Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | UNC5A (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of UNC5A mRNA | CTD | PMID:24763279 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Testosterone co-treated with Estradiol] results in increased expression of UNC5A mRNA | CTD | PMID:32741896 | 17beta-estradiol | increases expression | ISO | UNC5A (Homo sapiens) | 6480464 | Estradiol results in increased expression of UNC5A mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Unc5a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of UNC5A mRNA | CTD | PMID:21570461 | 2-methylcholine | affects expression | ISO | UNC5A (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of UNC5A mRNA | CTD | PMID:21179406 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Unc5a (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of UNC5A exon | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Unc5a (Mus musculus) | 6480464 | bisphenol S affects the methylation of UNC5A gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Unc5a (Mus musculus) | 6480464 | Fenretinide results in decreased expression of UNC5A mRNA | CTD | PMID:28973697 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of UNC5A mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | ISO | UNC5A (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of UNC5A mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | UNC5A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of UNC5A intron | CTD | PMID:30157460 | Aflatoxin B2 alpha | increases methylation | ISO | UNC5A (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of UNC5A intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | UNC5A (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of UNC5A mRNA | CTD | PMID:23724009 | atrazine | increases expression | ISO | UNC5A (Homo sapiens) | 6480464 | Atrazine results in increased expression of UNC5A mRNA | CTD | PMID:22378314 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of UNC5A gene | CTD | PMID:35440735 | benzo[a]pyrene | multiple interactions | ISO | Unc5a (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to UNC5A promoter] | CTD | PMID:19654925 | benzo[a]pyrene | decreases expression | ISO | UNC5A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of UNC5A mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | UNC5A (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of UNC5A intron | CTD | PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | UNC5A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of UNC5A 3' UTR and Benzo(a)pyrene results in increased methylation of UNC5A promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | Unc5a (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of UNC5A intron | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | UNC5A (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of UNC5A intron | CTD | PMID:30157460 | Benzo[ghi]perylene | increases expression | ISO | Unc5a (Mus musculus) | 6480464 | 1 and 12-benzoperylene results in increased expression of UNC5A mRNA | CTD | PMID:26377693 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of UNC5A mRNA | CTD | PMID:25607892 | bisphenol A | increases methylation | ISO | UNC5A (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of UNC5A gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | UNC5A (Homo sapiens) | 6480464 | bisphenol A results in increased expression of UNC5A mRNA | CTD | PMID:31715268 | bisphenol A | increases expression | ISO | Unc5a (Mus musculus) | 6480464 | bisphenol A results in increased expression of UNC5A mRNA | CTD | PMID:30245210 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of UNC5A mRNA | CTD | PMID:25181051 and PMID:30816183 | Butylparaben | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of UNC5A mRNA | CTD | PMID:25607892 | cadmium atom | multiple interactions | ISO | Unc5a (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of UNC5A mRNA and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of UNC5A mRNA | CTD | PMID:36114956 and PMID:37325564 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of UNC5A promoter | CTD | PMID:22457795 | cadmium dichloride | multiple interactions | ISO | Unc5a (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of UNC5A mRNA and [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of UNC5A mRNA | CTD | PMID:36114956 and PMID:37325564 | carbon nanotube | decreases expression | ISO | Unc5a (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of UNC5A mRNA | CTD | PMID:25620056 | CGP 52608 | multiple interactions | ISO | UNC5A (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to UNC5A gene] | CTD | PMID:28238834 | chlorpyrifos | increases expression | ISO | Unc5a (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of UNC5A mRNA | CTD | PMID:32715474 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of UNC5A mRNA | CTD | PMID:26033743 