Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-nicotine | multiple interactions | ISO | RGD:1552783 | 6480464 | Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UBB mRNA]; more ... | CTD | PMID:20230807 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | increases expression | ISO | RGD:1552783 | 6480464 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UBB mRNA | CTD | PMID:20230807 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | ISO | RGD:1552783 | 6480464 | Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of UBB mRNA]; more ... | CTD | PMID:20230807 | 17beta-estradiol | multiple interactions | ISO | RGD:1344008 | 6480464 | diindolylmethane promotes the reaction [Estradiol results in increased expression of UBB mRNA]; more ... | CTD | PMID:11179685 | 17beta-estradiol | decreases expression | ISO | RGD:1344008 | 6480464 | Estradiol results in decreased expression of UBB mRNA | CTD | PMID:23019147 | 17beta-estradiol | increases expression | ISO | RGD:1344008 | 6480464 | Estradiol results in increased expression of UBB mRNA | CTD | PMID:20106945 PMID:11179685 | 17beta-estradiol | increases expression | ISO | RGD:1344008 | 6480464 | Estradiol results in increased expression of UBB mRNA | CTD | PMID:11179685 PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1344008 | 6480464 | Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of UBB mRNA] | CTD | PMID:11179685 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1552783 | 6480464 | Tetrachlorodibenzodioxin affects the expression of UBB mRNA | CTD | PMID:21570461 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:1552783 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of UBB mRNA | CTD | PMID:18648102 | 4-hydroperoxycyclophosphamide | decreases expression | ISO | RGD:1552783 | 6480464 | perfosfamide results in decreased expression of UBB mRNA | CTD | PMID:19429390 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of UBB mRNA | CTD | PMID:16483693 | astaxanthin | multiple interactions | ISO | RGD:1552783 | 6480464 | astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of UBB mRNA] | CTD | PMID:16964424 | bisphenol A | increases expression | ISO | RGD:1344008 | 6480464 | bisphenol A results in increased expression of UBB mRNA | CTD | PMID:15223131 | cadmium sulfate | increases expression | ISO | RGD:1344008 | 6480464 | cadmium sulfate results in increased expression of UBB mRNA | CTD | PMID:21783983 | cadmium sulfate | increases expression | ISO | RGD:1344008 | 6480464 | cadmium sulfate results in increased expression of UBB mRNA | CTD | PMID:12064557 PMID:21783983 | cadmium sulfate | increases expression | ISO | RGD:1344008 | 6480464 | cadmium sulfate results in increased expression of UBB mRNA | CTD | PMID:21783983 PMID:12064557 | caffeine | multiple interactions | ISO | RGD:1552783 | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of UBB mRNA; more ... | CTD | PMID:20230807 | calcium atom | affects expression | EXP | | 6480464 | Calcium affects the expression of UBB mRNA | CTD | PMID:15913539 | calcium(0) | affects expression | EXP | | 6480464 | Calcium affects the expression of UBB mRNA | CTD | PMID:15913539 | cisplatin | decreases expression | ISO | RGD:1344008 | 6480464 | Cisplatin results in decreased expression of UBB protein | CTD | PMID:20540955 | cobalt dichloride | increases expression | ISO | RGD:1344008 | 6480464 | cobaltous chloride results in increased expression of UBB mRNA | CTD | PMID:19320972 | cobalt dichloride | increases expression | ISO | RGD:1344008 | 6480464 | cobaltous chloride results in increased expression of UBB mRNA | CTD | PMID:17553155 PMID:19320972 | copper(2+) sulfate | affects expression | ISO | RGD:1344008 | 6480464 | Copper Sulfate affects the expression of UBB mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | RGD:1344008 | 6480464 | Cyclosporine results in increased expression of UBB mRNA | CTD | PMID:20106945 | diazoxide | increases expression | ISO | RGD:1552783 | 6480464 | Isoproterenol results in increased expression of UBB mRNA | CTD | PMID:21335049 | isoprenaline | increases expression | ISO | RGD:1552783 | 6480464 | Isoproterenol results in increased expression of UBB mRNA | CTD | PMID:21335049 | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of UBB mRNA | CTD | PMID:20737472 | menadione | affects expression | ISO | RGD:1344008 | 6480464 | Vitamin K 3 affects the expression of UBB mRNA | CTD | PMID:20044591 | nickel atom | multiple interactions | ISO | RGD:1552783 | 6480464 | MT1 affects the reaction [Nickel affects the expression of UBB mRNA]; more ... | CTD | PMID:16166738 | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of UBB mRNA | CTD | PMID:16330353 | paracetamol | affects expression | ISO | RGD:1552783 | 6480464 | Acetaminophen affects the expression of UBB mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1552783 | 6480464 | Acetaminophen results in increased expression of UBB protein | CTD | PMID:21329376 | phlorizin | increases expression | ISO | RGD:1552783 | 6480464 | Phlorhizin results in increased expression of UBB mRNA | CTD | PMID:22538082 | propiconazole | increases expression | ISO | RGD:1552783 | 6480464 | propiconazole results in increased expression of UBB mRNA | CTD | PMID:21278054 | propiconazole | increases expression | ISO | RGD:1552783 | 6480464 | propiconazole results in increased expression of UBB mRNA | CTD | PMID:21278054 PMID:22334560 | pyrogallol | increases expression | ISO | RGD:1552783 | 6480464 | Pyrogallol results in increased expression of UBB mRNA | CTD | PMID:20362636 | quercetin | decreases expression | EXP | | 6480464 | Quercetin results in decreased expression of UBB protein | CTD | PMID:18095365 | raloxifene | affects expression | EXP | | 6480464 | Raloxifene affects the expression of UBB mRNA | CTD | PMID:16079270 | resveratrol | affects expression | EXP | | 6480464 | resveratrol affects the expression of UBB mRNA | CTD | PMID:15748624 | rosiglitazone | affects expression | ISO | RGD:1552783 | 6480464 | rosiglitazone affects the expression of UBB protein | CTD | PMID:21347706 | toluene | affects expression | EXP | | 6480464 | Toluene affects the expression of UBB mRNA | CTD | PMID:21827849 | trans-resveratrol | affects expression | EXP | | 6480464 | resveratrol affects the expression of UBB mRNA | CTD | PMID:15748624 | valproic acid | affects expression | ISO | RGD:1552783 | 6480464 | Valproic Acid affects the expression of UBB mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Parkinson's disease |
Disease AnnotationsGene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
Molecular Pathway AnnotationsReferences - curated| 1. |
Hayashi T, etal., Biochim Biophys Acta 1994 Jun 21;1218(2):232-4. |
| 2. |
MGD data from the GO Consortium |
| 3. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 4. |
Noga M, etal., Neuroreport 1997 Mar 24;8(5):1239-41. |
| 5. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 6. |
RGD automated data pipeline |
| 7. |
RGD automated import pipeline for gene-chemical interactions |
| 8. |
RGD Automated Pipelines |
| 9. |
Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
References - uncuratedRGD Disease Portals| Ubb has been annotated in the following RGD Disease Portals. |
|||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
Comparative Map Data| Ubb (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| UBB (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Ubb (Mus musculus) |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_138895 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06064169 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06064170 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01064310 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01064311 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC060312 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC070919 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC078726 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D16554 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X92661 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_138895 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_620250 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_620250 | (Get FASTA) |
| GenBank Protein | AAH60312 | (Get FASTA) |
| AAH70919 | (Get FASTA) | |
| BAA03983 | (Get FASTA) | |
| CAA63349 | (Get FASTA) | |
| EDM04743 | (Get FASTA) | |
| P0CG51 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Entrez Gene | 192255 | ENTREZGENE |
| Germonline | ENSRNOG00000004426 | UniProtKB/Swiss-Prot |
| ENSRNOG00000019974 | UniProtKB/Swiss-Prot | |
| ENSRNOG00000028756 | UniProtKB/Swiss-Prot | |
| ENSRNOG00000032872 | UniProtKB/Swiss-Prot | |
| ENSRNOG00000034246 | UniProtKB/Swiss-Prot | |
| ENSRNOG00000037930 | UniProtKB/Swiss-Prot | |
| HomoloGene Group ID | 74981 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:6919609 | IMAGE-MGC_LOAD |
| IMAGE:7104905 | IMAGE-MGC_LOAD | |
| IMAGE:7126996 | IMAGE-MGC_LOAD | |
| InterPro | Ubiquitin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| Ubiquitin_CS | UniProtKB/Swiss-Prot | |
| Ubiquitin_subgroup | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| Ubiquitin_supergroup | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| IPI | IPI00882520 | UniProtKB/Swiss-Prot |
| IPI00968520 | UniProtKB/TrEMBL | |
| KEGG Report | rno:192255 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:72686 | IMAGE-MGC_LOAD |
| MGC:91487 | IMAGE-MGC_LOAD | |
| MGC:93171 | IMAGE-MGC_LOAD | |
| Pfam | ubiquitin | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| PRINTS | UBIQUITIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
| PROSITE | UBIQUITIN_1 | UniProtKB/Swiss-Prot |
| UBIQUITIN_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
| SMART | UBQ | UniProtKB/Swiss-Prot |
| UniGene | Rn.110618 | ENTREZGENE |
| Rn.1253 | ENTREZGENE | |
| Rn.3761 | ENTREZGENE | |
| UniProt | Q63654_RAT | UniProtKB/TrEMBL |
| UBB_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-02-25 | Ubb | ubiquitin B | Ubb | polyubiquitin | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2004-09-10 | Ubb | polyubiquitin | Loc192255 | Symbol and Name updated | 10779 | APPROVED | |
| 2002-08-07 | Loc192255 | polyubiquitin | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_regulation | mRNA highly induced following ischaemia in the central zone of the middle cerebral artery (MCA) | 724407 |
| More on Ubb | |
|
Entrez Gene |
|
Ensembl Gene |
| Genome Browser |
|
NCBI Map Viewer |
|
Vista |
|
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621562 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.