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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-amphetamine | increases expression | ISO | RGD:61986 | 6480464 | Dextroamphetamine results in increased expression of GRK6 mRNA | CTD | PMID:16715494 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRK6 mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | ISO | RGD:61986 | 6480464 | 2,4-dinitrotoluene affects the expression of GRK6 mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRK6 mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of GRK6 mRNA | CTD | PMID:18648102 | ammonium chloride | affects expression | ISO | RGD:61986 | 6480464 | Ammonium Chloride affects the expression of GRK6 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of GRK6 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of GRK6 mRNA | CTD | PMID:15034205 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | AHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of GRK6 mRNA] | CTD | PMID:15034205 | C60 fullerene | decreases expression | ISO | RGD:61986 | 6480464 | fullerene C60 results in decreased expression of GRK6 mRNA | CTD | PMID:19167457 | capsaicin | multiple interactions | EXP | | 6480464 | GRK6 mutant form promotes the reaction [Dextran Sulfate promotes the reaction [Capsaicin results in increased expression of FOS protein]] | CTD | PMID:18687398 | capsaicin | decreases response to substance | EXP | | 6480464 | GRK6 results in decreased susceptibility to Capsaicin | CTD | PMID:18687398 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRK6 gene | CTD | PMID:20938992 | clozapine | decreases expression | ISO | RGD:61986 | 6480464 | Clozapine results in decreased expression of GRK6 mRNA | CTD | PMID:16715494 | cocaine | affects expression | ISO | RGD:61986 | 6480464 | Cocaine affects the expression of GRK6 mRNA | CTD | PMID:20187946 | copper(2+) sulfate | decreases expression | ISO | RGD:1350771 | 6480464 | Copper Sulfate results in decreased expression of GRK6 mRNA | CTD | PMID:19549813 | coumestrol | increases expression | ISO | RGD:1350771 | 6480464 | Coumestrol results in increased expression of GRK6 mRNA | CTD | PMID:19167446 | dexamethasone | multiple interactions | ISO | RGD:61986 | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of GRK6 mRNA] | CTD | PMID:20032058 | dexamethasone | decreases expression | ISO | RGD:61986 | 6480464 | Dexamethasone results in decreased expression of GRK6 mRNA | CTD | PMID:20032058 | dextran sulfate | multiple interactions | EXP | | 6480464 | GRK6 mutant form promotes the reaction [Dextran Sulfate promotes the reaction [Capsaicin results in increased expression of FOS protein]] | CTD | PMID:18687398 | dextran sulfate | decreases response to substance | EXP | | 6480464 | GRK6 results in decreased susceptibility to Dextran Sulfate | CTD | PMID:18687398 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of GRK6 mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | RGD:61986 | 6480464 | Dibutyl Phthalate results in increased expression of GRK6 mRNA | CTD | PMID:21266533 | disodium selenite | increases expression | ISO | RGD:1350771 | 6480464 | Sodium Selenite results in increased expression of GRK6 mRNA | CTD | PMID:18175754 | dopamine | multiple interactions | ISO | RGD:61986 | 6480464 | GRK6 protein affects the reaction [Dopamine binds to DRD2 protein] | CTD | PMID:15716360 | elemental selenium | increases expression | ISO | RGD:1350771 | 6480464 | Selenium results in increased expression of GRK6 mRNA | CTD | PMID:19244175 | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRK6 gene | CTD | PMID:20938992 | haloperidol | decreases expression | ISO | RGD:61986 | 6480464 | Haloperidol results in decreased expression of GRK6 mRNA | CTD | PMID:16715494 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRK6 gene | CTD | PMID:20938992 | lead(0) | decreases expression | ISO | RGD:1350771 | 6480464 | Lead results in decreased expression of GRK6 mRNA | CTD | PMID:19921347 | nitroglycerin | decreases expression | ISO | RGD:61986 | 6480464 | Nitroglycerin results in decreased expression of GRK6 mRNA | CTD | PMID:12102619 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of GRK6 mRNA | CTD | PMID:17562736 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of GRK6 mRNA | CTD | PMID:18301758 | pirinixic acid | increases expression | ISO | RGD:61986 | 6480464 | pirinixic acid results in increased expression of GRK6 mRNA | CTD | PMID:19162173 | selenium atom | increases expression | ISO | RGD:1350771 | 6480464 | Selenium results in increased expression of GRK6 mRNA | CTD | PMID:19244175 | selenomethionine | affects expression | ISO | RGD:1350771 | 6480464 | Selenomethionine affects the expression of GRK6 mRNA | CTD | PMID:17222674 | testosterone | multiple interactions | ISO | RGD:61986 | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of GRK6 mRNA] | CTD | PMID:20032058 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Endocytosis | |
| Morphine addiction | |
| Pathway Interaction Database | CXCR4-mediated signaling events (PID:200099) |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Endocytosis | |
| Morphine addiction | |
| Pathway Interaction Database | CXCR4-mediated signaling events (PID:200099) |
Phenotype Annotations
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References - curated| 1. |
Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7. |
| 2. |
Ahmed MR, etal., Sci Transl Med. 2010 Apr 21;2(28):28ra28. |
| 3. |
Fong AM, etal., Proc Natl Acad Sci U S A 2002 May 28;99(11):7478-83. |
| 4. |
Gainetdinov RR, etal., Neuron. 2003 Apr 24;38(2):291-303. |
| 5. |
Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16. |
| 6. |
Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25. |
| 7. |
MGD and Homologene mouse data transfer |
| 8. |
MGD data from the GO Consortium |
| 9. |
MGD IEA |
| 10. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 11. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 12. |
Premont RT, etal., J Biol Chem 1999 Oct 8;274(41):29381-9. |
| 13. |
RGD automated import pipeline |
| 14. |
RGD automated import pipeline for gene-chemical interactions |
| 15. |
Sato H, etal., J Neurosci. 2011 Nov 16;31(46):16884-94. |
| 16. |
Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14. |
| 17. |
Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26. |
References - uncurated| PubMed | 10349636 |
| 10486211 | |
| 11042159 | |
| 11076861 | |
| 11217851 | |
| 12477932 | |
| 12520002 | |
| 14610273 | |
| 14634128 | |
| 14704365 | |
| 15716360 | |
| 15782199 | |
| 16141072 | |
| 16141073 | |
| 16302968 | |
| 16602821 | |
| 16980298 | |
| 17060617 | |
| 17538017 | |
| 17786238 | |
| 18180038 | |
| 18799693 | |
| 18977289 | |
| 19497686 | |
| 19801552 | |
| 20530803 | |
| 21267068 | |
| 22869904 | |
| 8889548 |
RGD Disease Portals| Grk6 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Grk6 (Mus musculus) |
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| GRK6 (Homo sapiens) |
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| Grk6 (Rattus norvegicus) |
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Position Markers| Gprk6 |
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| Y15798 |
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| RH141163 |
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| Grk6 |
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QTLs in Region (Mouse Genome Assembly Build 37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001038018 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001112711 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_011938 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHY01106492 | (Get FASTA) | Search GEO for Microarray Profiles |
| AF040747 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF040748 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF040749 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF040754 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK051405 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK146119 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK161142 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK179644 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK180303 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK192356 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AW048460 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC057206 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC075719 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466546 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CJ179645 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CT009762 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y15797 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y15798 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y15799 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y15800 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y17967 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_011938 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_036068 | |||||||||||||||||||||||||
| Peptide Label: | isoform b | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001038018 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001033107 | |||||||||||||||||||||||||
| Peptide Label: | isoform a | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001112711 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001106182 | |||||||||||||||||||||||||
| Peptide Label: | isoform c | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001033107 | (Get FASTA) |
| NP_001106182 | (Get FASTA) | |
| NP_036068 | (Get FASTA) | |
| GenBank Protein | AAC09263 | (Get FASTA) |
| AAC09264 | (Get FASTA) | |
| AAC09265 | (Get FASTA) | |
| AAC09268 | (Get FASTA) | |
| AAC09269 | (Get FASTA) | |
| AAC09270 | (Get FASTA) | |
| AAH75719 | (Get FASTA) | |
| BAE26914 | (Get FASTA) | |
| BAE36212 | (Get FASTA) | |
| CAA75788 | (Get FASTA) | |
| CAA75789 | (Get FASTA) | |
| CAA75790 | (Get FASTA) | |
| CAA75791 | (Get FASTA) | |
| CAA76974 | (Get FASTA) | |
| CAA76975 | (Get FASTA) | |
| CAA76976 | (Get FASTA) | |
| CAA76977 | (Get FASTA) | |
| EDL41192 | (Get FASTA) | |
| EDL41193 | (Get FASTA) | |
| EDL41194 | (Get FASTA) | |
| EDL41195 | (Get FASTA) | |
| EDL41196 | (Get FASTA) | |
| O70293 | (Get FASTA) |
Promoters| RGD ID: | 6824001 | ||||||||||
| Promoter ID: | MM_KWN:14241 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen | ||||||||||
| Transcripts: | NM_001038018, NM_001112711, NM_011938, UC007QQW.1, UC007QQY.1, UC007QQZ.1, UC007QRA.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000074886 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000001115 | ENTREZGENE |
| ENSMUSP00000097081 | ENTREZGENE | |
| Ensembl Transcript | ENSMUST00000001115 | ENTREZGENE |
| ENSMUST00000099482 | ENTREZGENE | |
| Entrez Gene | 26385 | ENTREZGENE |
| Germonline | ENSMUSG00000074886 | |
| HomoloGene Group ID | 37570 | ENTREZGENE |
| InterPro | AGC-kinase_C | UniProtKB/Swiss-Prot |
| GPCR_kinase | UniProtKB/Swiss-Prot | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Regulat_G_prot_signal | UniProtKB/Swiss-Prot | |
| Regulat_G_prot_signal_superfam | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_AS | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00230631 | UniProtKB/Swiss-Prot |
| IPI00467856 | UniProtKB/Swiss-Prot | |
| IPI00875987 | UniProtKB/TrEMBL | |
| IPI01023290 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:26385 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1347078 | ENTREZGENE |
| Pfam | Pkinase | UniProtKB/Swiss-Prot |
| RGS | UniProtKB/Swiss-Prot | |
| PRINTS | GPCRKINASE | UniProtKB/Swiss-Prot |
| PROSITE | AGC_KINASE_CTER | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| RGS | UniProtKB/Swiss-Prot | |
| SMART | RGS | UniProtKB/Swiss-Prot |
| S_TK_X | UniProtKB/Swiss-Prot | |
| S_TKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| Regulat_G_prot_signal_superfam | UniProtKB/Swiss-Prot | |
| UniGene | Mm.10193 | ENTREZGENE |
| UniProt | GRK6_MOUSE | UniProtKB/Swiss-Prot |
| Q3TTW2_MOUSE | UniProtKB/TrEMBL | |
| Q3UK88_MOUSE | UniProtKB/TrEMBL | |
| Q9EP84_MOUSE | UniProtKB/TrEMBL | |
| Q9EPB9_MOUSE | UniProtKB/TrEMBL |
| More on Grk6 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 62278 |
| Created: | 2001-04-11 |
| Species: | Mus musculus |
| Last Modified: | 2013-02-27 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