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of UNC5A mRNA | CTD | PMID:26033743 | diazinon | affects expression | EXP | | 6480464 | Diazinon affects the expression of UNC5A mRNA | CTD | PMID:22546817 | dibenz[a,h]anthracene | increases expression | ISO | Unc5a (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | dorsomorphin | multiple interactions | ISO | UNC5A (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | enzacamene | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of UNC5A mRNA | CTD | PMID:25607892 | ethanol | affects splicing | ISO | Unc5a (Mus musculus) | 6480464 | Ethanol affects the splicing of UNC5A mRNA | CTD | PMID:30319688 | ethanol | increases expression | ISO | Unc5a (Mus musculus) | 6480464 | Ethanol results in increased expression of UNC5A mRNA | CTD | PMID:30319688 | lead(0) | affects expression | ISO | UNC5A (Homo sapiens) | 6480464 | Lead affects the expression of UNC5A mRNA | CTD | PMID:28903495 | methapyrilene | increases methylation | ISO | UNC5A (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of UNC5A intron | CTD | PMID:30157460 | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of UNC5A gene | CTD | PMID:35440735 | methylmercury chloride | increases expression | ISO | UNC5A (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of UNC5A mRNA | CTD | PMID:34089799 | N-nitrosodiethylamine | multiple interactions | ISO | Unc5a (Mus musculus) | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of UNC5A gene | CTD | PMID:23968726 | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of UNC5A mRNA | CTD | PMID:22546817 | ozone | decreases expression | EXP | | 6480464 | Ozone results in decreased expression of UNC5A mRNA | CTD | PMID:16330353 | panobinostat | multiple interactions | ISO | UNC5A (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UNC5A mRNA | CTD | PMID:27188386 | panobinostat | decreases expression | ISO | UNC5A (Homo sapiens) | 6480464 | panobinostat results in decreased expression of UNC5A mRNA | CTD | PMID:26272509 | paracetamol | decreases expression | ISO | UNC5A (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of UNC5A mRNA | CTD | PMID:29067470 | phenylmercury acetate | decreases expression | ISO | UNC5A (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of UNC5A mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | UNC5A (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UNC5A mRNA | CTD | PMID:27188386 | piperonyl butoxide | multiple interactions | ISO | Unc5a (Mus musculus) | 6480464 | [Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of UNC5A gene | CTD | PMID:23968726 | propanal | decreases expression | ISO | UNC5A (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of UNC5A mRNA | CTD | PMID:26079696 | resveratrol | multiple interactions | ISO | UNC5A (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of UNC5A mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | UNC5A (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silver atom | decreases expression | ISO | Unc5a (Mus musculus) | 6480464 | Silver results in decreased expression of UNC5A mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Unc5a (Mus musculus) | 6480464 | Silver results in decreased expression of UNC5A mRNA | CTD | PMID:27131904 | sodium arsenite | decreases expression | ISO | UNC5A (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of UNC5A mRNA | CTD | PMID:29301061 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of UNC5A mRNA | CTD | PMID:35314868 | testosterone | multiple interactions | EXP | | 6480464 | [Testosterone co-treated with Estradiol] results in increased expression of UNC5A mRNA | CTD | PMID:32741896 | tetrachloromethane | affects expression | ISO | Unc5a (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of UNC5A mRNA | CTD | PMID:17484886 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of UNC5A mRNA | CTD | PMID:31150632 | titanium dioxide | decreases expression | ISO | Unc5a (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of UNC5A mRNA | CTD | PMID:29264374 | trichostatin A | decreases expression | ISO | UNC5A (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of UNC5A mRNA | CTD | PMID:24935251 | trichostatin A | increases expression | ISO | UNC5A (Homo sapiens) | 6480464 | trichostatin A results in increased expression of UNC5A mRNA | CTD | PMID:24935251 | triptonide | increases expression | ISO | Unc5a (Mus musculus) | 6480464 | triptonide results in increased expression of UNC5A mRNA | CTD | PMID:33045310 | valproic acid | affects expression | ISO | UNC5A (Homo sapiens) | 6480464 | Valproic Acid affects the expression of UNC5A mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | UNC5A (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of UNC5A mRNA | CTD | PMID:23179753 and PMID:27188386 | zoledronic acid | increases expression | ISO | UNC5A (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of UNC5A mRNA | CTD | PMID:24714768 | |