947 Ptnu5_m proteinuria 5 (mouse) Not determined 15 64032515 98032665 Mouse 1301004 Hdlq27_m HDL QTL 27 (mouse) Not determined 15 64032515 98032665 Mouse 4141135 Cia35_m collagen induced arthritis 35 (mouse) Not determined 15 64758055 98758175 Mouse 4141870 Dbsq2_m diabetes susceptibility QTL 2 (mouse) Not determined 15 67216927 101217076 Mouse 4141921 Pstc3_m periosteal circumference 3 (mouse) Not determined 15 67216927 101217076 Mouse 1558848 Marq5_m methamphetamine response QTL 5 (mouse) Not determined 15 67545799 101545941 Mouse 1300627 Sluc26_m susceptibility to lung cancer 26 (mouse) Not determined 15 70291882 103440060 Mouse 1300648 Dbsty4_m diabesity 4 (mouse) Not determined 15 70295500 103440060 Mouse 1300726 Pitm4_m prion incubation time 4 (mouse) Not determined 15 70295500 103440060 Mouse 1301721 Lipq3_m lipoprotein QTL 3 (mouse) Not determined 15 70295500 103440060 Mouse 4141363 Nhdlq9_m non-HDL QTL 9 (mouse) Not determined 15 72887788 103440060 Mouse 1558785 Ablp_m absorbance of eye lens protein (mouse) Not determined 15 72887788 103440060 Mouse 1357569 Fmgty13_m femur geometry 13 (mouse) Not determined 15 72887788 103440060 Mouse 1558995 Tsiq3_m T-cell secretion of IL-4 QTL 3 (mouse) Not determined 15 73583806 103440060 Mouse 4141515 Blmpf4_m bleomycin-induced pulmonary fibrosis 4 (mouse) Not determined 15 76461597 103440060 Mouse 1300851 Heal4_m wound healing/regeneration 4 (mouse) Not determined 15 77460142 103440060 Mouse 1301185 Hdlq4_m HDL QTL 4 (mouse) Not determined 15 79095961 103440060 Mouse